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Uric Acid Renal Function

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83 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27906625/uric-acid-metabolism-of-kidney-and-intestine-in-a-rat-model-of-chronic-kidney-disease
#1
Michito Nagura, Yoshifuru Tamura, Takanori Kumagai, Makoto Hosoyamada, Shunya Uchida
Uric acid (UA) is a potential risk factor of the progression of chronic kidney disease (CKD). Recently, we reported that intestinal UA excretion might be enhanced via upregulation of the ATP-binding cassette transporter G2 (Abcg2) in a 5/6 nephrectomy (Nx) rat model. In the present study, we examined the mRNA and protein expressions of UA transporters, URAT1, GLUT9/URATv1, ABCG2 and NPT4 in the kidney and ileum in the same rat model. Additionally, we investigated the Abcg2 mRNA expression of ileum in hyperuricemic rat model by orally administering oxonic acid...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27871785/hyperuricemia-is-an-independent-competing-risk-factor-for-atrial-fibrillation
#2
Masanari Kuwabara, Koichiro Niwa, Shuzo Nishihara, Yutaro Nishi, Osamu Takahashi, Kazuomi Kario, Kazuhiro Yamamoto, Takeshi Yamashita, Ichiro Hisatome
BACKGROUNDS: The relationship between serum uric acid (SUA) and atrial fibrillation (AF) remains unclear because many parameters and diseases influence AF. This study was conducted to clarify the role of hyperuricemia as an independent competing risk factor for AF in an apparently healthy general population. METHODS: We retrospectively analyzed the medical records of 90,143 Japanese subjects who underwent annual regular health check-up in St. Luke's International Hospital, Tokyo, between January 2004 and June 2010...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27852432/febuxostat-hypersensitivity-another-cause-of-dress-syndrome-in-chronic-kidney-disease
#3
E Paschou, E Gavriilaki, G Papaioannou, A Tsompanakou, A Kalaitzoglou, N Sabanis
Febuxostat is a xanthine oxidase inhibitor that during the last years has successfully replaced allopurinol treatment in patients with chronic kidney disease (CKD) and hyperuricemia. Several adverse events have been observed during therapy with febuxostat. DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome induced by febuxostat has been poorly described, mainly in patient with CKD who previously developed allopurinol hypersensitivity syndrome. DRESS syndrome is characterized by manifold cutaneous reactions and systemic disorders with potential devastating consequences...
November 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#4
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27807327/hyperuricemia-is-an-independent-risk-factor-for-%C3%A2-renal-pathological-damage-and-poor-prognosis-in-%C3%A2-lupus-nephritis-patients
#5
Tingting Xie, Mengying Chen, Xiangling Tang, Hongling Yin, Xuan Wang, Guoli Li, Jiarong Li, Xiaoxia Zuo, Weiru Zhang
To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN).
 Methods: The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage.
 Results: LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0...
October 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27774887/lipoprotein-subfractions-uric-acid-and-cardiovascular-risk-in-end-stage-renal-disease-esrd-patients
#6
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27776720/identifying-different-causes-of-hyponatremia-with-fractional-excretion-of-uric-acid
#7
Louis J Imbriano, Joseph Mattana, James Drakakis, John K Maesaka
BACKGROUND: There is controversy over the prevalence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral or renal salt wasting (RSW), 2 syndromes with identical common clinical and laboratory parameters but different therapies. The traditional approach to the hyponatremic patient relies on volume assessment, but there are limitations to this method. METHODS: We used an algorithm that relies on fractional excretion of urate (FEurate) to evaluate patients with hyponatremia and present 4 illustrative cases...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27769920/allopurinol-attenuates-rhabdomyolysis-associated-acute-kidney-injury-renal-and-muscular-protection
#8
Pedro H F Gois, Daniele Canale, Rildo A Volpini, Daniela Ferreira, Mariana M Veras, Vinicius Andrade-Oliveira, Niels O S Câmara, Maria H M Shimizu, Antonio C Seguro
BACKGROUND: Acute kidney injury (AKI) is the most severe complication of rhabdomyolysis. Allopurinol (Allo), a xanthine oxidase inhibitor, has been in the spotlight in the last decade due to new therapeutic applications related to its potent antioxidant effect. The aim of this study was to evaluate the efficacy of Allo in the prevention and treatment of rhabdomyolysis-associated AKI. METHODS: Male Wistar rats were divided into five groups: saline control group; prophylactic Allo (300mg/L of drinking water, 7 days); glycerol (50%, 5ml/kg, IM); prophylactic Allo + glycerol; and therapeutic Allo (50mg/Kg, IV, 30min after glycerol injection) + glycerol...
October 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27733763/a-j-shaped-association-between-serum-uric-acid-levels-and-poor-renal-survival-in-female-patients-with-iga-nephropathy
#9
Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Ritsuko Katafuchi, Hideki Hirakata, Kazuhiko Tsuruya, Takanari Kitazono
Recently, low serum uric acid (SUA) levels and high SUA levels, have emerged as risk factors for cardiovascular disease, as well as for the incidence of acute kidney injury and chronic kidney disease (CKD). However, the effect of low SUA on the progression of CKD remains unclear. To evaluate the association between SUA and renal prognosis in patients with immunoglobulin A nephropathy (IgAN), one of the most common causes of CKD, we retrospectively followed 1218 patients who were diagnosed with primary IgAN by kidney biopsy between October 1979 and December 2010...
October 13, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27665399/hyperuricemia-and-contrast-induced-acute-kidney-injury-a-systematic-review-and-meta-analysis
#10
Tian Zuo, Lu Jiang, Shuai Mao, Xuehui Liu, Xin Yin, Liheng Guo
BACKGROUND: Hyperuricemia may be associated with an increased risk of contrast-induced acute kidney injury (CI-AKI). In recent years, studies about the relationship between them gradually appeared. We performed a systematic review and meta-analysis to investigate whether hyperuricemia is an independent risk factor for CI-AKI. METHODS: Relevant studies were searched in PubMed, Embase, Cochrane Library, and CBM (Chinese Biomedical Literature database) databases until April 18, 2016, without language restriction...
December 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27620990/vascular-function-and-uric-acid-lowering-in-stage-3-ckd
#11
Diana I Jalal, Emily Decker, Loni Perrenoud, Kristen L Nowak, Nina Bispham, Tapan Mehta, Gerard Smits, Zhiying You, Douglas Seals, Michel Chonchol, Richard J Johnson
Hyperuricemia may contribute to endothelial dysfunction in CKD. We evaluated whether lowering serum uric acid levels with allopurinol improves endothelial dysfunction in 80 participants ≥18 years of age with stage 3 CKD and asymptomatic hyperuricemia (≥7 mg/dl in men and ≥6 mg/dl in women) randomized in a double-blinded manner to receive placebo or allopurinol for 12 weeks. Randomization was stratified according to presence or absence of diabetes mellitus. We measured vascular endothelial function by brachial artery flow-mediated dilation...
September 12, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27577941/evaluation-of-cardiovascular-risk-in-stages-of-gout-by-a-complex-multimodal-ultrasonography
#12
Rada Gancheva, Atanas Kundurdjiev, Mariana Ivanova, Todor Kundurzhiev, Zlatimir Kolarov
The aim of our work was to assess ultrasound features of cardiovascular (CV) risk in stages of gout. Cross-sectional complex multimodal ultrasound study of 169 age-matched patients, with similar distribution of arterial hypertension, diabetes mellitus, obesity and chronic renal failure, was divided into four groups: 41 with asymptomatic hyperuricemia, 52 gout without tophi, 42 gouty tophi and 34 controls with osteoarthritis. Parameters independently associated with CV risk were measured: renal resistive index (RRI), left ventricular mass index (LVMi), mitral annulus early diastolic velocity (e'), intima-media thickness (IMT) and common carotid artery resistive index (CCARI)...
August 30, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27548821/serum-uric-acid-exhibits-inverse-relationship-with-estimated-glomerular-filtration-rate
#13
Abhilash Koratala, Girish Singhania, Kawther F Alquadan, Michiko Shimada, Richard J Johnson, A Ahsan Ejaz
BACKGROUND: In this study, we investigated the relationship between serum uric acid (SUA) and renal function in a unique patient cohort wherein SUA levels fluctuate during the course of standard care. METHODS: Correlation coefficients between SUA and serum creatinine (SCr) and kinetic estimated GFR (KeGFR) were retrospectively investigated in acute myeloid leukemia (AML) patients, and statistically significant and clinically relevant determinants were studied in multiple regression models...
2016: Nephron
https://www.readbyqxmd.com/read/27339448/time-to-target-uric-acid-to-retard-ckd-progression
#14
Takanori Kumagai, Tatsuru Ota, Yoshifuru Tamura, Wen Xiu Chang, Shigeru Shibata, Shunya Uchida
Uric acid (UA) remains a possible risk factor of chronic kidney disease (CKD) but its potential role should be elucidated given a fact that multidisciplinary treatments assure a sole strategy to inhibit the progression to end-stage renal disease (ESRD). In clinical setting, most observational studies showed that elevation of serum uric acid (SUA) independently predicts the incidence and the development of CKD. The meta-analysis showed that SUA-lowering therapy with allopurinol may retard the progression of CKD but did not reach conclusive results due to small-sized studies...
June 23, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27319408/serum-uric-acid-as-a-risk-factor-for-chronic-kidney-disease-in-a-japanese-community%C3%A3-the-hisayama-study
#15
Keita Takae, Masaharu Nagata, Jun Hata, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Kazuhiko Tsuruya, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
BACKGROUND: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. METHODS AND RESULTS: A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1...
July 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26903390/oral-prednisolone-in-the-treatment-of-acute-gout-a-pragmatic-multicenter-double-blind-randomized-trial
#16
MULTICENTER STUDY
Timothy Hudson Rainer, Chi Hung Cheng, Hein J E M Janssens, Chi Yin Man, Lai Shan Tam, Yu Fai Choi, Wah Hon Yau, Ka Hing Lee, Colin Alexander Graham
BACKGROUND: Two recent double-blind, randomized, controlled trials (RCTs) showed that oral steroids and nonsteroidal anti-inflammatory drugs have similar analgesic effectiveness for management of gout, but the trials had small sample sizes and other methodological limitations. OBJECTIVE: To compare the effectiveness and safety of oral prednisolone versus oral indomethacin in patients presenting to emergency departments (EDs) with acute gout. DESIGN: Multicenter, double-blind, randomized equivalence trial...
April 5, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27106252/serum-uric-acid-and-risk-for-acute-kidney-injury-following-contrast-an-evaluation-of-epidemiology-clinical-trials-and-potential-mechanisms
#17
Mehmet Kanbay, Yalcin Solak, Baris Afsar, Ionut Nistor, Gamze Aslan, Ozlem Hilal Çağlayan, Asli Aykanat, Mihaela-Dora Donciu, Miguel A Lanaspa, Ahsan A Ejaz, Richard J Johnson, Adrian Covic
Contrast-induced acute kidney injury (CI-AKI) is a common cause of hospital-acquired acute kidney injury (AKI). We evaluated the evidence that uric acid (UA) plays a pathogenic role in CI-AKI. Ten studies were eligible for inclusion for meta-analysis. Hyperuricemia predicted risk for cases with AKI in prospective cohort studies. Higher levels of serum UA (SUA), as defined by the authors, were associated with a 2-fold increased risk to develop AKI (pooled odds ratio 2.03; 95% confidence interval [CI] 1.48-2...
April 21, 2016: Angiology
https://www.readbyqxmd.com/read/27093645/uric-acid-renal-function-and-risk-of-hypoglycemia-in-chinese-type-2-diabetes-patients
#18
Yanfeng Ren, Linong Ji, Yiming Mu, Tianpei Hong, Qiuhe Ji, Lixin Guo, Qin Huang, Xilin Yang
BACKGROUND: This study aimed to explore independent associations between serum uric acid (SUA) and hypoglycemia, and whether mildly increased SUA exacerbates the association between mild decline in estimated glomerular filtration rate (eGFR) and hypoglycemia. METHODS: A cross-sectional survey of 6713 inpatients with type 2 diabetes and eGFR ≥60 ml/min/1.73 m(2) and admitted to 81 tertiary care hospitals in China was conducted. Self-reported asymptotic hypoglycemia with plasma glucose ≤3...
April 19, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26990793/bmi-fat-free-mass-uric-acid-and-renal-function-as-blood-pressure-levels-determinants-in-young-adults
#19
Antonino Sidoti, Santi Nigrelli, Alberto Rosati, Roberto Bigazzi, Raffaele Caprioli, Roberto Fanelli, Pasqualina Acconcia, Donella Borracelli, Marina Biagioli, Daniela Angelini, Manuela Parrini, Luigi Tonelli, Pierluigi Tosi, Diego Manzoni
AIM: We assessed some major determinants of blood pressure (BP) in young adulthood to plan a lifestyle changes policy METHODS: A cross sectional survey was held, involving 2334 high school people (age 18-21), measuring BP, body mass index (BMI), waist circumference (WCirc), fat free mass (FFM); alcohol and smoking habits were evaluated by a questionnaire. In a subset of this population (n = 60) uric acid (UA), estimated glomerular filtration rate (eGFR) were also evaluated. RESULTS: Smoking and not alcohol was correlated to systolic blood pressure (SBP) through quartiles (31...
March 15, 2016: Nephrology
https://www.readbyqxmd.com/read/26947600/impact-of-serum-uric-acid-levels-on-coronary-plaque-stability-evaluated-using-integrated-backscatter-intravascular-ultrasound-in-patients-with-coronary-artery-disease
#20
Kaoru Ando, Hiroki Takahashi, Tetsu Watanabe, Hyuma Daidoji, Yoichiro Otaki, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Isao Kubota
AIM: Because the prevalence of hyperuricemia is lower in females than in males, the association between hyperuricemia and cardiovascular disease has been frequently reported in females. Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. However, it is controversial whether hyperuricemia is an independent risk factor for coronary artery disease in both the genders...
August 1, 2016: Journal of Atherosclerosis and Thrombosis
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