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By EFRAIN PAEZ Internal Medicine since 1988. Interested in all aspects of Medicine.
Simon Greulich, Vanessa M Ferreira, Erica Dall'Armellina, Heiko Mahrholdt
Several exogenous or endogenous factors can lead to inflammatory heart disease. Beside infectious myocarditis, other systemic inflammatory disorders such as sarcoidosis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Churg-Strauss syndrome, and rheumatoid arthritis can affect the myocardium. Myocardial inflammation may have a major impact on the outcome of these patients, resulting in sudden cardiac death, severe arrhythmias, or end-stage heart failure. The current gold standard for definite confirmation of inflammatory heart disease is endomyocardial biopsy (EMB), but is invasive and suffers low sensitivity and specificity due to sampling errors...
2015: Current Cardiovascular Imaging Reports
Mario Silva, Hilario Nunes, Dominique Valeyre, Nicola Sverzellati
The diagnostic imaging contributes significantly to the diagnosis and management of sarcoidosis. Imaging techniques are widely employed in the assessment of thoracic and extra-thoracic involvement from sarcoidosis. For the diagnosis of sarcoidosis, chest radiograph has been the cornerstone of sarcoidosis since 1961, when Scadding proposed a standardized staging system. Currently, computed tomography (CT) represents the reference standard for the assessment of both mediastinal lymph nodes and pulmonary findings...
August 2015: Clinical Reviews in Allergy & Immunology
Nabeel Hamzeh, David A Steckman, William H Sauer, Marc A Judson
Cardiac sarcoidosis is a potentially life-threatening condition characterized by formation of granulomas in the heart, resulting in conduction disturbances, atrial and ventricular arrhythmias, and ventricular dysfunction. The presentation of cardiac sarcoidosis ranges from asymptomatic with an abnormal imaging scan, to palpitations, syncope, symptoms of congestive heart failure, and sudden cardiac death. Screening for cardiac sarcoidosis has not been standardized, but the presence of cardiac symptoms on medical history and physical examination, and an abnormal electrocardiogram (ECG), Holter monitoring, or echocardiogram has been shown to be highly sensitive for detecting cardiac sarcoidosis...
May 2015: Nature Reviews. Cardiology
Marc A Judson, Haroon Chaudhry, Amanda Louis, Kevin Lee, Recai Yucel
BACKGROUND: Both sarcoidosis and its treatment may worsen health related quality of life (HRQoL). We performed a propensity analysis of sarcoidosis-specific HRQoL patient reported outcome measures (PRO) to disentangle the effects of sarcoidosis and corticosteroid therapy on HRQoL in sarcoidosis outpatients. METHODS: Consecutive outpatient sarcoidosis patients were administered modules from two sarcoidosis-specific HRQoL PROs: the Sarcoidosis Health Questionnaire (SHQ) and the Sarcoidosis Assessment Tool (SAT)...
April 2015: Respiratory Medicine
Preetam Chappity, Rajeev Kumar, Anjan K Sahoo
Heerfordt's syndrome is defined as a combination of facial palsy, parotid swelling, uveitis and fever in sarcoidosis cases. Heerfordt's syndrome as a cause of facial palsy is very rare. We report a case of alternating facial nerve palsy in a 52-year-old female initially treated for Bell's palsy. The patient was referred to the All India Institute of Medical Sciences, Bhubaneswar, India, in January 2013 for clinical evaluation. She was found to have a parotid swelling and anterior intermediate uveitis. A pathoradiological evaluation suggested sarcoidosis and a final diagnosis of Heerfordt's syndrome was made...
February 2015: Sultan Qaboos University Medical Journal
É Chalayer, E Bachy, P Occelli, L Weiler, P Faurie, H Ghesquieres, M Pavic, C Broussolle, P Sève
AIM: To assess the clinical features and outcome of lymphoma when associated with sarcoidosis and to determine whether this association gives lymphoma a better prognosis. DESIGN: Multicentre retrospective cohort study. METHODS: Retrospective chart review. RESULTS: Twenty-one patients were included (9 males, 12 females). Median age at sarcoidosis diagnosis was 48 years (range: 24-68 years). In 14 cases, lymphoma occurred within a previously known sarcoidosis...
November 2015: QJM: Monthly Journal of the Association of Physicians
Yang Jiao, Jie Ning, Wen-DI Zhao, Yan-Li Li, Hong-Yang Wu, Kang-Sheng Gu
Sarcoidosis is a multisystemic inflammatory disease that commonly affects the lungs and lymphatic system and is characterized by the formation of non-caseating granulomas. Although the association between sarcoidosis and malignant diseases has been well described, it remains controversial whether this association is merely a coincidence or the consequence of a common pathophysiological mechanism. The present study reports a rare case of sarcoidosis that was present in a patient with gastric cancer at the time of diagnosis...
March 2015: Oncology Letters
Jerome M Reich
No abstract text is available yet for this article.
February 2015: Chest
S Le Reun, M Poulain, A Perlat, B Mortemousque
INTRODUCTION: Sarcoidosis is a multisystem granulomatous inflammatory disease, which may present as uveitis. Work-up includes the search for pulmonary and extra-pulmonary sites, with the assistance of PET-scanning. MATERIAL AND METHODS: We present six patients enrolled retrospectively from March 2012 to November 2013 with uveitis, for whom a systemic work-up was performed, along with specific tests for sarcoidosis. 18-FDG PET-scan was performed when histology was inconclusive for epithelioid granulomata and giant cells, or when CT and/or chest X-ray were normal, in cases of uveitis clinically suggestive of sarcoidosis...
February 2015: Journal Français D'ophtalmologie
Michiru Sawahata, Yukihiko Sugiyama, Yosikazu Nakamura, Masayuki Nakayama, Naoko Mato, Hideaki Yamasawa, Masashi Bando
BACKGROUND: National surveys conducted in Japan between 1960 and 2004 suggest a gradually increasing incidence of sarcoidosis in women >50 years old with increased involvement of the eye, skin, and heart. However, whether this involvement is due to the increased age at diagnosis is still unclear. We aimed here to identify the age-related differences in organ involvement in sarcoidosis in Japan, as well as the historical changes in clinical characteristics and the age-specific distribution of cases at diagnosis...
February 2015: Respiratory Medicine
R Vishwanath Rangdhol, N Madhulika, A Dany, S Jeelani, G S Asokan
Orofacial granulomatosis is an uncommon disease, usually presenting as recurrent or persistent swelling of the soft tissues, predominantly lips - termed as Cheilitis Granulomatosa. Though various aetiological factors like foreign body reactions, infections, Crohn's disease and Sarcoidosis have been implicated in the disease process. Delayed Hypersensitivity reaction with a predominant Th1-mediated immune response provide further evidence to the etiopathogenesis in Orofacial granulomatosis. The term Idiopathic Orofacial Granulomatosis is used in cases with unknown aetiology...
November 2014: Journal of Clinical and Diagnostic Research: JCDR
Robert P Baughman, Elyse E Lower
BACKGROUND: The clinical outcome of sarcoidosis is variable. Several features have been proposed as predictive of chronic sarcoidosis. OBJECTIVES: To examine the predictive role of clinical features on the clinical outcome score (COS) of sarcoidosis patients five years after initial diagnosis. METHODS: A cohort of newly diagnosed sarcoidosis patients seen at one clinic were re-evaluated five years after initial diagnosis. The COS was determined at this five year time point and compared to initial age, race, sex, forced vital capacity (FVC) and chest roentgenogram...
2014: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Giuseppe Troiano, Mario Dioguardi, Giovanni Giannatempo, Luigi Laino, Nunzio Francesco Testa, Roberto Cocchi, Alfredo De Lillo, Lorenzo Lo Muzio
Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and laboratory investigations. In fact, the diagnosis of OFG may be confirmed only by histopathological identification of noncaseating granulomas...
2015: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Yale Rosen
CONTEXT: In the 4 decades since Dr Averill A. Liebow introduced necrotizing sarcoid granulomatosis, there have been publications of numerous cases, but its nature and possible relationship to classical and nodular sarcoidosis have been and remain controversial. Liebow introduced necrotizing sarcoid granulomatosis as a provisional diagnostic term and stated that "the problem is whether the disease represents necrotizing angiitis with sarcoid reaction, or sarcoidosis with necrosis of the granulomas and of the vessels...
February 2015: Archives of Pathology & Laboratory Medicine
A A Chokoeva, G Tchernev, C Tana, J Ananiev, U Wollina
For several decades the “mystery” of sarcoidosis has continued to evade revelation. Nowadays, due to medical progress and the opportunity of performing highly specialized tests which assist the identification of this condition as a separate disease, the understanding of the eternal mystery appears closer. Nevertheless, many contemporary studies focus on the putative link between sarcoidosis and infectious antigens isolated from skin lesions. On the other hand, a golden rule to differentiate sarcoidosis from other conditions such as tuberculosis and sarcoid-like reactions is the sterility of granulomas...
October 2014: Journal of Biological Regulators and Homeostatic Agents
Stefania Carmagnola, Ludovica Venezia, Andrea Anderloni, Roberta Nicali, Filippo Patrucco, Piero Emilio Balbo
During routine follow-up of a 60-year-old man with an endoluminal lesion of the duodenum, we found a persistent reactive abdominal adenopathy of unknown origin, later diagnosed as an abdominal localization of sarcoidosis. This article focuses on the differential diagnosis of abdominal granulomatous lymphadenopathies, the management of abdominal adenopathy of unknown origin, and the difficult decision making about sampling lymph nodes with reactive and inflammatory echographic appearance.
February 2015: JAAPA: Official Journal of the American Academy of Physician Assistants
C Leroy, C Girard, M-H Girard-Madoux, B Coppéré, H Desmurs-Clavel, L Pérard, A Hot, J Ninet
INTRODUCTION: Sarcoidosis is a systemic granulomatous disorder of unknown aetiology. It may rarely affect the gastrointestinal tract. CASE REPORT: We reported a 54-year-old woman with a delayed diagnosis of duodenal sarcoidosis. She presented with gastric and right upper abdominal pain associated with vomiting and marked weight loss. Abdominal computed tomographic scan showed non-compressive retroperitoneal lymph nodes and histological examination revealed non-caseating epithelioid granulomas typical of sarcoidosis...
November 2015: La Revue de Médecine Interne
Sinem Gungor, Ferhan Ozseker, Murat Yalcinsoy, Esen Akkaya, Günay Can, Hacer Eroglu, Nilgün Sema Genc
AIM AND BACKGROUND: Currently, there are no objective criteria to determine sarcoidosis activity. The present study aimed to discover a sensitive serum marker that would determine the activity of sarcoidosis and can be used during disease follow-up. METHODS: Forty-eight patients with sarcoidosis and twenty healthy volunteers as a control group were included in the study. On their control visits, the patients were divided into active and inactive groups based on their clinical, physiological, and radiological status...
March 2015: International Immunopharmacology
Michael M Braun, Keith Petersen, Sophia Hermann, Erika Overbeek-Wager, Miles Layton, David Trowbridge
Sarcoidosis is a multisystem granulomatous disease that affects 10 to 20 people per 100,000 in the United States. Hypercalcemia is a known side effect of the disease and in rare instances has been shown to cause ST-segment elevation on electrocardiogram testing that mimics myocardial infarction. Herein, we present a rare case of a 55-year-old, asymptomatic African-American male with sarcoidosis and hydrochlorothiazide usage presenting with ST-segment elevation of the anterior leads secondary to hypercalcemia...
January 2015: Military Medicine
Coen van Kan, Jan Peringa, Armin W Walter, P H J Jos Frissen, Paul Bresser
BACKGROUND: In view of the diminished number of CD4+ lymphocytes, the co-existence of an HIV infection and sarcoidosis seems paradoxical. Immune reconstitution inflammatory syndrome (IRIS) may be observed in response to anti-retroviral therapy (ART). According to the conventional definition, this is caused by an overwhelming immune response to an already present or to a new agent. CASE DESCRIPTION: We describe the case of a 47-year-old HIV-positive patient, who presented with an exacerbation of his sarcoidosis nine months after initiation of ART...
2015: Nederlands Tijdschrift Voor Geneeskunde
2015-01-13 13:36:44
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