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Nephrology

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26 papers 1000+ followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
https://www.readbyqxmd.com/read/26796493/unique-renal-manifestation-of-type-i-cryoglobulinemia-with-massive-crystalloid-deposits-in-glomerular-histiocytes-podocytes-and-endothelial-cells
#1
Joris Hoelbeek, Raphaël Duivenvoorden, Onno J de Boer, Nike Claessen, Marius A Van den Bergh Weerman, Joris J T H Roelofs, Jesper Kers, Ineke J M Ten Berge, Sandrine Florquin
OBJECTIVES: We describe a 62-year-old woman with a 15-year history of a plasma cell dyscrasia (monoclonal IgGκ), manifested by type I cryoglobulinemia and dermal vasculitis. METHODS: In addition to the clinical examinations, light microscopy with immunohistochemistry, sequential multicolor immunohistochemistry, and electron microscopy were used to characterize the crystalline deposits. RESULTS: At initial presentation and for a later flare, she was treated with cyclophosphamide and prednisolone with good clinical response...
February 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26806825/a-sprint-to-the-finish-or-just-the-beginning-implications-of-the-sprint-results-for-nephrologists
#2
Michael V Rocco, Alfred K Cheung
The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated a significant reduction in major cardiovascular events and all-cause mortality with intensive blood pressure control in older individuals at high cardiovascular risk, including patients with chronic kidney disease and mild proteinuria. Nephrologists should consider the SPRINT results when determining the optimal blood pressure target for patients with chronic kidney disease.
February 2016: Kidney International
https://www.readbyqxmd.com/read/26680759/star-fruit-toxicity-a-cause-of-both-acute-kidney-injury-and-chronic-kidney-disease-a-report-of-two-cases
#3
R A Abeysekera, S Wijetunge, N Nanayakkara, A W M Wazil, N V I Ratnatunga, T Jayalath, A Medagama
BACKGROUND: Star fruit (Averrhoa carambola) is commonly consumed as a herbal remedy for various ailments in tropical countries. However, the dangers associated with consumption of star fruit are not commonly known. Although star fruit induced oxalate nephrotoxicity in those with existing renal impairment is well documented, reports on its effect on those with normal renal function are infrequent. We report two unique clinical presentation patterns of star fruit nephrotoxicity following consumption of the fruit as a remedy for diabetes mellitus-the first, in a patient with normal renal function and the second case which we believe is the first reported case of chronic kidney disease (CKD) due to prolonged and excessive consumption of star fruits...
December 17, 2015: BMC Research Notes
https://www.readbyqxmd.com/read/26616536/managing-urolithiasis
#4
REVIEW
Ralph C Wang
No abstract text is available yet for this article.
April 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/26616336/development-of-clinical-practice-guidelines-in-the-care-of-people-with-kidney-disease-core-curriculum-2016
#5
Angela C Webster, Evi V Nagler, Martin Gallagher
No abstract text is available yet for this article.
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26032627/glomerular-diseases-dependent-on-complement-activation-including-atypical-hemolytic-uremic-syndrome-membranoproliferative-glomerulonephritis-and-c3-glomerulopathy-core-curriculum-2015
#6
REVIEW
Marina Noris, Giuseppe Remuzzi
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/21441397/multiorgan-gadolinium-gd-deposition-and-fibrosis-in-a-patient-with-nephrogenic-systemic-fibrosis-an-autopsy-based-review
#7
REVIEW
Soma Sanyal, Peter Marckmann, Susanne Scherer, Jerrold L Abraham
BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a systemic disorder of patients with severe renal insufficiency who have received gadolinium (Gd)-based magnetic resonance contrast agents (GBCAs). The causative association with Gd exposure was strengthened by the demonstration of Gd in various tissues of NSF patients, predominantly at the bulk chemical level. The distribution of Gd at the histologic level of organs other than skin has not been reported previously. METHODS: We analysed tissues from an autopsy case with verified advanced NSF by light microscopy and scanning electron microscopy/energy-dispersive X-ray spectroscopy...
November 2011: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25415805/patiromer-in-patients-with-kidney-disease-and-hyperkalemia-receiving-raas-inhibitors
#8
RANDOMIZED CONTROLLED TRIAL
Matthew R Weir, George L Bakris, David A Bushinsky, Martha R Mayo, Dahlia Garza, Yuri Stasiv, Janet Wittes, Heidi Christ-Schmidt, Lance Berman, Bertram Pitt
BACKGROUND: Hyperkalemia increases the risk of death and limits the use of inhibitors of the renin-angiotensin-aldosterone system (RAAS) in high-risk patients. We assessed the safety and efficacy of patiromer, a nonabsorbed potassium binder, in a multicenter, prospective trial. METHODS: Patients with chronic kidney disease who were receiving RAAS inhibitors and who had serum potassium levels of 5.1 to less than 6.5 mmol per liter received patiromer (at an initial dose of 4...
January 15, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25366328/effect-of-intravenous-iron-use-on-hospitalizations-in-patients-undergoing-hemodialysis-a-comparative-effectiveness-analysis-from-the-decide-esrd-study
#9
COMPARATIVE STUDY
Navdeep Tangri, Dana C Miskulin, Jing Zhou, Karen Bandeen-Roche, Wieneke M Michels, Patti L Ephraim, Aidan McDermott, Deidra C Crews, Julia J Scialla, Stephen M Sozio, Tariq Shafi, Bernard G Jaar, Klemens Meyer, L Ebony Boulware
BACKGROUND: Intravenous iron use in hemodialysis patients has greatly increased over the last decade, despite limited studies on the safety of iron. METHODS: We studied the association of receipt of intravenous iron with hospitalizations in an incident cohort of hemodialysis patients. We examined 9544 patients from Dialysis Clinic, Inc. (DCI). We ascertained intravenous iron use from DCI electronic medical record and USRDS data files, and hospitalizations through Medicare claims...
April 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/24145991/screening-monitoring-and-treatment-of-stage-1-to-3-chronic-kidney-disease-a-clinical-practice-guideline-from-the-american-college-of-physicians
#10
Amir Qaseem, Robert H Hopkins, Donna E Sweet, Melissa Starkey, Paul Shekelle
DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the screening, monitoring, and treatment of adults with stage 1 to 3 chronic kidney disease. METHODS: This guideline is based on a systematic evidence review evaluating the published literature on this topic from 1985 through November 2011 that was identified by using MEDLINE and the Cochrane Database of Systematic Reviews...
December 17, 2013: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25190600/alterations-of-intestinal-barrier-and-microbiota-in-chronic-kidney-disease
#11
REVIEW
Alice Sabatino, Giuseppe Regolisti, Irene Brusasco, Aderville Cabassi, Santo Morabito, Enrico Fiaccadori
Recent studies have highlighted the close relationship between the kidney and the gastrointestinal (GI) tract--frequently referred to as the kidney--gut axis--in patients with chronic kidney disease (CKD). In this regard, two important pathophysiological concepts have evolved: (i) production and accumulation of toxic end-products derived from increased bacterial fermentation of protein and other nitrogen-containing substances in the GI tract, (ii) translocation of endotoxins and live bacteria from gut lumen into the bloodstream, due to damage of the intestinal epithelial barrier and quantitative/qualitative alterations of the intestinal microbiota associated with the uraemic milieu...
June 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25168831/familial-fsgs
#12
REVIEW
Martin R Pollak
Focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome can be caused by rare highly penetrant mutations in number of genes. FSGS can follow both recessive and dominant inheritance patterns. In general, recessive forms present early, whereas the autosomal dominant forms present in adolescence or adulthood. Many of the genes found to be mutated in FSGS and nephrotic syndrome patients encode proteins essential for normal podocyte structure and/or function. An exception appears to be APOL1, which harbors common variants responsible for the high rate of FSGS and other nephropathies in people of recent African ancestry...
September 2014: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/25168505/the-incidence-of-iga-nephropathy-is-associated-with-socioeconomic-deprivation
#13
LETTER
Keng-Thye Woo, Marjorie Foo, Hui-Lin Choong, Han-Kim Tan, Kok-Seng Wong, Choong-Meng Chan
No abstract text is available yet for this article.
September 2014: Kidney International
https://www.readbyqxmd.com/read/25145928/the-cardiovascular-effect-of-the-uremic-solute-indole-3-acetic-acid
#14
Laetitia Dou, Marion Sallée, Claire Cerini, Stéphane Poitevin, Bertrand Gondouin, Noemie Jourde-Chiche, Karim Fallague, Philippe Brunet, Raymond Calaf, Bertrand Dussol, Bernard Mallet, Françoise Dignat-George, Stephane Burtey
In CKD, uremic solutes may induce endothelial dysfunction, inflammation, and oxidative stress, leading to increased cardiovascular risk. We investigated whether the uremic solute indole-3 acetic acid (IAA) predicts clinical outcomes in patients with CKD and has prooxidant and proinflammatory effects. We studied 120 patients with CKD. During the median study period of 966 days, 29 patients died and 35 experienced a major cardiovascular event. Kaplan-Meier analysis revealed that mortality and cardiovascular events were significantly higher in the higher IAA group (IAA>3...
April 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25140911/tnf-receptors-signaling-pathways-and-contribution-to-renal-dysfunction
#15
REVIEW
Rafia S Al-Lamki, Tanya N Mayadas
Tumor necrosis factor (TNF), initially reported to induce tumor cell apoptosis and cachexia, is now considered a central mediator of a broad range of biological activities from cell proliferation, cell death and differentiation to induction of inflammation and immune modulation. TNF exerts its biological responses via interaction with two cell surface receptors: TNFR1 and TNFR2. (TNFRs). These receptors trigger shared and distinct signaling pathways upon TNF binding, which in turn result in cellular outputs that may promote tissue injury on one hand but may also induce protective, beneficial responses...
February 2015: Kidney International
https://www.readbyqxmd.com/read/25127970/warfarin-related-nephropathy-prevalence-risk-factors-and-prognosis
#16
REVIEW
Yajuan Yang, Tong Liu, Jianping Zhao, Guangping Li
No abstract text is available yet for this article.
October 20, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/25115616/a-randomized-placebo-controlled-trial-of-pentoxifylline-on-erythropoiesis-stimulating-agent-hyporesponsiveness-in-anemic-patients-with-ckd-the-handling-erythropoietin-resistance-with-oxpentifylline-hero-trial
#17
RANDOMIZED CONTROLLED TRIAL
David W Johnson, Elaine M Pascoe, Sunil V Badve, Kim Dalziel, Alan Cass, Philip Clarke, Paolo Ferrari, Stephen P McDonald, Alicia T Morrish, Eugenie Pedagogos, Vlado Perkovic, Donna Reidlinger, Anish Scaria, Rowan Walker, Liza A Vergara, Carmel M Hawley
BACKGROUND: Erythropoiesis-stimulating agent (ESA)-hyporesponsive anemia is common in chronic kidney disease (CKD). Pentoxifylline shows promise as a treatment for ESA-hyporesponsive anemia, but has not been rigorously evaluated. STUDY DESIGN: Multicenter, double-blind, randomized, controlled trial. SETTING & PARTICIPANTS: 53 adult patients with CKD stage 4 or 5 (including dialysis) and ESA-hyporesponsive anemia (hemoglobin≤120g/L and ESA resistance index [calculated as weight-adjusted weekly ESA dose in IU/kg/wk divided by hemoglobin concentration in g/L]≥1...
January 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25114536/optimal-management-of-renal-artery-fibromuscular-dysplasia
#18
REVIEW
Anders Gottsäter, Bengt Lindblad
Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory angiopathy of unknown cause affecting medium-sized (most commonly renal) arteries and causing renovascular hypertension. The most common medial multifocal type of FMD (with the "string of beads" appearance) is more than four times more prevalent in females than in males. FMD accounts for up to 10% of cases of renovascular hypertension. Compared with patients with atherosclerotic renal artery stenosis, patients with FMD are younger, have fewer risk factors for atherosclerosis, and a lower occurrence of atherosclerosis in other vessels...
2014: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/25111593/role-of-troponin-in-patients-with-chronic-kidney-disease-and-suspected-acute-coronary-syndrome-a-systematic-review
#19
REVIEW
Sylvie R Stacy, Catalina Suarez-Cuervo, Zackary Berger, Lisa M Wilson, Hsin-Chieh Yeh, Eric B Bass, Erin D Michos
BACKGROUND: Patients with chronic kidney disease (CKD) have high prevalence of elevated serum troponin levels, which makes diagnosis of acute coronary syndrome (ACS) challenging. PURPOSE: To evaluate the utility of troponin in ACS diagnosis, treatment, and prognosis among patients with CKD. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through May 2014. STUDY SELECTION: Studies examining elevated versus normal troponin levels in terms of their diagnostic performance in detection of ACS, effect on ACS management strategies, and prognostic value for mortality or cardiovascular events after ACS among patients with CKD...
October 7, 2014: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25111499/prognostic-value-of-cardiac-troponin-in-patients-with-chronic-kidney-disease-without-suspected-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#20
REVIEW
Erin D Michos, Lisa M Wilson, Hsin-Chieh Yeh, Zackary Berger, Catalina Suarez-Cuervo, Sylvie R Stacy, Eric B Bass
BACKGROUND: Clinicians face uncertainty about the prognostic value of troponin testing in patients with chronic kidney disease (CKD) without suspected acute coronary syndrome (ACS). PURPOSE: To systematically review the literature on troponin testing in patients with CKD without ACS. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through May 2014. STUDY SELECTION: Studies examining elevated versus normal troponin levels in patients with CKD without ACS...
October 7, 2014: Annals of Internal Medicine
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