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Kidney Imaging

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89 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29279887/regional-variation-of-computed-tomographic-imaging-in-the-united-states-and-the-risk-of-nephrectomy
#1
H Gilbert Welch, Jonathan S Skinner, Florian R Schroeck, Weiping Zhou, William C Black
Importance: While computed tomography (CT) represents a tremendous advance in diagnostic imaging, it also creates the problem of incidental detection-the identification of tumors unrelated to the clinical symptoms that initiate the test. Objective: To determine the geographic variation in the United States in CT imaging and the corresponding association with one of the most consequential sequelae of incidental detection: nephrectomy. Design, Setting, and Participants: This study is a cross-sectional analysis of age-, sex-, and race-adjusted Medicare data (January 2010-December 2014) from 306 hospital referral regions (HRRs) in the United States and includes information from 15 million fee-for-service Medicare beneficiaries age 65 to 85 years...
December 26, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29193529/renal-ultrasound-and-doppler-parameters-as-markers-of-renal-function-and-histopathological-damage-in-children-with-ckd
#2
Happy Sawires, Doaa Salah, Rania Hachem, Wesam Ismail, Amr Salem, Osama Botros, Hadeel Seif
BACKGROUND: Doppler ultrasonography can be used to assess the progression of vascular (arterial sclerosis) and parenchymal (glomerular sclerosis and crescents) renal damage. The aim of this study was to evaluate the significance of some sonographic and Doppler parameters as non-invasive markers of glomerular filtration rate (GFR) and renal histopathological damage in children. METHODOLOGY: A cohort of 84 children were enrolled in a case-control study (42 with CKD stages 2-5 and 42 healthy children)...
November 30, 2017: Nephrology
https://www.readbyqxmd.com/read/29167169/cutting-edge-microangio-ct-new-dimensions-in-vascular-imaging-and-kidney-morphometry
#3
Ruslan Hlushchuk, Cédric Zubler, Sébastien Barré, Carlos Correa Shokiche, Laura Schaad, Raphael Röthlisberger, Monika L Wnuk, Christoph Daniel, Oleksiy Khoma, Stefan A Tschanz, Mauricio Reyes, Valentin Djonov
In the last decades the contrast-enhanced microCT-imaging of whole animal kidney became increasingly important. The visualization was mainly limited to middle-sized vessels. Since modern desktop microCT-scanners provide the necessary detail resolution, we developed an approach for rapid visualization and consistent assessment of kidney vasculature and glomeruli number. This method is based on μAngiofil®, a new polymerizing contrast agent with homogenous X-ray absorption, which provides continuous filling of the complete vasculature and enables correlative imaging approaches...
November 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#4
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29104734/monitoring-kidney-microanatomy-changes-during-ischemia-reperfusion-process-using-texture-analysis-of-oct-images
#5
Zhifang Li, Qinggong Tang, Lili Jin, Peter M Andrews, Yu Chen
kidney ischemia-reperfusion (I/R) accounts for the majority of acute kidney injury cases, whose consequences are commonly encountered after kidney transplantation. Optical coherence tomography (OCT) has been applied to image changes in kidney microanatomy and microcirculation. In this paper, we demonstrate a quantitative method for monitoring kidney status during ischemia-reperfusion process using texture properties of OCT images. This approach employs skewness to measure the distribution of en face OCT image intensities at different depths, thus allowing differentiating ischemia-reperfusion status of kidney...
April 2017: IEEE Photonics Journal
https://www.readbyqxmd.com/read/29092847/measuring-rat-kidney-glomerular-number-and-size-in-vivo-with-mri
#6
Edwin J Baldelomar, Jennifer R Charlton, Scott C Beeman, Kevin M Bennett
Nephron number is highly variable in humans and is thought to play an important role in renal health. Chronic kidney disease (CKD) is the result of too few nephrons to maintain homeostasis. Currently, nephron number estimates can only be determined invasively or as a terminal assessment. Due to a lack of tools to measure and track nephron number in the living, the early stages of CKD often go unrecognized, preventing early intervention that might halt the progression of CKD. In this work, we present a technique to directly measure glomerular number (Nglom) and volume in vivo in the rat kidney (n=8) using MRI enhanced with the novel contrast agent cationized ferritin (CFE-MRI)...
November 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29047410/association-between-kidney-intracapsular-pressure-and-ultrasound-elastography
#7
Kianoush B Kashani, Shennen A Mao, Sami Safadi, Bruce P Amiot, Jaime M Glorioso, John C Lieske, Scott L Nyberg, Xiaoming Zhang
BACKGROUND: Kidney congestion is a common pathophysiologic pathway of acute kidney injury (AKI) in sepsis and heart failure. There is no noninvasive tool to measure kidney intracapsular pressure (KIP) directly. METHODS: We evaluated the correlation of KIP with kidney elasticity measured by ultrasound surface wave elastography (USWE). We directly measured transcatheter KIP in three pigs at baseline and after bolus infusion of normal saline, norepinephrine, vasopressin, dopamine, and fenoldopam; infiltration of 2-L peritoneal dialysis solution in the intra-abdominal space; and venous, arterial, and ureteral clamping...
October 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28931522/three-dimensional-morphometric-analysis-of-the-renal-vasculature
#8
Zohaib Khan, Jennifer P Ngo, Bianca Le, Roger G Evans, James Todd Pearson, Bruce S Gardiner, David W Smith
Vascular topology and morphology is critical in the regulation of blood flow and the transport of small solutes including oxygen, carbon dioxide, nitric oxide and hydrogen sulfide. Renal vascular morphology is particularly challenging as many arterial walls are partially wrapped by the walls of veins. In the absence of a precise characterization of three-dimensional branching vascular geometry, accurate computational modeling of the intrarenal transport of small diffusible molecules is impossible. An enormous manual effort was required to achieve a relatively precise characterization of rat renal vascular geometry, highlighting the need for an automated method for analysis of branched vasculature morphology to allow characterization of the renal vascular geometry of other species, including humans...
September 20, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28877041/sodium-mri-a-new-frontier-in-imaging-in-nephrology
#9
Susan Francis, Charlotte E Buchanan, Ben Prestwich, Maarten W Taal
PURPOSE OF REVIEW: This review focuses on the recent technological advances in quantitative sodium (Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. Na MRI is the only noninvasive imaging technique that allows for the absolute spatial quantification of tissue sodium concentration (TSC), providing assessment of the corticomedullary sodium gradient (CMSG) in the kidney, and allowing measures of TSC in the skin and muscle...
November 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28750926/label-free-molecular-imaging-of-the-kidney
#10
REVIEW
Boone M Prentice, Richard M Caprioli, Vincent Vuiblet
In this review, we will highlight technologies that enable scientists to study the molecular characteristics of tissues and/or cells without the need for antibodies or other labeling techniques. Specifically, we will focus on matrix-assisted laser desorption/ionization imaging mass spectrometry, infrared spectroscopy, and Raman spectroscopy.
September 2017: Kidney International
https://www.readbyqxmd.com/read/28682040/-imaging-in-ckd
#11
REVIEW
Carlo Ratti, Laura Grassi, Emiliana Ferramosca, Paolo Raggi
Imaging has contributed to the successful reduction of cardiovascular morbidity and mortality in the general population and it has demonstrated excellent potential among patients with chronic kidney disease (CKD). The well-known severity of cardiovascular disease in patients suffering from CKD requires an accurate risk stratification of these patients in several clinical situations. Alterations of both structure and function of the myocardium as well as severe vasculopathy are highly prevalent in patients with advanced CKD...
March 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28618770/clinical-significance-of-renal-cortical-thickness-in-patients-with-chronic-kidney-disease
#12
Mehmet Korkmaz, Bekir Aras, Serkan Güneyli, Mümtaz Yılmaz
Purpose: The aim of this study was to evaluate the correlations between laboratory findings and ultrasonographic measurements of renal length and cortical thickness in patients receiving follow-up for chronic kidney disease (CKD). Methods: CKD patients with a low glomerular filtration rate who did not require renal replacement therapy were included in this prospective study. Patients were followed up with laboratory assays at bimonthly intervals and with ultrasonography performed twice a year...
May 6, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28523502/maldi-ms-imaging-in-the-study-of-glomerulonephritis
#13
Andrew Smith, Manuel Galli, Vincenzo L'Imperio, Fabio Pagni, Fulvio Magni
Glomerulonephritis (GNs) are one of the most frequent causes of chronic kidney disease (CKD), a renal condition that often leads to end-stage renal failure, and a careful assessment of these diseases is essential for prognostic and therapeutic purposes. The application of MALDI-MSI directly on bioptic renal tissue represents a new stimulating perspective and facilitates the detection of specific proteomic indicators that are directly correlated with the pathological alterations that occur within the glomeruli during the development of glomerulonephritis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28593430/the-prevalence-and-significance-of-renal-perfusion-defects-in-early-kidney-transplants-quantified-using-3d-contrast-enhanced-ultrasound-ceus
#14
Ben Stenberg, M Wilkinson, S Elliott, N Caplan
OBJECTIVES: Vascular complications are one of the most common causes of early kidney transplant dysfunction. Contrast enhanced ultrasound increases sensitivity to vascular changes. The aim of this study was to assess the prevalence and size of vascular abnormalities in early renal transplants using 3D CEUS and the significance of perfusion defects on renal function. METHODS: Ninety-nine renal transplant patients underwent 3D CEUS after surgery to quantify perfusion defects as percentage total renal volume (TRV)...
June 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28573489/ultrasonic-evaluation-of-renal-cortex-arterial-area-enables-differentiation-between-hypertensive-and-glomerulonephritis-related-chronic-kidney-disease
#15
Arkadiusz Lubas, Grzegorz Kade, Robert Ryczek, Piotr Banasiak, Przemysław Dyrla, Katarzyna Szamotulska, Daniel Schneditz, Stanisław Niemczyk
PURPOSE: Identifying the primary etiology of cardio-renal syndrome in a timely manner remains an ongoing challenge in nephrology. We hypothesized that hypertensive kidney damage can be distinguished from chronic glomerulonephritis at an early stage of chronic kidney disease (CKD) using ultrasound (US) Doppler sonography. METHODS: Fifty-six males (age 54 ± 15, BMI 28.3 ± 3.5 kg/m(2)) with hypertension and stable CKD at stages 2-4 [38 with essential hypertension (HT-CKD); 18 with glomerulonephritis (GN-CKD)] were studied...
June 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28527200/contrast-enhanced-ultrasound-ceus-in-renal-imaging-at-an-interdisciplinary-ultrasound-centre-possibilities-of-dynamic-microvascularisation-and-perfusion
#16
Franz Josef Putz, Anna Erlmeier, Isabel Wiesinger, Niklas Verloh, Christian Stroszczynski, Bernhard Banas, Ernst Michael Jung
OBJECTIVE: To identify the indications for CEUS in renal imaging in an interdisciplinary ultrasound department. METHODS: 102 CEUS examinations of the kidney in 82 patients between September 2014 and July 2016 were analysed regarding the indication for ultrasound. CEUS was performed by one experienced sonographer agent after bolus injection of 1.0 up to 2.4 ml sulphur hexafluoride microbubbles using multifrequency probes with Contrast Harmonic imaging. RESULTS: CEUS of the kidney was performed in patients from 20 to 87 years...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28490528/combining-new-tools-to-assess-renal-function-and-morphology-a-holistic-approach-to-study-the-effects-of-aging-and-a-congenital-nephron-deficit
#17
Stefania Geraci, Jorge Chacon-Caldera, Luise Cullen-McEwen, Lothar R Schad, Carsten Sticht, Victor G Puelles, John F Bertram, Norbert Gretz
Recently, new methods for assessing renal function in conscious mice (transcutaneous assessment) and for counting and sizing all glomeruli in whole kidneys (MRI) have been described. In the present study, these methods were used to assess renal structure and function in aging mice, and in mice born with a congenital low-nephron endowment. Age-related nephron loss was analyzed in adult C57BL/6 mice (10-50 wk of age), and congenital nephron deficit was assessed in glial cell line-derived neurotrophic factor heterozygous (GDNF HET)-null mutant mice...
September 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28434822/current-and-potential-imaging-applications-of-ferumoxytol-for-magnetic-resonance-imaging
#18
REVIEW
Gerda B Toth, Csanad G Varallyay, Andrea Horvath, Mustafa R Bashir, Peter L Choyke, Heike E Daldrup-Link, Edit Dosa, John Paul Finn, Seymur Gahramanov, Mukesh Harisinghani, Iain Macdougall, Alexander Neuwelt, Shreyas S Vasanawala, Prakash Ambady, Ramon Barajas, Justin S Cetas, Jeremy Ciporen, Thomas J DeLoughery, Nancy D Doolittle, Rongwei Fu, John Grinstead, Alexander R Guimaraes, Bronwyn E Hamilton, Xin Li, Heather L McConnell, Leslie L Muldoon, Gary Nesbit, Joao P Netto, David Petterson, William D Rooney, Daniel Schwartz, Laszlo Szidonya, Edward A Neuwelt
Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of i.v. ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacologic, metabolic, and imaging properties, ferumoxytol may play a crucial role in future magnetic resonance imaging of the central nervous system, various organs outside the central nervous system, and the cardiovascular system...
July 2017: Kidney International
https://www.readbyqxmd.com/read/28382533/quantified-kidney-echogenicity-in-mice-with-renal-ischemia-reperfusion-injury-evaluation-as-a-noninvasive-biomarker-of-acute-kidney-injury
#19
Shinya Murata, Noriyuki Sugiyama, Kentaro Maemura, Yoshinori Otsuki
The purpose is to evaluate quantified kidney echogenicity as a biomarker for the early diagnosis of acute kidney injury (AKI) and predicting progression to chronic kidney disease (CKD) in a mouse model of ischemia-reperfusion injury (IRI). Two separate protocols of murine models of IRI were used: (1) 10, 30, and 40 min of bilateral ischemia duration and (2) 45 and 60 min of unilateral ischemia duration. Renal echogenicity was measured with ultrasound and compared with serum creatinine or urine neutrophil gelatinase-associated lipocalin (NGAL) at various timepoints after IRI...
September 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28374888/value-of-prior-imaging-review-before-ordering-renal-sonography-in-the-evaluation-of-abnormal-renal-function
#20
Timothy J Niesen, Nathan Finch, Mandip Gakhal, Robert M Dressler, Howard M Levy
BACKGROUND: To determine the prognostic relevance of prior imaging studies in the evaluation of patients referred for renal ultrasound (US) examination to investigate abnormal renal function tests. METHODS: We conducted a retrospective study of 208 consecutive renal US examinations performed for abnormal renal function tests. RESULTS: 68% (142/208) of patients reviewed for the study had prior abdominal imaging with 15% (21/142) receiving that imaging within 1 month prior to the renal US study and 56% (80/142) within the prior year...
April 4, 2017: Journal of Clinical Ultrasound: JCU
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