collection
MENU ▼
Read by QxMD icon Read
search

Substance Use Disorders

shared collection
220 papers 500 to 1000 followers Substance Related and Addictive Disorders
By Edwin Kim Resident Physician, Aspiring Addiction Psychiatrist
https://www.readbyqxmd.com/read/28705244/smoking-cessation-in-severe-mental-ill-health-what-works-an-updated-systematic-review-and-meta-analysis
#1
Emily Peckham, Sally Brabyn, Liz Cook, Garry Tew, Simon Gilbody
BACKGROUND: People with severe mental ill health are more likely to smoke than those in the general population. It is therefore important that effective smoking cessation strategies are used to help people with severe mental ill health to stop smoking. This study aims to assess the effectiveness and cost -effectiveness of smoking cessation and reduction strategies in adults with severe mental ill health in both inpatient and outpatient settings. METHODS: This is an update of a previous systematic review...
July 14, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/27332619/state-legal-restrictions-and-prescription-opioid-use-among-disabled-adults
#2
Ellen Meara, Jill R Horwitz, Wilson Powell, Lynn McClelland, Weiping Zhou, A James O'Malley, Nancy E Morden
BACKGROUND: In response to rising rates of opioid abuse and overdose, U.S. states enacted laws to restrict the prescribing and dispensing of controlled substances. The effect of these laws on opioid use is unclear. METHODS: We tested associations between prescription-opioid receipt and state controlled-substances laws. Using Medicare administrative data for fee-for-service disabled beneficiaries 21 to 64 years of age who were alive throughout the calendar year (8...
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28644052/a-little-dab-will-do-ya-in-a-case-report-of-neuro-and-cardiotoxicity-following-use-of-cannabis-concentrates
#3
Shannon S Rickner, Dazhe Cao, Kurt Kleinschmidt, Steven Fleming
CONTEXT: The use of marijuana and cannabis concentrates is increasing, especially following decriminalization in several states. Psychosis and cardiotoxicity have been reported following cannabis use; however, myocardial injury from "dabbing" has not yet been reported. We report a case of hyperthermia, tachycardia, hypertension, severe agitation, neuro-, and cardiotoxicity following the use of "dabs" where there is concomitant confirmatory biological and sample testing. CASE DETAILS: A 17-year-old athletic man developed agitation requiring sedation and intubation for safety, with peak systolic blood pressures in the 190s and hyperthermia (to 102 °F)...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28600754/substance-use-disorder-treatment-following-clinician-initiated-discontinuation-of-long-term-opioid-therapy-resulting-from-an-aberrant-urine-drug-test
#4
Shannon M Nugent, Steven K Dobscha, Benjamin J Morasco, Michael I Demidenko, Thomas H A Meath, Joseph W Frank, Travis I Lovejoy
BACKGROUND: It is unclear whether substance use disorder (SUD) treatment is offered to, or utilized by, patients who are discontinued from long-term opioid therapy (LTOT) following aberrant urine drug tests (UDTs). OBJECTIVE: To describe the proportion of patients who were referred to, and engaged in, SUD treatment following LTOT discontinuation and to examine differences in SUD treatment referral and engagement based on the substances that led to discontinuation...
June 9, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/26816013/neurobiologic-advances-from-the-brain-disease-model-of-addiction
#5
REVIEW
Nora D Volkow, George F Koob, A Thomas McLellan
This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. In the past two decades, research has increasingly supported the view that addiction is a disease of the brain. Although the brain disease model of addiction..
January 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28301219/management-of-comorbid-bipolar-disorder-and-substance-use-disorders
#6
Ihsan M Salloum, Edson Sherwood Brown
BACKGROUND: The comorbidity of substance use disorders (SUDs) in bipolar disorder is among the highest in psychiatric disorders. Evidence-based controlled psychosocial or pharmacological interventions trials, which may guide treatment decisions, have not been systematically reviewed. OBJECTIVE: To present a narrative review of the public health and clinical significance of this condition, including diagnostic and treatment implications, and to evaluate controlled trials conducted to date...
July 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28514963/patient-centered-primary-care-for-adults-at-high-risk-for-auds-the-choosing-healthier-drinking-options-in-primary-care-choice-trial
#7
Katharine A Bradley, Evette Joy Ludman, Laura J Chavez, Jennifer F Bobb, Susan J Ruedebusch, Carol E Achtmeyer, Joseph O Merrill, Andrew J Saxon, Ryan M Caldeiro, Diane M Greenberg, Amy K Lee, Julie E Richards, Rachel M Thomas, Theresa E Matson, Emily C Williams, Eric Hawkins, Gwen Lapham, Daniel R Kivlahan
BACKGROUND: Most patients with alcohol use disorders (AUDs) never receive alcohol treatment, and experts have recommended management of AUDs in primary care. The Choosing Healthier Drinking Options In primary CarE (CHOICE) trial was a randomized controlled effectiveness trial of a novel intervention for primary care patients at high risk for AUDs. This report describes the conceptual and scientific foundation of the CHOICE model of care, critical elements of the CHOICE trial design consistent with the Template for Intervention Description and Replication (TIDieR), results of recruitment, and baseline characteristics of the enrolled sample...
May 17, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/26948856/buprenorphine%C3%A2-%C3%A2-naloxone-plus-naltrexone-for-the-treatment-of-cocaine-dependence-the-cocaine-use-reduction-with-buprenorphine-curb-study
#8
Walter Ling, Maureen P Hillhouse, Andrew J Saxon, Larissa J Mooney, Christie M Thomas, Alfonso Ang, Abigail G Matthews, Albert Hasson, Jeffrey Annon, Steve Sparenborg, David S Liu, Jennifer McCormack, Sarah Church, William Swafford, Karen Drexler, Carolyn Schuman, Stephen Ross, Katharina Wiest, P Todd Korthuis, William Lawson, Gregory S Brigham, Patricia C Knox, Michael Dawes, John Rotrosen
AIMS: To examine the safety and effectiveness of buprenorphine + naloxone sublingual tablets (BUP, as Suboxone(®) ) provided after administration of extended-release injectable naltrexone (XR-NTX, as Vivitrol(®) ) to reduce cocaine use in participants who met DSM-IV criteria for cocaine dependence and past or current opioid dependence or abuse. METHODS: This multi-centered, double-blind, placebo-controlled study, conducted under the auspices of the National Drug Abuse Treatment Clinical Trials Network, randomly assigned 302 participants at sites in California, Oregon, Washington, Colorado, Texas, Georgia, Ohio, New York and Washington DC, USA to one of three conditions provided with XR-NTX: 4 mg/day BUP (BUP4, n = 100), 16 mg/day BUP (BUP16, n = 100, or no buprenorphine (placebo; PLB, n = 102)...
August 2016: Addiction
https://www.readbyqxmd.com/read/20078677/psychopathology-in-methamphetamine-dependent-adults-3-years-after-treatment
#9
Suzette Glasner-Edwards, Larissa J Mooney, Patricia Marinelli-Casey, Maureen Hillhouse, Alfonso Ang, Richard A Rawson
INTRODUCTION AND AIMS: Although psychiatric symptoms are frequently observed in methamphetamine (MA) users, little is known about the prevalence of psychiatric disorders in MA-dependent individuals. This is the first study to examine the association of psychiatric disorders with substance use and psychosocial functioning in a large sample of MA users 3 years after treatment. We predicted that psychiatric diagnoses and severity would be associated with substance use and poorer overall functioning over the 3 year post-treatment course...
January 2010: Drug and Alcohol Review
https://www.readbyqxmd.com/read/20428303/asian-americans-addictions-and-barriers-to-treatment
#10
Timothy W Fong, John Tsuang
Asian-American Pacific Islanders (AAPI) are one of the fastest growing minority groups in America. Due to model minority stereotypes and a lack of empirical data, AAPI have been thought to have lower than expected rates of substance use disorders and behavioral addictions. Recent data demonstrated that this conception is not true for all AAPI subgroups. As an example, rates of alcohol use disorders remain close to that of non-AAPI populations, even among AAPI that experience the flushing syndrome thought to protect from alcoholism...
November 2007: Psychiatry
https://www.readbyqxmd.com/read/841320/conditioned-narcotic-withdrawal-in-humans
#11
C P O'Brien, T Testa, T J O'Brien, J P Brady, B Wells
Subjective and physiological manifestations of the narcotic withdrawal syndrome were produced as a conditioned response. Withdrawal reactions precipitated by the narcotic antagonist naloxone in methadone-dependent volunteers were the unconditioned response. These data support clinical anecdotes of withdrawal symptoms occurring in former addicts when they return to their drug-related environment.
March 11, 1977: Science
https://www.readbyqxmd.com/read/21744309/theoretical-frameworks-and-mechanistic-aspects-of-alcohol-addiction-alcohol-addiction-as-a-reward-deficit-disorder
#12
REVIEW
George F Koob
Alcoholism can be defined by a compulsion to seek and take drug, loss of control in limiting intake, and the emergence of a negative emotional state when access to the drug is prevented. Alcoholism impacts multiple motivational mechanisms and can be conceptualized as a disorder that includes a progression from impulsivity (positive reinforcement) to compulsivity (negative reinforcement). The compulsive drug seeking associated with alcoholism can be derived from multiple neuroadaptations, but the thesis argued here is that a key component involves the construct of negative reinforcement...
2013: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/23996457/efficacy-of-psychostimulant-drugs-for-amphetamine-abuse-or-dependence
#13
REVIEW
Clara Pérez-Mañá, Xavier Castells, Marta Torrens, Dolors Capellà, Magi Farre
BACKGROUND: Amphetamine dependence is a public health problem with medical, psychiatric, cognitive, legal and socioeconomic consequences. To date, no pharmacological treatment has been approved for this disorder, and psychotherapy remains the mainstay of treatment. In recent years, psychostimulants have been investigated as a possible replacement therapy. OBJECTIVES: To evaluate the efficacy and safety of psychostimulant medications for amphetamine abuse or dependence...
September 2, 2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22534658/a-retrospective-analysis-of-two-randomized-trials-of-bupropion-for-methamphetamine-dependence-suggested-guidelines-for-treatment-discontinuation-augmentation
#14
RANDOMIZED CONTROLLED TRIAL
Matthew Brensilver, Keith G Heinzerling, Aimee-Noelle Swanson, Steven J Shoptaw
BACKGROUND: Two clinical trials have shown efficacy for bupropion in treating methamphetamine (MA) dependence among those with moderate baseline MA use. However, treatment response is highly variable and it is unclear what duration of treatment is necessary to determine if maintaining the treatment course is indicated or if discontinuation or augmentation is appropriate. The present study assessed the relationship among early bupropion treatment response for moderate MA users and end-of-treatment (EOT) abstinence...
September 1, 2012: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27861439/trends-in-tramadol-pharmacology-metabolism-and-misuse
#15
REVIEW
Karen Miotto, Arthur K Cho, Mohamed A Khalil, Kirsten Blanco, Jun D Sasaki, Richard Rawson
Tramadol is a unique analgesic medication, available in variety of formulations, with both monoaminergic reuptake inhibitory and opioid receptor agonist activity increasingly prescribed worldwide as an alternative for high-affinity opioid medication in the treatment of acute and chronic pain. It is a prodrug that is metabolized by cytochrome P450 (CYP) enzymes CYP2D6 and CYP3A4 to its more potent opioid analgesic metabolites, particularly the O-demethylation product M1. The opioid analgesic potency of a given dose of tramadol is influenced by an individual's CYP genetics, with poor metabolizers experiencing little conversion to the active M1 opioid metabolite and individuals with a high metabolic profile, or ultra-metabolizers, experiencing the greatest opioid analgesic effects...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25801501/the-effects-of-naltrexone-on-subjective-response-to-methamphetamine-in-a-clinical-sample-a-double-blind-placebo-controlled-laboratory-study
#16
RANDOMIZED CONTROLLED TRIAL
Lara A Ray, Spencer Bujarski, Kelly E Courtney, Nathasha R Moallem, Katy Lunny, Daniel Roche, Adam M Leventhal, Steve Shoptaw, Keith Heinzerling, Edythe D London, Karen Miotto
Methamphetamine (MA) use disorder is a serious psychiatric condition for which there are no FDA-approved medications. Naltrexone (NTX) is an opioid receptor antagonist with demonstrated efficacy, albeit moderate, for the treatment of alcoholism and opioid dependence. Preclinical and clinical studies suggest that NTX may be useful for the treatment of MA use disorder. To inform treatment development, we conducted a double-blind, randomized, crossover, placebo-controlled human laboratory study of NTX. Non-treatment-seeking individuals meeting DSM-IV criteria for MA abuse or dependence (n=30) completed two separate 5-day inpatient stays...
September 2015: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/17174602/reward-system-and-addiction-what-dopamine-does-and-doesn-t-do
#17
REVIEW
Gaetano Di Chiara, Valentina Bassareo
Addictive drugs share with palatable food the property of increasing extracellular dopamine (DA), preferentially in the nucleus accumbens shell rather than in the core. However, by acting directly on the brain, drugs bypass the adaptive mechanisms (habituation) that constrain the responsiveness of accumbens shell DA to food reward, abnormally facilitating Pavlovian incentive learning and promoting the acquisition of abnormal DA-releasing properties by drug conditioned stimuli. Thus, whereas Pavlovian food conditioned stimuli release core but not shell DA, drug conditioned stimuli do the opposite, releasing shell but not core DA...
February 2007: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/24524926/change-in-mental-health-after-smoking-cessation-systematic-review-and-meta-analysis
#18
REVIEW
Gemma Taylor, Ann McNeill, Alan Girling, Amanda Farley, Nicola Lindson-Hawley, Paul Aveyard
OBJECTIVE: To investigate change in mental health after smoking cessation compared with continuing to smoke. DESIGN: Systematic review and meta-analysis of observational studies. DATA SOURCES: Web of Science, Cochrane Central Register of Controlled Trials, Medline, Embase, and PsycINFO for relevant studies from inception to April 2012. Reference lists of included studies were hand searched, and authors were contacted when insufficient data were reported...
February 13, 2014: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28234432/cigarette-smoking-is-associated-with-increased-risk-of-substance-use-disorder-relapse-a-nationally-representative-prospective-longitudinal-investigation
#19
Andrea H Weinberger, Jonathan Platt, Hannah Esan, Sandro Galea, Debra Erlich, Renee D Goodwin
OBJECTIVE: Little is known about the relationship between cigarette smoking and long-term outcomes for substance use disorder (SUD). The current study examined the association between smoking and SUD relapse among adults with remitted SUDs. METHODS: Analyses were conducted on respondents who completed Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions and met DSM-IV criteria for substance abuse and dependence prior to but not during the year before the Wave 1 interview (n = 5,515)...
February 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/15612860/a-meta-analysis-of-smoking-cessation-interventions-with-individuals-in-substance-abuse-treatment-or-recovery
#20
Judith J Prochaska, Kevin Delucchi, Sharon M Hall
This meta-analysis examined outcomes of smoking cessation interventions evaluated in 19 randomized controlled trials with individuals in current addictions treatment or recovery. Smoking and substance use outcomes at posttreatment and long-term follow-up (> or = 6 months) were summarized with random effects models. Intervention effects for smoking cessation were significant at posttreatment and comparable for participants in addictions treatment and recovery; however, intervention effects for smoking cessation were nonsignificant at long-term follow-up...
December 2004: Journal of Consulting and Clinical Psychology
label_collection
label_collection
2830
1
2
2017-05-11 19:50:52
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"