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Internal Medicine

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30 papers 100 to 500 followers
By Ronald Lands Benign hematologist
https://www.readbyqxmd.com/read/26948435/guillain-barr%C3%A3-syndrome
#1
REVIEW
Hugh J Willison, Bart C Jacobs, Pieter A van Doorn
Guillain-Barré syndrome is the most common and most severe acute paralytic neuropathy, with about 100,000 people developing the disorder every year worldwide. Under the umbrella term of Guillain-Barré syndrome are several recognisable variants with distinct clinical and pathological features. The severe, generalised manifestation of Guillain-Barré syndrome with respiratory failure affects 20-30% of cases. Treatment with intravenous immunoglobulin or plasma exchange is the optimal management approach, alongside supportive care...
August 13, 2016: Lancet
https://www.readbyqxmd.com/read/25089103/thoughts-on-jim-flaherty-when-should-physicians-retire
#2
C Jacobs, M Clemons
No abstract text is available yet for this article.
August 2014: Current Oncology
https://www.readbyqxmd.com/read/26362561/effects-of-running-on-chronic-diseases-and-cardiovascular-and-all-cause-mortality
#3
REVIEW
Carl J Lavie, Duck-chul Lee, Xuemei Sui, Ross Arena, James H O'Keefe, Timothy S Church, Richard V Milani, Steven N Blair
Considerable evidence has established the link between high levels of physical activity (PA) and all-cause and cardiovascular disease (CVD)-specific mortality. Running is a popular form of vigorous PA that has been associated with better overall survival, but there is debate about the dose-response relationship between running and CVD and all-cause survival. In this review, we specifically reviewed studies published in PubMed since 2000 that included at least 500 runners and 5-year follow-up so as to analyze the relationship between vigorous aerobic PA, specifically running, and major health consequences, especially CVD and all-cause mortality...
November 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26605508/the-brain-fights-back-new-approaches-to-mitigating-cognitive-decline
#4
Bridget M Kuehn
No abstract text is available yet for this article.
December 15, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26380652/hepatocellular-carcinoma-from-clinical-practice-to-evidence-based-treatment-protocols
#5
REVIEW
Danijel Galun, Dragan Basaric, Marinko Zuvela, Predrag Bulajic, Aleksandar Bogdanovic, Nemanja Bidzic, Miroslav Milicevic
Hepatocellular carcinoma (HCC) is one of the major malignant diseases in many healthcare systems. The growing number of new cases diagnosed each year is nearly equal to the number of deaths from this cancer. Worldwide, HCC is a leading cause of cancer-related deaths, as it is the fifth most common cancer and the third most important cause of cancer related death in men. Among various risk factors the two are prevailing: viral hepatitis, namely chronic hepatitis C virus is a well-established risk factor contributing to the rising incidence of HCC...
September 18, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26608257/a-lean-treatment-for-non-alcoholic-steatohepatitis
#6
COMMENT
Vincent Wai-Sun Wong, Grace Lai-Hung Wong
No abstract text is available yet for this article.
February 13, 2016: Lancet
https://www.readbyqxmd.com/read/26535514/functional-dyspepsia
#7
REVIEW
Nicholas J Talley, Alexander C Ford
No abstract text is available yet for this article.
November 5, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26524584/in-the-clinic-restless-legs-syndrome
#8
REVIEW
Suzanne Bertisch
This issue provides a clinical overview of restless legs syndrome, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
November 3, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26465826/toward-evidence-based-end-of-life-care
#9
Scott D Halpern
The disquieting patterns of end-of-life care in the United States have been well documented. In the last month of life, one in two Medicare beneficiaries visits an emergency department, one in three is admitted to an intensive care unit, and one in five has inpatient surgery. But one of the most..
November 19, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26188836/understanding-the-complexities-of-cirrhosis
#10
REVIEW
Andrew J Muir
PURPOSE: Cirrhosis and its related complications remain a prominent global health concern despite advances in understanding and treating the disorder. Early diagnosis and intervention strategies may reduce the impact of cirrhosis; however, it can be difficult for initial point-of-care health care providers to identify and refer patients with cirrhosis due to lack of knowledge and resources. This review examines current diagnostic strategies for cirrhosis and cirrhosis-related complications and the potential benefits of multidisciplinary care for patients with the disorder...
August 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/26259761/the-complexity-of-complex-patients
#11
COMMENT
Monika M Safford
No abstract text is available yet for this article.
December 2015: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/26141332/peripheral-neuropathy-a-practical-approach-to-diagnosis-and-symptom-management
#12
REVIEW
James C Watson, P James B Dyck
Peripheral neuropathy is one of the most prevalent neurologic conditions encountered by physicians of all specialties. Physicians are faced with 3 distinct challenges in caring for patients with peripheral neuropathy: (1) how to efficiently and effectively screen (in less than 2 minutes) an asymptomatic patient for peripheral neuropathy when they have a disorder in which peripheral neuropathy is highly prevalent (eg, diabetes mellitus), (2) how to clinically stratify patients presenting with symptoms of neuropathy to determine who would benefit from specialty consultation and what testing is appropriate for those who do not need consultation, and (3) how to treat the symptoms of painful peripheral neuropathy...
July 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26107053/clinical-practice-advanced-dementia
#13
REVIEW
Susan L Mitchell
New England Journal of Medicine, Volume 372, Issue 26, Page 2533-2540, June 2015.
June 25, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/22335741/the-autosomal-recessive-cerebellar-ataxias
#14
REVIEW
Mathieu Anheim, Christine Tranchant, Michel Koenig
No abstract text is available yet for this article.
February 16, 2012: New England Journal of Medicine
https://www.readbyqxmd.com/read/23527737/liver-disease-in-alpha-1-antitrypsin-deficiency-current-understanding-and-future-therapy
#15
REVIEW
Jeffrey H Teckman
Alpha-1 antitrypsin Deficiency (AATD) is a common, but under recognized metabolic genetic disease. Although many mutations in the alpha-1 antitrypsin (AAT) gene are described, the Z variant is the allele overwhelmingly associated with liver disease. PI*ZZ homozygotes occur in approximately 1 in 2,000-5,000 births in North American and European populations. The AAT protein is synthesized in large quantities by the liver, and then secreted into serum. Its physiologic function is to inhibit neutrophil proteases in order to protect host tissues from non-specific injury during periods of inflammation...
March 2013: COPD
https://www.readbyqxmd.com/read/26151285/jama-patient-page-treatment-duration-for-pulmonary-embolism
#16
Jill Jin
No abstract text is available yet for this article.
July 7, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26093175/fever-of-unknown-origin-a-clinical-approach
#17
REVIEW
Burke A Cunha, Olivier Lortholary, Cheston B Cunha
Fevers of unknown origin remain one of the most difficult diagnostic challenges in medicine. Because fever of unknown origin may be caused by over 200 malignant/neoplastic, infectious, rheumatic/inflammatory, and miscellaneous disorders, clinicians often order non-clue-based imaging and specific testing early in the fever of unknown origin work-up, which may be inefficient/misleading. Unlike most other fever-of-unknown-origin reviews, this article presents a clinical approach. Characteristic history and physical examination findings together with key nonspecific test abnormalities are the basis for a focused clue-directed fever of unknown origin work-up...
October 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/26093176/management-of-hyperkalemia-an-update-for-the-internist
#18
REVIEW
Csaba P Kovesdy
Hyperkalemia is a clinically important electrolyte abnormality that occurs most commonly in patients with chronic kidney disease. Due to its propensity to induce electrophysiological disturbances, severe hyperkalemia is considered a medical emergency. The management of acute and chronic hyperkalemia can be achieved through the implementation of various interventions, one of which is the elimination of medications that can raise serum potassium levels. Because many such medications (especially inhibitors of the renin-angiotensin aldosterone system) have shown beneficial effects in patients with cardiovascular and renal disease, their discontinuation for reasons of hyperkalemia represent an undesirable clinical compromise...
December 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/25970055/understanding-bias-the-case-for-careful-study
#19
Lisa Rosenbaum
No abstract text is available yet for this article.
May 14, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25946288/conflicts-of-interest-part-1-reconnecting-the-dots-reinterpreting-industry-physician-relations
#20
Lisa Rosenbaum
New England Journal of Medicine, Volume 372, Issue 19, Page 1860-1864, May 2015.
May 7, 2015: New England Journal of Medicine
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2015-06-12 01:20:20
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