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Achieving Depression Remission

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119 papers 500 to 1000 followers
By Edwin Kim Resident Physician, Aspiring Addiction Psychiatrist
https://www.readbyqxmd.com/read/28335624/effects-of-patient-preferences-on-outcomes-in-the-predictors-of-remission-in-depression-to-individual-and-combined-treatments-predict-study
#1
Boadie W Dunlop, Mary E Kelley, Vivianne Aponte-Rivera, Tanja Mletzko-Crowe, Becky Kinkead, James C Ritchie, Charles B Nemeroff, W Edward Craighead, Helen S Mayberg
OBJECTIVE: The Predictors of Remission in Depression to Individual and Combined Treatments [PReDICT] study aimed to identify clinical and biological factors predictive of treatment outcomes in major depressive disorder among treatment-naive adults. The authors evaluated the efficacy of cognitive-behavioral therapy (CBT) and two antidepressant medications (escitalopram and duloxetine) in patients with major depression and examined the moderating effect of patients' treatment preferences on outcomes...
March 24, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/26997505/therapeutic-modulation-of-glutamate-receptors-in-major-depressive-disorder
#2
REVIEW
Brittany A Jaso, Mark J Niciu, Nicolas D Iadarola, Niall Lally, Erica M Richards, Minkyung Park, Elizabeth D Ballard, Allison C Nugent, Rodrigo Machado-Vieira, Carlos A Zarate
Current pharmacotherapies for major depressive disorder (MDD) have a distinct lag of onset that can prolong distress and impairment for patients, and realworld effectiveness trials further suggest that antidepressant efficacy is limited in many patients. All currently approved antidepressant medications for MDD act primarily through monoaminergic mechanisms, e.g., receptor/reuptake agonists or antagonists with varying affinities for serotonin, norepinephrine, or dopamine. Glutamate is the major excitatory neurotransmitter in the central nervous system, and glutamate and its cognate receptors are implicated in the pathophysiology of MDD, as well as in the development of novel therapeutics for this disorder...
2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/27738380/treatment-resistant-depression-with-loss-of-antidepressant-response-rapid-acting-antidepressant-action-of-dextromethorphan-a-possible-treatment-bridging-molecule
#3
Edward C Lauterbach
Dextromethorphan (DM) may have ketamine-like rapid-acting, treatment-resistant, and conventional antidepressant effects.(1,2) This reports our initial experience with DM in unipolar Major Depressive Disorder (MDD). A patient with treatment-resistant MDD (failing adequate trials of citalopram and vortioxetine) with loss of antidepressant response (to fluoxetine and bupropion) twice experienced a rapid-acting antidepressant effect within 48 hours of DM administration and lasting 7 days, sustained up to 20 days with daily administration, then gradually developing labile loss of antidepressant response over the ensuing 7 days...
August 15, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/17205639/the-expert-consensus-guideline-series-pharmacotherapy-of-depressive-disorders-in-older-patients
#4
G S Alexopoulos, I R Katz, C F Reynolds, D Carpenter, J P Docherty
OBJECTIVES: Depression in older patients contributes to personal suffering and family disruption and increases disability, medical morbidity, mortality, suicide risk, and healthcare utilization. The majority of clinical trials of antidepressant treatments are conducted in younger patients. For this reason, clinicians often have to extrapolate from studies in populations that do not present the same problems as older patients. For example, older patients often have serious coexisting medical conditions that may contribute to the depression and complicate the choice of treatment...
October 2001: Postgraduate Medicine
https://www.readbyqxmd.com/read/28252882/effectiveness-of-supplementary-cognitive-behavioral-therapy-for-pharmacotherapy-resistant-depression-a-randomized-controlled-trial
#5
Atsuo Nakagawa, Dai Mitsuda, Mitsuhiro Sado, Takayuki Abe, Daisuke Fujisawa, Toshiaki Kikuchi, Satoru Iwashita, Masaru Mimura, Yutaka Ono
OBJECTIVE: Antidepressant medication is efficacious in the treatment of depression, but not all patients improve with antidepressant medication alone. Despite this treatment gap, limited evidence regarding the effectiveness of supplementing psychotherapy for pharmacotherapy-resistant depression is available. Therefore, we investigated the effectiveness of supplementing usual medication management (treatment as usual [TAU]) with cognitive-behavioral therapy (CBT) in patients with pharmacotherapy-resistant depression seeking psychiatric specialty care...
February 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27816323/association-between-low-serum-25-hydroxyvitamin-d-and-depression-in-a-large-sample-of-chinese-patients-with-type-2-diabetes-mellitus
#6
Yuhong Wang, Hui Yang, Pan Meng, Yuanshan Han
BACKGROUND: Because of the absence of data on the direct association between vitamin D and depression in patients with diabetes, we examined the association between vitamin D state (assessed by 25-hydroxyvitamin D [25(OH)D]) and the prevalence of depression in adult patients with type 2 diabetes mellitus(T2DM). METHOD: Cross-sectional data were obtained from 2786 patients with T2DM recruited from a Chinese diabetes registry. Patients' records were reviewed to obtain data pertaining to age, sex, Body Mass Index (BMI), marital status, level of education, smoking status, duration of diabetes mellitus, use of insulin, and presence of additional illnesses...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27056608/a-double-blind-randomized-placebo-controlled-dose-frequency-study-of-intravenous-ketamine-in-patients-with-treatment-resistant-depression
#7
Jaskaran B Singh, Maggie Fedgchin, Ella J Daly, Peter De Boer, Kimberly Cooper, Pilar Lim, Christine Pinter, James W Murrough, Gerard Sanacora, Richard C Shelton, Benji Kurian, Andrew Winokur, Maurizio Fava, Husseini Manji, Wayne C Drevets, Luc Van Nueten
OBJECTIVE: Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with treatment-resistant depression. This study evaluated the efficacy of twice- and thrice-weekly intravenous administration of ketamine in sustaining initial antidepressant effects in patients with treatment-resistant depression. METHOD: In a multicenter, double-blind study, adults (ages 18-64 years) with treatment-resistant depression were randomized to receive either intravenous ketamine (0...
August 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27282362/efficacy-and-safety-of-antidepressants-added-to-antipsychotics-for-schizophrenia-a-systematic-review-and-meta-analysis
#8
Bartosz Helfer, Myrto T Samara, Maximilian Huhn, Elisabeth Klupp, Claudia Leucht, Yikang Zhu, Rolf R Engel, Stefan Leucht
OBJECTIVE: The authors examined the safety and efficacy of antidepressants added to antipsychotic drugs in the treatment of schizophrenia. METHOD: Multiple databases and previous publications were searched through June 2015 to identify all randomized controlled trials of any add-on antidepressants compared with placebo or no-treatment in schizophrenia. Depressive and negative symptoms (primary outcomes), overall symptoms, positive symptoms, side effects, exacerbation of psychosis, and responder rates were examined...
September 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28068463/long-term-acute-phase-treatment-with-antidepressants-8-weeks-and-beyond-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#9
Jonathan Henssler, Mona Kurschus, Jeremy Franklin, Tom Bschor, Christopher Baethge
OBJECTIVE: In clinical practice, acute antidepressant treatment is often applied for several months until remission is achieved. However, data on treatment outcomes beyond 8 weeks are sparse and no systematic review exists to date. This study aims at assessing efficacy and tolerability of antidepressants compared to placebo in acute treatment at and beyond 8 weeks. DATA SOURCES: MEDLINE, Embase, PsycINFO, and CENTRAL databases were systematically searched through March 2014 using generic terms for depressive and affective disorders combined with generic terms for individual drugs and placebo...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27929611/switching-the-antidepressant-after-nonresponse-in-adults-with-major-depression-a-systematic-literature-search-and-meta-analysis
#10
Tom Bschor, Hannah Kern, Jonathan Henssler, Christopher Baethge
OBJECTIVE: Nonresponders to antidepressant monotherapy during acute treatment of major depression are often switched to a new antidepressant. The objective of this meta-analysis was to compare the efficacy of switching to a new antidepressant with continuation of the first antidepressant. DATA SOURCES: PubMed, Embase, PsycINFO, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and additional sources were systematically searched independently by 2 authors up to March 2015 without language limitations...
December 6, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27908897/cortisol-as-a-predictor-of-psychological-therapy-response-in-depressive-disorders-systematic-review-and-meta-analysis
#11
REVIEW
Susanne Fischer, Rebecca Strawbridge, Andres Herane Vives, Anthony J Cleare
BACKGROUND: Many patients with depressive disorders demonstrate resistance to psychological therapy. A frequent finding is hypothalamic-pituitary-adrenal (HPA) axis alterations. As cortisol is known to modulate cognitive processes, those patients may be less likely to profit from psychological therapy. AIMS: To conduct a systematic review and meta-analysis on cortisol as a predictor of psychological therapy response. METHOD: The Cochrane Library, EMBASE, MEDLINE and PsycINFO databases were searched...
February 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27784055/toward-an-evidence-based-operational-definition-of-treatment-resistant-depression-when-enough-is-enough
#12
Charles R Conway, Mark S George, Harold A Sackeim
No abstract text is available yet for this article.
January 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/27726982/placebo-response-rates-in-antidepressant-trials-a-systematic-review-of-published-and-unpublished-double-blind-randomised-controlled-studies
#13
Toshi A Furukawa, Andrea Cipriani, Lauren Z Atkinson, Stefan Leucht, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
BACKGROUND: Previous studies have shown that placebo response rates in antidepressant trials have been increasing since the 1970s. However, these studies have been based on outdated or limited datasets and have used inappropriate statistical methods. We did a systematic review of placebo-controlled randomised controlled trials of antidepressants to examine associations between placebo-response rates and study and patient characteristics. METHODS: In this systematic review, we searched for published and unpublished double-blind randomised placebo-controlled trials of first-generation and second-generation antidepressants for acute treatment of major depression in adults (update: Jan 8, 2016)...
November 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/20331548/mindfulness-based-treatments-for-co-occurring-depression-and-substance-use-disorders-what-can-we-learn-from-the-brain
#14
Judson A Brewer, Sarah Bowen, Joseph T Smith, G Alan Marlatt, Marc N Potenza
Both depression and substance use disorders represent major global public health concerns and are often co-occurring. Although there are ongoing discoveries regarding the pathophysiology and treatment of each condition, common mechanisms and effective treatments for co-occurring depression and substance abuse remain elusive. Mindfulness training has been shown recently to benefit both depression and substance use disorders, suggesting that this approach may target common behavioral and neurobiological processes...
October 2010: Addiction
https://www.readbyqxmd.com/read/27508501/the-safety-tolerability-and-risks-associated-with-the-use-of-newer-generation-antidepressant-drugs-a-critical-review-of-the-literature
#15
André F Carvalho, Manu S Sharma, André R Brunoni, Eduard Vieta, Giovanni A Fava
Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later...
2016: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27487573/comparative-effectiveness-of-cognitive-therapy-and-dynamic-psychotherapy-for-major-depressive-disorder-in-a-community-mental-health-setting-a-randomized-clinical-noninferiority-trial
#16
Mary Beth Connolly Gibbons, Robert Gallop, Donald Thompson, Debra Luther, Kathryn Crits-Christoph, Julie Jacobs, Seohyun Yin, Paul Crits-Christoph
IMPORTANCE: Dynamic psychotherapy (DT) is widely practiced in the community, but few trials have established its effectiveness for specific mental health disorders relative to control conditions or other evidence-based psychotherapies. OBJECTIVE: To determine whether DT is not inferior to cognitive therapy (CT) in the treatment of major depressive disorder (MDD) in a community mental health setting. DESIGN, SETTING, AND PARTICIPANTS: From October 28, 2010, to July 2, 2014, outpatients with MDD were randomized to treatment delivered by trained therapists...
September 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27113121/adjunctive-nutraceuticals-for-depression-a-systematic-review-and-meta-analyses
#17
Jerome Sarris, Jenifer Murphy, David Mischoulon, George I Papakostas, Maurizio Fava, Michael Berk, Chee H Ng
OBJECTIVE: There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The adjunctive use of standardized pharmaceutical-grade nutrients, known as nutraceuticals, has the potential to modulate several neurochemical pathways implicated in depression. While many studies have been conducted in this area, to date no specialized systematic review (or meta-analysis) has been conducted. METHOD: A systematic search of PubMed, CINAHL, Cochrane Library, and Web of Science was conducted up to December 2015 for clinical trials using adjunctive nutrients for depression...
June 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27130726/managing-patients-who-are-ultra-rapid-metabolisers-of-antidepressant-medications
#18
Gordon Parker
OBJECTIVE: The objective of this study was to increase recognition of ultra-rapid metabolising status as a cause of treatment-resistant depression and consider management options. CONCLUSIONS: The incidence of ultra-rapid metabolising status is not rare in patients who fail to report improvement with antidepressant medication. Two broad options are available for identifying ultra-metabolising status. While there are several management options available to the clinician, combination therapy is likely of low utility while there are risks associated with mega-prescribing...
August 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27138588/the-phenomenology-of-major-depression-and-the-representativeness-and-nature-of-dsm-criteria
#19
Kenneth S Kendler
How should DSM criteria relate to the disorders they are designed to assess? To address this question empirically, the author examines how well DSM-5 symptomatic criteria for major depression capture the descriptions of clinical depression in the post-Kraepelin Western psychiatric tradition as described in textbooks published between 1900 and 1960. Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia. For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks...
August 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27004670/antidepressants-in-parkinson-s-disease-recommendations-by-the-movement-disorder-study-group-of-the-neurological-association-of-madrid
#20
E Peña, M Mata, L López-Manzanares, M Kurtis, M Eimil, J C Martínez-Castrillo, I Navas, I J Posada, C Prieto, C Ruíz-Huete, L Vela, B Venegas
INTRODUCTION: Although antidepressants are widely used in Parkinson's disease (PD), few well-designed studies to support their efficacy have been conducted. DEVELOPMENT: These clinical guidelines are based on a review of the literature and the results of an AMN movement disorder study group survey. CONCLUSIONS: Evidence suggests that nortriptyline, venlafaxine, paroxetine, and citalopram may be useful in treating depression in PD, although studies on paroxetine and citalopram yield conflicting results...
March 19, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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