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By Miguel Gaitan I'm a dermatologist and dermatopathologist from Colombia
https://www.readbyqxmd.com/read/27004972/mucosal-malignant-melanoma-a-clinical-oncological-pathological-and-genetic-survey
#1
Lauge H Mikkelsen, Ann-Cathrine Larsen, Christian von Buchwald, Krzysztof T Drzewiecki, Jan U Prause, Steffen Heegaard
Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people...
June 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/25582536/predictive-value-of-biopsy-specimens-suspicious-for-melanoma-support-for-6-mm-criterion-in-the-abcd-rule
#2
Razieh Soltani-Arabshahi, Carol Sweeney, Benjamin Jones, Scott R Florell, Nan Hu, Douglas Grossman
OBJECTIVE: Clinical detection of melanoma can be challenging. The number of biopsy specimens performed to diagnose 1 melanoma is a measure of efficiency of skin cancer detection, but few data are available to describe this measure from US health care. We studied the diagnosis of melanoma among biopsy specimens of clinically concerning pigmented lesions at an academic dermatology department. METHODS: We searched for all biopsy specimens that were performed because of clinical suspicion of melanoma in 2013...
March 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/25631244/-treatment-side-effects-and-follow-up-of-malignant-melanoma
#3
T Stahl, C Loquai
Side effects in the therapy of malignant melanoma are primarily of importance for radiologists in advanced tumor stages. The available treatment options and their respective side effect profiles have undergone a profound change in recent years after the introduction of modern oncological therapies (e.g. immunotherapy and targeted therapy) with an increasing focus on individual tumor biology and differ significantly from those of classical chemotherapy. The immunotherapeutic agents, in particular ipilimumab, take on a special position because of their specific immune-mediated mechanisms of action and the associated side effects, so-called immune-related adverse events (irAE)...
February 2015: Der Radiologe
https://www.readbyqxmd.com/read/25643778/-cutaneous-melanoma-cm-current-diagnosis-and-treatment
#4
José Francisco Gallegos Hernández, Omgo E Nieweg
Cutaneous melanoma (CM) is the third most common cancer of the skin, but it is the neoplasia with the greatest impact on mortality. Its etiology is multifactorial and it has been reported that its prevalence has increased in the last two decades. In Mexico, CM ranks seventh in frequency among all malignancies and 80% of cases are in locally advanced stages. The prognosis depends on the stage. The prognostic factors with greatest impact in survival are nodal status, tumor thickness or Breslow depth, ulceration, and in thin melanomas (< 1 mm thickness, without ulceration and Clarck level III), the mitotic index...
December 2014: Gaceta Médica de México
https://www.readbyqxmd.com/read/25384702/melanoma-of-the-vulva-and-vagina-principles-of-staging-and-their-relevance-to-management-based-on-a-clinicopathologic-analysis-of-85-cases
#5
COMPARATIVE STUDY
Susan Seifried, Lauren E Haydu, Michael J Quinn, Richard A Scolyer, Jonathan R Stretch, John F Thompson
BACKGROUND: Primary melanomas of the vulva and vagina are rare. As a result, it has been difficult to develop evidence-based guidelines for their management. By analyzing a large series of patients with vulval and vaginal melanomas, this study sought to document the most common presenting features, identify clinical and pathologic predictors of outcome, and provide management guidelines. METHODS: A clinicopathologic analysis of 85 patients with primary melanomas of the vulva or vagina diagnosed and treated at Melanoma Institute Australia and associated units in Sydney, Australia, between 1960 and 2011 was performed...
2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25474450/tumor-volume-an-adjunct-prognostic-factor-in-cutaneous-melanoma
#6
Robert G Walton, Jinah Kim, Cruz Velasco, Susan M Swetter
Measurement of tumor volume may be a helpful adjunct to established prognostic factors in cutaneous melanoma, including Breslow depth, presence or absence of ulceration, mitotic index, lymphovascular invasion, and microsatellites. This report expands on the theory that a tumor volume cutoff point of 250 mm³ as measured by surface area of the lesion (ie, longest vertical and horizontal measurements either based on clinical or gross pathological assessment) multiplied by the Breslow depth could serve as a potentially relevant predictor of sentinel lymph node (SLN) metastasis in both thin and thick invasive cutaneous melanomas, which prompted investigation of a larger sample size using the pathology database at our institution...
November 2014: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/25532790/molecular-alterations-in-melanoma-and-targeted-therapies
#7
Samia Mourah, Céleste Lebbé
Melanoma is a skin cancer whose incidence is increasing steadily. The recent discovery of frequent and recurrent genetic alterations in cutaneous melanoma allowed a molecular classification of tumors into distinct subgroups, and paved the way for targeted therapy. Several signaling pathways are involved in the progression of this disease with oncogenic mutations affecting signaling pathways: MAPK, PI3K, cAMP and cyclin D1/CDK4. In each of these pathways, several potential therapeutic targets have been identified and specific inhibitors have already been developed and have shown clinical efficacy...
December 2014: Bulletin du Cancer
https://www.readbyqxmd.com/read/25572745/wrong-melanoma-thickness-measurement-check-it-or-leave-it
#8
LETTER
A A Chokoeva, G Tchernev, S Philipov, J C Cardoso, M Zanardelli, T Lotti
Cutaneous malignant melanoma (CMM) is one of the most aggressive forms of skin cancer, accounting for about 90% of deaths from cutaneous neoplasms, and its incidence has increased significantly in recent years. According to the 2012 European criteria for diagnosis and treatment of malignant melanoma, diagnosis should be based on the combination of clinical features, dermoscopic data and histological examination, preferably after excisional biopsy. Tumour thickness and other parameters for local staging according to the AJCC classification should be included in the pathology report...
October 2014: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/25605514/tumor-mitotic-rate-added-to-the-equation-melanoma-prognostic-factors-changed-a-single-institution-database-study-on-the-prognostic-value-of-tumor-mitotic-rate-for-sentinel-lymph-node-status-and-survival-of-cutaneous-melanoma-patients
#9
M J Speijers, E Bastiaannet, S Sloot, A J H Suurmeijer, H J Hoekstra
BACKGROUND: This study aimed to investigate the predictive value of the tumor mitotic rate per mm(2) (TMR) for sentinel lymph node (SLN) status and survival in intermediate and thick cutaneous melanoma. METHODS: Patients treated for stage I and II melanoma with wide local excision and SLN biopsy between May 1995 and May 2013 were analyzed. In case of insufficient data regarding TMR, pathology slides were reanalyzed. Prognostic factors for SLN status and survival were analyzed with the emphasis on TMR, which was analyzed as a continuous variable, dichotomized (median value) and categorized by two methods...
September 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25623140/prognostic-and-predictive-values-of-oncogenic-braf-nras-c-kit-and-mitf-in-cutaneous-and-mucous-melanoma
#10
M Pracht, A Mogha, A Lespagnol, A Fautrel, N Mouchet, F Le Gall, V Paumier, C Lefeuvre-Plesse, N Rioux-Leclerc, J Mosser, E Oger, H Adamski, M-D Galibert, T Lesimple
BACKGROUND: Mutations of BRAF, NRAS and c-KIT oncogenes are preferentially described in certain histological subtypes of melanoma and linked to specific histopathological features. BRAF-, MEK- and KIT-inhibitors led to improvement in overall survival of patients harbouring mutated metastatic melanoma. OBJECTIVES: To assess the prevalence and types of BRAF, NRAS, c-KIT and MITF mutations in cutaneous and mucous melanoma and to correlate mutation status with clinicopathological features and outcome...
August 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/25592837/melanoma-characteristics-in-brazil-demographics-treatment-and-survival-analysis
#11
Vinicius de Lima Vazquez, Thiago Buosi Silva, Marcelo de Andrade Vieira, Antônio Talvane Torres de Oliveira, Marcílio Vital Lisboa, Diocésio Alves Pinto de Andrade, José Humberto Tavares Guerreiro Fregnani, Estela Cristina Carneseca
BACKGROUND: The incidence of melanoma, one of the most aggressive of the skin cancers, has been increasing worldwide in the last few decades. Data from Latin America and Brazil remain scarce. We aimed to describe the demographic, clinical, and histopathological data; therapy characteristics; and survival rates of the Brazilian melanoma patient population. RESULTS: We collected and analysed retrospective data from 15 years at a tertiary cancer centre. We describe patient characteristics and treatment...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/25595509/quality-assurance-in-melanoma-surgery-the-evolving-experience-at-a-large-tertiary-referral-centre
#12
COMPARATIVE STUDY
R L Read, S Pasquali, L Haydu, J F Thompson, J R Stretch, R P M Saw, M J Quinn, K Shannon, A J Spillane
BACKGROUND: The quality of melanoma surgery needs to be assessed by oncological outcome and complication rates. There is no published consensus on complication rates for common melanoma surgeries, namely wide excision (WE), sentinel node biopsy (SNB) and regional lymph node dissection (RLND). Consequently there are no agreed standards by which surgeons can audit their practices. METHODS: Surgical standards were proposed in 2008 following review of the literature and from expert opinion...
July 2015: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25526608/interventions-for-melanoma-in-situ-including-lentigo-maligna
#13
REVIEW
Thrasivoulos Tzellos, Athanassios Kyrgidis, Simone Mocellin, An-Wen Chan, Pierluigi Pilati, Zoe Apalla
BACKGROUND: Malignant melanoma is a form of skin cancer associated with significant mortality once it has spread beyond the skin. Melanoma in situ (MIS) is the earliest histologically recognisable stage of malignant melanoma and represents a precursor of invasive melanoma. Lentigo maligna (LM) represents a subtype of pre-invasive intraepidermal melanoma associated specifically with chronic exposure to ultraviolet (UV) radiation. Over the past two decades, the incidence of MIS has increased significantly, even more than the invasive counterpart...
December 19, 2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25338349/primary-penile-melanoma
#14
R Andrei, Mirela Cioplea, V Mageriu, A Chuaibi, V Cauni, Sabina Zurac, Florica Staniceanu
Primary penile melanomas are exceedingly rare (less than 1% of primary penile cancers), 221 cases being reported to date in PubMed indexed medical literature. More than half of the cases occur on the gland, usually in older people than on cutaneous counterpart and have unfavourable prognosis mainly due to the belated diagnosis. We report the case of a 77 years old male diagnosed with a pigmented ulcerated nodular melanoma of the gland with maximal thickness of 4.5 mm, mitotic index 8 mitoses/mm2 and vascular emboli...
April 2014: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/25341653/immunohistochemistry-is-highly-sensitive-and-specific-for-the-detection-of-nrasq61r-mutation-in-melanoma
#15
Daniela Massi, Lisa Simi, Elisa Sensi, Gianna Baroni, Gongda Xue, Cristian Scatena, Adele Caldarella, Pamela Pinzani, Gabriella Fontanini, Alessandra Carobbio, Carmelo Urso, Mario Mandalà
Testing for NRAS is now integral part in the assessment of metastatic melanoma patients because there is evidence that NRAS-mutated patients may be sensitive to MEK inhibitors, and RAS mutation is a common mechanism of acquired resistance during treatment with BRAF inhibitors. This study evaluated the sensitivity and specificity of immunohistochemical analysis using an N-Ras (Q61R) antibody to detect the presence of the NRASQ61R mutation in melanoma patients. A total of 98 primary cutaneous melanomas that have undergone examination of NRAS mutation were retrieved from a multicentric database...
April 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25329125/desmoplastic-melanoma-challenges-in-the-diagnosis-and-management-of-a-rare-cutaneous-tumor
#16
Irina Mărgăritescu, Aurel Doru Chiriţă
Desmoplastic melanoma (DM) represents a distinctive rare variant of spindle cell melanoma with a predilection for chronically sun-exposed skin of the elderly. This neoplasm is notoriously difficult to diagnose, both clinically and histopathologically. Therefore, DM is deeply infiltrative at the time of presentation. Histologically, the tumor presents as a proliferation consisting of non-pigmented spindle cells arranged in poorly formed fascicles. The neoplastic cells have a deceptively bland appearance with slightly pleomorphic and hyperchromatic nuclei, inconspicuous nucleoli and low mitotic activity...
2014: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/25324906/melanoma-of-the-oral-cavity-pathogenesis-dermoscopy-clinical-features-staging-and-management
#17
Olga Warszawik-Hendzel, Monika Słowińska, Małgorzata Olszewska, Lidia Rudnicka
Primary mucosal melanoma of the oral cavity is an exceedingly rare neoplasm which is estimated to comprise 1-2% of all oral malignancies. In contrast to cutaneous melanomas, the risk factors and pathogenesis are poorly understood. The predominate localization of primary oral melanoma is hard palate and maxillary alveolus. Dermoscopy may be utilized as an adjunctive tool in the clinical differential diagnosis of oral mucosal melanoma whenever the lesion is accessible with a dermoscope. Surgery is the mainstay of treatment, but it may be challenging depending on the location of the tumor within the oral cavity and its size...
September 30, 2014: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/25324658/epidermotropic-metastatic-melanoma-clinically-resembling-agminated-spitz-nevi
#18
Hee Joo Kim, Byoung Joon So, Min Gun You, Il-Hwan Kim
Herein, we report a 36-year-old Asian male patient who presented with grouped multiple erythematous waxy papules and nodules on his right medial thigh. He had undergone amputation of the right second toe because of a stage IIa malignant melanoma, 3 years previously. At the time of surgery for the primary tumor, right inguinal lymph node dissection revealed no nodal involvement. Three years after the diagnosis of the primary tumor, crops of multiple erythematous papules and nodules developed. Initial histopathologic evaluation of the papules showed nests of small epithelioid cells similar to compound nevi...
October 2014: Annals of Dermatology
https://www.readbyqxmd.com/read/25304454/angiotropism-pericytic-mimicry-and-extravascular-migratory-metastasis-in-melanoma-an-alternative-to-intravascular-cancer-dissemination
#19
Claire Lugassy, Sohila Zadran, Laurent A Bentolila, Madhuri Wadehra, Roshini Prakash, S Thomas Carmichael, Hynda K Kleinman, Bruno Péault, Lionel Larue, Raymond L Barnhill
For more than 15 years, angiotropism in melanoma has been emphasized as a marker of extravascular migration of tumor cells along the abluminal vascular surface, unveiling an alternative mechanism of tumor spread distinct from intravascular dissemination. This mechanism has been termed extravascular migratory metastasis (EVMM). During EVMM, angiotropic tumor cells migrate in a 'pericytic-like' manner (pericytic mimicry) along the external surfaces of vascular channels, without intravasation. Through this pathway, melanoma cells may spread to nearby or more distant sites...
December 2014: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/25256128/in-transit-melanoma-metastases-incidence-prognosis-and-the-role-of-lymphadenectomy
#20
Rebecca L Read, Lauren Haydu, Robyn P M Saw, Michael J Quinn, Kerwin Shannon, Andrew J Spillane, Jonathan R Stretch, Richard A Scolyer, John F Thompson
PURPOSE: To analyze a large, single-institution database to further understanding of melanoma in-transit metastases (ITM) with regard to incidence, prognosis, and the role of lymphadenectomy. METHODS: A total of 11,614 patients with single primary cutaneous melanomas were treated at Melanoma Institute Australia between January 1994 and December 2009. Of these, 505 developed ITM. Clinicopathologic characteristics, sentinel node (SN) status, patterns of disease progression, and outcomes were analyzed...
February 2015: Annals of Surgical Oncology
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