Daniel O Thomas-Rueddel, Bernhard Poidinger, Manfred Weiss, Friedhelm Bach, Karin Dey, Helene Häberle, Udo Kaisers, Hendrik Rüddel, Dirk Schädler, Christian Scheer, Torsten Schreiber, Tobias Schürholz, Philipp Simon, Armin Sommerer, Daniel Schwarzkopf, Andreas Weyland, Gabriele Wöbker, Konrad Reinhart, Frank Bloos
PURPOSE: Current guidelines and most trials do not consider elevated lactate (Lac) serum concentrations when grading sepsis severity. We therefore assessed the association of different types of circulatory dysfunction regarding presence of hyperlactatemia and need for vasopressor support with clinical presentation and outcome of sepsis. METHODS: In a secondary analysis of a prospective observational multicenter cohort study, 988 patients with severe sepsis were investigated regarding vasopressor support, Lac levels, and outcome...
April 2015: Journal of Critical Care