collection
MENU ▼
Read by QxMD icon Read
search

Pregnancy issues

shared collection
96 papers 1000+ followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
https://www.readbyqxmd.com/read/27732715/neurodevelopmental-implications-of-fetal-exposure-to-selective-serotonin-reuptake-inhibitors-and-untreated-maternal-depression-weighing-relative-risks
#1
Lee S Cohen, Ruta Nonacs
No abstract text is available yet for this article.
October 12, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27555797/current-best-practice-in-the-management-of-hypertensive-disorders-in-pregnancy
#2
REVIEW
Rosemary Townsend, Patrick O'Brien, Asma Khalil
Preeclampsia is a potentially serious complication of pregnancy with increasing significance worldwide. Preeclampsia is the cause of 9%-26% of global maternal mortality and a significant proportion of preterm delivery, and maternal and neonatal morbidity. Incidence is increasing in keeping with the increase in obesity, maternal age, and women with medical comorbidities entering pregnancy. Recent developments in the understanding of the pathophysiology of preeclampsia have opened new avenues for prevention, screening, and management of this condition...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/22544624/when-one-drug-affects-2-patients-a-review-of-medication-for-the-management-of-nonlabor-related-pain-sedation-infection-and-hypertension-in-the-hospitalized-pregnant-patient
#3
REVIEW
Marilyn N Bulloch, Dana G Carroll
One of the most difficult challenges health care providers encounter is drug selection for pregnant patients. Drug selection can be complex as efficacy and maternal side effects must be weighed against potential risk to the embryo or fetus. Verification of an individual drug's fetal safety is limited as most evidence is deduced from epidemiologic, prospective cohort, or case-control studies. Medication selection for the pregnant inpatient is a particularly complex task as the illnesses and conditions that require hospitalization mandate different medications, and the risk versus benefit ratio can vary significantly compared to the outpatient setting...
June 2012: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/15346815/anti-hypertensive-therapy-and-the-feto-placental-circulation-effects-on-umbilical-artery-resistance
#4
COMPARATIVE STUDY
Diarmaid D Houlihan, Michael C Dennedy, Nandini Ravikumar, John J Morrison
OBJECTIVE: To investigate and compare the direct effects of compounds used in the treatment of hypertensive disease in pregnancy on human umbilical artery resistance in vitro. METHODS: Isometric tension recordings were performed under physiological conditions on human umbilical arterial rings (n=30). The in vitro effects of labetolol, hydralazine, alpha-methyldopa, nifedepine and magnesium sulphate (at concentration ranges from 1 nanomolar to 1 millimolar), and their respective vehicle controls, were measured...
2004: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/25370900/a-case-of-probable-labetalol-induced-hyperkalaemia-in-pre-eclampsia
#5
Binny Thomas, P V Abdul Rouf, Wessam El Kassem, Moza Al Hail, Derek Stewart, Asma Tharannum, Afif Ahmed, Muna Al Saadi
CASE DESCRIPTION: Hyperkalemia can cause altered cardiac electrical conduction resulting in death. We describe a case of a 23-year old pregnant patient who presented with severe epigastric pain and vomiting. She was severely pre- eclamptic and received initial treatment with intravenous labetalol and decision was taken to deliver. She quickly became hyperkalaemic (serum potassium level 6.4 mmol/L) and labetalol was discontinued and intravenous hydralazine commenced. Post-surgery, her potassium levels were normal but due to rapidly rising blood pressure labetalol was recommenced, resulting in elevated potassium levels...
December 2014: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/20591204/nicardipine-for-the-treatment-of-severe-hypertension-in-pregnancy-a-review-of-the-literature
#6
REVIEW
Sebastiaan W A Nij Bijvank, Johannes J Duvekot
UNLABELLED: To evaluate the efficacy and safety of intravenous nicardipine for the treatment of severe hypertension in pregnancy. Articles were identified through electronic databases (Medline and Cochrane). No date or language restrictions were placed. Relevant citations were hand searched. The following search terms were used: pregnancy, severe hypertension and nicardipine. Patients included had chronic or gestational hypertension with or without marked proteinuria. Primary outcomes were reduction of systolic/diastolic and/or mean arterial pressure, time to target blood pressure, and severe maternal (hypotension, tachycardia) or severe fetal side effects (CTG abnormalities needing direct intervention)...
May 2010: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/24572430/antihypertensive-drugs-methyldopa-labetalol-hydralazine-and-clonidine-improve-trophoblast-interaction-with-endothelial-cellular-networks-in-vitro
#7
Bei Xu, Francesca Charlton, Angela Makris, Annemarie Hennessy
OBJECTIVES: The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circulating cytokines. This study investigated whether selected antihypertensive drugs can modulate the interaction between trophoblast and endothelial cells. METHODS: Human uterine myometrial microvascular endothelial cells were preincubated with (or without) low-dose tumor necrosis factor-α (TNF-α; 0...
May 2014: Journal of Hypertension
https://www.readbyqxmd.com/read/26222708/effects-of-pravastatin-on-human-placenta-endothelium-and-women-with-severe-preeclampsia
#8
Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino
UNLABELLED: Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin causes maternal endothelial and multisystem organ injury. Clinical trials have commenced examining whether pravastatin can be used to treat preeclampsia. However, the preclinical evidence supporting pravastatin as a treatment is limited to animal models, with almost no studies in human tissues. Therefore, we examined whether pravastatin reduced sFlt-1 and soluble endoglin secretion and decreased endothelial dysfunction in primary human tissues...
September 2015: Hypertension
https://www.readbyqxmd.com/read/27400005/perinatal-and-hemodynamic-evaluation-of-sildenafil-citrate-for-preeclampsia-treatment-a-randomized-controlled-trial
#9
Alberto Trapani, Luis Flavio Gonçalves, Thamyris Finger Trapani, Simone Vieira, Marilen Pires, Maria Marlene de Souza Pires
OBJECTIVE: To evaluate whether therapy with sildenafil citrate prolongs gestation in women with preeclampsia. METHODS: In a randomized double-blind, placebo-controlled trial, 100 singleton pregnancies with preeclampsia between 24 and 33 weeks of gestation were randomized to 50 mg oral sildenafil citrate every 8 hours or placebo. The primary outcome was prolongation of pregnancy from randomization to delivery. Secondary outcomes were changes in resistance indices of uterine, umbilical, and middle cerebral arteries by Doppler, fetal and maternal complications, and adverse neonatal outcomes...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26930536/adverse-outcomes-following-serotonin-reuptake-inhibitor-exposure-during-pregnancy
#10
COMMENT
Chittaranjan Andrade
No abstract text is available yet for this article.
February 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26850983/induction-of-labour-at-term-with-oral-misoprostol-versus-a-foley-catheter-probaat-ii-a-multicentre-randomised-controlled-non-inferiority-trial
#11
RANDOMIZED CONTROLLED TRIAL
Mieke L G Ten Eikelder, Katrien Oude Rengerink, Marta Jozwiak, Jan W de Leeuw, Irene M de Graaf, Mariëlle G van Pampus, Marloes Holswilder, Martijn A Oudijk, Gert-Jan van Baaren, Paula J M Pernet, Caroline Bax, Gijs A van Unnik, Gratia Martens, Martina Porath, Huib van Vliet, Robbert J P Rijnders, A Hanneke Feitsma, Frans J M E Roumen, Aren J van Loon, Hans Versendaal, Martin J N Weinans, Mallory Woiski, Erik van Beek, Brenda Hermsen, Ben Willem Mol, Kitty W M Bloemenkamp
BACKGROUND: Labour is induced in 20-30% of all pregnancies. In women with an unfavourable cervix, both oral misoprostol and Foley catheter are equally effective compared with dinoprostone in establishing vaginal birth, but each has a better safety profile. We did a trial to directly compare oral misoprostol with Foley catheter alone. METHODS: We did an open-label randomised non-inferiority trial in 29 hospitals in the Netherlands. Women with a term singleton pregnancy in cephalic presentation, an unfavourable cervix, intact membranes, and without a previous caesarean section who were scheduled for induction of labour were randomly allocated to cervical ripening with 50 μg oral misoprostol once every 4 h or to a 30 mL transcervical Foley catheter...
April 16, 2016: Lancet
https://www.readbyqxmd.com/read/26819104/early-nasogastric-tube-feeding-in-optimising-treatment-for-hyperemesis-gravidarum-the-mother-randomised-controlled-trial-maternal-and-offspring-outcomes-after-treatment-of-hyperemesis-by-refeeding
#12
RANDOMIZED CONTROLLED TRIAL
Iris J Grooten, Ben W Mol, Joris A M van der Post, Carrie Ris-Stalpers, Marjolein Kok, Joke M J Bais, Caroline J Bax, Johannes J Duvekot, Henk A Bremer, Martina M Porath, Wieteke M Heidema, Kitty W M Bloemenkamp, Hubertina C J Scheepers, Maureen T M Franssen, Martijn A Oudijk, Tessa J Roseboom, Rebecca C Painter
BACKGROUND: Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality of life and has repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women with HG are admitted to hospital for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding is sometimes used as last resort treatment...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/21840574/thromboprophylaxis-following-cesarean-delivery-one-site-prospective-pilot-study-to-evaluate-the-application-of-a-risk-score-model
#13
Stefania Cavazza, Maria Pia Rainaldi, Angelina Adduci, Gualtiero Palareti
BACKGROUND: Venous thromboembolism (VTE) remains an important cause of maternal mortality and morbidity. Cesarean delivery (CD) is a known risk factor for VTE. Data from clinical trials of thomboprophylaxis following CD are lacking and current guidelines are based on experts opinion. Our aim was to assess the efficacy of a risk score model, established at our institution, in preventing CD-related VTE. METHODS: Before undergoing CD women received a risk score assessment based on age, weight, history of thrombosis, thrombophilia, immobility, parity and varicose vein...
January 2012: Thrombosis Research
https://www.readbyqxmd.com/read/26609305/dermatological-diseases-associated-with-pregnancy-pemphigoid-gestationis-polymorphic-eruption-of-pregnancy-intrahepatic-cholestasis-of-pregnancy-and-atopic-eruption-of-pregnancy
#14
REVIEW
Christine Sävervall, Freja Lærke Sand, Simon Francis Thomsen
Dermatoses unique to pregnancy are important to recognize for the clinician as they carry considerable morbidity for pregnant mothers and in some instances constitute a risk to the fetus. These diseases include pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. This review discusses the pathogenesis, clinical importance, and management of the dermatoses of pregnancy.
2015: Dermatology Research and Practice
https://www.readbyqxmd.com/read/26557371/antirheumatic-drugs-and-reproduction-in-women-and-men-with-chronic-arthritis
#15
REVIEW
Chiara Bazzani, Laura Andreoli, Michele Agosti, Cecilia Nalli, Angela Tincani
The impact of rheumatic disease on fertility and reproduction can be remarkable. Many disease-related factors can influence patients' sexual functioning, perturb fertility and limit family planning. Antirheumatic pharmacological treatment can also have a crucial role in this field. Proper counselling, preferably provided by a multidisciplinary team of rheumatologists, obstetricians, gynaecologists and neonatologists, is recommended for patients taking antirheumatic drugs, not only at the beginning, but also during the course of treatment...
2015: RMD Open
https://www.readbyqxmd.com/read/26295966/impact-of-prophylactic-continuous-positive-airway-pressure-on-transient-tachypnea-of-the-newborn-and-neonatal-intensive-care-admission-in-newborns-delivered-by-elective-cesarean-section
#16
RANDOMIZED CONTROLLED TRIAL
Miray Yilmaz Celebi, Serdar Alan, Dilek Kahvecioglu, Ufuk Cakir, Duran Yildiz, Omer Erdeve, Saadet Arsan, Begum Atasay
OBJECTIVE: This study aims to evaluate the effect of the prophylactic continuous positive airway pressure (CPAP) administration in the delivery room to newborns who were delivered by elective cesarean section (CS). STUDY DESIGN: Inborn infants with gestational age between 34(0/7) to 38(6/7) and born by elective CS were prospectively randomized to receive either prophylactic CPAP for 20 minutes via face mask or standardized care without CPAP in the delivery room...
January 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26240703/gestational-diabetes-a-clinical-update
#17
REVIEW
Ulla Kampmann, Lene Ring Madsen, Gitte Oeskov Skajaa, Ditte Smed Iversen, Niels Moeller, Per Ovesen
Gestational diabetes mellitus (GDM) is increasing in prevalence in tandem with the dramatic increase in the prevalence of overweight and obesity in women of childbearing age. Much controversy surrounds the diagnosis and management of gestational diabetes, emphasizing the importance and relevance of clarity and consensus. If newly proposed criteria are adopted universally a significantly growing number of women will be diagnosed as having GDM, implying new therapeutic challenges to avoid foetal and maternal complications related to the hyperglycemia of gestational diabetes...
July 25, 2015: World Journal of Diabetes
https://www.readbyqxmd.com/read/26309128/continuation-versus-discontinuation-of-oxytocin-infusion-during-the-active-phase-of-labour-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
P Bor, S Ledertoug, S Boie, N O Knoblauch, I Stornes
OBJECTIVE: To investigate whether discontinuation of oxytocin infusion increases the duration of the active phase of labour and reduces maternal and neonatal complications. DESIGN: Randomised controlled trial. SETTING: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Denmark. POPULATION: Women with singleton pregnancy in the vertex position undergoing labour induction or augmentation. METHODS: Two hundred women were randomised when cervical dilation was ≤4 cm to either continue or discontinue oxytocin infusion when cervical dilation reached 5 cm...
January 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26116874/maternal-obesity-and-neuroprotective-magnesium-sulfate
#19
Jessica McPherson, Sarah Smiley, David Stamilio
OBJECTIVE: Given the association between risk of cerebral palsy and children born to obese women, the study aim was to estimate whether maternal obesity is associated with reduced effectiveness of conventional antenatal magnesium sulfate dosing for the prevention of cerebral palsy and death. STUDY DESIGN: This is a secondary cohort analysis of a multicenter randomized clinical trial completed by the Maternal-Fetal Medicine Units Network. Women were included in the original trial if deemed high risk for preterm delivery in the subsequent 24 hours...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25830321/cell-free-dna-analysis-for-noninvasive-examination-of-trisomy
#20
MULTICENTER STUDY
Mary E Norton, Bo Jacobsson, Geeta K Swamy, Louise C Laurent, Angela C Ranzini, Herb Brar, Mark W Tomlinson, Leonardo Pereira, Jean L Spitz, Desiree Hollemon, Howard Cuckle, Thomas J Musci, Ronald J Wapner
BACKGROUND: Cell-free DNA (cfDNA) testing for fetal trisomy is highly effective among high-risk women. However, there have been few direct, well-powered studies comparing cfDNA testing with standard screening during the first trimester in routine prenatal populations. METHODS: In this prospective, multicenter, blinded study conducted at 35 international centers, we assigned pregnant women presenting for aneuploidy screening at 10 to 14 weeks of gestation to undergo both standard screening (with measurement of nuchal translucency and biochemical analytes) and cfDNA testing...
April 23, 2015: New England Journal of Medicine
label_collection
label_collection
3234
1
2
2015-05-28 20:50:55
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"