Peter Bader, Hermann Kreyenberg, Arend von Stackelberg, Cornelia Eckert, Emilia Salzmann-Manrique, Roland Meisel, Ulrike Poetschger, Daniel Stachel, Martin Schrappe, Julia Alten, Andre Schrauder, Ansgar Schulz, Peter Lang, Ingo Müller, Michael H Albert, Andre M Willasch, Thomas E Klingebiel, Christina Peters
PURPOSE: To elucidate the impact of minimal residual disease (MRD) after allogeneic transplantation, the Acute Lymphoblastic Leukemia Berlin-Frankfurt-Münster Stem Cell Transplantation Group (ALL-BFM-SCT) conducted a prospective clinical trial. PATIENTS AND METHODS: In the ALL-BFM-SCT 2003 trial, MRD was assessed in the bone marrow at days +30, +60, +90, +180, and +365 after transplantation in 113 patients with relapsed disease. Standardized quantification of MRD was performed according to the guidelines of the Euro-MRD Group...
April 10, 2015: Journal of Clinical Oncology