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Rheumatic diseases

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106 papers 1000+ followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
https://www.readbyqxmd.com/read/27733943/updates-in-anca-associated-vasculitis
#1
Christian Pagnoux
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknown cause(s), research pertaining to ANCA-associated vasculitides has been very active over the past decades. The pathogenic role of antimyeloperoxidase ANCA (MPO-ANCA) has been supported using several animal models, but that of antiproteinase 3 ANCA (PR3-ANCA) has not been as strongly demonstrated...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27567298/myelitis-and-lupus-clinical-manifestations-diagnosis-and-treatment-review
#2
Edson Hernán Chiganer, Javier Pablo Hryb, Edgar Carnero Contentti
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Myelopathy is one of 19 neuropsychiatric syndromes related to SLE defined by the American College of Rheumatology. Although infrequent, it is a severe manifestation, leading to motor and sensory deficits, and sphincter dysfunction. The pathogenesis is not clearly known, but may be related to arterial thrombosis and vasculitis. Diagnosis is based on clinical findings, laboratory tests and the use of gadolinium-enhanced magnetic resonance imaging...
August 23, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27638912/prevalence-incidence-and-prognosis-of-chronic-kidney-disease-classified-according-to-current-guidelines-a-large-retrospective-cohort-study-of-rheumatoid-arthritis-patients
#3
Takeshi Tokoroyama, Minoru Ando, Kyogo Setoguchi, Ken Tsuchiya, Kosaku Nitta
BACKGROUND: The prevalence, incidence and prognosis of chronic kidney disease (CKD) have not been fully understood in rheumatoid arthritis (RA) patients. METHODS: A retrospective cohort study was performed in 1077 RA patients from July 2004 to June 2014. CKD was defined as either proteinuria ≥1+ or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or both, according to the current CKD classification with risk categories for future death, end-stage renal disease and cardiovascular disease...
September 16, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/17617900/variations-in-corticosteroid-anesthetic-injections-for-painful-shoulder-conditions-comparisons-among-orthopaedic-surgeons-rheumatologists-and-physical-medicine-and-primary-care-physicians
#4
COMPARATIVE STUDY
John G Skedros, Kenneth J Hunt, Todd C Pitts
BACKGROUND: Variations in corticosteroid/anesthetic doses for injecting shoulder conditions were examined among orthopaedic surgeons, rheumatologists, and primary-care sports medicine (PCSMs) and physical medicine and rehabilitation (PMRs) physicians to provide data needed for documenting inter-group differences for establishing uniform injection guidelines. METHODS: 264 surveys, sent to these physicians in our tri-state area of the western United States, addressed corticosteroid/anesthetic doses and types used for subacromial impingement, degenerative glenohumeral and acromioclavicular arthritis, biceps tendinitis, and peri-scapular trigger points...
July 6, 2007: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/22186921/the-chondrotoxicity-of-single-dose-corticosteroids
#5
Jason L Dragoo, Christina M Danial, Hillary J Braun, Michael A Pouliot, Hyeon Joo Kim
PURPOSE: Corticosteroids are commonly injected into the joint space. However, studies have not examined the chondrotoxicity of one-time injection doses. The purpose of this study is to evaluate the effect of dexamethasone sodium phosphate (Decadron), methylprednisolone acetate (Depo-Medrol), betamethasone sodium phosphate and betamethasone acetate (Celestone Soluspan), and triamcinolone acetonide (Kenalog) on human chondrocyte viability in vitro. METHODS: Single-injection doses of each of the corticosteroids were separately delivered to human chondrocytes for their respective average duration of action and compared to controls using a bioreactor containing a continuous infusion pump constructed to mimic joint fluid metabolism...
September 2012: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27457514/2016-updated-eular-evidence-based-recommendations-for-the-management-of-gout
#6
P Richette, M Doherty, E Pascual, V Barskova, F Becce, J Castañeda-Sanabria, M Coyfish, S Guillo, T L Jansen, H Janssens, F Lioté, C Mallen, G Nuki, F Perez-Ruiz, J Pimentao, L Punzi, T Pywell, A So, A K Tausche, T Uhlig, J Zavada, W Zhang, F Tubach, T Bardin
BACKGROUND: New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against Rheumatism (EULAR) recommendations for the management of gout, in 2006. This situation has prompted a systematic review and update of the 2006 recommendations. METHODS: The EULAR task force consisted of 15 rheumatologists, 1 radiologist, 2 general practitioners, 1 research fellow, 2 patients and 3 experts in epidemiology/methodology from 12 European countries...
July 25, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27377815/eular-revised-recommendations-for-the-management-of-fibromyalgia
#7
G J Macfarlane, C Kronisch, L E Dean, F Atzeni, W Häuser, E Fluß, E Choy, E Kosek, K Amris, J Branco, F Dincer, P Leino-Arjas, K Longley, G M McCarthy, S Makri, S Perrot, P Sarzi-Puttini, A Taylor, G T Jones
OBJECTIVE: The original European League Against Rheumatism recommendations for managing fibromyalgia assessed evidence up to 2005. The paucity of studies meant that most recommendations were 'expert opinion'. METHODS: A multidisciplinary group from 12 countries assessed evidence with a focus on systematic reviews and meta-analyses concerned with pharmacological/non-pharmacological management for fibromyalgia. A review, in May 2015, identified eligible publications and key outcomes assessed were pain, fatigue, sleep and daily functioning...
July 4, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27284161/bsr-and-bhpr-guideline-for-the-treatment-of-systemic-sclerosis
#8
REVIEW
Christopher P Denton, Michael Hughes, Nataliya Gak, Josephine Vila, Maya H Buch, Kuntal Chakravarty, Kim Fligelstone, Luke L Gompels, Bridget Griffiths, Ariane L Herrick, Jay Pang, Louise Parker, Anthony Redmond, Jacob van Laar, Louise Warburton, Voon H Ong
No abstract text is available yet for this article.
October 2016: Rheumatology
https://www.readbyqxmd.com/read/27338776/eular-era-edta-recommendations-for-the-management-of-anca-associated-vasculitis
#9
M Yates, R A Watts, I M Bajema, M C Cid, B Crestani, T Hauser, B Hellmich, J U Holle, M Laudien, M A Little, R A Luqmani, A Mahr, P A Merkel, J Mills, J Mooney, M Segelmark, V Tesar, K Westman, A Vaglio, N Yalçındağ, D R Jayne, C Mukhtyar
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Association and the European Vasculitis Society (EUVAS). The recommendations are based upon evidence from systematic literature reviews, as well as expert opinion where appropriate...
September 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27161602/laboratory-testing-for-antiphospholipid-syndrome
#10
REVIEW
V Pengo, A Banzato, E Bison, G Denas, G Zoppellaro, A Bracco, S Padayattil Jose, A Hoxha, A Ruffatti
This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome (APS). After a general definition of APS, this study deals with appropriateness and timing in requesting the determination of antiphospholipid (aPL) antibodies. Lupus anticoagulant (LAC), anticardiolipin (aCL), and anti β2-glycoprotein I (aβGPI) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians...
May 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27037326/clinical-trials-of-new-drugs-for-the-treatment-of-rheumatoid-arthritis-focus-on-early-disease
#11
REVIEW
Josef S Smolen, Sabine Collaud Basset, Maarten Boers, Ferdinand Breedveld, Christopher J Edwards, Tore K Kvien, Pierre Miossec, Tuulikki Sokka-Isler, Ronald F van Vollenhoven, Eric C Abadie, Olivier Bruyère, Cyrus Cooper, Heidi Mäkinen, Thierry Thomas, Peter Tugwell, Jean-Yves Reginster
The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial methodology to comment on the new draft 'Guideline on clinical investigation of medicinal products for the treatment of RA' released by the European Medicines Agency (EMA). Special emphasis was placed by the group on the development of new drugs for the treatment of early RA. In the absence of a clear definition of early RA, it was suggested that clinical investigations in this condition were conducted in disease-modifying antirheumatic drugs naïve patients with no more than 1 year disease duration...
July 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26622326/treatment-of-rheumatoid-arthritis-associated-interstitial-lung-disease-a-perspective-review
#12
REVIEW
Kundan Iqbal, Clive Kelly
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 0.5-1% of the worldwide population. Whilst predominantly causing chronic pain and inflammation in synovial joints, it is also associated with significant extra-articular manifestations in a large proportion of patients. Among the various pulmonary manifestations, interstitial lung disease (ILD), a progressive fibrotic disease of the lung parenchyma, is the commonest and most important, contributing significantly to increased morbidity and mortality...
December 2015: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/26920998/nsaids-in-axial-spondyloarthritis-to-be-continued%C3%A2
#13
EDITORIAL
G Varkas, F Van den Bosch
No abstract text is available yet for this article.
August 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26888948/the-eular-points-to-consider-for-use-of-antirheumatic-drugs-before-pregnancy-and-during-pregnancy-and-lactation
#14
Carina Götestam Skorpen, Maria Hoeltzenbein, Angela Tincani, Rebecca Fischer-Betz, Elisabeth Elefant, Christina Chambers, Josè da Silva, Catherine Nelson-Piercy, Irene Cetin, Nathalie Costedoat-Chalumeau, Radboud Dolhain, Frauke Förger, Munther Khamashta, Guillermo Ruiz-Irastorza, Angela Zink, Jiri Vencovsky, Maurizio Cutolo, Nele Caeyers, Claudia Zumbühl, Monika Østensen
A European League Against Rheumatism (EULAR) task force was established to define points to consider on use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Based on a systematic literature review and pregnancy exposure data from several registries, statements on the compatibility of antirheumatic drugs during pregnancy and lactation were developed. The level of agreement among experts in regard to statements and propositions of use in clinical practice was established by Delphi voting...
May 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26886206/clinical-features-pathogenesis-and-treatment-of-myasthenia-gravis-a-supplement-to-the-guidelines-of-the-german-neurological-society
#15
REVIEW
Nico Melzer, Tobias Ruck, Peter Fuhr, Ralf Gold, Reinhard Hohlfeld, Alexander Marx, Arthur Melms, Björn Tackenberg, Berthold Schalke, Christiane Schneider-Gold, Fritz Zimprich, Sven G Meuth, Heinz Wiendl
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and weakness affecting ocular, bulbar and (proximal) limb skeletal muscle groups. MG may either occur as an autoimmune disease with distinct immunogenetic characteristics or as a paraneoplastic syndrome associated with tumors of the thymus. Impairment of central thymic and peripheral self-tolerance mechanisms in both cases is thought to favor an autoimmune CD4(+) T cell-mediated B cell activation and synthesis of pathogenic high-affinity autoantibodies of either the IgG1 and 3 or IgG4 subclass...
August 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26557369/canvasc-recommendations-for-the-management-of-antineutrophil-cytoplasm-antibody-anca-associated-vasculitides-executive-summary
#16
REVIEW
Lucy McGeoch, Marinka Twilt, Leilani Famorca, Volodko Bakowsky, Lillian Barra, Susan Benseler, David A Cabral, Simon Carette, Gerald P Cox, Navjot Dhindsa, Christine Dipchand, Aurore Fifi-Mah, Michele Goulet, Nader Khalidi, Majed M Khraishi, Patrick Liang, Nataliya Milman, Christian A Pineau, Heather Reich, Nooshin Samadi, Kam Shojania, Regina Taylor-Gjevre, Tanveer E Towheed, Judith Trudeau, Michael Walsh, Elaine Yacyshyn, Christian Pagnoux
The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties, including rheumatology and nephrology and researchers with expertise in vasculitis. One of its aims was to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides in Canada. This executive summary features the 19 recommendations and 17 statements addressing general AAV diagnosis and management, developed by CanVasc group based on a synthesis of existing international guidelines, other published supporting evidence and expert consensus considering the Canadian healthcare context...
2015: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/26523024/canvasc-recommendations-for-the-management-of-antineutrophil-cytoplasm-antibody-associated-vasculitides
#17
REVIEW
Lucy McGeoch, Marinka Twilt, Leilani Famorca, Volodko Bakowsky, Lillian Barra, Susan M Benseler, David A Cabral, Simon Carette, Gerald P Cox, Navjot Dhindsa, Christine S Dipchand, Aurore Fifi-Mah, Michelle Goulet, Nader Khalidi, Majed M Khraishi, Patrick Liang, Nataliya Milman, Christian A Pineau, Heather N Reich, Nooshin Samadi, Kam Shojania, Regina Taylor-Gjevre, Tanveer E Towheed, Judith Trudeau, Michael Walsh, Elaine Yacyshyn, Christian Pagnoux
OBJECTIVE: The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties and researchers with expertise in vasculitis. One of its aims is to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. METHODS: Diagnostic and therapeutic questions were developed based on the results of a national needs assessment survey. A systematic review of existing non-Canadian recommendations and guidelines for the diagnosis and management of AAV and studies of AAV published after the 2009 European League Against Rheumatism/European Vasculitis Society recommendations (publication date: January 2009) until November 2014 was performed in the Medline database, Cochrane library, and main vasculitis conference proceedings...
January 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26802180/eular-recommendations-for-the-management-of-familial-mediterranean-fever
#18
Seza Ozen, Erkan Demirkaya, Burak Erer, Avi Livneh, Eldad Ben-Chetrit, Gabriella Giancane, Huri Ozdogan, Illana Abu, Marco Gattorno, Philip N Hawkins, Sezin Yuce, Tilmann Kallinich, Yelda Bilginer, Daniel Kastner, Loreto Carmona
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals in the treatment and follow-up of patients with FMF. A multidisciplinary panel, including rheumatologists, internists, paediatricians, a nurse, a methodologist and a patient representative, was assembled. Panellists came from the Eastern Mediterranean area, Europe and North America...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26806839/the-case-a-man-with-hypertension-respiratory-distress-and-rapidly-progressive-renal-failure
#19
Mohamad Zaidan, Eugénie Koumakis, Alexandre Karras, Patrick Bruneval, Eric Thervet, Dominique Nochy
No abstract text is available yet for this article.
February 2016: Kidney International
https://www.readbyqxmd.com/read/18806706/indications-and-challenges-of-probiotics-prebiotics-and-synbiotics-in-the-management-of-arthralgias-and-spondyloarthropathies-in-inflammatory-bowel-disease
#20
REVIEW
Ouafae Karimi, Amado Salvador Peña
Arthralgia and spondyloarthropathy of the peripheral and the axial joints are common in patients with inflammatory bowel diseases. Evidence for this association has been provided by clinical, epidemiologic, and immunologic studies confirming the presence of shared inflammatory pathways in gut and joint. Bacterial gut infections such as Salmonella typhimurium, Yersinia enterocolitica, Shigella, Campylobacter jejuni may induce reactive peripheral arthritis and 20% of these patients may develop chronic spondyloarthropathy...
September 2008: Journal of Clinical Gastroenterology
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