Maro Ohanian, Hagop M Kantarjian, Alfonso Quintas-Cardama, Elias Jabbour, Lynne Abruzzo, Srdan Verstovsek, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Richard Champlin, Sherry Pierce, Mona Lisa Alattar, Long Xuan Trinh, Raja Luthra, Alessandra Ferrajoli, Tapan Kadia, Susan O'Brien, Jorge E Cortes
BACKGROUND: Accelerated phase CML most frequently represents a progression state in CML. However, some patients present with AP features at the time of diagnosis. There is limited information on the outcome of these patients who received TKIs as initial therapy. PATIENTS AND METHODS: We analyzed the outcome of 51 consecutive patients with CML who presented with features of AP at the time of diagnosis, including blasts ≥ 15% (n = 6), basophils ≥ 20% (n = 22), platelets < 100 × 10(9)/L (n = 3), cytogenetic clonal evolution (n = 17), or more than 1 feature (n = 3)...
April 2014: Clinical Lymphoma, Myeloma & Leukemia