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AKI Biomarkers

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119 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27906719/diagnosis-of-cardiac-surgery-associated-acute-kidney-injury-from-functional-to-damage-biomarkers
#1
Wim Vandenberghe, Jorien De Loor, Eric A J Hoste
PURPOSE OF REVIEW: Acute kidney injury (AKI) occurs in up to 30% after cardiac surgery and is associated with adverse outcome. Currently, cardiac surgery-associated acute kidney injury (CSA-AKI) is diagnosed by Kidney Disease: Improving Global Outcomes criteria based on creatinine and urine output. To detect and treat AKI earlier, various biomarkers have been evaluated. This review addresses the current position of the two damage biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and [TIMP-2] [IGFBP7] in clinical practice...
November 30, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27827308/biomarkers-for-the-early-detection-and-prognosis-of-acute-kidney-injury
#2
Rakesh Malhotra, Edward D Siew
AKI is an increasingly common disorder that is strongly linked to short- and long-term morbidity and mortality. Despite a growing heterogeneity in its causes, providing a timely and certain diagnosis of AKI remains challenging. In this review, we summarize the evolution of AKI biomarker studies over the past few years, focusing on two major areas of investigation: the early detection and prognosis of AKI. We highlight some of the lessons learned in conducting AKI biomarker studies, including ongoing attempts to address the limitations of creatinine as a reference standard and the recent shift toward evaluating the prognostic potential of these markers...
November 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27760486/micro-rna-320-as-a-novel-potential-biomarker-in-renal-ischemia-reperfusion
#3
Aydın Güçlü, Cengiz Koçak, Fatma Emel Koçak, Raziye Akçılar, Yavuz Dodurga, Aydın Akçılar, Mücahit Seçme
AIM: MicroRNAs (miR) are important diagnostic and treatment targets due to their different tissue expressions and their central position in the regulation of gene expressions. miR studies might pioneer emerging of new diagnostic tools and treatment goals in kidney diseases. Captopril (CAP) and telmisartan (TEL) were shown to be effective in ischemia reperfusion (IR) injury. There is not any study about the effect of TEL and CAP over miR-21-320-146a. Our aim was to study the effects of CAP and TEL over miR on renal IR model...
October 19, 2016: Renal Failure
https://www.readbyqxmd.com/read/27767358/urinary-l-type-fatty-acid-binding-protein-is-a-predictor-of-early-renal-function-after-partial-nephrectomy
#4
Masaaki Yanishi, Hidefumi Kinoshita, Takao Mishima, Hisanori Taniguchi, Kenji Yoshida, Yoshihiro Komai, Kaneki Yasuda, Masato Watanabe, Motohiko Sugi, Tadashi Matsuda
PURPOSE: Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed. METHODS: This study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy...
October 21, 2016: Renal Failure
https://www.readbyqxmd.com/read/27758121/kidney-injury-molecule-1-in-kidney-disease
#5
Caixia Yin, Ningning Wang
Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome...
October 19, 2016: Renal Failure
https://www.readbyqxmd.com/read/27759760/validity-of-klotho-cyr61-and-ykl-40-as-ideal-predictive-biomarkers-for-acute-kidney-injury-review-study
#6
Osama Mosa, Milan Skitek, Ales Jerin
CONTEXT AND OBJECTIVE: Acute kidney injury (AKI) is still a headache for clinicians and scientists as a possible reason for increased death among intensive care unit (ICU) patients after invasive cardiac surgery. Furthermore, the diagnostic process for AKI using conventional biomarkers is not sufficient to ensure early warning of this condition because of the morbid influence of non-renal factors that definitively delay the time for the prognosis. These imposed limitations have led to significant amounts of research targeted towards identifying novel biomarkers for AKI with a sustained degree of sensitivity and specificity...
October 13, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27717384/preoperative-plasma-growth-differentiation-factor-15-for-prediction-of-acute-kidney-injury-in-patients-undergoing-cardiac-surgery
#7
Matthias Heringlake, Efstratios I Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann
BACKGROUND: Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in patients undergoing cardiac surgery, is associated with poor prognosis. The present secondary analysis of an observational cohort study aimed to determine the role of GDF-15 in predicting CSA-AKI compared with the Cleveland-Clinic Acute Renal Failure (CC-ARF) score and a logistic regression model including variables associated with renal dysfunction...
October 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27709557/erythrocyte-superoxide-dismutase-as-a-biomarker-of-septic-acute-kidney-injury
#8
Nara Aline Costa, Ana Lúcia Gut, Paula Schmidt Azevedo, Suzana Erico Tanni, Natália Baraldi Cunha, Eloá Siqueira Magalhães, Graziela Biude Silva, Bertha Furlan Polegato, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, André Luís Balbi, Daniela Ponce, Marcos Ferreira Minicucci
BACKGROUND: Oxidative stress is a key feature of sepsis and could be a common pathophysiological pathway between septic shock and acute kidney injury (AKI) Our objective was to evaluate the erythrocyte superoxide dismutase (SOD1) activity as predictor of AKI in patients with septic shock. METHODS: This is a prospective observational study that evaluated 175 consecutive patients over the age of 18 years with septic shock upon intensive care unit (ICU) admission...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27692160/dcoh-a-novel-biomarker-for-diagnosing-acute-kidney-injury
#9
Varsha Singh
Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis prevents proper treatment and timely delay in providing putative therapeutic agents. The cost effective therapies to get delayed, patient health gets compromised and ultimately requires renal transplant due to end-stage renal disease, which is another major problematic factor due to shortage kidney donors...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27613644/high-urinary-excretion-of-kidney-injury-molecule-1-predicts-adverse-outcomes-in-acute-kidney-injury-a-case-control-study
#10
Yuanyuan Xie, Qin Wang, Chunlin Wang, Chaojun Qi, Zhaohui Ni, Shan Mou
BACKGROUND: Acute kidney injury (AKI) is a common clinical syndrome with poor prognosis. The insensitivity and non-specificity of traditional markers of renal dysfunction prevent timely estimation of the severity of renal injury, and the administration of possible therapeutic agents. Urinary kidney injury molecule-1 (uKIM-1) is a marker of epithelial injury of renal tubules. Different uKIM-1 levels are associated with various degrees of renal injury. This study sought to evaluate uKIM-1 as a predictor of renal prognosis by analyzing uKIM-1 levels in patients with AKI...
September 10, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27538426/urinary-biomarkers-at-the-time-of-aki-diagnosis-as-predictors-of-progression-of-aki-among-patients-with-acute-cardiorenal-syndrome
#11
Chunbo Chen, Xiaobing Yang, Ying Lei, Yan Zha, Huafeng Liu, Changsheng Ma, Jianwei Tian, Pingyan Chen, Tiecheng Yang, Fan Fan Hou
BACKGROUND AND OBJECTIVES: A major challenge in early treatment of acute cardiorenal syndrome (CRS) is the lack of predictors for progression of AKI. We aim to investigate the utility of urinary angiotensinogen and other renal injury biomarkers in predicting AKI progression in CRS. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: In this prospective, multicenter study, we screened 732 adults who admitted for acute decompensated heart failure from September 2011 to December 2014, and evaluated whether renal injury biomarkers measured at time of AKI diagnosis can predict worsening of AKI...
September 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27609347/early-prediction-of-acute-kidney-injury-after-transapical-and-transaortic-aortic-valve-implantation-with-urinary-g1-cell-cycle-arrest-biomarkers
#12
Fabian Dusse, Michaela Edayadiyil-Dudásova, Matthias Thielmann, Daniel Wendt, Philipp Kahlert, Ender Demircioglu, Heinz Jakob, Simon T Schaefer, Kevin Pilarczyk
BACKGROUND: Acute kidney injury (AKI) is a common complication following transcatheter aortic valve implantation (TAVI) leading to increased mortality and morbidity. Urinary G1 cell cycle arrest proteins TIMP-2 and IGFBP7 have recently been suggested as sensitive biomarkers for early detection of AKI in critically ill patients. However, the precise role of urinary TIMP-2 and IGFBP7 in patients undergoing TAVI is unknown. METHODS: In a prospective observational trial, 40 patients undergoing TAVI (either transaortic or transapical) were enrolled...
September 8, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27605390/impact-of-clinical-context-on-acute-kidney-injury-biomarker-performances-differences-between-neutrophil-gelatinase-associated-lipocalin-and-l-type-fatty-acid-binding-protein
#13
Toshifumi Asada, Rei Isshiki, Naoki Hayase, Maki Sumida, Ryota Inokuchi, Eisei Noiri, Masaomi Nangaku, Naoki Yahagi, Kent Doi
Application of acute kidney injury (AKI) biomarkers with consideration of nonrenal conditions and systemic severity has not been sufficiently determined. Herein, urinary neutrophil gelatinase-associated lipocalin (NGAL), L-type fatty acid-binding protein (L-FABP) and nonrenal disorders, including inflammation, hypoperfusion and liver dysfunction, were evaluated in 249 critically ill patients treated at our intensive care unit. Distinct characteristics of NGAL and L-FABP were revealed using principal component analysis: NGAL showed linear correlations with inflammatory markers (white blood cell count and C-reactive protein), whereas L-FABP showed linear correlations with hypoperfusion and hepatic injury markers (lactate, liver transaminases and bilirubin)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27586401/urinary-c-type-natriuretic-peptide-excretion-a-promising-biomarker-to-detect-underlying-renal-injury-and-remodeling-both-acutely-and-chronically
#14
Peng Hu, Si Yan Liu, Dong Dong Zhang, Yao Xu, Xun Xia
Acute kidney injury (AKI) refers to a sudden decline in renal function. A growing body of evidence demonstrates that AKI is a risk factor for the future development or accelerated progression of chronic kidney disease (CKD), whereas the actual distinction between AKI and CKD remains unknown. CNP is predominantly present in the kidney and possesses multiple renoprotective properties. Urinary CNP excretion tends to be high in AKI, whereas back to the baseline in CKD. The dynamic changes in urinary CNP excretion may help detect underlying renal injury and remodeling both acutely and chronically...
September 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27608623/micrornas-in-acute-kidney-injury
#15
REVIEW
Pei-Chun Fan, Chia-Chun Chen, Yung-Chang Chen, Yu-Sun Chang, Pao-Hsien Chu
Acute kidney injury (AKI) is an important clinical issue that is associated with significant morbidity and mortality. Despite research advances over the past decades, the complex pathophysiology of AKI is not fully understood. The regulatory mechanisms underlying post-AKI repair and fibrosis have not been clarified either. Furthermore, there is no definitively effective treatment for AKI. MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs of 19~23 nucleotides that have been shown to be crucial to the post-transcriptional regulation of various cellular biological functions, including proliferation, differentiation, metabolism, and apoptosis...
September 8, 2016: Human Genomics
https://www.readbyqxmd.com/read/27527370/urinary-%C3%AF-glutathione-s-transferase-predicts-advanced-acute-kidney-injury-following-cardiovascular-surgery
#16
Kai-Hsiang Shu, Chih-Hsien Wang, Che-Hsiung Wu, Tao-Min Huang, Pei-Chen Wu, Chien-Heng Lai, Li-Jung Tseng, Pi-Ru Tsai, Rory Connolly, Vin-Cent Wu
Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analyzed for urinary alpha-(α-) and pi-(π-) GSTs. The outcomes of advanced AKI (KDIGO stage 2, 3) and all-cause in-patient mortality, as composite outcome, were recorded. Areas under the receiver operator characteristic (ROC) curves and multivariate generalized additive model (GAM) were applied to predict outcomes...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27505067/neutrophil-gelatinase-associated-lipocalin-as-a-diagnostic-marker-for-acute-kidney-injury-in-oliguric-critically-ill-patients-a-post-hoc-analysis
#17
Mohamud Egal, Hilde R H de Geus, A B Johan Groeneveld
BACKGROUND: Oliguria occurs frequently in critically ill patients, challenging clinicians to distinguish functional adaptation from serum-creatinine-defined acute kidney injury (AKIsCr). We investigated neutrophil gelatinase-associated lipocalin (NGAL)'s ability to differentiate between these 2 conditions. METHODS: This is a post-hoc analysis of a prospective cohort of adult critically ill patients. Patients without oliguria within the first 6 h of admission were excluded...
2016: Nephron
https://www.readbyqxmd.com/read/27528406/circulating-microrna-188-30a-and-30e-as-early-biomarkers-for-contrast-induced-acute-kidney-injury
#18
Shi-Qun Sun, Tuo Zhang, Ding Ding, Wei-Feng Zhang, Xiao-Lei Wang, Zhe Sun, Liu-Hua Hu, Sheng-Ying Qin, Ling-Hong Shen, Ben He
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because creatinine is an unreliable indicator of acute changes in kidney function, we assessed whether circulating microRNAs (miRNAs) could serve as biomarkers for early detection of CI-AKI. METHODS AND RESULTS: Using a rat model of CI-AKI, we first evaluated the miRNA profile of rat plasma and kidney...
August 15, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27465990/bench-to-bedside-the-next-steps-for-biomarkers-in-acute-kidney-injury
#19
John W Pickering, Zoltan H Endre
No new biomarker of acute kidney injury (AKI) has entered routine clinical practice after a decade of promise, although liver-fatty acid binding protein (L-FABP), neutrophil gelatinase-associated lipoprotein (NGAL), and the combination of tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7) are approved for use in some jurisdictions. Acceptance of creatinine as a surrogate of not just glomerular filtration rate (GFR) but also renal injury, changes in nephrologist workloads, failure to establish the added value of each biomarker to current clinical variables across multiple clinical settings, the lack of treatment options, and simply an insufficient passage of time, have all contributed to the lack of progress...
October 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27436854/urinary-angiogenin-reflects-the-magnitude-of-kidney-injury-at-the-infrahistologic-level
#20
Quentin Tavernier, Iadh Mami, Marion Rabant, Alexandre Karras, Pierre Laurent-Puig, Eric Chevet, Eric Thervet, Dany Anglicheau, Nicolas Pallet
The ribonuclease angiogenin is a component of the mammalian stress response that is secreted by renal epithelial cells on activation of the inositol-requiring enzyme 1α (IRE1α)-active spliced X-box binding protein 1 (sXBP1) axis and instrumental to the adaptation to AKI associated with endoplasmic reticulum stress. To determine whether the amount of angiogenin in urine of individuals with a kidney injury reflects the magnitude of the lesions and provides information on the risk of organ failure, we examined individuals referred for a kidney injury and determined the biochemical characteristics of urinary angiogenin and its diagnostic and prognostic values...
July 19, 2016: Journal of the American Society of Nephrology: JASN
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