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By Ronald Lands Benign hematologist
Gabriele Röhrig
Anemia and frailty are two common findings in geriatric patients and have been shown to be associated with poor outcomes in this patient group. Recent studies have contributed to the growing evidence of a possible association with the age-related chronic inflammatory status known as "inflammaging". These findings do not only give a better insight into the pathogenesis of anemia in frailty, but also offer new treatment options. The present article focuses on this assumed association between anemia, frailty, and inflammaging and summarizes current management options for anemia in frail patients...
2016: Clinical Interventions in Aging
(no author information available yet)
The 2015 American Geriatrics Society (AGS) Beers Criteria are presented. Like the 2012 AGS Beers Criteria, they include lists of potentially inappropriate medications to be avoided in older adults. New to the criteria are lists of select drugs that should be avoided or have their dose adjusted based on the individual's kidney function and select drug-drug interactions documented to be associated with harms in older adults. The specific aim was to have a 13-member interdisciplinary panel of experts in geriatric care and pharmacotherapy update the 2012 AGS Beers Criteria using a modified Delphi method to systematically review and grade the evidence and reach a consensus on each existing and new criterion...
November 2015: Journal of the American Geriatrics Society
Margaret P Battin
No abstract text is available yet for this article.
July 2015: Hastings Center Report
M E Charlson, P Pompei, K L Ales, C R MacKenzie
The objective of this study was to develop a prospectively applicable method for classifying comorbid conditions which might alter the risk of mortality for use in longitudinal studies. A weighted index that takes into account the number and the seriousness of comorbid disease was developed in a cohort of 559 medical patients. The 1-yr mortality rates for the different scores were: "0", 12% (181); "1-2", 26% (225); "3-4", 52% (71); and "greater than or equal to 5", 85% (82). The index was tested for its ability to predict risk of death from comorbid disease in the second cohort of 685 patients during a 10-yr follow-up...
1987: Journal of Chronic Diseases
Wendy P J den Elzen, Rudi G J Westendorp, Marijke Frölich, Wouter de Ruijter, Willem J J Assendelft, Jacobijn Gussekloo
BACKGROUND: Screening for deficiencies in vitamin B(12) and folate is advocated to prevent anemia in very elderly individuals. However, the effects of vitamin B(12) and folate deficiency on the development of anemia in old age have not yet been established. METHODS: The current study is embedded in the Leiden 85-Plus Study, a population-based prospective study of subjects aged 85 years. Levels of vitamin B(12), folate, and homocysteine were determined at baseline...
November 10, 2008: Archives of Internal Medicine
Parag Agnihotri, Margaret Telfer, Zeeshan Butt, Abhay Jella, David Cella, Chris M Kozma, Mukesh Ahuja, Shahbaz Riaz, Joseph Akamah
OBJECTIVES: To evaluate the effect of epoetin alfa treatment on hemoglobin (Hb), fatigue, quality of life (QOL), and mobility in elderly patients with chronic anemia. DESIGN: An exploratory, 32 week, randomized, double-blind, crossover treatment trial. PARTICIPANTS: Sixty-two community-dwelling individuals aged 65 and older with chronic anemia (Hb < or =11.5 g/dL). INTERVENTION: Subcutaneous epoetin alfa or placebo weekly for 16 weeks (Phase I) with crossover to the opposite treatment (Phase II)...
October 2007: Journal of the American Geriatrics Society
Isla Rippon, Andrew Steptoe
No abstract text is available yet for this article.
February 2015: JAMA Internal Medicine
Erin K Zahradnik, Hillel Grossman
PURPOSE: The goal of this narrative review was to identify and summarize the ways in which palliative care could benefit patients who have advanced dementia. METHODS: This case-based discussion article examines current literature on palliative care for dementia. FINDINGS: Dementia is an incurable, progressive disease that affects millions of subjects. The prevalence has grown in the last decade and is projected to continue on this trajectory...
November 1, 2014: Clinical Therapeutics
Gene H Stollerman
No abstract text is available yet for this article.
April 2007: Journal of the American Geriatrics Society
G H Stollerman
No abstract text is available yet for this article.
August 12, 1995: Lancet
Gene H Stollerman
No abstract text is available yet for this article.
November 2006: Journal of the American Geriatrics Society
James B Dale, Alan L Bisno
No abstract text is available yet for this article.
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Gene H Stollerman
No abstract text is available yet for this article.
January 2013: Journal of the American Geriatrics Society
Gene H Stollerman
No abstract text is available yet for this article.
January 2002: Journal of the American Geriatrics Society
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