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JOURNAL ARTICLE
Alec Vahanian, Friedhelm Beyersdorf, Fabien Praz, Milan Milojevic, Stephan Baldus, Johann Bauersachs, Davide Capodanno, Lenard Conradi, Michele De Bonis, Ruggero De Paulis, Victoria Delgado, Nick Freemantle, Martine Gilard, Kristina H Haugaa, Anders Jeppsson, Peter Jüni, Luc Pierard, Bernard D Prendergast, J Rafael Sádaba, Christophe Tribouilloy, Wojtek Wojakowski
No abstract text is available yet for this article.
February 12, 2022: European Heart Journal
#2
RANDOMIZED CONTROLLED TRIAL
Gregg W Stone, JoAnn Lindenfeld, William T Abraham, Saibal Kar, D Scott Lim, Jacob M Mishell, Brian Whisenant, Paul A Grayburn, Michael Rinaldi, Samir R Kapadia, Vivek Rajagopal, Ian J Sarembock, Andreas Brieke, Steven O Marx, David J Cohen, Neil J Weissman, Michael J Mack
BACKGROUND: Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor. Transcatheter mitral-valve repair may improve their clinical outcomes. METHODS: At 78 sites in the United States and Canada, we enrolled patients with heart failure and moderate-to-severe or severe secondary mitral regurgitation who remained symptomatic despite the use of maximal doses of guideline-directed medical therapy. Patients were randomly assigned to transcatheter mitral-valve repair plus medical therapy (device group) or medical therapy alone (control group)...
December 13, 2018: New England Journal of Medicine
#3
JOURNAL ARTICLE
Sabine Bleiziffer, Matheus Simonato, John G Webb, Josep Rodés-Cabau, Philippe Pibarot, Ran Kornowski, Stephan Windecker, Magdalena Erlebach, Alison Duncan, Moritz Seiffert, Axel Unbehaun, Christian Frerker, Lars Conzelmann, Harindra Wijeysundera, Won-Keun Kim, Matteo Montorfano, Azeem Latib, Didier Tchetche, Abdelhakim Allali, Mohamed Abdel-Wahab, Katia Orvin, Stefan Stortecky, Henrik Nissen, Andreas Holzamer, Marina Urena, Luca Testa, Marco Agrifoglio, Brian Whisenant, Janarthanan Sathananthan, Massimo Napodano, Antonio Landi, Claudia Fiorina, Armin Zittermann, Verena Veulemans, Jan-Malte Sinning, Francesco Saia, Stephen Brecker, Patrizia Presbitero, Ole De Backer, Lars Søndergaard, Giuseppe Bruschi, Luis Nombela Franco, Anna Sonia Petronio, Marco Barbanti, Alfredo Cerillo, Konstantinos Spargias, Joachim Schofer, Mauricio Cohen, Antonio Muñoz-Garcia, Ariel Finkelstein, Matti Adam, Vicenç Serra, Rui Campante Teles, Didier Champagnac, Alessandro Iadanza, Piotr Chodor, Holger Eggebrecht, Robert Welsh, Adriano Caixeta, Stefano Salizzoni, Antonio Dager, Vincent Auffret, Asim Cheema, Timm Ubben, Marco Ancona, Tanja Rudolph, Jan Gummert, Elaine Tseng, Stephane Noble, Matjaz Bunc, David Roberts, Malek Kass, Anuj Gupta, Martin B Leon, Danny Dvir
AIMS: Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There are no data on long-term outcomes after aortic ViV. Our aim was to perform a large-scale assessment of long-term survival and reintervention after aortic ViV. METHODS AND RESULTS: A total of 1006 aortic ViV procedures performed more than 5 years ago [mean age 77.7 ± 9.7 years; 58.8% male; median STS-PROM score 7.3% (4.2-12.0)] were included in the analysis...
August 1, 2020: European Heart Journal
#4
REVIEW
Yan Topilsky
The normal mitral valve is a dynamic structure that permits blood to flow from the left atrial (LA) to left ventricle (LV) during diastole and sealing of the LA from the LV during systole. The main components of the mitral apparatus are the mitral annulus (MA), the mitral leaflets, the chordae tendineae, and the papillary muscles (PM) (Figure 1). Normal valve function is dependent on the integrity and normal interplay of these components. Abnormal function of any one of the components, or their interplay can result in mitral regurgitation (MR)...
2020: Frontiers in Cardiovascular Medicine
#5
JOURNAL ARTICLE
Ronald K Binder, Marc Dweck, Bernard Prendergast
No abstract text is available yet for this article.
February 21, 2020: European Heart Journal
#6
EDITORIAL
Dirk Westermann, Benedikt Schrage
No abstract text is available yet for this article.
May 2020: Heart
#7
RANDOMIZED CONTROLLED TRIAL
Federico M Asch, Paul A Grayburn, Robert J Siegel, Saibal Kar, D Scott Lim, Jonathan G Zaroff, Jacob M Mishell, Brian Whisenant, Michael J Mack, JoAnn Lindenfeld, William T Abraham, Gregg W Stone, Neil J Weissman
BACKGROUND: In the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial among patients with heart failure (HF) and moderate-to-severe (3+) or severe (4+) secondary mitral regurgitation, patients treated with transcatheter mitral valve repair (TMVr) through leaflet approximation had reduced rates of HF hospitalization and mortality compared with guideline-directed medical therapy (GDMT) alone...
December 17, 2019: Journal of the American College of Cardiology
#8
JOURNAL ARTICLE
Rick A Nishimura, Patrick T O'Gara, Joseph E Bavaria, Ralph G Brindis, John D Carroll, Clifford J Kavinsky, Brian R Lindman, Jane A Linderbaum, Stephen H Little, Michael J Mack, Laura Mauri, William R Miranda, David M Shahian, Thoralf M Sundt
No abstract text is available yet for this article.
May 28, 2019: Journal of the American College of Cardiology
#9
JOURNAL ARTICLE
Thomas F Lüscher
No abstract text is available yet for this article.
October 14, 2018: European Heart Journal
#10
MULTICENTER STUDY
Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic Severe Aortic Stenosis.
Ron Waksman, Toby Rogers, Rebecca Torguson, Paul Gordon, Afshin Ehsan, Sean R Wilson, John Goncalves, Robert Levitt, Chiwon Hahn, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Nicholas Hanna, Robert Garrett, Federico Asch, Gaby Weissman, Itsik Ben-Dor, Christian Shults, Roshni Bastian, Paige E Craig, Hector M Garcia-Garcia, Paul Kolm, Quan Zou, Lowell F Satler, Paul J Corso
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is now the standard of care for patients with symptomatic severe aortic stenosis who are extreme, high, or intermediate risk for surgical aortic valve replacement (SAVR). OBJECTIVES: The authors sought to evaluate TAVR in a prospective multicenter trial involving low-risk patients. METHODS: The Low Risk TAVR (Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis) trial was the first U...
October 30, 2018: Journal of the American College of Cardiology
#11
JOURNAL ARTICLE
Tasnim F Imran, Eric H Awtry
A 47-year-old man presented to the emergency department with a 6-month history of worsening exertional dyspnea. He had recently emigrated from Honduras and had a history of cardiac surgery as a child, but the initial diagnosis and specific procedure that had been performed were not known. The..
July 19, 2018: New England Journal of Medicine
#12
MULTICENTER STUDY
Hideyuki Kawashima, Yusuke Watanabe, Ken Kozuma, Akihisa Kataoka, Makoto Nakashima, Hirofumi Hioki, Fukuko Nagura, Yugo Nara, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
The midterm safety and feasibility of transcatheter aortic valve implantation (TAVI) for patients with a history of coronary artery bypass graft (CABG) and high operative risk are unclear. This study compared the midterm outcomes of patients undergoing TAVI with or without previous CABG surgery. Between October 2013 and July 2016, 1,613 patients underwent TAVI according to the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI registry (previous CABG: n = 120; no previous CABG: n = 1493). The propensity score comprised the variables of the Society of Thoracic Surgeons Score, previous myocardial infarction, peripheral artery disease, chronic kidney disease > stage 2 (estimated glomerular filtration rate < 60 mL/min/1...
October 2018: Heart and Vessels
#13
COMMENT
David Thaler
No abstract text is available yet for this article.
July 2018: Lancet Neurology
#14
REVIEW
Erwan Salaun, Marie-Annick Clavel, Josep Rodés-Cabau, Philippe Pibarot
The main limitation of bioprosthetic valves is their limited durability, which exposes the patient to the risk of aortic valve reintervention. Transcatheter aortic valve implantation (TAVI) is considered a reasonable alternative to surgical aortic valve replacement (SAVR) in patients with intermediate or high surgical risk. TAVI is now rapidly expanding towards the lower risk populations. Although the results of midterm durability of the transcatheter bioprostheses are encouraging, their long-term durability remains largely unknown...
August 2018: Heart
#15
REVIEW
Tasalak Thonghong, Ole De Backer, Lars Søndergaard
New European guidelines on the management of valvular heart disease-supported by the European Society of Cardiology (ESC) and European Association of CardioThoracic Surgery (EACTS)-were recently published. Although these guidelines are very comprehensive, these typically are not very inviting to read. In this document, we aimed to distil all the information about transcatheter aortic valve replacement (TAVR) in the new 2017 ESC/EACTS guidelines to the essential and give additional comments on the position of TAVR in 2017...
2018: Open Heart
#16
MULTICENTER STUDY
Joji B Kuramatsu, Jochen A Sembill, Stefan T Gerner, Maximilian I Sprügel, Manuel Hagen, Sebastian S Roeder, Matthias Endres, Karl Georg Haeusler, Jan Sobesky, Johannes Schurig, Sarah Zweynert, Miriam Bauer, Peter Vajkoczy, Peter A Ringleb, Jan Purrucker, Timolaos Rizos, Jens Volkmann, Wolfgang Müllges, Peter Kraft, Anna-Lena Schubert, Frank Erbguth, Martin Nueckel, Peter D Schellinger, Jörg Glahn, Ulrich J Knappe, Gereon R Fink, Christian Dohmen, Henning Stetefeld, Anna Lena Fisse, Jens Minnerup, Georg Hagemann, Florian Rakers, Heinz Reichmann, Hauke Schneider, Sigrid Wöpking, Albert Christian Ludolph, Sebastian Stösser, Hermann Neugebauer, Joachim Röther, Peter Michels, Michael Schwarz, Gernot Reimann, Hansjörg Bäzner, Henning Schwert, Joseph Claßen, Dominik Michalski, Armin Grau, Frederick Palm, Christian Urbanek, Johannes C Wöhrle, Fahid Alshammari, Markus Horn, Dirk Bahner, Otto W Witte, Albrecht Günther, Gerhard F Hamann, Hannes Lücking, Arnd Dörfler, Stephan Achenbach, Stefan Schwab, Hagen B Huttner
Aims: Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH. Methods and results: We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n = 137) with anticoagulation-associated ICH for outcome analyses...
May 14, 2018: European Heart Journal
#17
REVIEW
Erin A Fender, Chad J Zack, Rick A Nishimura
Isolated tricuspid regurgitation (TR) can be caused by primary valvular abnormalities such as flail leaflet or secondary annular dilation as is seen in atrial fibrillation, pulmonary hypertension and left heart disease. There is an increasing recognition of a subgroup of patients with isolated TR in the absence of other associated cardiac abnormalities. Left untreated isolated TR significantly worsens survival. Stand-alone surgery for isolated TR is rarely performed due to an average operative mortality of 8%-10% and a paucity of data demonstrating improved survival...
May 2018: Heart
#18
JOURNAL ARTICLE
John U Doherty, Smadar Kort, Roxana Mehran, Paul Schoenhagen, Prem Soman
No abstract text is available yet for this article.
September 26, 2017: Journal of the American College of Cardiology
#19
REVIEW
Kuo-Li Pan, Daniel E Singer, Bruce Ovbiagele, Yi-Ling Wu, Mohamed A Ahmed, Meng Lee
BACKGROUND: The original non-vitamin K antagonist oral anticoagulant (NOAC) trials in nonvalvular atrial fibrillation (AF) enrolled patients with native valve pathologies. The object of this study was to quantify the benefit-risk profiles of NOACs versus warfarin in AF patients with native valvular heart disease (VHD). METHODS AND RESULTS: Trials were identified by exhaustive literature search. Trial data were combined using inverse variance weighting to produce a meta-analytic summary hazard ratio (HR) and 95% confidence interval (CI) of efficacy and safety of NOACs versus warfarin...
July 18, 2017: Journal of the American Heart Association
#20
JOURNAL ARTICLE
Selim Topcu, Uğur Aksu, Kamuran Kalkan, Oktay Gülcü, Arzu Kalayci Karabay, Enbiya Aksakal, İbrahim Halil Tanboğa, Serdar Sevimli
BACKGROUND/AIM: Aortic valve sclerosis (AVS) is characterized by lipid deposition and calcific infiltration on the edge of aortic leaflets without significant restriction of motion. The SYNTAX Score (SS) is an important method for evaluating coronary artery disease (CAD). Many studies showed that there is an important relation between the SS and undesired cardiac outcomes. In our study, we investigated the correlation between the SS and AVS by including both ACS and stable CAD cases. MATERIALS AND METHODS: We enrolled 543 patients with CAD who underwent coronary angiography into this cross-sectional study between September 2013 and September 2014...
April 18, 2017: Turkish Journal of Medical Sciences
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