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Growth hormone deficiency in adults

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2 papers 0 to 25 followers
By Ehud Ur Professor and Head, Endocrinology, UBC, Vancouver
Daojun Mo, Werner F Blum, Myriam Rosilio, Susan M Webb, Rong Qi, Christian J Strasburger
CONTEXT: Previous studies showed improvement in impaired quality of life (QoL) in adult patients with growth hormone (GH) deficiency (GHD) who were treated with GH; improvement was sustained over a few years after GH therapy. OBJECTIVE: To evaluate the QoL over 10 years. DESIGN: This was a prospective observational study. SETTING: The study was conducted in clinical practice. PATIENTS: 1436 adult patients with adult-onset (AO) GHD (mean age [standard deviation (SD)]: 49...
December 2014: Journal of Clinical Endocrinology and Metabolism
Meryl Brod, Lise Højbjerre, Johan Erpur Adalsteinsson, Michael Højby Rasmussen
CONTEXT: Approximately 50 000 adults in the United States are diagnosed with GH deficiency, which has negative impacts on cognitive functioning, psychological well-being, and quality of life. OBJECTIVE: This paper presents development and validation of a patient-reported outcome measure (PRO), the Treatment-Related Impact Measure-Adult Growth Hormone Deficiency (TRIM-AGHD). The TRIM-AGHD was developed to measure the impact of GH deficiency and its treatment. DESIGN AND SETTINGS: The development and validation of the TRIM-AGHD was conducted according to the Food and Drug Administration guidance on the development of PROs...
April 2014: Journal of Clinical Endocrinology and Metabolism
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