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Linazolid better than vanc

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By David Bennett Pediatric Orthopaedic Surgeon in the United States
Mao Mao An, Hui Shen, Jun Dong Zhang, Guo Tong Xu, Yuan Ying Jiang
Linezolid is the first available oxazolidinone, possessing broad-spectrum activity against Gram-positive bacteria and a favourable pharmacokinetic profile. The aim of this study was to compare the efficacy and safety of linezolid with vancomycin, the gold-standard treatment, for meticillin-resistant Staphylococcus aureus (MRSA)-related infections. A meta-analysis of randomised controlled trials (RCTs) identified in PubMed, the Cochrane Library and Embase was performed. Nine RCTs, involving 5249 patients, were included in the meta-analysis...
May 2013: International Journal of Antimicrobial Agents
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