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Miocardiopatias

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39 papers 25 to 100 followers
By Eduardo Roque Cardiologista com foco em cardiologia hospitalar e cuidados intensivos. Professor de clínica médica.
https://www.readbyqxmd.com/read/28431892/a-humanized-hla-dr4-mouse-model-for-autoimmune-myocarditis
#1
M Emrah Şelli, Anita C Thomas, David C Wraith, Andrew C Newby
Myocarditis, the principal cause of dilated cardiomyopathy and heart failure in young adults, is associated with autoimmunity to human cardiac α-myosin (hCAM) and the DR4 allele of human major histocompatibility II (MHCII). We developed an hCAM-induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes, demonstrating that immunization for 3weeks significantly increased splenic T-cell proliferative responses and titres of IgG1 and IgG2c antibodies, abolished weight gain, provoked cardiac inflammation and significantly impaired cardiac output and fractional shortening, by echocardiography, compared to adjuvant-injected mice...
April 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28398370/-catecholamine-induced-myocarditis-in-pheochromocytoma
#2
Davide Muratori, Patrizia Pedrotti, Matteo Baroni, Armando Belloni, Giuseppina Quattrocchi, Angela Milazzo, Cristina Giannattasio, Alberto Roghi
Pheochromocytoma is a rare tumor, usually benign, potentially lethal in case of crisis with acute release of catecholamines. The heart is a target and the clinical presentation can mimic various cardiac conditions, thus rendering diagnosis elusive. Cardiac magnetic resonance is a valuable non-invasive diagnostic tool for the evaluation of cardiomyopathies; it allows the identification of catecholamine-induced myocarditis pattern and, in some cases, it can detect the primary tumor. The definitive treatment of pheochromocytoma is surgical, while the acute crisis may require mechanical support to circulation...
February 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28400924/risk-of-ventricular-arrhythmia-in-patients-with-myocardial-infarction-and-non-obstructive-coronary-arteries-and-normal-ejection-fraction
#3
Loïc Bière, Marjorie Niro, Hervé Pouliquen, Jean-Baptiste Gourraud, Fabrice Prunier, Alain Furber, Vincent Probst
AIM: To assess the arrhythmic determinants and prognosis of patients presenting with myocardial infarction and non-obstructive coronary arteries (MINOCA) with normal ejection fraction (EF). METHODS: This is an observational analysis of 131 MINOCA patients with normal EF. Three cardiac magnetic resonance (CMR) diagnosis classes were recognized according to the late gadolinium enhancement (LGE) pattern: Myocardial infarction (MI) (n = 34), myocarditis (n = 47), and "no LGE" (n = 50)...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28359509/autosomal-recessive-cardiomyopathy-presenting-as-acute-myocarditis
#4
Serkan Belkaya, Amy R Kontorovich, Minji Byun, Sonia Mulero-Navarro, Fanny Bajolle, Aurelie Cobat, Rebecca Josowitz, Yuval Itan, Raphaelle Quint, Lazaro Lorenzo, Soraya Boucherit, Cecile Stoven, Sylvie Di Filippo, Laurent Abel, Shen-Ying Zhang, Damien Bonnet, Bruce D Gelb, Jean-Laurent Casanova
BACKGROUND: Myocarditis is inflammation of the heart muscle that can follow various viral infections. Why children only rarely develop life-threatening acute viral myocarditis (AVM), given that the causal viral infections are common, is unknown. Genetic lesions might underlie such susceptibilities. Mouse genetic studies demonstrated that interferon (IFN)-α/β immunity defects increased susceptibility to virus-induced myocarditis. Moreover, variations in human TLR3, a potent inducer of IFNs, were proposed to underlie AVM...
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28359510/myocarditis-an-intersection-between-genetic-and-acquired-causes-of-human-cardiomyopathy
#5
EDITORIAL
Kirk U Knowlton
No abstract text is available yet for this article.
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28364177/magnetic-resonance-imaging-for-characterizing-myocardial-diseases
#6
REVIEW
Maythem Saeed, Hui Liu, Chang-Hong Liang, Mark W Wilson
The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases. It provides information on myocardial structure/orientation, perfusion, function and viability in diseases related to cardiomyopathy. The standard cardiac magnetic resonance imaging (MRI) sequences can reveal insight on left ventricular (LV) mass, volumes and regional contractile function in all types of cardiomyopathy diseases...
March 31, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28190577/dilated-cardiomyopathy
#7
REVIEW
Robert G Weintraub, Christopher Semsarian, Peter Macdonald
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. The most common presenting symptoms relate to congestive heart failure, but can also include circulatory collapse, arrhythmias, and thromboembolic events...
February 9, 2017: Lancet
https://www.readbyqxmd.com/read/28220466/cardiovascular-toxicities-associated-with-cancer-immunotherapies
#8
REVIEW
Daniel Y Wang, Gosife Donald Okoye, Thomas G Neilan, Douglas B Johnson, Javid J Moslehi
PURPOSE OF REVIEW: We review the cardiovascular toxicities associated with cancer immune therapies and discuss the cardiac manifestations, potential mechanisms, and management strategies. RECENT FINDINGS: The recent advances in cancer immune therapy with immune checkpoint inhibitors and adoptive cell transfer have improved clinical outcomes in numerous cancers. The rising use of cancer immune therapy will lead to a higher incidence in immune-related adverse events...
March 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28329387/map-to-the-future-of-cardiac-magnetic-resonance-in-myocarditis
#9
Philip Haaf, Peter T Buser
No abstract text is available yet for this article.
March 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28345541/a-risk-prediction-model-for-in-hospital-mortality-in-patients-with-suspected-myocarditis
#10
Duo Xu, Ruo-Chi Zhao, Wen-Hui Gao, Han-Bin Cui
BACKGROUND: Myocarditis is an inflammatory disease of the myocardium that may lead to cardiac death in some patients. However, little is known about the predictors of in-hospital mortality in patients with suspected myocarditis. Thus, the aim of this study was to identify the independent risk factors for in-hospital mortality in patients with suspected myocarditis by establishing a risk prediction model. METHODS: A retrospective study was performed to analyze the clinical medical records of 403 consecutive patients with suspected myocarditis who were admitted to Ningbo First Hospital between January 2003 and December 2013...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/19389557/cardiovascular-magnetic-resonance-in-myocarditis-a-jacc-white-paper
#11
Matthias G Friedrich, Udo Sechtem, Jeanette Schulz-Menger, Godtfred Holmvang, Pauline Alakija, Leslie T Cooper, James A White, Hassan Abdel-Aty, Matthias Gutberlet, Sanjay Prasad, Anthony Aletras, Jean-Pierre Laissy, Ian Paterson, Neil G Filipchuk, Andreas Kumar, Matthias Pauschinger, Peter Liu
Cardiovascular magnetic resonance (CMR) has become the primary tool for noninvasive assessment of myocardial inflammation in patients with suspected myocarditis. The International Consensus Group on CMR Diagnosis of Myocarditis was founded in 2006 to achieve consensus among CMR experts and develop recommendations on the current state-of-the-art use of CMR for myocarditis. The recommendations include indications for CMR in patients with suspected myocarditis, CMR protocol standards, terminology for reporting CMR findings, and diagnostic CMR criteria for myocarditis (i...
April 28, 2009: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25428778/accuracy-of-administrative-data-for-detection-and-categorization-of-adult-congenital-heart-disease-patients-from-an-electronic-medical-record
#12
Craig Broberg, Joel McLarry, Julie Mitchell, Christiane Winter, Julie Doberne, Patricia Woods, Luke Burchill, Joseph Weiss
Diagnostic codes used in healthcare administration have been employed extensively in clinical research to identify target patient populations, including demonstration of important clinical outcomes among adults with congenital heart disease. However, little is known about the reliability of code-derived data in this context. We sought to determine the accuracy of International Classification of Disease-9th Revision (ICD-9) diagnoses and the reliability of retrieval algorithms in adults with congenital heart disease (ACHD)...
April 2015: Pediatric Cardiology
https://www.readbyqxmd.com/read/26701966/right-heart-catheterisation-indications-and-interpretation
#13
REVIEW
Paul Callan, Andrew L Clark
No abstract text is available yet for this article.
January 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26675198/comments-on-the-2015-esc-guidelines-for-the-diagnosis-and-management-of-pericardial-diseases-a-report-by-the-spanish-society-of-cardiology-guidelines-committee-working-group
#14
COMMENT
https://www.readbyqxmd.com/read/26678842/common-long-term-complications-of-adult-congenital-heart-disease-avoid-falling-in-a-h-e-a-p
#15
REVIEW
M Ministeri, R Alonso-Gonzalez, L Swan, K Dimopoulos
Advances in cardiology and cardiac surgery have transformed the outlook for patients with congenital heart disease (CHD) so that currently 85% of neonates with CHD survive into adult life. Although early surgery has transformed the outcome of these patients, it has not been curative. Heart failure, endocarditis, arrhythmias and pulmonary hypertension are the most common long term complications of adults with CHD. Adults with CHD benefit from tertiary expert care and early recognition of long-term complications and timely management are essential...
2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/26316767/pulmonary-hypertension-diagnostic-and-therapeutic-challenges
#16
REVIEW
Isabel S Bazan, Wassim H Fares
Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic state that can be found in multiple conditions with associated symptoms of dyspnea, decreased exercise tolerance, and progression to right heart failure. The World Health Organization has classified PH into five groups. The first group is pulmonary arterial hypertension (PAH), which can be idiopathic, heritable, due to drugs and toxins, or associated with conditions such as connective tissue diseases, congenital heart disease, portal hypertension, and others...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26135552/barriers-to-cardiovascular-device-innovation-in-europe
#17
REVIEW
Fausto Pinto, Alan G Fraser, Josef Kautzner, Katja Kreutzer, Stéphane Piat, Markus Siebert, Panos Vardas, Stephan Windecker
No abstract text is available yet for this article.
January 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26135803/riociguat-for-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease
#18
RANDOMIZED CONTROLLED TRIAL
Stephan Rosenkranz, Hossein-Ardeschir Ghofrani, Maurice Beghetti, Dunbar Ivy, Reiner Frey, Arno Fritsch, Gerrit Weimann, Soundos Saleh, Christian Apitz
OBJECTIVE: The Pulmonary Arterial hyperTENsion sGC-stimulator Trial-1 (PATENT-1) was a randomised, double-blind, placebo-controlled phase III trial evaluating riociguat in patients with pulmonary arterial hypertension (PAH). PATENT-2 was an open-label long-term extension to PATENT-1. Here, we explore the efficacy and safety of riociguat in the subgroup of patients with persistent/recurrent PAH after correction of congenital heart disease (PAH-CHD) from the PATENT studies. METHODS: In PATENT-1, patients received riociguat (maximum 2...
November 2015: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26112887/pregnancy-in-women-with-congenital-heart-disease
#19
REVIEW
Matthias Greutmann, Petronella G Pieper
Congenital heart defects are the most common birth defects. Major advances in open-heart surgery have led to rapidly evolving cohorts of adult survivors and the majority of affected women now survive to childbearing age. The risk of cardiovascular complications during pregnancy and peripartum depends on the type of the underlying defect, the extent and severity of residual haemodynamic lesions and comorbidities. Careful individualized, multi-disciplinary pre-pregnancy risk assessment and counselling, including assessment of risks in the offspring and estimation on long-term outcomes of the underlying heart defect, will enable informed decision making...
October 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25865865/left-ventricular-non-compaction-cardiomyopathy
#20
REVIEW
Jeffrey A Towbin, Angela Lorts, John Lynn Jefferies
Left ventricular non-compaction, the most recently classified form of cardiomyopathy, is characterised by abnormal trabeculations in the left ventricle, most frequently at the apex. It can be associated with left ventricular dilation or hypertrophy, systolic or diastolic dysfunction, or both, or various forms of congenital heart disease. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be induced by exercise or be persistent at rest, but many patients are asymptomatic...
August 22, 2015: Lancet
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