Louise E Glover, Brittelle E Bowers, Bejan Saeedi, Stefan F Ehrentraut, Eric L Campbell, Amanda J Bayless, Evgenia Dobrinskikh, Agnieszka A Kendrick, Caleb J Kelly, Adrianne Burgess, Lauren Miller, Douglas J Kominsky, Paul Jedlicka, Sean P Colgan
Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpressed in mucosal epithelia that constitute the barrier between the lumen and the underlying immune milieu, we sought to define the discrete contribution of HIF-1 and HIF-2 transactivation pathways to intestinal epithelial cell homeostasis...
December 3, 2013: Proceedings of the National Academy of Sciences of the United States of America