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AKI Biomarkers

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Daniel Guldager Kring Rasmussen, Per Mose Nielsen, Özlem Yashar Kasab-Oglo, Signe Holm Nielsen, Casper Kierulf-Lassen, Morten Asser Karsdal, Federica Genovese, Rikke Nørregaard
Background: Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace the functional tissue. We assessed the concentrations of a neo-epitope fragment of COL III generated by matrix metalloproteinase-9 cleavage (C3M) in two rat models resembling the ischaemic injury taking place following kidney transplantation...
December 7, 2018: Nephrology, Dialysis, Transplantation
Kevin T Barton, Aadil Kakajiwala, Dennis J Dietzen, Charles W Goss, Hongjie Gu, Vikas R Dharnidharka
Beta-2-microglobulin (B2M) is a marker of proximal tubular injury and glomerular filtration. Analyses using older/non-standardized definitions have shown low efficacy of B2M to predict acute kidney injury (AKI). We assessed if elevated levels of B2M would associate with either the diagnosis of AKI [under current Kidney Disease: Improving Global Outcomes (KDIGO) criteria] or recovery from AKI. We performed a retrospective study, including children who had urine B2M (uB2M) and/or serum B2M (sB2M) measured by immunoturbidimetry in our clinical laboratory between January 2011 and December 2015...
December 2018: Clinical Kidney Journal
Holly L Hutton, Maliha A Alikhan, A Richard Kitching
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions...
2018: Experientia. Supplementum
Junyu Liang, Guanfeng Lin, Jianwei Tian, Jiejing Chen, Rongliang Liang, Zhenhua Chen, Qiaoting Deng, Zhining Dong, Tiancai Liu, Yingsong Wu
The morbidity and mortality associated with acute kidney injury (AKI) remain obstinately high. Early diagnosis is urgently required and should be pursued in at-risk populations. Recently, a newly validated biomarker, matrix metalloproteinase-7 (MMP-7), was reported as a novel indicator for early AKI prediction and a noninvasive surrogate biomarker of kidney function. Monitoring urinary MMP-7 (uMMP-7) levels fills the gaps in early diagnosis of AKI at early onset. However, the lack of available reagents for its rapid detection limits its use...
December 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Daniel T Engelman, Michael J Germain
No abstract text is available yet for this article.
October 14, 2018: Journal of Thoracic and Cardiovascular Surgery
Hui-Miao Jia, Yue Zheng, Li-Feng Huang, Xin Xin, Wen-Liang Ma, Yi-Jia Jiang, Xi Zheng, Shu-Yan Guo, Wen-Xiong Li
BACKGROUND: Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcomes. The aim of the current study was to explore and validate the value of endostatin for predicting failure to recover from AKI. METHODS: We conducted a prospective cohort study of 198 patients without known chronic kidney disease who underwent noncardiac major surgery and developed new-onset AKI in the first 48 h after admission to the ICU...
November 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
Phillip S Adams, Diana Vargas, Tracy Baust, Lucas Saenz, Wonshill Koh, Brian Blasiole, Patrick M Callahan, Aparna S Phadke, Khoa N Nguyen, Yuliya Domnina, Mahesh Sharma, John A Kellum, Joan Sanchez-de-Toledo
OBJECTIVES: Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass. DESIGN: Prospective, observational. SETTING: Cardiac operating room and cardiac ICU. PATIENTS: Neonates and infants without history of kidney injury or anatomic renal abnormality. INTERVENTIONS: None...
November 2, 2018: Pediatric Critical Care Medicine
Timo Brandenburger, Antonio Salgado Somoza, Yvan Devaux, Johan M Lorenzen
Acute kidney injury (AKI) is an important health issue concerning ∼50% of patients treated in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity, or hypoxia and leads to severe damage of the kidney and to an increased risk of mortality. The diagnosis of AKI is currently based on creatinine urea levels and diuresis. Yet, novel markers may improve the accuracy of this diagnosis at an early stage of the disease, thereby allowing early prevention and therapy, ultimately leading to a reduction in the need for renal replacement therapy and decreased mortality...
November 2018: Kidney International
Moritz Wyler von Ballmoos, Donald S Likosky, Michael Rezaee, Kevin Lobdell, Shama Alam, Devin Parker, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie, Jeremiah R Brown
BACKGROUND: Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. METHODS: Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007...
October 20, 2018: BMC Nephrology
Beata Bieniaś, Przemysław Sikora
Obstructive nephropathy (ON) secondary to the congenital hydronephrosis (HN) is one of the most common causes of chronic kidney disease in children. Neither currently used imaging techniques nor conventional laboratory parameters are sufficient to assess the onset and outcome of this condition; hence, there is a need to prove the usefulness of newly discovered biomarkers of kidney injury in this respect. The purpose of the study was to assess the urinary excretion of alpha-GST, pi-GST, NGAL, and KIM-1 and the serum level of NGAL in children with congenital unilateral hydronephrosis secondary to ureteropelvic junction obstruction...
2018: Disease Markers
Zhi-Hao Zhang, Jun-Qiu He, Wei-Wei Qin, Ying-Yong Zhao, Ning-Hua Tan
Chronic kidney disease (CKD) has become a major public health problem worldwide and has a great impact on the quality of life of millions of people. Long-term obstructive uropathy is an important cause of CKD. We hypothesized diagnostic biomarkers for early stage obstructive nephropathy can be discovered by metabolomic profiling of biofluid. Unilateral ureteral occlusion (UUO) surgery was performed on rats to induce renal interstitial fibrosis. Sham-operated rats were used as controls. Plasma and urine metabolites were analyzed by UPLC-MS based metabolomic approach...
October 17, 2018: Chemico-biological Interactions
Cheney Li, Long Zhao, Yanfei Wang, Lin Che, Hong Luan, Congjuan Luo, Yan Xu
AIM: Studies have shown that cysteine-rich protein 61 (Cyr61) increased in the post-ischemic human kidney tissue. However, it is still unknown whether Cyr61 can be used as a biomarker in kidney ischemia/reperfusion (I/R) injury METHODS: Microarray data were collected from GSE58438 and GSE52004. The rat I/R model was established to evaluate the mRNA and protein expression of Cyr61, localization of Cyr61 by immunohistochemical and immunofluorescence staining, and changes in serum creatinine (Scr) at the same time...
October 17, 2018: Nephrology
Pei-Chun Fan, Chih-Hsiang Chang, Yung-Chang Chen
Cardiorenal syndromes are disorders of the heart and kidneys whereby dysfunction in one organ may lead to dysfunction in the other organ. Cardiorenal syndrome type I (CRS I) is defined as acute kidney injury caused by acute cardiac dysfunction such as acute decompensated heart failure and acute coronary syndrome. Traditional markers like serum creatinine may delay the diagnosis of acute kidney injury and provide limited information regarding the underlying pathophysiology in the setting of CRS I. Herein, we briefly review some emerging biomarkers, including brain natriuretic peptide, soluble ST2, angiopoietin, soluble thrombomodulin, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C, interleukin-18 and calprotectin...
October 2018: Nephrology
Jiadi Gan, Xiaodong Zhou
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) were considered as the most promising biomarkers in prediction of acute kidney injury (AKI), but the priority of them remains unclear. METHODS: Databases of PubMed, Elsevier, Cochrane library, and Web of science were searched until August 23, 2017 for studies investigated the diagnostic value of urine NGAL (uNGAL) and urine IL-18 (uIL-18) for AKI in adults. Statistical analysis and investigation of heterogeneity source were using RevMan5...
September 2018: Medicine (Baltimore)
Romina Paula Bulacio, Evangelina Cecilia Nosetto, Anabel Brandoni, Adriana Mónica Torres
Caveolin-2 (Cav-2) is expressed in a variety of cell tissue, and it has also been found in renal tissue. The expression of Cav-2 in proximal tubules is still unclear. The aim of this study was to carry out a complete evaluation of the expression pattern of Cav-2 in rat renal cortex to clarify and deepen the knowledge about the localization of Cav-2 in the proximal tubules and also to evaluate its presence in urine. Male Wistar rats were used to assess Cav-2 expression by Western blot analysis in homogenates, apical, and basolateral membranes from kidney cortex, in lysates and total plasma membranes from renal cortical cell suspensions, in urine, and in urinary exosomes...
September 30, 2018: Journal of Cellular Biochemistry
Qi Wu, Robert A Fenton
Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to detect alterations in protein abundances and/or post-translational modifications in plasma, urine or tissue. Such approaches can provide a large unbiased database to facilitate identification of potential biomarkers. In the diagnosis of kidney diseases, urine is usually a more favorable specimen than plasma and kidney tissue due to its non-invasive collection and simplicity of processing...
September 19, 2018: American Journal of Physiology. Renal Physiology
Nora Choi, Reid Whitlock, Jessica Klassen, Michael Zappitelli, Rakesh C Arora, Claudio Rigatto, Julie Ho
OBJECTIVES: Iron regulation is an important modifier of renal ischemia-reperfusion injury, but the role of iron-binding proteins during cardiopulmonary bypass remains unclear. The goal was to characterize iron-binding proteins throughout ischemia-reperfusion injury to determine their association with acute kidney injury development. METHODS: A prospective observational cohort of adult patients who underwent cardiac surgery (n = 301) was obtained, and acute kidney injury was defined by Kidney Disease Improving Global Outcomes...
July 27, 2018: Journal of Thoracic and Cardiovascular Surgery
Malte Kölling, Harald Seeger, George Haddad, Andreas Kistler, Albina Nowak, Robert Faulhaber-Walter, Jan Kielstein, Hermann Haller, Danilo Fliser, Thomas Mueller, Rudolf P Wüthrich, Johan M Lorenzen
Introduction: Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They might have an impact on microRNA expression by their sponging activity. The detectability in blood of these RNA transcripts has been demonstrated in patients with cancer and cardiovascular disease. We tested the hypothesis that circulating circRNAs in blood of critically ill patients with acute kidney injury (AKI) at inception of renal replacement therapy may also be dysregulated and associated with patient survival...
September 2018: KI Reports
Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen, Pei-Chun Fan, Su-Wei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai
BACKGROUND: Although urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising biomarker for the early detection of kidney injury, previous studies of adult patients who underwent cardiac surgery have reported only moderate discrimination. The age, creatinine, and ejection fraction (ACEF) score is a preoperative validated risk model with satisfactory accuracy for predicting AKI following cardiac surgery. It remains unknown whether combining preoperative risk assessment through ACEF scores followed by urinary NGAL test in a population of high-risk individuals is an optimal approach with improved predictive performance...
2018: PloS One
Zoltán H Endre
While there are no clear definitions of recovery, it is clear that the goals of recovery depend on the severity of acute kidney injury and the clinical context. The degree of renal recovery affects both renal and clinical prognosis. There are presently few guidelines on recovery targets, which range in extent from dialysis independence via normalization of serum creatinine to recovery of renal functional reserve. However, while there are no validated biomarkers for predicting recovery, evidence suggests that both functional and damage biomarkers can aid the assessment of recovery...
2018: Nephron
2018-08-30 07:12:21
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