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By Tonya Zeczycki Enzymologist
Jan Philipp Schuchardt, Inga Schneider, Ina Willenberg, Jun Yang, Bruce D Hammock, Andreas Hahn, Nils Helge Schebb
INTRODUCTION: Several supplementation studies with long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) describe an increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acids in blood, while changes in levels of other LC n-3 and n-6 PUFA-derived oxylipins were minor. In order to investigate the kinetics of changes in oxylipin levels in response to LC n-3 PUFA ingestion, we conducted a single dose treatment study with healthy subjects. SUBJECTS AND METHODS: In the present kinetic study, we compared patterns of hydroxy, epoxy and dihydroxy fatty acids in plasma of 6 healthy men before and after 6, 8, 24, and 48h of fish oil (1008mg EPA and 672mg DHA) ingestion...
June 2014: Prostaglandins & Other Lipid Mediators
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