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56 papers 100 to 500 followers GWAS? SNP? Psychopharmacogenomics? Gut microbiomes? Metagenomics?
By Edwin Kim Resident Physician, Aspiring Addiction Psychiatrist
S Rangaraju, D F Levey, K Nho, N Jain, K D Andrews, H Le-Niculescu, D R Salomon, A J Saykin, M Petrascheck, A B Niculescu
Antidepressants have been shown to improve longevity in C. elegans. It is plausible that orthologs of genes involved in mood regulation and stress response are involved in such an effect. We sought to understand the underlying biology. First, we analyzed the transcriptome from worms treated with the antidepressant mianserin, previously identified in a large-scale unbiased drug screen as promoting increased lifespan in worms. We identified the most robust treatment-related changes in gene expression, and identified the corresponding human orthologs...
August 2016: Molecular Psychiatry
Anita Cservenka, Megan M Yardley, Lara A Ray
BACKGROUND AND OBJECTIVES: Pharmacogenetic studies of alcohol use disorder (AUD) have suggested that the efficacy of treatments for AUD is, in part, influenced by the genetic background of an individual. Since the frequency of alleles associated with pharmacotherapy for AUD varies by ancestral background, the effectiveness of medications used to treat AUD may vary among different populations. The purpose of this review is to summarize the existing pharmacogenetic studies of treatments for AUD in individuals of European, East Asian, African, and American Indian/Alaska Native ancestry...
November 4, 2016: American Journal on Addictions
Ian James Martins
The early diagnosis of Alzheimer's disease (AD) has become important to the reversal and treatment of neurodegeneration, which may be relevant to premature brain aging that is associated with chronic disease progression. Clinical proteomics allows the detection of various proteins in fluids such as the urine, plasma, and cerebrospinal fluid for the diagnosis of AD. Interest in lipidomics has accelerated with plasma testing for various lipid biomarkers that may with clinical proteomics provide a more reproducible diagnosis for early brain aging that is connected to other chronic diseases...
March 31, 2016: Proteomes
Timothy G Dinan, John F Cryan
No abstract text is available yet for this article.
February 2017: Nature Reviews. Gastroenterology & Hepatology
Robert Maier, Gerhard Moser, Guo-Bo Chen, Stephan Ripke, William Coryell, James B Potash, William A Scheftner, Jianxin Shi, Myrna M Weissman, Christina M Hultman, Mikael Landén, Douglas F Levinson, Kenneth S Kendler, Jordan W Smoller, Naomi R Wray, S Hong Lee
Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the accuracy of risk prediction is low. Here we use a multivariate linear mixed model and apply multi-trait genomic best linear unbiased prediction for genetic risk prediction. This method exploits correlations between disorders and simultaneously evaluates individual risk for each disorder...
February 5, 2015: American Journal of Human Genetics
Sebastian Mohnke, Susanne Erk, Knut Schnell, Claudia Schütz, Nina Romanczuk-Seiferth, Oliver Grimm, Leila Haddad, Lydia Pöhland, Maria Garbusow, Mike M Schmitgen, Peter Kirsch, Christine Esslinger, Marcella Rietschel, Stephanie H Witt, Markus M Nöthen, Sven Cichon, Manuel Mattheisen, Thomas Mühleisen, Jimmy Jensen, Björn H Schott, Wolfgang Maier, Andreas Heinz, Andreas Meyer-Lindenberg, Henrik Walter
The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people's mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic resonance imaging, we previously showed that in healthy individuals rs1344706 impacted on activity and connectivity of key areas of the ToM network, including the dorsomedial prefrontal cortex, temporo-parietal junction, and the posterior cingulate cortex, which show aberrant activity in schizophrenia patients, too...
April 2014: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Maude Schneider, Martial Van der Linden, Sarah Menghetti, Martin Debbané, Stephan Eliez
AIMS: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic condition associated with an increased risk of developing schizophrenia. Previous studies have shown that negative symptoms represent the most specific clinical characteristic of psychosis in 22q11.2DS and are strongly associated with outcome. However, the psychological mechanisms associated with these symptoms in this population are poorly understood. In accordance with recent conceptualizations in the field of schizophrenia, the present study aims at investigating whether negative symptoms are associated with the presence of negative performance beliefs and cognitive deficits...
April 2017: Early Intervention in Psychiatry
Dai Wang, Dong-Jing Fu, Xiaodong Wu, Alice Shapiro, Reyna Favis, Adam Savitz, Hedy Chung, Larry Alphs, Srihari Gopal, Magali Haas, Nadine Cohen, Qingqin Li
OBJECTIVE: Clinical response to antipsychotic medications can vary markedly in patients with schizophrenia. Identifying genetic variants associated with treatment response could help optimize patient care and outcome. To this end, we carried out a large-scale candidate gene study to identify genetic risk factors predictive of paliperidone efficacy. PATIENTS AND METHODS: A central nervous system custom chip containing single nucleotide polymorphisms from 1204 candidate genes was utilized to genotype a discovery cohort of 684 schizophrenia patients from four clinical studies of paliperidone extended-release and paliperidone palmitate...
April 2015: Pharmacogenetics and Genomics
James P Evans, Michael S Watson
No abstract text is available yet for this article.
February 17, 2015: JAMA: the Journal of the American Medical Association
Emeran A Mayer, Kirsten Tillisch, Arpana Gupta
Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems...
March 2, 2015: Journal of Clinical Investigation
Michael J Ostacher, Dan V Iosifescu, Aleena Hay, Sarah R Blumenthal, Pamela Sklar, Roy H Perlis
OBJECTIVES: Motivated by genetic association data implicating L-type calcium channels in bipolar disorder liability, we sought to estimate the tolerability, safety, and efficacy of isradipine in the adjunctive treatment of bipolar depression. METHODS: A total of 12 patients with bipolar I or II depression entered this pilot, proof-of-concept eight-week investigation and 10 returned for at least one post-baseline visit. They were initiated on isradipine at 2.5 mg and titrated up to 10 mg daily, with blinded assessments of depression using the Montgomery-Åsberg Depression Rating Scale (MADRS) as well as adverse effects...
March 2014: Bipolar Disorders
Kenneth S Kendler, Michael C O'Donovan
No abstract text is available yet for this article.
December 1, 2014: JAMA Psychiatry
Enda M Byrne, Uttam K Raheja, Sarah H Stephens, Andrew C Heath, Pamela A F Madden, Dipika Vaswani, Gagan V Nijjar, Kathleen A Ryan, Hassaan Youssufi, Philip R Gehrman, Alan R Shuldiner, Nicholas G Martin, Grant W Montgomery, Naomi R Wray, Elliot C Nelson, Braxton D Mitchell, Teodor T Postolache
OBJECTIVE: To test common genetic variants for association with seasonality (seasonal changes in mood and behavior) and to investigate whether there are shared genetic risk factors between psychiatric disorders and seasonality. METHOD: Genome-wide association studies (GWASs) were conducted in Australian (between 1988 and 1990 and between 2010 and 2013) and Amish (between May 2010 and December 2011) samples in whom the Seasonal Pattern Assessment Questionnaire (SPAQ) had been administered, and the results were meta-analyzed in a total sample of 4,156 individuals...
February 2015: Journal of Clinical Psychiatry
Rohan H C Palmer, Leslie Brick, Nicole R Nugent, L Cinnamon Bidwell, John E McGeary, Valerie S Knopik, Matthew C Keller
BACKGROUND AND AIMS: Twin and family studies suggest that genetic influences are shared across substances of abuse. However, despite evidence of heritability, genome-wide association and candidate gene studies have indicated numerous markers of limited effects, suggesting that much of the heritability remains missing. We estimated (1) the aggregate effect of common single nucleotide polymorphisms (SNPs) on multiple indicators of comorbid drug problems that are typically employed across community and population-based samples, and (2) the genetic covariance across these measures...
March 2015: Addiction
Alexis C Edwards, Fazil Aliev, Aaron R Wolen, Jessica E Salvatore, Charles O Gardner, George McMahon, David M Evans, John Macleod, Matthew Hickman, Danielle M Dick, Kenneth S Kendler
AIMS: Alcohol problems (AP) contribute substantially to the global disease burden. Twin and family studies suggest that AP are genetically influenced, although few studies have identified variants or genes that are robustly associated with risk. This study identifies genetic and genomic influences on AP during young adulthood, which is often when drinking habits are established. DESIGN: We conducted a genome-wide association study of AP. We further conducted gene-based tests, gene ontology analyses and functional genomic enrichment analyses to assess genomic factors beyond single variants that are relevant to AP...
March 2015: Addiction
Shaw-Ji Chen, Yu-Lin Chao, Chuan-Yu Chen, Chia-Ming Chang, Erin Chia-Hsuan Wu, Chi-Shin Wu, Hsueh-Han Yeh, Chia-Hsiang Chen, Hui-Ju Tsai
BACKGROUND: The association between autoimmune diseases and schizophrenia has rarely been systematically investigated. AIMS: To investigate the association between schizophrenia and a variety of autoimmune diseases and to explore possible gender variation in any such association. METHOD: Taiwan's National Health Insurance Research Database was used to identify 10 811 hospital in-patients with schizophrenia and 108 110 age-matched controls...
May 2012: British Journal of Psychiatry: the Journal of Mental Science
Carl Sellgren, Thomas Frisell, Paul Lichtenstein, Mikael Landèn, Johan Askling
Numerous studies have reported a reduced risk of rheumatoid arthritis (RA) in schizophrenia. The mechanisms are unknown, but recent genome-wide association studies of schizophrenia have shown strong associations with markers spanning the major histocompatibility complex region, indicating a possible role for adaptive immunity also in schizophrenia. In this population-based cohort study, we assess the associations between RA and schizophrenia and the extent to which any observed associations are specific to RA/schizophrenia...
November 2014: Schizophrenia Bulletin
Lynn M Almli, Richard Duncan, Hao Feng, Debashis Ghosh, Elisabeth B Binder, Bekh Bradley, Kerry J Ressler, Karen N Conneely, Michael P Epstein
IMPORTANCE: Genetic association studies of psychiatric outcomes often consider interactions with environmental exposures and, in particular, apply tests that jointly consider gene and gene-environment interaction effects for analysis. Using a genome-wide association study (GWAS) of posttraumatic stress disorder (PTSD), we report that heteroscedasticity (defined as variability in outcome that differs by the value of the environmental exposure) can invalidate traditional joint tests of gene and gene-environment interaction...
December 1, 2014: JAMA Psychiatry
Ming T Tsuang, Joyce van de Leemput
No abstract text is available yet for this article.
October 1, 2014: American Journal of Psychiatry
Lingjun Zuo, Lingeng Lu, Yunlong Tan, Xinghua Pan, Yiqiang Cai, Xiaoping Wang, Jiang Hong, Chunlong Zhong, Fei Wang, Xiang-Yang Zhang, Lauren A Vanderlinden, Boris Tabakoff, Xingguang Luo
OBJECTIVE: To report the genome-wide significant and/or replicable risk variants for alcohol dependence and explore their potential biological functions. METHODS: We searched in PubMed for all genome-wide association studies (GWASs) of alcohol dependence. The following three types of the results were extracted: genome-wide significant associations in an individual sample, the combined samples, or the meta-analysis (p < 5 × 10(-8) ); top-ranked associations in an individual sample (p < 10(-5) ) that were nominally replicated in other samples (p < ...
November 2014: American Journal on Addictions
2014-10-20 14:07:28
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