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Vitamin D and skin

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52 papers 25 to 100 followers Studies into the effects of vitamin in the skin, including links to cancer.
By Clare Dix Dietitian, PhD candidate, researching vitamin D and obesity
https://www.readbyqxmd.com/read/27462278/disruption-of-vitamin-d-and-calcium-signaling-in-keratinocytes-predisposes-to-skin-cancer
#1
REVIEW
Daniel D Bikle, Yan Jiang, Thai Nguyen, Yuko Oda, Chia-Ling Tu
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family, whereas calcium acts through the calcium sensing receptor (Casr), a membrane bound member of the G protein coupled receptor family. We have developed mouse models in which the Vdr and Casr have been deleted in the epidermis ((epid) Vdr (-∕-) and (epid) Casr (-∕-))...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27440288/promoting-uv-exposure-awareness-with-persuasive-wearable-technologies
#2
M Sazzad Hussain, Liam Cripwell, Shlomo Berkovsky, Jill Freyne
Current methods to promote awareness of the sun's ultraviolet (UV) radiation have focussed on delivering population level information and some location-based reporting of UV Index (UVI). However, diseases related to excessive (e.g. sunburn, skin cancer) or insufficient (e.g. vitamin D deficiency) exposure to sunlight still remain a global burden. The emergence of wearable sensors and the application of persuasive technology in health domains raise the possibility for technology to influence awareness of sufficient sun intake for vitamin D production, as well as preventing risk of skin damage...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27447175/targeting-the-vitamin-d-endocrine-system-vdes-for-the-management-of-inflammatory-and-malignant-skin-diseases-an-historical-view-and-outlook
#3
Jörg Reichrath, Christos C Zouboulis, Thomas Vogt, Michael F Holick
Vitamin D represents one of the major driving factors for the development of life on earth and for human evolution. While up to 10-20 % of the human organism's requirements in vitamin D can be obtained by the diet (under most living conditions in the USA and Europe), approximately 90 % of all needed vitamin D has to be photosynthesized in the skin through the action of the sun (ultraviolet-B (UV-B)). The skin represents a key organ of the human body's vitamin D endocrine system (VDES), being both the site of vitamin D synthesis and a target tissue for biologically active vitamin D metabolites...
July 22, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27434043/sustained-increase-of-25-hydroxyvitamin-d-levels-in-healthy-young-women-during-wintertime-after-three-suberythemal-uv-irradiations-the-muvy-pilot-study
#4
Maria Gudrun Biersack, Malgorzata Hajdukiewicz, Ralf Uebelhack, Leonora Franke, Helmut Piazena, Pascal Klaus, Vera Höhne-Zimmer, Tanja Braun, Frank Buttgereit, Gerd-Rüdiger Burmester, Jacqueline Detert
OBJECTIVES: Vitamin D (VitD) deficiency is a health problem prevalent not only in the elderly but also in young adults. The primary objective of our observational pilot study "MUVY" (Mood, UVR, Vitamin D in Young women) was to test both the short-term and long-term effects of a series of three suberythemal UV radiation (UVR) exposures on the VitD status and well-being of young healthy women during winter in a repeat measure design. METHODS: 20 healthy young women (Fitzpatrick skin types I-III, aged 21-25 years) received three full body broad band UVR exposures with an escalating erythemally weighted dose schedule during one week in winter, and completed self-report questionnaires monitoring symptoms of depression (Beck Depression Inventory, BDI) and affective state/well-being (Profile of Mood States, POMS) at baseline and three days after the last UVR exposure...
2016: PloS One
https://www.readbyqxmd.com/read/27416086/could-a-specific-dietary-intake-be-a-risk-factor-for-cutaneous-melanoma
#5
Clarissa B Hohmann, Renan R Bonamigo, Majoriê M Segatto, Manuela M Costa, Simona Mastroeni, Cristina Fortes
The incidence of cutaneous melanoma (CM) has increased in the last decade. Some risk factors are well known, but there are other possible risk factors being studied, such as those involving nutrition. The objective of this case-control study was to assess the association between diet and CM. Classical risk factors, dietary intake, and body mass index were assessed. Binary logistic regression was used to study the association between dietary intake and the risk for CM. Classical risk factors associated with CM were confirmed...
June 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27411377/concurrent-beneficial-vitamin-d-production-and-hazardous-cutaneous-dna-damage-impact-of-repeated-low-level-summer-sunlight-exposures
#6
S J Felton, M S Cooke, R Kift, J L Berry, A R Webb, P M W Lam, F R de Gruijl, A Vail, L E Rhodes
BACKGROUND: Concurrent impact of repeated low-level summer sunlight exposures on vitamin D production and cutaneous DNA damage, potentially leading to mutagenesis/skin cancer, is unknown. OBJECTIVES: Experimental study (i) determining dual impact of repeated low-level sunlight exposures on vitamin D status and DNA damage/repair (via both skin and urinary biomarkers) in light-skin adults (ii) comparing outcomes following same exposures in brown-skin adults. METHODS: Ten white Caucasians (phototype II) and six South Asians (V), 23-59y, received 6-weeks' simulated summer sunlight exposures (95% UVA/5% UVB, 1...
July 14, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26442223/assessment-of-the-feasibility-of-using-sunlight-exposure-to-obtain-the-recommended-level-of-vitamin-d-in-canada
#7
Pavandeep Gill, Sunil Kalia
BACKGROUND: Endogenous vitamin D synthesis can be affected by a number of variables, including skin colour, amount of skin exposed and levels of ultraviolet radiation. The objective of this study was to assess the feasibility of using only sunlight exposure in Canada to meet the daily recommended level of vitamin D, given differences in these variables and adherence to guidelines for sun protection. METHODS: Ultraviolet index data for 13 Canadian sites were obtained from Environment Canada...
July 2015: CMAJ Open
https://www.readbyqxmd.com/read/26350811/varying-relationship-between-25-hydroxy-vitamin-d-high-density-lipoprotein-cholesterol-and-serum-7-dehydrocholesterol-reductase-with-sunlight-exposure
#8
Vivek G Patwardhan, Anuradha V Khadilkar, Shashi A Chiplonkar, Zulf M Mughal, Vaman V Khadilkar
BACKGROUND: Cholesterol and cholecalciferol are synthesized from a common substrate 7-dehydrocholesterol. 7-dehydrocholesterol is converted to cholesterol by 7-dehydrocholesterol reductase enzyme (DHCR7) and to cholecalciferol by ultraviolet B radiation from sunlight. OBJECTIVE: To examine the effect of sunlight exposure and serum DHCR7 levels on cholecalciferol and cholesterol levels and studying any interrelationship. METHODS: In a cross-sectional observational study, 307 apparently healthy men (aged 40-60 years) were assessed for sunlight exposure, lipid levels, serum DHCR7, 25 hydroxyvitamin D (25(OH)D), body composition, and dietary milk calcium intake...
September 2015: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26248819/tolerance-evaluation-of-overdosed-dietary-levels-of-25-hydroxyvitamin-d3-in-growing-piglets
#9
S J von Rosenberg, G M Weber, A Erhardt, U Höller, U A Wehr, W A Rambeck
Forty-eight, cross-bred (GL × LW × P) piglets were used in a 42-day tolerance trial to assess the effects of feeding diets supplemented with vitamin D or increasing levels of 25-hydroxyvitamin D3 (25-OH-D3 ). Six-week-old piglets (24 castrate males, 24 females) were used. Two replicate groups of 6 piglets were randomized by weight and allocated to four dietary treatments. The control group (T1) was supplemented with 50 μg vitamin D3 /kg feed. The experimental groups received 25-OH-D3 at the recommended dose (T2: 50 μg/kg = 1x), at 250 μg/kg (T3: 5x) or at 500 μg/kg (T4: 10x) respectively...
April 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/26315479/a-promoter-polymorphism-of-the-vitamin-d-metabolism-gene-cyp24a1-is-associated-with-severe-atopic-dermatitis-in-adults
#10
Jana Hallau, Lutz Hamann, Ralf R Schumann, Margitta Worm, Guido Heine
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which genetic and environmental factors result in impaired epidermal barrier functioning and an altered immune response. Vitamin D influences these 2 pathomechanisms, and beneficial results have been suggested in AD. The aim of this study was to investigate the potential roles of the 2 essential vitamin D metabolizing enzymes. The frequencies of 6 common polymorphisms in the genes encoding the vitamin D synthesizing enzyme Cyp27b1 or the inactivating enzyme Cyp24a1 were assessed in 281 patients with AD and 278 healthy donors in a case-control setting...
February 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/26214382/androgens-attenuate-vitamin-d-production-induced-by-uvb-irradiation-of-the-skin-of-male-mice-by-an-enzymatic-mechanism
#11
Yingben Xue, Lee Ying, Ronald L Horst, Gordon Watson, David Goltzman
Cutaneous exposure to UVB irradiation is an important source of vitamin D. Here, we examined sex-specific differences in cutaneous vitamin D production in mice. Both male and female mice on a vitamin D-deficient diet manifested vitamin D deficiency, with mineral abnormalities, secondary hyperparathyroidism, and osteomalacia. UVB irradiation significantly increased vitamin D levels in the skin of female mice and normalized serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 levels, as well as mineral and skeletal abnormalities...
December 2015: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26111868/vitamin-d-supplementation-does-not-improve-the-severity-or-the-resolution-of-ultraviolet-b-induced-acute-erythema
#12
RANDOMIZED CONTROLLED TRIAL
Florence Libon, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
BACKGROUND: Whether vitamin D supplementation alleviates the severity of ultraviolet B (UVB)-induced erythema and/or facilitates its resolution remains undetermined. OBJECTIVE: To study the effect of oral vitamin D on UVB-induced erythema and its resolution in fair-skinned subjects. METHODS: UVB-induced erythema was quantified using a Chroma Meter® in 50 volunteers 48 h before and 10 days after the random administration of 200,000 IU vitamin D (n = 40) or placebo (n = 10)...
2015: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26093795/size-of-the-exposed-body-surface-area-skin-erythema-and-body-mass-index-predict-skin-production-of-vitamin-d
#13
Amra Osmancevic, Martin Gillstedt, Kerstin Landin-Wilhelmsen, Ann-Marie Wennberg Larkö, Olle Larkö, Michael F Holick, Anne-Lene Krogstad
BACKGROUND: Cholecalciferol (vitamin D3), produced in the skin by UVB irradiation (290-315nm) of 7-dehydrocholesterol, is metabolized in the liver into 25-hydroxyvitamin D [25(OH)D] which is a major circulating metabolite. AIM: To examine changes in serum concentrations of cholecalciferol and its metabolites after UVB exposure of different skin areas. METHODS: 21 healthy Caucasians (skin type II and III, aged 23-47years) were exposed to broadband UVB (290-320nm) and randomized to either exposure to one minimal erythema dose given as a single dose, or a suberythemic dose given for 3 subsequent days...
August 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26068789/1%C3%AE-25-dihydroxyvitamin-d%C3%A2-and-the-vitamin-d-receptor-regulates-%C3%AE-np63%C3%AE-levels-and-keratinocyte-proliferation
#14
N T Hill, J Zhang, M K Leonard, M Lee, H N Shamma, M Kadakia
1α, 25-dihydroxyvitamin D3 (VD3), a secosteriod that has been explored as an anti-cancer agent, was also shown to promote cell survival. Its receptor, the Vitamin D Receptor (VDR), is a direct target of the proto-oncogene ΔNp63α, which is overexpressed in non-melanoma skin cancers. The interconnection between VDR/VD3 signaling and ΔNp63α, led us to examine whether VDR/VD3 signaling promotes keratinocyte proliferation by regulating ΔNp63α levels. Our data demonstrate that VDR regulates ΔNp63α expression at both the transcript and protein level...
June 11, 2015: Cell Death & Disease
https://www.readbyqxmd.com/read/26049767/risks-and-benefits-of-uv-radiation-in-older-people-more-of-a-friend-than-a-foe
#15
REVIEW
Fiona Wright, Richard B Weller
Incident ultraviolet radiation from sunlight varies in intensity and spectrum with season and latitude and has both deleterious and beneficial effects on health in older people. Sunlight is the major preventable risk factor for skin cancer. Non-melanoma skin cancer is the commonest malignancy in a pale skinned older population, but the mortality is extremely low. Intermittent sun exposure is a risk factor for the more dangerous melanoma but chronic sun exposure and outdoor occupation may be protective. Public health advice has tended to concentrate on the dangers of sun exposure despite the absence of any data that increased sun exposure correlates with raised all-cause mortality...
August 2015: Maturitas
https://www.readbyqxmd.com/read/26053952/projected-changes-in-erythemal-and-vitamin-d-effective-irradiance-over-northern-hemisphere-high-latitudes
#16
I Fountoulakis, A F Bais
Simulations of the monthly mean noon UV index and the effective dose for the production of vitamin D in the human skin have been performed for local noon for the latitude band 55°N-85°N using a radiative transfer model. The magnitude and spatial distribution of the changes estimated for the two quantities between the past (1955-1965 mean), the present (2010-2020 mean) and the future (2085-2095 mean) are discussed and the main drivers for these changes are identified. The irradiance simulations are based on simulations and projections of total ozone, surface reflectivity and aerosol optical depth derived from models used in the fifth phase of the Coupled Model Intercomparison Project (CMIP-5)...
July 2015: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/26010336/mitochondrial-and-lipogenic-effects-of-vitamin-d-on-differentiating-and-proliferating-human-keratinocytes
#17
Marco Consiglio, Marta Viano, Stefania Casarin, Carlotta Castagnoli, Gianpiero Pescarmona, Francesca Silvagno
Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. The aim of this study was to investigate whether vitamin D is effective also in modulating mitochondria and biosynthetic metabolism of differentiating cells. We compared the effect of vitamin D on two cellular models: the primary human keratinocytes, differentiating and sensitive to the genomic action of VDR, and the human keratinocyte cell line HaCaT, characterized by a rapid growth and resistance to vitamin D...
October 2015: Experimental Dermatology
https://www.readbyqxmd.com/read/25994798/the-angular-distributions-of-ultraviolet-spectral-irradiance-at-different-solar-elevation-angles-under-clear-sky-conditions
#18
Yan Liu, LiWen Hu, Fang Wang, YanYan Gao, Yang Zheng, Yu Wang, Yang Liu
To investigate the angular distributions of UVA, UVB, and effective UV for erythema and vitamin D (vitD) synthesis, the UV spectral irradiances were measured at ten inclined angles (from 0° to 90°) and seven azimuths (from 0° to 180°) at solar elevation angle (SEA) that ranged from 18.8° to 80° in Shanghai (31.22° N, 121.55° E) under clear sky and the albedo of ground was 0.1. The results demonstrated that in the mean azimuths and with the back to the sun, the UVA, UVB, and erythemally and vitD-weighted irradiances increased with the inclined angles and an increase in SEA...
January 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/25887475/variants-fok1-and-bsm1-on-vdr-are-associated-with-the-melanoma-risk-evidence-from-the-published-epidemiological-studies
#19
Wei Hou, Xuefeng Wan, Junwei Fan
BACKGROUND: The vitamin D receptor (VDR) mediates the major cellular activities of vitamin D and regulates various signaling pathways implicated in cancer development and progression. VDR variants have been found associated with the risk of developing melanoma; however, previous epidemiological studies are inconsistent. We have systematically reviewed the published epidemiological literature and conducted a meta-analysis to assess associations between common VDR variants and melanoma risk...
2015: BMC Genetics
https://www.readbyqxmd.com/read/25878189/vitamin-d-beyond-metabolism
#20
REVIEW
Mark Lucock, Patrice Jones, Charlotte Martin, Emma Beckett, Zoe Yates, John Furst, Martin Veysey
Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin influences circadian rhythm, and how it may have helped drive the evolution of skin pigmentation. To this end, the nutrient-nutrient relationship with folate is also explored...
October 2015: Journal of Evidence-based Complementary & Alternative Medicine
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