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HIV

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By Howie Real Anesthetist
https://www.readbyqxmd.com/read/25075786/in-vivo-assessment-of-antiretroviral-therapy-associated-side-effects
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Eduardo Milton Ramos-Sanchez, Hiro Goto, Dolores Helena Rodriguez Ferreira Rivero, Thais Mauad, Fernando Nogueira de Souza, Andrea Moreira Monteiro, Magnus Gidlund
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart...
July 2014: Memórias do Instituto Oswaldo Cruz
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