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Kidney Imaging

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135 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Lena Berchtold, Iris Friedli, Lindsey A Crowe, Chantal Martinez, Solange Moll, Karine Hadaya, Thomas de Perrot, Christophe Combescure, Pierre-Yves Martin, Jean-Paul Vallée, Sophie de Seigneux
Background: Kidney cortical interstitial fibrosis (IF) is highly predictive of renal prognosis and is currently assessed by the evaluation of a biopsy. Diffusion magnetic resonance imaging (MRI) is a promising tool to evaluate kidney fibrosis via the apparent diffusion coefficient (ADC), but suffers from inter-individual variability. We recently applied a novel MRI protocol to allow calculation of the corticomedullary ADC difference (ΔADC). We here present the validation of ΔADC for fibrosis assessment in a cohort of 164 patients undergoing biopsy and compare it with estimated glomerular filtration rate (eGFR) and other plasmatic parameters for the detection of fibrosis...
January 4, 2019: Nephrology, Dialysis, Transplantation
Maximilian Peter Brandt, Thomas Lehnert, Theresa Czilwik, Hendrik Borgmann, Tatjana Gruber-Rouh, Axel Thalhammer, Elisabeth Hannah Adam, Christian Thomas, Georg Bartsch, Axel Haferkamp, Thomas Joseph Vogl, Igor Tsaur
INTRODUCTION & OBJECTIVES: Percutaneous nephrostomy [1] has emerged as a pivotal approach in the therapeutic management of the obstructed urinary tract. A consecutive incorporation of ultrasonic and radiographic guidance, the approach experienced an almost ubiquitious distribution while most centers currently applying either one or both of these tools jointly. However, success of ultrasound-guidance is limited in obese patients and non-dilated uropathy. In turn, fluoroscopy usually requires an opacification of the urinary collecting system by intravenous or antegrade contrast media injection, which might be harmful for already impaired renal function, raise intrapelvic pressure and augment the risk of sepsis and hemorrhage...
January 2019: European Journal of Radiology
Ozkan Gungor, Fatma Betul Guzel, Mehmet Akif Sarica, Gulay Gungor, Berivan Ganidagli, Nursel Yurttutan, Ahmet Fazil Gorgel, Orcun Altunoren
Renal elastography is an ultrasonographic method that has been recently found to provide information on renal functions and fibrosis. In this study, we aimed to investigate the relationship between elastography scores and renal functions and proteinuria levels in patient populations with various kidney diseases. Seventy-five diabetic nephropathy patients, 66 kidney transplant patients, and 45 glomerulonephritis patients were included in the study. The amount of proteinuria was measured according to the protein-to-creatinine ratio in spot urine samples...
December 28, 2018: Ultrasound Quarterly
Diya Wang, Shanshan Xu, Kejia Zhang, Xinyu Zhang, Xuan Yang, Mengnan Xiao, Qiang Su, Mingxi Wan
PURPOSE: This study aimed to develop a fast scheme of multi-parametric perfusion functional imaging (PFI) based on dynamic contrast-enhanced ultrasound (DCEUS) for assessing renal microvascular hemodynamics. METHOD: The flow process in the DCEUS-based PFI was modified step-by-step to improve its operational efficiency, which was validated through in vivo renal perfusion experiments. A multi-parametric model with a comprehensive coefficient of imaging quality (CIQ) was then built on four terms of the average information entropy, contrast, gray, and noise coefficient of PFIs to evaluate the sacrifice of imaging quality during modifications of DCEUS-based PFI...
December 26, 2018: Medical Physics
Min Jeong Choi, Pyeong Hwa Kim, Ji Hoon Shin, Jong Woo Kim, Dong Il Gwon, Jin Hyoung Kim, Gi-Young Ko, Hyun-Ki Yoon, Joon Young Ohm
OBJECTIVES: To present the radiological and clinical results of transcatheter arterial embolization in patients with active bleeding after percutaneous renal procedures. METHODS: A total of 79 consecutive patients who underwent angiography for percutaneous renal procedure-related bleeding were included in the present retrospective analysis. Patient characteristics, angiographic management and clinical outcomes were analyzed. RESULTS: On angiography, bleeding foci were observed in 81...
December 21, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Stephanie Preuss, Charlotte Rother, Lutz Renders, Stefan Wagenpfeil, Maike Büttner-Herold, Julia Slotta-Huspenina, Christopher Holtzmann, Claudius Kuechle, Uwe Heemann, Konrad Friedrich Stock
INTRODUCTION: Allograft rejection (AR), chronic allograft injury (CAI) and acute tubular necrosis (ATN) can lead to renal allograft dysfunction after kidney transplantation. Interstitial fibrosis/tubular atrophy (Banff classification 2005) describes chronic allograft injury with no specific etiology, thus explaining the common final endpoint of various (immunologic and non immunologic) etiologies. The aim of this study was to evaluate correlations between the Doppler sonographic RI-values and histopathological changes of renal allografts biopsies during rejection, acute tubular necrosis and chronic allograft injury as well as the influence of donor and recipient features on the intrarenal RI-values...
December 12, 2018: Clinical Hemorheology and Microcirculation
Pierpaolo Di Nicolò, Antonio Granata
The use of renal resistive indices (RRIs) for the study of renal microcirculation has in the past been proposed for the identification of renal organ damage or even to specifically identify injury to some areas of the renal parenchyma. Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels...
December 11, 2018: Journal of Nephrology
Fabio Nery, Enrico De Vita, Chris A Clark, Isky Gordon, David L Thomas
PURPOSE: To develop a robust renal arterial spin labeling (ASL) acquisition and processing strategy for mapping renal blood flow (RBF) in a pediatric cohort with severe kidney disease. METHODS: A single-shot background-suppressed 3D gradient and spin-echo (GRASE) flow-sensitive alternating inversion recovery (FAIR) ASL acquisition method was used to perform 2 studies. First, an evaluation of the feasibility of single-shot 3D-GRASE and retrospective noise reduction methods was performed in healthy volunteers...
December 7, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Jamie R Privratksy, Nian Wang, Yi Qi, Jiafa Ren, Benjamin T Morris, John C Hunting, G Allan Johnson, Steven D Crowley
Acute kidney injury (AKI) is a common cause of morbidity and mortality in hospitalized patients. Nevertheless, there is limited ability to diagnose AKI in its earliest stages through the collection of structural and functional information. Imaging modalities such as magnetic resonance imaging (MRI) are increasingly being utilized to provide structural and functional data that characterize the injured kidney. Dynamic contrast-enhanced (DCE) MRI is an imaging modality that measures changes in kidney structure and contrast transit times; however, its ability to detect these parameters following AKI has not been determined...
December 5, 2018: American Journal of Physiology. Renal Physiology
Shuangtao Ma, Chunqi Qian, Donna H Wang
No abstract text is available yet for this article.
December 1, 2018: American Journal of Physiology. Renal Physiology
Michael E Hall, Jennifer H Jordan, Luis A Juncos, W Gregory Hundley, John E Hall
Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important...
2018: International Journal of Nephrology and Renovascular Disease
Milica Bugarski, Joana Raquel Martins, Dominik Haenni, Andrew M Hall
Kidney proximal tubules (PTs) are densely packed with mitochondria, and defects in mitochondrial function are implicated in many kidney diseases. However, little is known about intrinsic mitochondrial function within PT cells. Here, using intravital multiphoton microscopy and live slices of mouse kidney cortex, we show that autofluorescence signals provide important functional readouts of redox state and substrate metabolism and that there are striking axial differences in signals along the PT. Mitochondrial NAD(P)H intensity was similar in both PT segment (S)1 and S2 and was sensitive to changes in respiratory chain (RC) redox state, whereas cytosolic NAD(P)H intensity was significantly higher in S2...
December 1, 2018: American Journal of Physiology. Renal Physiology
Fen Chen, Shulin Li, Dong Sun
Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently been utilized as a noninvasive tool for evaluating renal oxygenation. Several methods have been proposed for analyzing BOLD images. Regional ROI selection is the earliest and most widely used method for BOLD analysis. In the last 20 years, many investigators have used this method to evaluate cortical and medullary oxygenation in patients with ischemic nephropathy, hypertensive nephropathy, diabetic nephropathy, chronic kidney disease (CKD), acute kidney injury and renal allograft rejection...
2018: Kidney & Blood Pressure Research
M Daneshi, G T Yusuf, C Fang, M E Sellars, D Y Huang, P S Sidhu
AIM: To establish the feasibility and accuracy of contrast-enhanced ultrasound (CEUS) nephrostogram in comparison to the reference standard, fluoroscopic nephrostogram, in providing alternative imaging of the urinary tract post-nephrostomy insertion. MATERIALS AND METHODS: This prospective study was approved by the institutional and national ethics committee. All patients for whom a fluoroscopic nephrostogram was requested were included. Fluoroscopic and CEUS nephrostograms were performed within 24 hours...
November 8, 2018: Clinical Radiology
Yun Lv, Dan Cheng, Dongdong Su, Mei Chen, Bin-Cheng Yin, Lin Yuan, Xiao-Bing Zhang
Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been regarded as a main problem in clinical pharmacology and practice. However, due to the lack of effective biomarkers and noninvasive real-time tools, the early diagnosis of drug-induced AKI is still a crucial challenge. The superoxide anion (O2 ˙- ), the preliminary reactive oxidative species, is closely related to drug-induced AKI. In this paper, we reported two new mitochondria-targeted fluorescent probes for investigating AKI via mapping the fluctuation of O2 ˙- with high sensitivity and selectivity by the combination of rational design and a probe-screening approach...
October 21, 2018: Chemical Science
X J Ye, S H Cui, J W Song, K Liu, X Y Huang, L Wang, Y J Zhou, Z H Yan, G B Wang
AIM: To investigate the clinical value of diffusion tensor imaging (DTI) in assessing renal function changes in diabetic patients with early-stage chronic kidney disease (CKD), and the relationship of DTI parameters with estimated glomerular filtration rate (eGFR) and urinary biomarkers. MATERIALS AND METHODS: Thirty-six patients with diabetes mellitus (DM; 30 CKD stage 1 and 6 CKD stage 2) and 26 healthy control subjects were enrolled. DTI was performed using a clinical 3 T MRI system...
October 22, 2018: Clinical Radiology
Genwen Hu, Zhong Yang, Wen Liang, Caiyong Lai, Yingjie Mei, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
BACKGROUND: Renal fibrosis is a common consequence of chronic kidney disease (CKD) and is the mechanism by which various forms of CKD progress to endstage renal failure. Accurate assessment of renal fibrosis is important for treatment. PURPOSE: To measure longitudinal changes of intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) before and after reversible unilateral ureteral obstruction in an animal model. STUDY TYPE: Self-controlled animal study...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Hanne Kirsch, Hans-Joachim Mentzel
Due to progress in the development of sequences and techniques magnetic resonance imaging (MRI) methods, such as functional MR urography (fMRU), arterial spin labeling (ASL), diffusion-weighted imaging (DWI), diffusion tension imaging (DTI) and blood oxygen level dependent MRI (BOLD-MRI) have become available for renal functional evaluation. In recent years research of these imaging techniques has demonstrated that they provide valid functional data with respect to renal perfusion, oxygenation and interstitial diffusion as well as glomerular filtration and the extent of an obstructive uropathy...
October 2018: Der Radiologe
Bryan Thomas Haddock, Susan T Francis, Henrik B W Larsson, Ulrik B Andersen
BACKGROUND: Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity. METHODS: To monitor medullary and cortical oxygenation under handgrip exercise-reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise...
October 2018: Journal of the American Society of Nephrology: JASN
Ilaria Petrucci, Anna Clementi, Concetto Sessa, Irene Torrisi, Mario Meola
Chronic kidney disease (CKD) includes all clinical features and complications during the progression of various kidney conditions towards end-stage renal disease (ESRD). These conditions include immune and inflammatory disease such as: primary and hepatitis C virus (HCV)-related glomerulonephritis; infectious disease such as pyelonephritis with or without reflux and tuberculosis; vascular disease such as chronic ischemic nephropathy; hereditary and congenital disease such as polycystic disease and congenital cystic dysplasia; metabolic disease including diabetes and hyperuricemia; and systemic disease (collagen disease, vasculitis, myeloma)...
December 2018: Journal of Nephrology
2018-09-09 10:15:26
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