Deborah G Hirtz, Steven J Weiner, Dorothy Bulas, Michael DiPietro, Joanna Seibert, Dwight J Rouse, Brian M Mercer, Michael W Varner, Uma M Reddy, Jay D Iams, Ronald J Wapner, Yoram Sorokin, John M Thorp, Susan M Ramin, Fergal D Malone, Marshall W Carpenter, Mary J O'Sullivan, Alan M Peaceman, Gary D V Hankins, Donald Dudley, Steve N Caritis
OBJECTIVE: To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP). STUDY DESIGN: In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly...
October 2015: Journal of Pediatrics