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https://www.readbyqxmd.com/read/28774293/the-clinical-utility-of-the-urine-based-lateral-flow-lipoarabinomannan-assay-in-hiv-infected-adults-in-myanmar-an-observational-study
#1
Swe Swe Thit, Ne Myo Aung, Zaw Win Htet, Mark A Boyd, Htin Aung Saw, Nicholas M Anstey, Tint Tint Kyi, David A Cooper, Mar Mar Kyi, Josh Hanson
BACKGROUND: The use of the point-of-care lateral flow lipoarabinomannan (LF-LAM) test may expedite tuberculosis (TB) diagnosis in HIV-positive patients. However, the test's clinical utility is poorly defined outside sub-Saharan Africa. METHODS: The study enrolled consecutive HIV-positive adults at a tertiary referral hospital in Yangon, Myanmar. On enrolment, patients had a LF-LAM test performed according to the manufacturer's instructions. Clinicians managing the patients were unaware of the LF-LAM result, which was correlated with the patient's clinical course over the ensuing 6 months...
August 4, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29765018/tracking-hiv-1-recombination-to-resolve-its-contribution-to-hiv-1-evolution-in-natural-infection
#2
Hongshuo Song, Elena E Giorgi, Vitaly V Ganusov, Fangping Cai, Gayathri Athreya, Hyejin Yoon, Oana Carja, Bhavna Hora, Peter Hraber, Ethan Romero-Severson, Chunlai Jiang, Xiaojun Li, Shuyi Wang, Hui Li, Jesus F Salazar-Gonzalez, Maria G Salazar, Nilu Goonetilleke, Brandon F Keele, David C Montefiori, Myron S Cohen, George M Shaw, Beatrice H Hahn, Andrew J McMichael, Barton F Haynes, Bette Korber, Tanmoy Bhattacharya, Feng Gao
Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of within-host diversification is less understood. Here we develop a novel computational tool (RAPR (Recombination Analysis PRogram)) to enable a detailed view of in vivo viral recombination during early infection, and we apply it to near-full-length HIV-1 genome sequences from longitudinal samples. Recombinant genomes rapidly replace transmitted/founder (T/F) lineages, with a median half-time of 27 days, increasing the genetic complexity of the viral population...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29940603/hiv-infection-is-associated-with-abnormal-bone-microarchitecture-measurement-of-trabecular-bone-score-in-the-women-s-interagency-hiv-study
#3
Anjali Sharma, Yifei Ma, Phyllis C Tien, Rebecca Scherzer, Kathryn Anastos, Mardge H Cohen, Didier Hans, Michael T Yin
OBJECTIVES: We compared skeletal microarchitecture using trabecular bone score (TBS) and evaluated relationships between change in TBS and lumbar spine (LS) bone mineral density (BMD) in women with and without HIV. METHODS: Dual-energy X-ray absorptiometry was performed on 319 women with HIV and 118 without HIV in the Women's Interagency HIV Study at baseline and 2 and 5 years, to measure regional BMD and lean and fat mass. TBS was extracted from LS dual-energy X-ray absorptiometry images and examined continuously and categorically [normal (≥1...
August 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29870269/models-of-hiv-preconception-care-and-key-elements-influencing-these-services-findings-from-healthcare-providers-in-seven-us-cities
#4
Joanne Simone, Mary Jo Hoyt, Deborah S Storm, Sarah Finocchario-Kessler
Preconception care can improve maternal and infant outcomes by identifying and modifying health risks before pregnancy and reducing unplanned pregnancies. However, information about how preconception care is provided to persons living with HIV (PLWH) is lacking. This study uses qualitative interviews with HIV care providers to describe current models of preconception care and explore factors influencing services. Single, anonymous, telephone interviews were conducted with 92 purposively selected HIV healthcare providers in Atlanta, Baltimore, Houston, Kansas City, Newark, Philadelphia, and San Francisco in 2013-2014...
July 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29927787/recent-trends-in-sexual-behaviours-among-msm-followed-since-primary-hiv-1-infection
#5
Karen Champenois, Rémonie Seng, Anne Persoz, Asma Essat, Catherine Gaud, Didier Laureillard, Olivier Robineau, Claudine Duvivier, Yazdan Yazdanpanah, Cécile Goujard, Laurence Meyer
BACKGROUND: With the advent of treatment as prevention of HIV infection (TasP), we assessed trends in sexual behaviours between 2000 and 2017 among HIV-infected MSM enrolled in the French ANRS PRIMO cohort. METHODS: At each cohort visit, a clinical questionnaire including laboratory values was completed and a self-administered questionnaire was used to collect sexual behaviours, that is, the number, type (steady/casual) and HIV status (positive or negative/unknown) of partners, and condom use...
June 20, 2018: AIDS
https://www.readbyqxmd.com/read/29808134/non-st-elevation-myocardial-infarction-and-severe-peripheral-artery-disease-in-a-20-year-old-with-perinatally-acquired-human-immunodeficiency-virus-infection
#6
Purva Sharma, Mohamad Kabach, Samineh Sehatbakhsh, Rashida Tharpe, Shaun Isaac, Robert Chait, Kleper De Almeida
Human immunodeficiency virus (HIV) infection confers an increased risk of cardiovascular disease, including acute coronary syndrome (ACS). Patients with perinatally acquired HIV may be at increased risk due to the viral infection itself and exposure to HAART in utero or as part of treatment. A 20-year-old female with transplacentally acquired HIV infection presented with symptoms of transient aphasia, headache, palpitations, and blurry vision. She was admitted for hypertensive emergency with blood pressure 203/100 mmHg...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29905808/pharmacokinetic-modelling-of-darunavir-ritonavir-dose-reduction-800-100-to-400-100-mg-once-daily-in-a-darunavir-ritonavir-containing-regimen-in-virologically-suppressed-hiv-infected-patients-anrs-165-darulight-sub-study
#7
Minh P Lê, Marie-Laure Chaix, Sylvie Chevret, Julie Bertrand, François Raffi, Sébastien Gallien, El Mountacer Billah El Abbassi, Christine Katlama, Pierre Delobel, Yazdan Yazdanpanah, Juliette Saillard, Jean-Michel Molina, Gilles Peytavin
Background: In the ANRS 165 DARULIGHT study (NCT02384967) carried out in HIV-infected patients, the use of a darunavir/ritonavir-containing regimen with a switch to a reduced dose of darunavir maintained virological efficacy (≤50 copies/mL) for 48 weeks with a good safety profile. Objectives: To assess the total and unbound blood plasma pharmacokinetics of darunavir and associated antiretrovirals, and their penetration into semen before and after dose reduction...
June 13, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29734221/long-term-trends-in-cd4-cell-counts-cd8-cell-counts-and-the-cd4-cd8-ratio-art-cohort-collaboration-art-cc-study
#8
Rachael A Hughes, Margaret T May, Kate Tilling, Ninon Taylor, Linda Wittkop, Peter Reiss, John Gill, Philipp Schommers, Dominique Costagliola, Jodie L Guest, Viviane D Lima, Antonella d'arminio Monforte, Colette Smith, Matthias Cavassini, Michael Saag, Tim R Sterling, Jonathan A C Sterne
OBJECTIVE: Model trajectories of CD4 and CD8 cell counts after starting combination antiretroviral therapy (ART), and use the model to predict trends in these counts and the CD4:CD8 ratio. DESIGN: Cohort study of antiretroviral-naïve HIV-positive adults who started ART after 1997 (ART Cohort Collaboration) with >6 months of follow-up data. METHODS: We jointly estimated CD4 and CD8 count trends and their correlation using a bivariate random effects model, with linear splines describing their population trends, and predicted the CD4:CD8 ratio trend from this model...
May 3, 2018: AIDS
https://www.readbyqxmd.com/read/29557189/use-of-testosterone-in-men-infected-with-human-immunodeficiency-virus-in-the-veterans-healthcare-system
#9
Guneet K Jasuja, Shalender Bhasin, Adam J Rose, Joel I Reisman, Avy Skolnik, Dan R Berlowitz, Allen L Gifford
Testosterone supplementation has been widely used in those infected with human immunodeficiency virus (HIV) for hypogonadism, and wasting. But with effective antiretroviral therapy and increasing recognition of atherosclerotic disease and adults infected with HIV, the risks of inappropriate testosterone use in HIV-infected patients are far better recognized than previously. Testosterone use has expanded among U.S. males, but few studies have examined prescribing in those infected with HIV. In a national cohort of males with at least one outpatient prescription in the Veterans Health Administration (VHA), we examined 9475 HIV-infected males, including 2484 who had received testosterone and a randomly selected 6991 who had not...
March 19, 2018: AIDS Care
https://www.readbyqxmd.com/read/29781885/improved-cognitive-performance-and-reduced-monocyte-activation-in-virally-suppressed-chronic-hiv-following-dual-ccr2-and-ccr5-antagonism
#10
Michelle L D'Antoni, Robert H Paul, Brooks I Mitchell, Lindsay Kohorn, Laurent Fischer, Eric Lefebvre, Star Seyedkazemi, Beau K Nakamoto, Maegen Walker, Kalpana J Kallianpur, Debra Ogata-Arakaki, Lishomwa C Ndhlovu, Cecilia Shikuma
OBJECTIVE: To evaluate changes in neuropsychological (NP) performance and in plasma and cell surface markers of peripheral monocyte activation/migration following treatment with cenicriviroc (CVC), a dual C-C chemokine receptor type 2 (CCR2) and type 5 (CCR5) antagonist, in treatment-experienced, HIV-infected individuals. SETTING: Single-arm, 24-week, open-label clinical trial. METHODS: HIV-infected individuals on antiretroviral therapy (ART) >1 year with plasma HIV RNA <50 copies/ml and below-normal cognitive performance [defined as age, gender and education-adjusted NP performance (NPZ) <-0...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29761920/prospective-plasma-efavirenz-concentration-assessment-in-chinese-hiv-infected-adults-enrolled-in-a-large-multicentre-study
#11
F Guo, X Cheng, E Hsieh, X Du, Q Fu, W Peng, Y Li, X Song, J-P Routy, T Li
OBJECTIVES: Few studies have explored the optimal dosing for efavirenz in individuals from China. We investigated plasma efavirenz concentrations and their association with efficacy and tolerance of efavirenz 600 mg daily in Chinese HIV-infected adults. METHODS: An analysis was performed using plasma samples from 455 patients enrolled in a prospective multicentre trial in China. A total of 1198 plasma samples collected at weeks 4, 24 and 48 following antiretroviral therapy initiation were analysed...
May 15, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29750552/correction-to-aids-patient-care-and-stds-2016-30-221-228-doi-10-1089-apc-2015-0333
#12
(no author information available yet)
No abstract text is available yet for this article.
May 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29334178/factors-associated-with-perceived-accuracy-of-the-undetectable-untransmittable-slogan-among-men-who-have-sex-with-men-implications-for-messaging-scale-up-and-implementation
#13
H Jonathon Rendina, Jeffrey T Parsons
INTRODUCTION: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29313714/decreased-lung-function-and-all-cause-mortality-in-hiv-infected-individuals
#14
Matthew R Gingo, Mehdi Nouraie, Cathy J Kessinger, Ruth M Greenblatt, Laurence Huang, Eric C Kleerup, Lawrence Kingsley, Deborah K McMahon, Alison Morris
RATIONALE: Human immunodeficiency virus (HIV) infection is associated with pulmonary disease and worse lung function, but the relationship of lung function with survival in HIV is unknown. OBJECTIVES: To determine whether lung function is associated with all-cause mortality in HIV-infected individuals. METHODS: HIV-infected participants from cohorts in three locations underwent pre- and post-bronchodilator spirometry and determination of single-breath diffusing capacity of the lung for carbon monoxide (DlCO ) in 2008-2009, computed tomographic (CT) scanning of the chest for quantitative emphysema and airway measures, and echocardiography for estimated left ventricular systolic and diastolic function and tricuspid regurgitant velocity...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29687590/a-systematic-review-of-risk-of-hiv-transmission-through-biting-or-spitting-implications-for-policy
#15
F V Cresswell, J Ellis, J Hartley, C A Sabin, C Orkin, D R Churchill
OBJECTIVES: The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of "spit hoods" by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmission as one justification. We aimed to review literature relating to the risk of HIV transmission through biting or spitting. METHODS: A systematic literature search was conducted using Medline, Embase and Northern Lights databases and conference websites using search terms relating to HIV, AIDS, bite, spit and saliva...
April 23, 2018: HIV Medicine
https://www.readbyqxmd.com/read/16364487/hepatotoxicity-of-antiretrovirals-incidence-mechanisms-and-management
#16
REVIEW
Marina Núñez
One of the toxicities linked to the use of antiretrovirals is the elevation of transaminases. Liver toxicity is a cause of morbidity, mortality, and treatment discontinuation in HIV-infected patients. While several antiretrovirals have been reported to cause fatal acute hepatitis, they most often cause asymptomatic elevations of transaminases. Liver toxicity is more frequent among subjects with chronic hepatitis C and/or B. The incidence of drug-induced liver toxicity is not well known for most antiretrovirals...
2006: Journal of Hepatology
https://www.readbyqxmd.com/read/29573535/prevalence-and-risk-factors-of-measles-seronegativity-in-a-cohort-of-hiv-positive-subjects-a-retrospective-study
#17
N Dauby, C Martin, M Hainaut, T Grammens, S Van den Wijngaert, M Delforge, S De Wit
OBJECTIVES: Measles infection is a vaccine-preventable disease currently resurging in Europe. HIV-infected subjects are at higher risk of complications following measles infection. We investigated the risk factors associated with being seronegative in a cohort of HIV-infected subjects. METHODS: All HIV-infected subjects in our cohort who had a measles serological test performed between December 2005 and May 2017 were retrospectively identified. A measles immunoglobulin G (IgG) titre > 275 mIU/mL was considered protective...
March 24, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29493093/highlights-of-the-2017-european-aids-clinical-society-eacs-guidelines-for-the-treatment-of-adult-hiv-positive-persons-version-9-0
#18
L Ryom, C Boesecke, M Bracchi, J Ambrosioni, A Pozniak, J Arribas, G Behrens, Pgm Mallon, M Puoti, A Rauch, J M Miro, O Kirk, C Marzolini, J D Lundgren, M Battegay
BACKGROUND: The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. GUIDELINE HIGHLIGHTS: Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management...
May 2018: HIV Medicine
https://www.readbyqxmd.com/read/29323557/neuropsychological-assessment-of-412-hiv-infected-individuals-in-s%C3%A3-o-paulo-brazil
#19
Maria Rita Polo Gascón, José Ernesto Vidal, Yolanda Marques Mazzaro, Jerusa Smid, Rosa Maria Nascimento Marcusso, Claudio Garcia Capitão, Elizeu Macedo Coutinho, Glaucia Rosana Guerra Benute, Mara Cristina Souza De Lucia, Augusto César Penalva de Oliveira
HIV-associated neurocognitive disorders (HAND) remain frequent even among individuals receiving combined antiretroviral therapy (cART). In addition, HAND may adversely affect the quality of life and adherence to cART. There is scarce epidemiological information about HAND in Latin America. This cross-sectional study recruited HIV-infected patients from a tertiary teaching institution in São Paulo, Brazil, between May 2013 and February 2015. The patients were adults with at least 4 years of education and patients with current neurological or psychiatric diseases were excluded...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29424697/patterns-of-efavirenz-use-as-first-line-antiretroviral-therapy-in-the-united-states-1999-2015
#20
Angela M Bengtson, Brian W Pence, Ellen F Eaton, Jessie K Edwards, Joseph J Eron, William C Mathews, Katie Mollan, Richard D Moore, Connall O'Cleirigh, Elvin Geng, Michael J Mugavero
BACKGROUND: Efavirenz has been a mainstay of antiretroviral therapy (ART) for over 15 years in the US. Its association with neuropsychiatric side effects may influence clinical prescribing and management. METHODS: We included HIV-infected adults enrolled in care at 7 sites across the US, who initiated combination ART between 1999 and 2015. We examined the proportion initiating and continuing on efavirenz, overall and by mental health status. Log binomial and Cox models were used to estimate associations between mental health, clinical, and sociodemographic characteristics and initiating or switching from efavirenz as first line ART...
February 9, 2018: Antiviral Therapy
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