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Ottavio Alfieri, Alec Vahanian
No abstract text is available yet for this article.
January 2, 2017: European Heart Journal
George D Dangas, Jeffrey I Weitz, Gennaro Giustino, Raj Makkar, Roxana Mehran
Although surgery was the mainstay of treatment for valvular heart disease, transcatheter valve therapies have grown exponentially over the past decade. Two types of artificial heart valve exist: mechanical heart valves (MHV), which are implanted surgically, and bioprosthetic heart valves (BHV), which can be implanted via a surgical or transcatheter approach. Whereas long-term anticoagulation is required to prevent thromboembolism after MHV replacement, its value in patients receiving BHVs is uncertain. Patients undergoing transcatheter BHV replacement are at risk for thromboembolism in the first few months, and recent data suggest that the risk continues thereafter...
December 20, 2016: Journal of the American College of Cardiology
Aditya Muralidharan, Karthy Thiagarajan, Raymond Van Ham, Thomas G Gleason, Suresh Mulukutla, John T Schindler, Vinodh Jeevanantham, Parthasarathy D Thirumala
Transcatheter aortic valve implantation (TAVI) is a rapidly evolving safe method with decreasing incidence of perioperative stroke. There is a void in literature concerning the impact of stroke after TAVI in predicting 30-day stroke-related mortality. The primary aim of this meta-analysis was to determine whether perioperative stroke increases risk of stroke-related mortality after TAVI. Online databases, using relevant keywords, and additional related records were searched to retrieve articles involving TAVI and stroke after TAVI...
October 1, 2016: American Journal of Cardiology
Ditte Dencker, Mikkel Taudorf, N H Vincent Luk, Michael B Nielsen, Klaus F Kofoed, Torben V Schroeder, Lars Søndergaard, Lars Lönn, Ole De Backer
Vascular access and closure remain a challenge in transcatheter aortic valve replacement (TAVR). This single-center study aimed to report the incidence, predictive factors, and clinical outcomes of access-related vascular injury and subsequent vascular intervention. During a 30-month period, 365 patients underwent TAVR and 333 patients (94%) were treated by true percutaneous transfemoral approach. Of this latter group, 83 patients (25%) had an access-related vascular injury that was managed by the use of a covered self-expanding stent (n = 49), balloon angioplasty (n = 33), or by surgical intervention (n = 1)...
October 15, 2016: American Journal of Cardiology
Alexandra J Lansky, David Brown, Constantino Pena, Cody G Pietras, Helen Parise, Vivian G Ng, Stephanie Meller, Kevin J Abrams, Michael Cleman, Pauliina Margolis, George Petrossian, Adam M Brickman, Szilard Voros, Jeffrey Moses, John K Forrest
Cerebral embolization during transcatheter aortic valve implantation (TAVI) can lead to a spectrum of clinically relevant manifestations, ranging from overt stroke to mild neurologic or cognitive deficits and subclinical cerebral infarcts. This study sought to determine the frequency of neurologic injury, cerebral ischemic lesions, and cognitive dysfunction in subjects undergoing contemporary commercial TAVI in the United States. Neuro-TAVR is the first prospective, multicenter study to use serial systematic neurologic and cognitive assessments and diffusion-weighted magnetic resonance imaging (at 4 ± 2 days after procedure) to investigate the incidence and severity of neurologic injury after contemporary unprotected TAVI in the United States...
November 15, 2016: American Journal of Cardiology
José López-Aguilera, José M Segura Saint-Gerons, Francisco Mazuelos Bellido, Javier Suárez de Lezo Herreros de Tejada, Soledad O Pineda, Manuel Pan Álvarez-Ossorio, Miguel Ángel Romero Moreno, Djordje Pavlovic, José Suárez de Lezo Cruz Conde
New-onset conduction disturbances are common after transcatheter aortic valve implantation (TAVI). The most common complication is left bundle branch block (LBBB). The clinical impact of new-onset LBBB after TAVI remains controversial. The aim of this study was to analyze the clinical impact of new-onset LBBB in terms of mortality and morbidity (need for pacemakers and admissions for heart failure) at long-term follow-up. From April 2008 to December 2014, 220 patients who had severe aortic stenosis were treated with the implantation of a CoreValve prosthesis...
November 1, 2016: American Journal of Cardiology
Ander Regueiro, Axel Linke, Azeem Latib, Nikolaj Ihlemann, Marina Urena, Thomas Walther, Oliver Husser, Howard C Herrmann, Luis Nombela-Franco, Asim N Cheema, Hervé Le Breton, Stefan Stortecky, Samir Kapadia, Antonio L Bartorelli, Jan Malte Sinning, Ignacio Amat-Santos, Antonio Munoz-Garcia, Stamatios Lerakis, Enrique Gutiérrez-Ibanes, Mohamed Abdel-Wahab, Didier Tchetche, Luca Testa, Helene Eltchaninoff, Ugolino Livi, Juan Carlos Castillo, Hasan Jilaihawi, John G Webb, Marco Barbanti, Susheel Kodali, Fabio S de Brito, Henrique B Ribeiro, Antonio Miceli, Claudia Fiorina, Guglielmo Mario Actis Dato, Francesco Rosato, Vicenç Serra, Jean-Bernard Masson, Harindra C Wijeysundera, Jose A Mangione, Maria-Cristina Ferreira, Valter C Lima, Luiz A Carvalho, Alexandre Abizaid, Marcos A Marino, Vinicius Esteves, Julio C M Andrea, Francesco Giannini, David Messika-Zeitoun, Dominique Himbert, Won-Keun Kim, Costanza Pellegrini, Vincent Auffret, Fabian Nietlispach, Thomas Pilgrim, Eric Durand, John Lisko, Raj R Makkar, Pedro A Lemos, Martin B Leon, Rishi Puri, Alberto San Roman, Alec Vahanian, Lars Søndergaard, Norman Mangner, Josep Rodés-Cabau
IMPORTANCE: Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). OBJECTIVE: To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR. DESIGN, SETTING, AND PARTICIPANTS: The Infectious Endocarditis after TAVR International Registry included patients with definite infective endocarditis after TAVR from 47 centers from Europe, North America, and South America between June 2005 and October 2015...
September 13, 2016: JAMA: the Journal of the American Medical Association
Hind A Beydoun, May A Beydoun, Hailun Liang, Greg A Dore, Danielle Shaked, Alan B Zonderman, Shaker M Eid
Aortic stenosis (AS) is the third most prevalent cardiovascular disease following hypertension and coronary artery disease. The primary objective of this cross-sectional study is to examine gender, racial, and socioeconomic disparities in AS-related health care utilization in patients aged ≥50 years using data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. AS was identified among inpatient discharges with International Classification of Diseases, Ninth Revision, Clinical Modification, code 424...
September 15, 2016: American Journal of Cardiology
John K Forrest, David H Adams, Jeffrey J Popma, Michael J Reardon, G Michael Deeb, Steven J Yakubov, James B Hermiller, Jian Huang, Kimberly A Skelding, Alexandra Lansky
Treatment for severe symptomatic aortic stenosis has changed significantly in recent years due to advances in transcatheter aortic valve replacement (TAVR). Recent studies with the CoreValve prosthesis have demonstrated superior results compared with surgical aortic valve replacement in patients at increased risk for surgery, but there are limited data on gender-related differences in patient characteristics and outcomes with this device. We compared baseline characteristics and clinical outcomes in women and men undergoing TAVR with the CoreValve prosthesis...
August 1, 2016: American Journal of Cardiology
Kimberly A Skelding, Steven J Yakubov, Neal S Kleiman, Michael J Reardon, David H Adams, Jian Huang, John K Forrest, Jeffrey J Popma
The objective of this study was to compare outcomes in women after surgical aortic valve replacement (SAVR) versus transcatheter aortic valve replacement (TAVR) using a self-expanding prosthesis in patients with severe aortic stenosis who were at high risk for SAVR. Although registries and meta-analyses have suggested that TAVR is of considerable benefit in women, perhaps even more so than in men, a rigorous evaluation of TAVR with a self-expanding valve versus SAVR in women from a randomized trial has not been performed...
August 15, 2016: American Journal of Cardiology
Mani Arsalan, Eustachio Agricola, Ottavio Alfieri, Stephan Baldus, Antonio Colombo, Giovanni Filardo, Christophe Hammerstingl, Michael Huntgeburth, Felix Kreidel, Karl-Heinz Kuck, Giovanni LaCanna, David Messika-Zeitoun, Francesco Maisano, Georg Nickenig, Benjamin D Pollock, Bradley J Roberts, Alec Vahanian, Paul A Grayburn
This study was performed to assess the acute intraprocedural effects of transcatheter direct mitral annuloplasty using the Cardioband device on 3-dimensional (3D) anatomy of the mitral annulus. Of 45 patients with functional mitral regurgitation (MR) enrolled in a single arm, multicenter, prospective trial, 22 had complete pre- and post-implant 3D transesophageal echocardiography (TEE) images stored in native data format that allowed off-line 3D reconstruction. Images with the highest volume rate and best image quality were selected for analysis...
September 1, 2016: American Journal of Cardiology
Marie-Annick Clavel, Julien Magne, Philippe Pibarot
An important proportion of patients with aortic stenosis (AS) have a 'low-gradient' AS, i.e. a small aortic valve area (AVA <1.0 cm(2)) consistent with severe AS but a low mean transvalvular gradient (<40 mmHg) consistent with non-severe AS. The management of this subset of patients is particularly challenging because the AVA-gradient discrepancy raises uncertainty about the actual stenosis severity and thus about the indication for aortic valve replacement (AVR) if the patient has symptoms and/or left ventricular (LV) systolic dysfunction...
September 7, 2016: European Heart Journal
Takeshi Yamada, Akihiko Takahashi
UNLABELLED: A 91-year-old man was admitted to our hospital with dyspnea and chest pain. His electrocardiogram showed ST-segment elevation in the V1-4 leads, and an emergency coronary angiogram revealed subtotal occlusion in the left descending coronary artery. A successful primary percutaneous coronary intervention was subsequently performed using aspiration thrombectomy and bare metal stent implantation. However, his hemodynamic condition deteriorated with severe pulmonary congestion...
January 2015: Acta Cardiologica Sinica
Chisato Izumi
Optimal management for asymptomatic severe aortic stenosis (AS) remains controversial. Considering the increase in elderly patients, improved surgical outcomes and the introduction of transcatheter aortic valve implantation, we must reconsider the optimal management of asymptomatic severe AS. In this article, previous studies regarding the natural history of asymptomatic severe AS were reviewed to obtain a clinical perspective of AS in the growing elderly patient population. The incidence of sudden death in asymptomatic severe AS varies among studies from 0...
August 1, 2016: Heart: Official Journal of the British Cardiac Society
Viviana de Egea, Patricia Muñoz, Maricela Valerio, Arístides de Alarcón, José Antonio Lepe, José M Miró, Juan Gálvez-Acebal, Pablo García-Pavía, Enrique Navas, Miguel Angel Goenaga, María Carmen Fariñas, Elisa García Vázquez, Mercedes Marín, Emilio Bouza
Streptococcus pneumoniae is an infrequent cause of severe infectious endocarditis (IE). The aim of our study was to describe the epidemiology, clinical and microbiological characteristics, and outcome of a series of cases of S. pneumoniae IE diagnosed in Spain and in a series of cases published since 2000 in the medical literature. We prospectively collected all cases of IE diagnosed in a multicenter cohort of patients from 27 Spanish hospitals (n = 2539). We also performed a systematic review of the literature since 2000 and retrieved all cases with complete clinical data using a pre-established protocol...
September 2015: Medicine (Baltimore)
Michael A Gaglia, Rebecca Torguson, Michael J Lipinski, Jiaxiang Gai, Edward Koifman, Sarkis Kiramijyan, Smita Negi, Toby Rogers, Arie Steinvil, William O Suddath, Lowell F Satler, Augusto D Pichard, Ron Waksman
Although metallic coronary stents significantly reduce angina pectoris compared with optimal medical therapy, angina after percutaneous coronary intervention (PCI) remains frequent. We, therefore, sought to compare the incidence of any angina during the 1 year after PCI among the spectrum of commercially available metallic stents. Metallic stent type was classified as bare metal stent, Cypher, Taxus Express, Xience V, Promus Element, and Resolute. The primary end point was patient-reported angina within 1 year of PCI...
February 15, 2016: American Journal of Cardiology
Neil Ruparelia, Azeem Latib, Nicola Buzzatti, Francesco Giannini, Filippo Figini, Antonio Mangieri, Damiano Regazzoli, Stefano Stella, Alessandro Sticchi, Hiroyoshi Kawamoto, Akihito Tanaka, Eustachio Agricola, Fabrizio Monaco, Alessandro Castiglioni, Marco Ancona, Micaela Cioni, Pietro Spagnolo, Alaide Chieffo, Matteo Montorfano, Ottavio Alfieri, Antonio Colombo
Transcatheter aortic valve implantation (TAVI) is now the treatment of choice for patients with symptomatic aortic stenosis who are inoperable or with high surgical risk. Data with regards to contemporary clinical practice and long-term outcomes are sparse. To evaluate temporal changes in TAVI practice and explore procedural and long-term clinical outcomes of patients in a contemporary "real-world" population, outcomes of 829 patients treated from November 2007 to May 2015, at the San Raffaele Scientific Institute, Milan, Italy, were retrospectively analyzed...
March 1, 2016: American Journal of Cardiology
Loren F Hiratzka, Mark A Creager, Eric M Isselbacher, Lars G Svensson, Rick A Nishimura, Robert O Bonow, Robert A Guyton, Thoralf M Sundt, Jonathan L Halperin, Glenn N Levine, Jeffrey L Anderson, Nancy M Albert, Sana M Al-Khatib, Kim K Birtcher, Biykem Bozkurt, Ralph G Brindis, Joaquin E Cigarroa, Lesley H Curtis, Lee A Fleisher, Federico Gentile, Samuel Gidding, Mark A Hlatky, John Ikonomidis, José Joglar, Richard J Kovacs, E Magnus Ohman, Susan J Pressler, Frank W Sellke, Win-Kuang Shen, Duminda N Wijeysundera
Two guidelines from the American College of Cardiology (ACC), the American Heart Association (AHA), and collaborating societies address the risk of aortic dissection in patients with bicuspid aortic valves and severe aortic enlargement: the "2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease" (Circulation. 2010;121:e266-e369) and the "2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease" (Circulation...
February 16, 2016: Circulation
Bernard Iung, Shahbudin H Rahimtoola, Alec Vahanian
No abstract text is available yet for this article.
February 1, 2016: European Heart Journal
Ashok Kondur, Alexandros Briasoulis, Mohan Palla, Anirudh Penumetcha, Sagar Mallikethi-Reddy, Apurva Badheka, Theodore Schreiber
Transcatheter aortic valve replacement (TAVR) is a viable option in the treatment of severe aortic stenosis in patients at high risk for surgery. We sought to further investigate outcomes in patients at low to intermediate risk with aortic stenosis who underwent surgical aortic valve replacement (SAVR) versus TAVR. We systematically searched the electronic databases, MEDLINE, PubMed, EMBASE, and Cochrane for prospective cohort studies of the effects of TAVR versus SAVR on clinical outcomes (30-day mortality, all-cause mortality, stroke and myocardial infarction, major vascular complications, paravalvular regurgitation, permanent pacemaker implantation, major bleeding, and acute kidney injury)...
January 15, 2016: American Journal of Cardiology
2015-12-09 04:01:15
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