Celine Busard, Jeffrey Zweegers, Jacqueline Limpens, Miranda Langendam, Phyllis I Spuls
IMPORTANCE: Combined use of systemic agents may be necessary to achieve disease control in therapy-resistant patients. However, to our knowledge, an overview of evidence, including quality assessments, is not yet available, and no guidance on monitoring, contraindications, and interactions exists. OBJECTIVES: To summarize and critically appraise the evidence on efficacy and safety of combination therapy with systemic agents in plaque-type psoriasis. EVIDENCE REVIEW: Through March 2013, an electronic search limited to randomized clinical trials was performed in MEDLINE, EMBASE, The Cochrane Library, and ongoing trial registers...
November 2014: JAMA Dermatology