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Treatment of lupus nephritis

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By Muhammad Masood Professor of Medicine Allamanda Iqbal Medical College/Jinnah Hospital Lahore Pakistan
Andrew S Bomback, Gerald B Appel
The treatment of lupus nephritis has changed significantly over the past decade in large part because of data from well-conducted randomized clinical trials. The concept of two phases of therapy-induction and maintenance-is widely accepted. The histopathologic classification of lupus nephritis continues to guide therapy, and treatment for all major classes of lupus nephritis has seen some shift in management during this time. New regimens using lower doses and shorter treatment durations of intravenous cyclophosphamide have been advanced to reduce toxicity without sacrificing efficacy of therapy...
December 2010: Journal of the American Society of Nephrology: JASN
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