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Kidney Imaging

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118 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Hanne Kirsch, Hans-Joachim Mentzel
Due to progress in the development of sequences and techniques magnetic resonance imaging (MRI) methods, such as functional MR urography (fMRU), arterial spin labeling (ASL), diffusion-weighted imaging (DWI), diffusion tension imaging (DTI) and blood oxygen level dependent MRI (BOLD-MRI) have become available for renal functional evaluation. In recent years research of these imaging techniques has demonstrated that they provide valid functional data with respect to renal perfusion, oxygenation and interstitial diffusion as well as glomerular filtration and the extent of an obstructive uropathy...
October 2018: Der Radiologe
Bryan Thomas Haddock, Susan T Francis, Henrik B W Larsson, Ulrik B Andersen
BACKGROUND: Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity. METHODS: To monitor medullary and cortical oxygenation under handgrip exercise-reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise...
September 11, 2018: Journal of the American Society of Nephrology: JASN
Ilaria Petrucci, Anna Clementi, Concetto Sessa, Irene Torrisi, Mario Meola
Chronic kidney disease (CKD) includes all clinical features and complications during the progression of various kidney conditions towards end-stage renal disease (ESRD). These conditions include immune and inflammatory disease such as: primary and hepatitis C virus (HCV)-related glomerulonephritis; infectious disease such as pyelonephritis with or without reflux and tuberculosis; vascular disease such as chronic ischemic nephropathy; hereditary and congenital disease such as polycystic disease and congenital cystic dysplasia; metabolic disease including diabetes and hyperuricemia; and systemic disease (collagen disease, vasculitis, myeloma)...
September 6, 2018: Journal of Nephrology
Tao Liao, Yannan Zhang, Jie Ren, Haofeng Zheng, Hongjun Zhang, Xiujie Li, Xiaonan Liu, Tinghui Yin, Qiquan Sun
Antibody-mediated rejection (AMR) has emerged as a major cause of renal allograft dysfunction. C4d, a specific marker for AMR diagnosis, was strongly recommended for routine surveillance; however, currently, C4d detection is dependent upon tissue biopsy, which is invasive and provides only local semi-quantitative data. Targeted ultrasound imaging has been used extensively for noninvasive and real-time molecular detection with advantages of high specificity and sensitivity. In this study, we designed C4d-targeted microbubbles (MBC4d ) using a streptavidin-biotin conjugated method and detected C4d deposition in vivo in a rat model of AMR by enhanced ultrasound imaging...
September 1, 2018: American Journal of Transplantation
Rong Zhu, Zhonghui Xu, Zhenhong Qi, We Ye, Jian Wang, Jing Kong, Jin Jin, Jianchu Li
AIM: Renal artery duplex ultrasonography (RDU) is an effective and non-invasive screening test in diagnosing renal artery stenosis. The discordance of results in multiple RDU is common. We aim to evaluate the discordance and the reasons for discordance between diagnoses and measurements from multiple RDU examinations. MATERIAL AND METHOD: A retrospective study was performed in 64 examinations of renal arteries from 32 patients that were referred for two or more RDU examinations and renal artery digital subtraction angiography (DSA) within six months, between August 2013 and January 2016...
August 30, 2018: Medical Ultrasonography
Emilio Quaia, Jean Michel Correas, Maithili Mehta, John T Murchison, Antonio Giulio Gennari, Edwin J R van Beek
Ultrasound (US), which may be combination of gray scale and spectral Doppler US, color and power Doppler US, with or without microbubble contrast agents, is usually the first imaging modality to be used in renal parenchymal diseases. The most typical appearance of diffuse renal parenchymal diseases on gray scale US is an increased renal cortical echogenicity and increased or reduced corticomedullary differentiation. Spectral Doppler analysis of intrarenal flows may reveal an increase in intrarenal resistive index value greater than 0...
August 31, 2018: Ultrasound Quarterly
K Müller-Peltzer, G Negrão de Figueiredo, V Schwarze, J Rübenthaler, D A Clevert
CLINICAL/METHODICAL ISSUE: Cystic renal lesions are commonly seen during routine ultrasound examinations of the abdomen. STANDARD RADIOLOGICAL METHODS: Some cystic renal lesions cannot be sufficiently characterized using native ultrasound. In these cases additional imaging might be necessary. METHODICAL INNOVATIONS: Contrast-enhanced ultrasound (CEUS) is a reliable imaging modality to characterize cystic renal lesions. Contrast enhancement of septations and the cystic wall are visualized in high resolution...
October 2018: Der Radiologe
Chenxia Li, Haitian Liu, Xiang Li, Li Zhou, Rong Wang, Yuelang Zhang
PURPOSE: The purpose of the study was to explore the application of blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-MRI) in classification of chronic kidney disease (CKD). METHODS: Twenty-nine cases with CKD and 27 healthy volunteers underwent renal BOLD-MRI. Cases of CKD were divided into two groups according to the estimated glomerular filtration rate (eGFR). The R2* values were measured in renal cortex and medulla, respectively. The difference of R2* between renal cortex and medulla was compared, and the correlations of R2* value in renal cortex and medulla with eGFR were analyzed...
August 27, 2018: Abdominal Radiology
Carsten Dittmayer, Eckhard Völcker, Irene Wacker, Rasmus R Schröder, Sebastian Bachmann
Recent progress in electron microscopy (EM) techniques has opened new pathways to study renal tissue in research and pathology. Modern field emission scanning EM may be utilized to scan thin sections of resin-embedded tissue mounted on a conductive support. Here we sought to achieve automated imaging without the typical limitations of transmission EM with equivalent or superior quality. Extended areas of tissue were either imaged in two (nanotomy) or in three dimensions (volume EM) by serial-section-based array tomography...
September 2018: Kidney International
Su-Faye Lee, Meir Lichtenstein, Peter Hughes, Dinesh Sivaratnam
OBJECTIVE: Major complications including acute tubular necrosis or rejection may occur after renal transplantation. We use a semiquantitative parameter, 2 min uptake (2MU), as part of Tc mercaptoacetyltriglycine (MAG3) scintigraphy for transplant evaluation. The aim of this study were (a) to examine the utility of Tc MAG3 scintigraphy in the assessment of postsurgical complications using the renal biopsy as the gold standard and (b) examine for any correlation with 2MU with serum creatinine (sCr) at 3 and 12 months...
October 2018: Nuclear Medicine Communications
Michał Błaszczyk, Paweł Cichocki, Małgorzata Bieńkiewicz, Janusz Dąbrowski, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: Ultrasound is the first-line imaging in the diagnostics of the urinary system. It provides valuable morphological information, but its usefulness in assessment of the function of renal parenchyma is limited. Dynamic renal scintigraphy provides much more accurate information about parenchymal function of kidneys and urinary outflow. The aim of the study was to establish morphological ultrasound criteria for high likelihood of obstructive uropathy. MATERIAL AND METHODS: 59 patients (38 women, 21 men, between 18 and 82 years old, average age 50) with the pelvis dilatation > 10 mm in one or both kidneys newly diagnosed in ultrasound, without earlier history of kidney and urinary tract diseases or renal surgery...
2018: Nuclear Medicine Review. Central & Eastern Europe
Harsh Singh, Om Biju Panta, Umesh Khanal, Ram Kumar Ghimire
Introduction: Renal cortical elastography has shown conflicting but promising results in evaluation of chronic kidney disease and other renal disorders. The purpose of this study was to establish a normogram of renal cortical elasticity values and assess their variation between right and left kidney and their relation with age, gender, body mass index, renal dimensions and skin to cortex distance. Methods: The study was a hospital based cross sectional study performed at Tribhuvan University Teaching Hospital, a tertiary care center in Kathmandu, Nepal...
October 2017: Journal of Medical Ultrasound
Shimona Saini, Vikas Kumar, Prakashini Koteshwara
Context: Diffusion Tensor Imaging (DTI) is a reliable noninvasive tool to assess renal function with medullary Fractional Anisotropy (FA) values showing the most consistent results. Aims: Evaluation of FA, Apparent Diffusion Coefficient (ADC) for detecting diabetic nephropathy (DN) using 1.5-Tesla magnetic resonance imaging (MRI). To determine FA and ADC values in chronic kidney disease (CKD) patients and controls, and comparing these with estimated glomerular filtiration rate (eGFR) and categorizing the stage of CKD...
April 2018: Indian Journal of Radiology & Imaging
Sharath K Bhagavatula, Paul B Shyn
Image-guided renal biopsies have an increasing role in clinical practice. Renal mass and renal parenchymal biopsy indications, techniques, and other clinical considerations are reviewed in this article. Image-guided renal mass ablation shows significant promise and increasing clinical usefulness as more studies demonstrate its safety and efficacy. Renal mass ablation indications, techniques, and other considerations are also reviewed.
August 2018: Urologic Clinics of North America
Gunnar Schley, Jutta Jordan, Stephan Ellmann, Seymour Rosen, Kai-Uwe Eckardt, Michael Uder, Carsten Willam, Tobias Bäuerle
OBJECTIVES: In human chronic kidney disease (CKD) the extent of renal tubulointerstitial fibrosis correlates with progressive loss of renal function. However, fibrosis can so far only be assessed by histology of kidney biopsies. Magnetic resonance imaging (MRI) can provide information about tissue architecture, but its potential to assess fibrosis and inflammation in diseased kidneys remains poorly defined. MATERIALS AND METHODS: We evaluated excised kidneys in a murine adenine-induced nephropathy model for CKD by MRI and correlated quantitative MRI parameters (T1, T2, and T2* relaxation times, apparent diffusion coefficient and fractional anisotropy) with histological hallmarks of progressive CKD, including renal fibrosis, inflammation, and microvascular rarefaction...
2018: PloS One
Saba Shirvani, Paweł Tokarczuk, Ben Statton, Marina Quinlan, Alaine Berry, James Tomlinson, Peter Weale, Bernd Kühn, Declan P O'Regan
OBJECTIVES: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1 . METHODS: In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL...
July 10, 2018: European Radiology
Shinji Tanaka, Mark D Okusa
BACKGROUND: No approved pharmacological agents are available for the treatment and prevention of acute kidney injury (AKI). The nervous system has been reported to play an important role, directly or indirectly via the immune system, in the pathophysiology of AKI. Neuromodulation, such as vagus nerve stimulation and pulsed ultrasound, is emerging as an innovative therapeutic treatment for various diseases including AKI. However, lack of effective methods to selectively stimulate or inhibit neurons has hampered the complete understanding of the roles of the nervous system in AKI because electrical stimulation is nonspecific for cell types...
2018: Nephron
Haitian Liu, Zhangjian Zhou, Xiang Li, Chenxia Li, Rong Wang, Yuelang Zhang, Gang Niu
OBJECTIVE: To evaluate stages of chronic kidney disease (CKD) by apparent diffusion coefficient (ADC) obtained from diffusion weighted imaging (DWI) using a meta-analysis. METHODS: Literature databases were searched from PubMed, Web of Science, Cochrane and Embase to identify relevant articles about DWI in CKD between 1999 and 2017. ADC values were extracted from the healthy group and CKD patients with different stages. Meta-analysis was conducted using STATA v...
June 21, 2018: British Journal of Radiology
Seth Winfree, Pierre C Dagher, Kenneth W Dunn, Michael T Eadon, Michael Ferkowicz, Daria Barwinska, Katherine J Kelly, Timothy A Sutton, Tarek M El-Achkar
Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney diseases. However, the ability to perform high resolution, quantitative, molecular and cellular interrogation of this precious tissue is still at a developing stage compared to other fields such as oncology. Here, we discuss recent advances in performing large-scale, three-dimensional (3D), multi-fluorescence imaging of kidney biopsies and quantitative analysis referred to as 3D tissue cytometry. This approach allows the accurate measurement of specific cell types and their spatial distribution in a thick section spanning the entire length of the biopsy...
2018: Nephron
Tobias Kummer, Laura Oh, Mary Beth Phelan, Robert D Huang, Jason T Nomura, Srikar Adhikari
INTRODUCTION: Contrast-enhanced ultrasound (CEUS) using intravascular microbubbles has potential to revolutionize point-of-care ultrasonography by expanding the use of ultrasonography into clinical scenarios previously reserved for computed tomography (CT), magnetic resonance imaging, or angiography. METHODS: We performed a literature search and report clinical experience to provide an introduction to CEUS and describe its current applications for point-of-care indications...
July 2018: American Journal of Emergency Medicine
2018-05-04 07:06:56
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