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3 papers 0 to 25 followers Próstata artigos
https://www.readbyqxmd.com/read/22277570/dutasteride-in-localised-prostate-cancer-management-the-redeem-randomised-double-blind-placebo-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
Neil E Fleshner, M Scott Lucia, Blair Egerdie, Lorne Aaron, Gregg Eure, Indrani Nandy, Libby Black, Roger S Rittmaster
BACKGROUND: We aimed to investigate the safety and efficacy of dutasteride, a 5α-reductase inhibitor, on prostate cancer progression in men with low-risk disease who chose to be followed up with active surveillance. METHODS: In our 3 year, randomised, double-blind, placebo-controlled study, undertaken at 65 academic medical centres or outpatient clinics in North America, we enrolled men aged 48-82 years who had low-volume, Gleason score 5-6 prostate cancer and had chosen to be followed up with active surveillance...
March 24, 2012: Lancet
https://www.readbyqxmd.com/read/22169269/conventional-versus-hypofractionated-high-dose-intensity-modulated-radiotherapy-for-prostate-cancer-preliminary-safety-results-from-the-chhip-randomised-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
David Dearnaley, Isabel Syndikus, Georges Sumo, Margaret Bidmead, David Bloomfield, Catharine Clark, Annie Gao, Shama Hassan, Alan Horwich, Robert Huddart, Vincent Khoo, Peter Kirkbride, Helen Mayles, Philip Mayles, Olivia Naismith, Chris Parker, Helen Patterson, Martin Russell, Christopher Scrase, Chris South, John Staffurth, Emma Hall
BACKGROUND: Prostate cancer might have high radiation-fraction sensitivity, implying a therapeutic advantage of hypofractionated treatment. We present a pre-planned preliminary safety analysis of side-effects in stages 1 and 2 of a randomised trial comparing standard and hypofractionated radiotherapy. METHODS: We did a multicentre, randomised study and recruited men with localised prostate cancer between Oct 18, 2002, and Aug 12, 2006, at 11 UK centres. Patients were randomly assigned in a 1:1:1 ratio to receive conventional or hypofractionated high-dose intensity-modulated radiotherapy, and all were given with 3-6 months of neoadjuvant androgen suppression...
January 2012: Lancet Oncology
https://www.readbyqxmd.com/read/24691606/tadalafil-for-prevention-of-erectile-dysfunction-after-radiotherapy-for-prostate-cancer-the-radiation-therapy-oncology-group-0831-randomized-clinical-trial
#3
RANDOMIZED CONTROLLED TRIAL
Thomas M Pisansky, Stephanie L Pugh, Richard E Greenberg, Nadeem Pervez, Daniel R Reed, Seth A Rosenthal, Rex B Mowat, Adam Raben, Mark K Buyyounouski, Lisa A Kachnic, Deborah W Bruner
IMPORTANCE: Tadalafil is used to treat erectile dysfunction after prostate cancer treatment, but its role as a preventive agent is undefined. OBJECTIVES: To determine primarily whether tadalafil preserved erectile function in men treated with radiotherapy for prostate cancer, and secondarily to determine whether participant- or partner-reported overall sexual function and sexual and marital satisfaction were affected. DESIGN, SETTING, AND PARTICIPANTS: Stratified, placebo-controlled, double-blind, parallel-group study with 1:1 randomization at 76 community-based and tertiary medical sites in the United States and Canada...
April 2, 2014: JAMA: the Journal of the American Medical Association
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