Mercedes Clemente-Postigo, Araceli Muñoz-Garach, Marta Serrano, Lourdes Garrido-Sánchez, M Rosa Bernal-López, Diego Fernández-García, Inmaculada Moreno-Santos, Nuria Garriga, Daniel Castellano-Castillo, Antonio Camargo, Jose M Fernández-Real, Fernando Cardona, Francisco J Tinahones, Manuel Macías-González
CONTEXT: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. OBJECTIVE: To analyze serum 25(OH)D and VDR gene expression in AT according to body mass index (BMI) and glycemic status and the effect of 1,25(OH)2D3 on AT according to BMI. DESIGN AND PATIENTS: Two cohorts were studied: 1) 118 subjects classified according to their BMI (lean, overweight, obese, or morbidly obese [MO]) and their glycemic status (normoglycemic [NG] and prediabetic and diabetic [P&D]); and 2) 30 obese subjects (BMI > 30 kg/m(2)) classified as NG and P&D...
April 2015: Journal of Clinical Endocrinology and Metabolism