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By Eduardo Roque Cardiologista com foco em cardiologia hospitalar e cuidados intensivos. Professor de clínica médica.
Matthias G Friedrich, Udo Sechtem, Jeanette Schulz-Menger, Godtfred Holmvang, Pauline Alakija, Leslie T Cooper, James A White, Hassan Abdel-Aty, Matthias Gutberlet, Sanjay Prasad, Anthony Aletras, Jean-Pierre Laissy, Ian Paterson, Neil G Filipchuk, Andreas Kumar, Matthias Pauschinger, Peter Liu
Cardiovascular magnetic resonance (CMR) has become the primary tool for noninvasive assessment of myocardial inflammation in patients with suspected myocarditis. The International Consensus Group on CMR Diagnosis of Myocarditis was founded in 2006 to achieve consensus among CMR experts and develop recommendations on the current state-of-the-art use of CMR for myocarditis. The recommendations include indications for CMR in patients with suspected myocarditis, CMR protocol standards, terminology for reporting CMR findings, and diagnostic CMR criteria for myocarditis (i...
April 28, 2009: Journal of the American College of Cardiology
Craig Broberg, Joel McLarry, Julie Mitchell, Christiane Winter, Julie Doberne, Patricia Woods, Luke Burchill, Joseph Weiss
Diagnostic codes used in healthcare administration have been employed extensively in clinical research to identify target patient populations, including demonstration of important clinical outcomes among adults with congenital heart disease. However, little is known about the reliability of code-derived data in this context. We sought to determine the accuracy of International Classification of Disease-9th Revision (ICD-9) diagnoses and the reliability of retrieval algorithms in adults with congenital heart disease (ACHD)...
April 2015: Pediatric Cardiology
Paul Callan, Andrew L Clark
No abstract text is available yet for this article.
January 2016: Heart: Official Journal of the British Cardiac Society
M Ministeri, R Alonso-Gonzalez, L Swan, K Dimopoulos
Advances in cardiology and cardiac surgery have transformed the outlook for patients with congenital heart disease (CHD) so that currently 85% of neonates with CHD survive into adult life. Although early surgery has transformed the outcome of these patients, it has not been curative. Heart failure, endocarditis, arrhythmias and pulmonary hypertension are the most common long term complications of adults with CHD. Adults with CHD benefit from tertiary expert care and early recognition of long-term complications and timely management are essential...
2016: Expert Review of Cardiovascular Therapy
Isabel S Bazan, Wassim H Fares
Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic state that can be found in multiple conditions with associated symptoms of dyspnea, decreased exercise tolerance, and progression to right heart failure. The World Health Organization has classified PH into five groups. The first group is pulmonary arterial hypertension (PAH), which can be idiopathic, heritable, due to drugs and toxins, or associated with conditions such as connective tissue diseases, congenital heart disease, portal hypertension, and others...
2015: Therapeutics and Clinical Risk Management
Fausto Pinto, Alan G Fraser, Josef Kautzner, Katja Kreutzer, Stéphane Piat, Markus Siebert, Panos Vardas, Stephan Windecker
No abstract text is available yet for this article.
January 7, 2016: European Heart Journal
Stephan Rosenkranz, Hossein-Ardeschir Ghofrani, Maurice Beghetti, Dunbar Ivy, Reiner Frey, Arno Fritsch, Gerrit Weimann, Soundos Saleh, Christian Apitz
OBJECTIVE: The Pulmonary Arterial hyperTENsion sGC-stimulator Trial-1 (PATENT-1) was a randomised, double-blind, placebo-controlled phase III trial evaluating riociguat in patients with pulmonary arterial hypertension (PAH). PATENT-2 was an open-label long-term extension to PATENT-1. Here, we explore the efficacy and safety of riociguat in the subgroup of patients with persistent/recurrent PAH after correction of congenital heart disease (PAH-CHD) from the PATENT studies. METHODS: In PATENT-1, patients received riociguat (maximum 2...
November 2015: Heart: Official Journal of the British Cardiac Society
Matthias Greutmann, Petronella G Pieper
Congenital heart defects are the most common birth defects. Major advances in open-heart surgery have led to rapidly evolving cohorts of adult survivors and the majority of affected women now survive to childbearing age. The risk of cardiovascular complications during pregnancy and peripartum depends on the type of the underlying defect, the extent and severity of residual haemodynamic lesions and comorbidities. Careful individualized, multi-disciplinary pre-pregnancy risk assessment and counselling, including assessment of risks in the offspring and estimation on long-term outcomes of the underlying heart defect, will enable informed decision making...
October 1, 2015: European Heart Journal
Jeffrey A Towbin, Angela Lorts, John Lynn Jefferies
Left ventricular non-compaction, the most recently classified form of cardiomyopathy, is characterised by abnormal trabeculations in the left ventricle, most frequently at the apex. It can be associated with left ventricular dilation or hypertrophy, systolic or diastolic dysfunction, or both, or various forms of congenital heart disease. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be induced by exercise or be persistent at rest, but many patients are asymptomatic...
August 22, 2015: Lancet
Ami B Bhatt, Elyse Foster, Karen Kuehl, Joseph Alpert, Stephen Brabeck, Stephen Crumb, William R Davidson, Michael G Earing, Brian B Ghoshhajra, Tara Karamlou, Seema Mital, Jennifer Ting, Zian H Tseng
No abstract text is available yet for this article.
May 26, 2015: Circulation
Francisco J de Abajo, Miguel J Gil, Antonio Rodríguez, Patricia García-Poza, Arturo Álvarez, Verónica Bryant, Luis A García-Rodríguez
OBJECTIVES: To quantify the risk of non-fatal acute myocardial infarction (AMI) among users of allopurinol. METHODS: We carried out a population-based case-control study over the period 2001-2007 in patients aged 40-90 years. Patients who had prescriptions of allopurinol or an episode of AMI before the start date of follow-up were excluded from the main analysis. Allopurinol initiators were classified as current users if their last prescription ended in the 30-day window before the recorded date of AMI for cases and a random date for controls...
May 2015: Heart: Official Journal of the British Cardiac Society
Petar M Seferović, Walter J Paulus
Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction. Recently however, clinical studies on DMCMP mainly describe a restrictive phenotype with concentric LV remodelling and diastolic LV dysfunction. Both phenotypes are not successive stages of DMCMP but evolve independently to respectively heart failure with preserved left ventricular ejection fraction (HFPEF) or reduced left ventricular ejection fraction (HFREF)...
July 14, 2015: European Heart Journal
Fadi G Hage, Gopal Ghimire, Davis Lester, Joshua Mckay, Steven Bleich, Stephanie El-Hajj, Ami E Iskandrian
BACKGROUND: Regadenoson (REGA), a selective adenosine A2A receptor agonist, is the most widely used stress agent for SPECT myocardial perfusion imaging (MPI) in the United States. The diagnostic accuracy of REGA MPI is comparable to Adenosine MPI, but its prognostic value is not well defined. METHODS: We categorized 1,400 patients (700 consecutive normal and 700 consecutive abnormal REGA-MPIs) into 4 groups based on the perfusion defect size using automated quantitative analysis: Group 1: normal perfusion; Group 2: <10% of left ventricle; Group 3: 10%-20%; Group 4: >20%...
December 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Harjit Chahal, David A Bluemke, Colin O Wu, Robyn McClelland, Kiang Liu, Steven J Shea, Gregory Burke, Pelbreton Balfour, David Herrington, PeiBei Shi, Wendy Post, Jean Olson, Karol E Watson, Aaron R Folsom, Joao A C Lima
OBJECTIVE: Heart failure (HF) is a leading cause of mortality especially in older populations. Early detection of high-risk individuals is imperative for primary prevention. The purpose of this study was to develop a HF risk model from a population without clinical cardiac disease. METHODS: The Multi-Ethnic Study of Atherosclerosis is a multicentre observational cohort study following 6814 subjects (mean age 62±10 years; 47% men) who were free of clinical cardiovascular disease at baseline...
January 2015: Heart: Official Journal of the British Cardiac Society
Selma F Mohammed, Imad Hussain, Omar F AbouEzzeddine, Omar F Abou Ezzeddine, Hiroyuki Takahama, Susan H Kwon, Paul Forfia, Véronique L Roger, Margaret M Redfield
BACKGROUND: The prevalence and clinical significance of right ventricular (RV) systolic dysfunction (RVD) in patients with heart failure and preserved ejection fraction (HFpEF) are not well characterized. METHODS AND RESULTS: Consecutive, prospectively identified HFpEF (Framingham HF criteria, ejection fraction ≥50%) patients (n=562) from Olmsted County, Minnesota, underwent echocardiography at HF diagnosis and follow-up for cause-specific mortality and HF hospitalization...
December 23, 2014: Circulation
Tevfik F Ismail, Andrew Jabbour, Ankur Gulati, Amy Mallorie, Sadaf Raza, Thomas E Cowling, Bibek Das, Jahanzaib Khwaja, Francisco D Alpendurada, Ricardo Wage, Michael Roughton, William J McKenna, James C Moon, Amanda Varnava, Carl Shakespeare, Martin R Cowie, Stuart A Cook, Perry Elliott, Rory O'Hanlon, Dudley J Pennell, Sanjay K Prasad
OBJECTIVE: Myocardial fibrosis identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM) is associated with adverse cardiovascular events, but its value as an independent risk factor for sudden cardiac death (SCD) is unknown. We investigated the role of LGE-CMR in the risk stratification of HCM. METHODS: We conducted a prospective cohort study in a tertiary referral centre. Consecutive patients with HCM (n=711, median age 56...
December 2014: Heart: Official Journal of the British Cardiac Society
Dhaval Kolte, Krishnaswami Vijayaraghavan, Sahil Khera, Domenic A Sica, William H Frishman
Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias. This review discusses the vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic properties of magnesium and its current role in the prevention and treatment of cardiovascular disorders...
July 2014: Cardiology in Review
Jean-Louis Vincent, Daniel De Backer
New England Journal of Medicine, Volume 369, Issue 18, Page 1726-1734, October 2013.
October 31, 2013: New England Journal of Medicine
Kumar Dharmarajan, Angela F Hsieh, Zhenqiu Lin, Héctor Bueno, Joseph S Ross, Leora I Horwitz, José Augusto Barreto-Filho, Nancy Kim, Susannah M Bernheim, Lisa G Suter, Elizabeth E Drye, Harlan M Krumholz
IMPORTANCE: To better guide strategies intended to reduce high rates of 30-day readmission after hospitalization for heart failure (HF), acute myocardial infarction (MI), or pneumonia, further information is needed about readmission diagnoses, readmission timing, and the relationship of both to patient age, sex, and race. OBJECTIVE: To examine readmission diagnoses and timing among Medicare beneficiaries readmitted within 30 days after hospitalization for HF, acute MI, or pneumonia...
January 23, 2013: JAMA: the Journal of the American Medical Association
2014-11-15 02:02:57
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