Read by QxMD icon Read


shared collection
6 papers 0 to 25 followers
By Sun Bo A medical student in China
Dalei Wu, Nalini Potluri, Jingping Lu, Youngchang Kim, Fraydoon Rastinejad
The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets. Transcriptionally active HIFs consist of HIF-α and ARNT (also called HIF-1β) subunits. Here we describe crystal structures for each of mouse HIF-2α-ARNT and HIF-1α-ARNT heterodimers in states that include bound small molecules and their hypoxia response element...
August 20, 2015: Nature
Oscar R Colegio, Ngoc-Quynh Chu, Alison L Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika Cyrus, Carolyn E Brokowski, Stephanie C Eisenbarth, Gillian M Phillips, Gary W Cline, Andrew J Phillips, Ruslan Medzhitov
Macrophages have an important role in the maintenance of tissue homeostasis. To perform this function, macrophages must have the capacity to monitor the functional states of their 'client cells': namely, the parenchymal cells in the various tissues in which macrophages reside. Tumours exhibit many features of abnormally developed organs, including tissue architecture and cellular composition. Similarly to macrophages in normal tissues and organs, macrophages in tumours (tumour-associated macrophages) perform some key homeostatic functions that allow tumour maintenance and growth...
September 25, 2014: Nature
Shih-Chin Cheng, Jessica Quintin, Robert A Cramer, Kelly M Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J Giamarellos-Bourboulis, Joost H A Martens, Nagesha Appukudige Rao, Ali Aghajanirefah, Ganesh R Manjeri, Yang Li, Daniela C Ifrim, Rob J W Arts, Brian M J W van der Veer, Brian M J W van der Meer, Peter M T Deen, Colin Logie, Luke A O'Neill, Peter Willems, Frank L van de Veerdonk, Jos W M van der Meer, Aylwin Ng, Leo A B Joosten, Cisca Wijmenga, Hendrik G Stunnenberg, Ramnik J Xavier, Mihai G Netea
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles of human monocytes trained with the Candida albicans cell wall constituent β-glucan, together with a genome-wide transcriptome, we identified the induced expression of genes involved in glucose metabolism. Trained monocytes display high glucose consumption, high lactate production, and a high ratio of nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH), reflecting a shift in metabolism with an increase in glycolysis dependent on the activation of mammalian target of rapamycin (mTOR) through a dectin-1-Akt-HIF-1α (hypoxia-inducible factor-1α) pathway...
September 26, 2014: Science
Giorgio Seano, Giulia Chiaverina, Paolo Armando Gagliardi, Laura di Blasio, Alberto Puliafito, Claire Bouvard, Roberto Sessa, Guido Tarone, Lydia Sorokin, Dominique Helley, Rakesh K Jain, Guido Serini, Federico Bussolino, Luca Primo
The mechanism by which angiogenic endothelial cells break the physical barrier of the vascular basement membrane and consequently sprout to form new vessels in mature tissues is unclear. Here, we show that the angiogenic endothelium is characterized by the presence of functional podosome rosettes. These extracellular-matrix-degrading and adhesive structures are precursors of de novo branching points and represent a key feature in the formation of new blood vessels. VEGF-A stimulation induces the formation of endothelial podosome rosettes by upregulating integrin α6β1...
October 2014: Nature Cell Biology
Ruth Scherz-Shouval, Sandro Santagata, Marc L Mendillo, Lynette M Sholl, Irit Ben-Aharon, Andrew H Beck, Dora Dias-Santagata, Martina Koeva, Salomon M Stemmer, Luke Whitesell, Susan Lindquist
Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy. HSF1 drives a transcriptional program in CAFs that complements, yet is completely different from, the program it drives in adjacent cancer cells...
July 31, 2014: Cell
Kol Jia Yong, Chong Gao, Joline S J Lim, Benedict Yan, Henry Yang, Todor Dimitrov, Akira Kawasaki, Chee Wee Ong, Kwong-Fai Wong, Sanghoon Lee, Sharada Ravikumar, Supriya Srivastava, Xi Tian, Ronnie T Poon, Sheung Tat Fan, John M Luk, Yock Young Dan, Manuel Salto-Tellez, Li Chai, Daniel G Tenen
BACKGROUND: Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. In the heterogeneous group of hepatocellular carcinomas, those with characteristics of embryonic stem-cell and progenitor-cell gene expression are associated with the worst prognosis. The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is associated with a poor prognosis and is a potential target for treatment. METHODS: We screened specimens obtained from patients with primary hepatocellular carcinoma for the expression of SALL4 and carried out a clinicopathological analysis...
June 13, 2013: New England Journal of Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"