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166 papers 100 to 500 followers
https://www.readbyqxmd.com/read/27662501/kaposi-sarcoma-herpesvirus-associated-cancers-and-related-diseases
#1
Priscila H Goncalves, Joseph Ziegelbauer, Thomas S Uldrick, Robert Yarchoan
PURPOSE OF REVIEW: This review discusses the pathogenesis and recent advances in the management of Kaposi sarcoma herpesvirus (KSHV)-associated diseases. RECENT FINDINGS: KSHV, a gammaherpesvirus, causes several tumors and related diseases, including Kaposi sarcoma, a form of multicentric Castleman disease (KSHV-MCD), and primary effusion lymphoma. These most often develop in patients infected with human immunodeficiency virus (HIV). KSHV inflammatory cytokine syndrome (KICS) is a newly described syndrome with high mortality that has inflammatory symptoms-like MCD but not the pathologic lymph node findings...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27905841/cell-delivered-entry-inhibitors-for-hiv-1-ccr5-downregulation-and-blocking-virus-membrane-fusion-in-defending-the-host-cell-population
#2
Geoff Symonds, Jeffrey S Bartlett, Hans-Peter Kiem, Marlene Tsie, Louis Breton
HIV-1 infection requires the presence of the CD4 receptor on the target cell surface and a coreceptor, predominantly CC-chemokine receptor 5 (CCR5). It has been shown that individuals who are homozygous for a defective CCR5 gene are protected from HIV-1 infection. A novel self-inactivating lentiviral vector LVsh5/C46 (Cal-1) has been engineered to block HIV-1 infection with two viral entry inhibitors, conferring resistance to HIV-1 infection from both CCR5 and CXCR4 tropic strains. Cal-1 encodes a short hairpin RNA (sh5) to downregulate CCR5 and C46, an HIV-1 fusion inhibitor...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27462361/antiretroviral-treatment-regardless-of-cd4-count-the-universal-answer-to-a-contextual-question
#3
REVIEW
Serge P Eholié, Anani Badje, Gérard M Kouame, Jean-Baptiste N'takpe, Raoul Moh, Christine Danel, Xavier Anglaret
After a period where it was recommended to start antiretroviral therapy (ART) early, the CD4 threshold for treating asymptomatic adults dropped to 200/mm(3) at the beginning of the 2000s. This was mostly due to a great prudence with regards to drug toxicity. The ART-start CD4 threshold in most international guidelines was then raised to 350/mm(3) in 2006-2009 and to 500/mm(3) in 2009-2013. Between 2012 and 2015, international guidelines went the last step further and recommended treating all HIV-infected adults regardless of their CD4 count...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27677169/intolerance-of-dolutegravir-containing-cart-regimens-in-real-life-clinical-practice
#4
Mark de Boer, Guido van den Berk, Natasja van Holten, Josephine Oryszczyn, Willemien Dorama, Daoud Ait Moha, Kees Brinkman
OBJECTIVE: Dolutegravir (DGV) is one of the preferred antiretroviral agents in first line cART. Though considered a well-tolerated drug, we aimed to determine the actual rate, timing, and detailed motivation of stopping DGV in a real life clinical setting. DESIGN: a cohort study including all patients that started DGV in two HIV treatment centers in the Netherlands. METHODS: All cART-naïve and cART-experienced patients who had started DGV were identified from the institutional HIV-databases...
September 24, 2016: AIDS
https://www.readbyqxmd.com/read/27286296/the-potential-of-pre-exposure-prophylaxis-for-women-in-violent-relationships
#5
Amy Braksmajer, Theresa E Senn, James McMahon
HIV and intimate partner violence (IPV) are significant intersecting threats to women's health. Women in violent relationships have few feasible HIV risk reduction options as traditional prevention methods are largely dependent on a partner's cooperation. The purpose of this review is to explore potential benefits and drawbacks of pre-exposure prophylaxis (PrEP) use among women in the United States experiencing IPV. Advantages of PrEP use in this population include the potential for covert or autonomous use, coital independence, dual protection against sexual and injection risk, and facilitated connections to social services...
June 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27308806/early-syphilis-among-men-who-have-sex-with-men-in-the-us-pacific-northwest-2008-2013-clinical-management-and-implications-for-prevention
#6
Emiko Petrosky, Robyn Neblett Fanfair, Kim Toevs, Malini DeSilva, Sean Schafer, Katrina Hedberg, Jim Braxton, Jaime Walters, Lauri Markowitz, Susan Hariri
Substantial increases in syphilis during 2008-2013 were reported in the US Pacific Northwest state of Oregon, especially among men who have sex with men (MSM). The authors aimed to characterize the ongoing epidemic and identify possible gaps in clinical management of early syphilis (primary, secondary, and latent syphilis ≤1 year) among MSM in Multnomah County, Oregon to inform public health efforts. Administrative databases were used to examine trends in case characteristics during 2008-2013. Medical records were abstracted for cases occurring in 2013 to assess diagnosis, treatment, and screening practices...
March 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27749111/invasive-pneumococcal-disease-among-hiv-infected-and-hiv-uninfected-adults-in-a-large-integrated-healthcare-system
#7
Julia L Marcus, Roger Baxter, Wendy A Leyden, Dharushana Muthulingam, Arnold Yee, Michael A Horberg, Daniel B Klein, William J Towner, Chun R Chao, Charles P Quesenberry, Michael J Silverberg
It is unclear whether HIV-infected individuals remain at higher risk of invasive pneumococcal disease (IPD) compared with HIV-uninfected individuals. We conducted a cohort study of HIV-infected and demographically matched HIV-uninfected adults within Kaiser Permanente Northern California during the period 1996-2011. We used Poisson models to obtain rate ratios (RRs) for incident IPD associated with HIV infection and other risk factors. Among 13,079 HIV-infected and 137,643 HIV-uninfected adults, the IPD rate per 100,000 person-years was 160 (n = 109 events) for HIV-infected and 8 (n = 75 events) for HIV-uninfected subjects, with an adjusted RR of 13...
October 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27714978/switching-regimens-in-virologically-suppressed-hiv-1-infected-patients-evidence-base-and-rationale-for-integrase-strand-transfer-inhibitor-insti-containing-regimens
#8
REVIEW
F Raffi, S Esser, G Nunnari, I Pérez-Valero, L Waters
In an era when most individuals with treated HIV infection can expect to live into old age, clinicians should proactively review their patients' current and future treatment needs and challenges. Clinical guidelines acknowledge that, in the setting of virological suppression, treatment switch may yield benefits in terms of tolerability, regimen simplification, adherence, convenience and long-term health considerations, particularly in the context of ageing. In this paper, we review evidence from six key clinical studies on switching virologically suppressed patients to regimens based on integrase strand transfer inhibitors (INSTIs), the antiretroviral class increasingly preferred as initial therapy in clinical guidelines...
October 2016: HIV Medicine
https://www.readbyqxmd.com/read/27649852/human-papillomavirus-16-hpv16-and-hpv52-e6-specific-immunity-in-hiv-infected-adults-on-combination-antiretroviral-therapy
#9
C Y Leng, H C Low, L L Chua, M L Chong, H Sulaiman, I Azwa, J M Roberts, A Kamarulzaman, R Rajasuriar, Y L Woo
OBJECTIVES: Human papillomavirus (HPV)-associated cancers disproportionately affect those infected with HIV despite effective combination antiretroviral therapy (cART). The primary aim of this study was to quantify HPV16 and HPV52 E6-specific interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) T-cell responses, a correlate of protective immunity, in the first year following cART initiation and subsequently in those patients with suboptimal (sIR) and optimal (oIR) immune reconstitution...
September 20, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27679418/effect-of-alcohol-consumption-on-all-cause-and-liver-related-mortality-among-hiv-infected-individuals
#10
C E Canan, B Lau, M E McCaul, J Keruly, R D Moore, G Chander
OBJECTIVES: The aim of the study was to examine the association between levels of past and current alcohol consumption and all-cause and liver-related mortality among people living with HIV (PLWH). METHODS: A prospective cohort study of 1855 PLWH in Baltimore, MD was carried out from 2000 to 2013. We ascertained alcohol use by (1) self-report (SR) through a computer-assisted self interview, and (2) medical record abstraction of provider-documented (PD) alcohol use...
September 28, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27683060/quantification-of-the-latent-hiv-1-reservoir-using-ultra-deep-sequencing-and-primer-id-in-a-viral-outgrowth-assay
#11
Sook-Kyung Lee, Shuntai Zhou, Pedro L Baldoni, Ean Spielvogel, Nancie M Archin, Michael G Hudgens, David M Margolis, Ronald Swanstrom
BACKGROUND: In this study, we measured the latent HIV-1 reservoir harboring replication-competent HIV-1 in resting CD4+ T cells in participants on highly active antiretroviral therapy (HAART), quantitating the frequency of latent infection through the use of a Primer ID-based Ultra Deep Sequencing Assay (UDSA), in comparison to the readout of the quantitative viral outgrowth assay (QVOA). METHODS: Viral RNA derived from culture wells of QVOA that scored as HIV-1 p24 capsid (CA) antigen-positive were tagged with a specific barcode during cDNA synthesis, and the sequences within the V1-V3 region of the HIV-1 env gene were analyzed for diversity using the Primer ID-based paired-end MiSeq platform...
September 27, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27677167/hydroxytyrosol-a-new-class-of-microbicide-displaying-broad-anti-hiv-1-activity
#12
Luis M Bedoya, Manuela Beltrán, Patricia Obregón-Calderón, Javier García-Pérez, Humberto E de la Torre, Nuria González, Mayte Pérez-Olmeda, David Auñón, Laura Capa, Eduardo Gómez-Acebo, José Alcamí
OBJECTIVE: To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide. DESIGN: The anti-HIV-1 activity of 5-hydroxytyrosol, a polyphenolic compound, was tested against wild-type HIV-1 and viral clones resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors and integrase inhibitors. In addition to its activity against founder viruses, different viral subtypes and potential synergy with tenofovir disoproxil fumarate, lamivudine and emtricitabine was also tested...
November 28, 2016: AIDS
https://www.readbyqxmd.com/read/27465879/tenofovir-alafenamide-a-review-of-its-use-in-the-treatment-of-hiv-1-infection
#13
Amanda K Gibson, Bhavik M Shah, Puja H Nambiar, Jason J Schafer
OBJECTIVE: To review the pharmacology, efficacy, safety, and place in therapy for tenofovir alafenamide (TAF). DATA SOURCES: A search using PubMed was conducted (2004 to May 2016) using the following keywords: tenofovir alafenamide, TAF, and GS-7340 Articles were evaluated for content, and bibliographies were reviewed. Data available exclusively as abstracts from major infectious diseases and HIV conferences were also evaluated for inclusion. STUDY SELECTION AND DATA EXTRACTION: Studies included were in vitro investigations; phase I, II, and III clinical trials; and pharmacokinetic and pharmacodynamic evaluations...
July 26, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27654814/flow-rate-of-csf-through-a-spinal-needle-can-accurately-predict-intracranial-pressure-in-cryptococcal-meningitis
#14
Tom H Boyles, Elizabeth Gately, Sean Wasserman, Graeme Meintjes
BACKGROUND: Patients with HIV-associated cryptococcal meningitis (CM) commonly present with raised intra-cranial pressure (ICP). Aggressive management of raised ICP reduces mortality but requires manometers which are unavailable in most resource-limited settings. The law of Poiseuille states that the rate of flow of liquid through a tube is directly proportional to the difference in pressure between each end and it may be possible to indirectly determine ICP by measuring flow of CSF through a spinal needle rather than using a manometer...
September 19, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27438424/hiv-and-hepatitis-c-virus-coinfection-who-is-this-patient-today
#15
Vicente Sperb Antonello, Ivan Carlos Ferreira Antonello, Rosana Ferrazza Zaltron, Cristiane Valle Tovo
BACKGROUND: - The increase in the survival following the introduction of highly active antiretroviral therapy (HAART) has seen the emergence of hepatitis C virus (HCV) infection, renal and cardiovascular diseases as important morbidity and mortality causes together with HIV. OBJECTIVE: - The present study aimed to investigate the differences between HIV/hepatitis C virus coinfected and HIV-monoinfected regarding demographic and clinical aspects from a HIV/AIDS clinic in Porto Alegre, Brazil...
July 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27537569/hepatic-fibrosis-and-immune-phenotype-vary-by-hcv-viremia-in-hcv-hiv-co-infected-subjects-a-women-s-interagency-hiv-study
#16
Seema N Desai, Jennifer L Dodge, Alan L Landay, Marshall J Glesby, Patricia S Latham, Maria C Villacres, Audrey L French, Stephen J Gange, Ruth M Greenblatt, Marion G Peters
HCV and HIV independently lead to immune dysregulation. The mechanisms leading to advanced liver disease progression in HCV/HIV coinfected subjects remain unclear.In this cross-sectional study, we assessed the association of HCV viremia, liver fibrosis, and immune response patterns in well-characterized HIV phenotypes: Elite controllers (Elites), HIV controlled (ARTc), and HIV uncontrolled (ARTuc) matched by age and race. Groups were stratified by HCV RNA status. Regulatory T-cell frequencies, T-cell activation (HLADR+CD38+), apoptosis (Caspase-3+), and intracellular cytokines (interferon-γ, IL-2, IL-17) were assessed using multiparametric flow-cytometry...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27588613/dolutegravir-monotherapy-as-treatment-de-escalation-in-hiv-infected-adults-with-virological-control-dolumono-cohort-results
#17
Celia Oldenbuettel, Eva Wolf, Ayla Ritter, Sebastian Noe, Silke Heldwein, Rita Pascucci, Carmen Wiese, Ariane Von Krosigk, Eva Jaegel-Guedes, Hans Jaeger, Annamaria Balogh, Christine Koegl, Christoph D Spinner
BACKGROUND: The potential toxicity of long-term antiretroviral treatment (ART) requires ongoing investigation of novel strategies for treatment of HIV-infected patients. Monotherapy with the integrase inhibitor (INSTI) dolutegravir (DTG) may offer a favorable safety profile. Additionally, DTG has a high barrier of resistance, crucial for successful maintenance of virologic control. However, published data is sparse. METHODS: Retrospective, single-center cohort study...
September 2, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27578404/life-expectancy-of-hiv-positive-people-after-starting-combination-antiretroviral-therapy-a-meta-analysis
#18
S Teeraananchai, S J Kerr, J Amin, K Ruxrungtham, M G Law
OBJECTIVES: Life expectancy is an important indicator informing decision making in policies relating to HIV-infected people. Studies estimating life expectancy after starting combination antiretroviral therapy (cART) have noted differences between income regions. The objective of our study was to perform a meta-analysis to assess life expectancy of HIV-positive people after starting cART, and to quantify differences between low/middle- and high-income countries. METHODS: Eight cohort studies estimating life expectancy in HIV-positive people initiating cART aged ≥ 14 years using the abridged life table method were identified...
August 31, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27568911/british-hiv-association-guidelines-for-the-treatment-of-hiv-1-positive-adults-with-antiretroviral-therapy-2015
#19
Duncan Churchill, Laura Waters, Nadia Ahmed, Brian Angus, Marta Boffito, Mark Bower, David Dunn, Simon Edwards, Carol Emerson, Sarah Fidler, Martin Fisher, Rob Horne, Saye Khoo, Clifford Leen, Nicola Mackie, Neal Marshall, Fernando Monteiro, Mark Nelson, Chloe Orkin, Adrian Palfreeman, Sarah Pett, Andrew Phillips, Frank Post, Anton Pozniak, Iain Reeves, Caroline Sabin, Roy Trevelion, John Walsh, Ed Wilkins, Ian Williams, Alan Winston
No abstract text is available yet for this article.
August 2016: HIV Medicine
https://www.readbyqxmd.com/read/27550993/ecil-guidelines-for-treatment-of-pneumocystis-jirovecii-pneumonia-in-non-hiv-infected-haematology-patients
#20
REVIEW
Georg Maschmeyer, Jannik Helweg-Larsen, Livio Pagano, Christine Robin, Catherine Cordonnier, Peter Schellongowski
The initiation of systemic antimicrobial treatment of Pneumocystis jirovecii pneumonia (PCP) is triggered by clinical signs and symptoms, typical radiological and occasionally laboratory findings in patients at risk of this infection. Diagnostic proof by bronchoalveolar lavage should not delay the start of treatment. Most patients with haematological malignancies present with a severe PCP; therefore, antimicrobial therapy should be started intravenously. High-dose trimethoprim/sulfamethoxazole is the treatment of choice...
September 2016: Journal of Antimicrobial Chemotherapy
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