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AKI Biomarkers

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Qi Wu, Robert A Fenton
Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to detect alterations in protein abundances and/or post-translational modifications in plasma, urine or tissue. Such approaches can provide a large unbiased database to facilitate identification of potential biomarkers. In the diagnosis of kidney diseases, urine is usually a more favorable specimen than plasma and kidney tissue due to its non-invasive collection and simplicity of processing...
September 19, 2018: American Journal of Physiology. Renal Physiology
Nora Choi, Reid Whitlock, Jessica Klassen, Michael Zappitelli, Rakesh C Arora, Claudio Rigatto, Julie Ho
OBJECTIVES: Iron regulation is an important modifier of renal ischemia-reperfusion injury, but the role of iron-binding proteins during cardiopulmonary bypass remains unclear. The goal was to characterize iron-binding proteins throughout ischemia-reperfusion injury to determine their association with acute kidney injury development. METHODS: A prospective observational cohort of adult patients who underwent cardiac surgery (n = 301) was obtained, and acute kidney injury was defined by Kidney Disease Improving Global Outcomes...
July 27, 2018: Journal of Thoracic and Cardiovascular Surgery
Malte Kölling, Harald Seeger, George Haddad, Andreas Kistler, Albina Nowak, Robert Faulhaber-Walter, Jan Kielstein, Hermann Haller, Danilo Fliser, Thomas Mueller, Rudolf P Wüthrich, Johan M Lorenzen
Introduction: Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They might have an impact on microRNA expression by their sponging activity. The detectability in blood of these RNA transcripts has been demonstrated in patients with cancer and cardiovascular disease. We tested the hypothesis that circulating circRNAs in blood of critically ill patients with acute kidney injury (AKI) at inception of renal replacement therapy may also be dysregulated and associated with patient survival...
September 2018: KI Reports
Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen, Pei-Chun Fan, Su-Wei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai
BACKGROUND: Although urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising biomarker for the early detection of kidney injury, previous studies of adult patients who underwent cardiac surgery have reported only moderate discrimination. The age, creatinine, and ejection fraction (ACEF) score is a preoperative validated risk model with satisfactory accuracy for predicting AKI following cardiac surgery. It remains unknown whether combining preoperative risk assessment through ACEF scores followed by urinary NGAL test in a population of high-risk individuals is an optimal approach with improved predictive performance...
2018: PloS One
Zoltán H Endre
While there are no clear definitions of recovery, it is clear that the goals of recovery depend on the severity of acute kidney injury and the clinical context. The degree of renal recovery affects both renal and clinical prognosis. There are presently few guidelines on recovery targets, which range in extent from dialysis independence via normalization of serum creatinine to recovery of renal functional reserve. However, while there are no validated biomarkers for predicting recovery, evidence suggests that both functional and damage biomarkers can aid the assessment of recovery...
August 28, 2018: Nephron
Axel Nierhaus, Frank Bloos, Darius Cameron Wilson, Gunnar Elke, Patrick Meybohm
No abstract text is available yet for this article.
August 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
Wenqing Yin, Ping L Zhang, Jacqueline Macknis, Fan Lin, Joseph V Bonventre
There is currently no technique to unambiguously diagnose antemortem kidney injury on postmortem examination since postmortem tissue damage and autolysis are common. We assessed the ability to detect kidney injury molecule-1 (KIM-1) expression in adult and fetal kidneys examined at autopsy. In adult kidneys (n=52 subjects), we found that the intensity of KIM-1 staining significantly correlated with the antemortem level of serum creatinine, and this was independent of the extent of tissue autolysis. Kidneys from a total of 52 fetal/neonatal subjects, 30 stillborns and 22 liveborns, were assessed for KIM-1 staining...
August 15, 2018: American Journal of Physiology. Renal Physiology
Vin-Cent Wu, Chih-Chung Shiao, Nai-Hsin Chi, Chih-Hsien Wang, Shih-Chieh Jeff Chueh, Hung-Hsiang Liou, Herbert D Spapen, Patrick M Honore, Tzong-Shinn Chu
: The ideal circumstances for whether and when to start RRT remain unclear. The outcome predictive ability of acute kidney injury (AKI) biomarkers measuring at dialysis initializing need more validation. This prospective, multi-center observational cohort study enrolled 257 patients with AKI undergoing renal replacement therapy (RRT) shortly after admission. At the start of RRT, blood and urine samples were collected for relevant biomarker measurement. RRT dependence and all-cause mortality were recorded up to 90 days after discharge...
August 6, 2018: Journal of Clinical Medicine
Ali C Johnson, Richard A Zager
P21 is up-regulated in renal tubules in response to AKI and localizes in the nucleus where it induces cell cycle arrest (CCA). These events can mitigate early injury, but can also facilitate the onset of the cellular senescence/"aging" process. Hence, we asked: i) Can renal p21 up-regulation be gauged by plasma and/or urinary p21 assay? ii) Might p21 serve as an AKI / CCA biomarker? and iii) Does p21 accumulate during normal renal aging, and might plasma p21 reflect this process? Mice were subjected to either ischemia-reperfusion (I/R) or nephrotoxic (maleate) AKI...
August 1, 2018: American Journal of Physiology. Renal Physiology
Tae Hyung Kim, Han Ah Lee, Yeon Seok Seo, Yoo Ra Lee, Sun Young Yim, Young Sun Lee, Sang Jun Suh, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
BACKGROUND AND AIM: For appropriate management of acute kidney injury (AKI) in cirrhotic patients, accurate differentiation of the types of AKI, prerenal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN) is very important. Urine N-acetyl-β-D-glucosaminidase (NAG) has been proposed as a good tubular injury marker in many studies, but its efficacy in cirrhosis is unclear. This study was performed to evaluate the usefulness of urine NAG in patients with decompensated cirrhosis...
July 30, 2018: Journal of Gastroenterology and Hepatology
J Zhang, C-J Wang, X-M Tang, Y-K Wei
OBJECTIVE: Acute kidney injury (AKI) is common in critically ill patients, and sepsis patients with AKI had a higher mortality rate. The aim of the present study was to determine the potential value of urinary miR-26b in the diagnosis of sepsis-associated AKI. PATIENTS AND METHODS: Urinary samples were collected from a cohort of 155 sepsis patients (68 AKI patients and 87 non-AKI patients) and 57 patients with non-infectious systemic inflammatory response syndrome (SIRS)...
July 2018: European Review for Medical and Pharmacological Sciences
L-J Su, Y-M Li, J A Kellum, Z-Y Peng
BACKGROUND: A biomarker test based on a combination of urine tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) has been used as a potential biomarker of acute kidney injury (AKI). This meta-analysis aimed to evaluate the predictive value of this biomarker for cardiac surgery-associated acute kidney injury (CSA-AKI). METHODS: We searched MEDLINE, PubMed, Cochrane, and EMBASE for studies. We evaluated the methodological quality of each included study using the Quality Assessment of Diagnostic Accuracy Studies 2 criteria...
August 2018: British Journal of Anaesthesia
Yousaku Okubo, Akinori Sairaku, Nobuyuki Morishima, Hiroshi Ogi, Takeshi Matsumoto, Hiroki Kinoshita, Yasuki Kihara
BACKGROUND: Urinary liver-type fatty acid-binding protein (L-FABP) is a potential biomarker for acute kidney injury, and it in turn increases cardiovascular mortality. We tested whether the urinary L-FABP level predicted short- and mid-term outcomes in patients with acute heart failure. METHODS AND RESULTS: We enrolled consecutive patients with acute heart failure, and measured their urinary L-FABP levels before acute treatment. Worsening renal function (WRF), defined as both an absolute increase in the serum creatinine level of ≥0...
August 2018: Journal of Cardiac Failure
Oded Volovelsky, Tara C Terrell, Hayley Swain, Michael R Bennett, David S Cooper, Stuart L Goldstein
BACKGROUND: Early detection of acute kidney injury (AKI) after cardiac surgery has improved recently with the discovery and validation of novel urinary biomarkers. However, objective tools to predict the risk of AKI before the insult are still missing. We tested the hypothesis that pre-operative serum fibroblast growth factor 23 (FGF23) concentrations would be elevated in children who develop AKI after heart surgery with cardiopulmonary bypass (CPB). We also compared post-operative FGF23 concentrations to other biomarkers for early detection of AKI...
July 19, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Sanja Sakan, Vedran Premuzic, Daniela Bandic Pavlovic, Nikolina Basic-Jukic
The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case-control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects were followed-up until the last enrolled patient survived 180 days or until the time of death. Higher FGF23 levels positively correlated with serum creatinine levels (P < 0.05). Significantly higher number of patients without diuresis and with FGF23 ≤ 709 RU/mL survived when compared to patients without diuresis and with FGF23 ≥ 709 RU/mL (P < 0...
July 15, 2018: Therapeutic Apheresis and Dialysis
Xiaohui Lin, Xin Huang, Lina Zhou, Weijie Ren, Jun Zeng, Weihong Yao, Xingyuan Wang
Analyzing the disease data from the view of combinatorial features may better characterize the disease phenotype. In this study, a novel method is proposed to construct feature combinations and a classification model (CFC-CM) by mining key feature relationships. CFC-CM iteratively tests for differences in the feature relationship between different groups. To do this, it uses a modified -top-scoring pair () algorithm and then selects the most discriminative feature pairs in the current feature set to infer the combinatorial features and build the classification model...
December 4, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
John M Arthur, Nithin Karakala, Ricky D Edmondson
The search for acute kidney injury (AKI) biomarkers has identified a number of urine proteins that can be used to predict the presence of AKI but has struggled to identify proteins that are prognostic for severe AKI. In this review, we discuss 2 currently available biomarkers and the designs of the studies in which they were identified and relate this to the AKI characteristics they predict clinically. We discuss recent advances in mass spectrometry and sample preparation, which have improved the ability to identify low abundance proteins as well as the ability to characterize more of the protein by mass spectrometry...
July 10, 2018: Nephron
Ali C M Johnson, Richard A Zager
BACKGROUND: Recent clinical data support the utility/superiority of a new AKI biomarker ("NephroCheck"), the arithmetic product of urinary TIMP × IGFBP7 concentrations. However, the pathophysiologic basis for its utility remains ill defined. METHODS: To clarify this issue, CD-1 mice were subjected to either nephrotoxic (glycerol, maleate) or ischemic AKI. Urinary TIMP2/IGFBP7 concentrations were determined at 4 and 18 hours postinjury and compared with urinary albumin levels...
August 2018: Journal of the American Society of Nephrology: JASN
Sameer H Fatani, Abeer Ahmed ALrefai, Hiba S Al-Amodi, Hala F Kamel, Kasem Al-Khatieb, Hamdy Bader
Critically ill patients revealed significant adverse outcomes (sepsis, septic shock, organ dysfunction/failure, and mortality) despite variable effort. AIM: this study evaluated the association of TNF-a-238 (rs 361525) with adverse outcomes in critically ill patients. TNF-α-238 (rs 361525) SNP was performed by RT-PCR on 200 critically-ill patients (112 had severe sepsis and septic shock and 88 were septic), 127 of them had AKI. Urinary N-acetyl-β-(D)-glucosaminidase and serum creatinine were assessed by modified Jaffé and ELISA respectively...
October 2018: Molecular Biology Reports
Y Naresh, N Srinivas, Kiranmayi S Vinapamula, P Pullaiah, P V L N Srinivasa Rao, V Sivakumar
Carbamylated hemoglobin (CarHb) was found to have a potential role in the differentiation of patients with acute kidney injury (AKI) from chronic kidney disease (CKD). This study was aimed at the evaluation of the diagnostic performance and usefulness of CarHb in the differentiation of AKI from CKD. Forty patients with renal disease and twenty age- and sex-matched healthy controls were included in the study. Urea, creatinine, Hb, and CarHb were measured in all the subjects. Patients with AKI and CKD were found to have significantly increased levels of CarHb when compared to controls ( P < 0...
May 2018: Indian Journal of Nephrology
2018-07-04 07:06:14
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