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Ebola: Knowledge foundation

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42 papers 25 to 100 followers Questioning Medicine collection. Feel free to tweet or email additional up-to-date articles and they will be included. @medquestioning or QuestioningMedicine@gmail.com
By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
https://www.readbyqxmd.com/read/25322080/drug-and-vaccine-access-in-the-ebola-epidemic-advising-caution-in-compassionate-use
#1
Andrew Hantel, Christopher Olusola Olopade
No abstract text is available yet for this article.
January 20, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25321902/potential-therapies-and-vaccines-to-combat-ebola
#2
M J Friedrich
No abstract text is available yet for this article.
October 15, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25321072/surveillance-and-preparedness-for-ebola-virus-disease-new-york-city-2014
#3
Isaac Benowitz, Joel Ackelsberg, Sharon E Balter, Jennifer C Baumgartner, Catherine Dentinger, Anne D Fine, Scott A Harper, Lucretia E Jones, Fabienne Laraque, Ellen H Lee, Giselle Merizalde, Kari A Yacisin, Jay K Varma, Marcelle C Layton
In July 2014, as the Ebola virus disease (Ebola) epidemic expanded in Guinea, Liberia, and Sierra Leone, an air traveler brought Ebola to Nigeria and two American health care workers in West Africa were diagnosed with Ebola and later medically evacuated to a U.S. hospital. New York City (NYC) is a frequent port of entry for travelers from West Africa, a home to communities of West African immigrants who travel back to their home countries, and a home to health care workers who travel to West Africa to treat Ebola patients...
October 17, 2014: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/25321071/developing-an-incident-management-system-to-support-ebola-response-liberia-july-august-2014
#4
Satish K Pillai, Tolbert Nyenswah, Edward Rouse, M Allison Arwady, Joseph D Forrester, Jennifer C Hunter, Almea Matanock, Patrick Ayscue, Benjamin Monroe, Ilana J Schafer, Luis Poblano, John Neatherlin, Joel M Montgomery, Kevin M De Cock
The ongoing Ebola virus disease (Ebola) outbreak in West Africa is the largest and most sustained Ebola epidemic recorded, with 6,574 cases. Among the five affected countries of West Africa (Liberia, Sierra Leone, Guinea, Nigeria, and Senegal), Liberia has had the highest number cases (3,458). This epidemic has severely strained the public health and health care infrastructure of Liberia, has resulted in restrictions in civil liberties, and has disrupted international travel. As part of the initial response, the Liberian Ministry of Health and Social Welfare (MOHSW) developed a national task force and technical expert committee to oversee the management of the Ebola-related activities...
October 17, 2014: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/25321070/cluster-of-ebola-cases-among-liberian-and-u-s-health-care-workers-in-an-ebola-treatment-unit-and-adjacent-hospital-liberia-2014
#5
Joseph D Forrester, Jennifer C Hunter, Satish K Pillai, M Allison Arwady, Patrick Ayscue, Almea Matanock, Ben Monroe, Ilana J Schafer, Tolbert G Nyenswah, Kevin M De Cock
The ongoing Ebola virus disease (Ebola) epidemic in West Africa, like previous Ebola outbreaks, has been characterized by amplification in health care settings and increased risk for health care workers (HCWs), who often do not have access to appropriate personal protective equipment. In many locations, Ebola treatment units (ETUs) have been established to optimize care of patients with Ebola while maintaining infection control procedures to prevent transmission of Ebola virus. These ETUs are considered essential to containment of the epidemic...
October 17, 2014: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/25320965/caring-for-patients-with-ebola-a-challenge-in-any-care-facility
#6
Mark G Kortepeter, Philip W Smith, Angela Hewlett, Theodore J Cieslak
No abstract text is available yet for this article.
January 6, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25318509/ebola-learn-from-the-past
#7
David L Heymann
No abstract text is available yet for this article.
October 16, 2014: Nature
https://www.readbyqxmd.com/read/25318501/ebola-by-the-numbers-the-size-spread-and-cost-of-an-outbreak
#8
Declan Butler, Lauren Morello
No abstract text is available yet for this article.
October 16, 2014: Nature
https://www.readbyqxmd.com/read/25317856/public-health-in-the-age-of-ebola-in-west-africa
#9
Michael T Osterholm, Kristine A Moore, Lawrence O Gostin
No abstract text is available yet for this article.
January 2015: JAMA Internal Medicine
https://www.readbyqxmd.com/read/25317743/ebola-virus-disease-in-the-democratic-republic-of-congo
#10
Gaël D Maganga, Jimmy Kapetshi, Nicolas Berthet, Benoît Kebela Ilunga, Felix Kabange, Placide Mbala Kingebeni, Vital Mondonge, Jean-Jacques T Muyembe, Eric Bertherat, Sylvie Briand, Joseph Cabore, Alain Epelboin, Pierre Formenty, Gary Kobinger, Licé González-Angulo, Ingrid Labouba, Jean-Claude Manuguerra, Jean-Marie Okwo-Bele, Christopher Dye, Eric M Leroy
BACKGROUND: The seventh reported outbreak of Ebola virus disease (EVD) in the equatorial African country of the Democratic Republic of Congo (DRC) began on July 26, 2014, as another large EVD epidemic continued to spread in West Africa. Simultaneous reports of EVD in equatorial and West Africa raised the question of whether the two outbreaks were linked. METHODS: We obtained data from patients in the DRC, using the standard World Health Organization clinical-investigation form for viral hemorrhagic fevers...
November 27, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25316902/wma-calls-for-urgent-support-to-fight-ebola
#11
Miriam Shuchman
No abstract text is available yet for this article.
November 18, 2014: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/25315776/the-ebola-virus-matrix-protein-vp40-selectively-induces-vesiculation-from-phosphatidylserine-enriched-membranes
#12
Smita P Soni, Robert V Stahelin
Ebola virus is from the Filoviridae family of viruses and is one of the most virulent pathogens known with ∼ 60% clinical fatality. The Ebola virus negative sense RNA genome encodes seven proteins including viral matrix protein 40 (VP40), which is the most abundant protein found in the virions. Within infected cells VP40 localizes at the inner leaflet of the plasma membrane (PM), binds lipids, and regulates formation of new virus particles. Expression of VP40 in mammalian cells is sufficient to form virus-like particles that are nearly indistinguishable from the authentic virions...
November 28, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25313927/surgical-infection-society-statement-on-ebola-hemorrhagic-fever
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2014: Surgical Infections
https://www.readbyqxmd.com/read/25306562/ebola-what-lessons-for-the-international-health-regulations
#14
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
October 11, 2014: Lancet
https://www.readbyqxmd.com/read/25305565/the-brighton-collaboration-viral-vector-vaccines-safety-working-group-v3swg
#15
Robert T Chen, Baevin Carbery, Lisa Mac, Kenneth I Berns, Louisa Chapman, Richard C Condit, Jean-Louis Excler, Marc Gurwith, Michael Hendry, Arifa S Khan, Najwa Khuri-Bulos, Bettina Klug, James S Robertson, Stephen J Seligman, Rebecca Sheets, Anna-Lise Williamson
Recombinant viral vectors provide an effective means for heterologous antigen expression in vivo and thus represent promising platforms for developing novel vaccines against human pathogens from Ebola to tuberculosis. An increasing number of candidate viral vector vaccines are entering human clinical trials. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to improve our ability to anticipate potential safety issues and meaningfully assess or interpret safety data, thereby facilitating greater public acceptance when licensed...
January 1, 2015: Vaccine
https://www.readbyqxmd.com/read/25303605/understand-and-prepare-for-ebola
#16
(no author information available yet)
No abstract text is available yet for this article.
October 10, 2014: British Dental Journal
https://www.readbyqxmd.com/read/25301596/infectious-diseases-imagining-ebola-s-next-move
#17
Kai Kupferschmidt
No abstract text is available yet for this article.
October 10, 2014: Science
https://www.readbyqxmd.com/read/25300956/transmission-dynamics-and-control-of-ebola-virus-disease-evd-a-review
#18
REVIEW
Gerardo Chowell, Hiroshi Nishiura
The complex and unprecedented Ebola epidemic ongoing in West Africa has highlighted the need to review the epidemiological characteristics of Ebola Virus Disease (EVD) as well as our current understanding of the transmission dynamics and the effect of control interventions against Ebola transmission. Here we review key epidemiological data from past Ebola outbreaks and carry out a comparative review of mathematical models of the spread and control of Ebola in the context of past outbreaks and the ongoing epidemic in West Africa...
2014: BMC Medicine
https://www.readbyqxmd.com/read/25299605/assessment-of-ebola-virus-disease-health-care-infrastructure-and-preparedness-four-counties-southeastern-liberia-august-2014
#19
Joseph D Forrester, Satish K Pillai, Karlyn D Beer, John Neatherlin, Moses Massaquoi, Tolbert G Nyenswah, Joel M Montgomery, Kevin De Cock
Ebola virus disease (Ebola) is a multisystem disease caused by a virus of the genus Ebolavirus. In late March 2014, Ebola cases were described in Liberia, with epicenters in Lofa County and later in Montserrado County. While information about case burden and health care infrastructure was available for the two epicenters, little information was available about remote counties in southeastern Liberia. Over 9 days, August 6-14, 2014, Ebola case burden, health care infrastructure, and emergency preparedness were assessed in collaboration with the Liberian Ministry of Health and Social Welfare in four counties in southeastern Liberia: Grand Gedeh, Grand Kru, River Gee, and Maryland...
October 10, 2014: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/25297522/tissue-and-cellular-tropism-pathology-and-pathogenesis-of-ebola-and-marburg-viruses
#20
REVIEW
Roosecelis Brasil Martines, Dianna L Ng, Patricia W Greer, Pierre E Rollin, Sherif R Zaki
Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with case fatality rates in the range 25-90%. The diagnosis of filovirus using formalin-fixed tissues from fatal cases poses a significant challenge. The most characteristic histopathological findings are seen in the liver; however, the findings overlap with many other viral and non-viral haemorrhagic diseases. The need to distinguish filovirus infections from other haemorrhagic fevers, particularly in areas with multiple endemic viral haemorrhagic agents, is of paramount importance...
January 2015: Journal of Pathology
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