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Uric Acid Renal Function

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177 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29340054/febuxostat-attenuates-er-stress-mediated-kidney-injury-in-a-rat-model-of-hyperuricemic-nephropathy
#1
Li He, Ying Fan, Wenzhen Xiao, Teng Chen, Jiejun Wen, Yang Dong, Yiyun Wang, Shiqi Li, Rui Xue, Liyang Zheng, John Cijiang He, Niansong Wang
Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression of RTN1A and ER stress markers was significantly increased in kidney biopsies of hyperuricemia patients with kidney injury. In a rat model of hyperuricemic nephropathy (HN) established by oral administration of a mixture of adenine and potassium oxonate, increased expression of RTN1A and ER stress was shown in tubular and interstitial compartment of rat kidneys...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29353133/maternal-serum-uric-acid-levels-and-blood-pressure-during-pregnancy-a-community-based-cohort-study
#2
Guoli Zhou, Claudia Holzman, Zhehui Luo, Claire Margerison
OBJECTIVE: Studies find both very low and high serum uric acid (UA) levels are related to oxidative stress and to conditions such as cardiovascular diseases and chronic kidney disease in the general population. Pregnancy studies have focused only on high maternal UA. In present study, we tested whether unusually high and low levels of maternal serum UA are associated with increases in blood pressure (BP) during pregnancy. STUDY DESIGN: The Pregnancy Outcomes and Community Health Study enrolled 3019 pregnant women between their 16th-27th week of pregnancy from 52 clinics in 5 Michigan communities (1998-2004)...
January 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29346798/uric-acid-in-the-follow-up-determines-30-decline-in-estimated-gfr-over-2-years-a-propensity-score-analysis
#3
Wen Xiu Chang, Ning Xu, Takanori Kumagai, Ryutaro Iijima, Kaito Waki, Masaki Yamanaka, Michito Nagura, Shigeyuki Arai, Yoshifuru Tamura, Shigeru Shibata, Yoshihide Fujigaki, Shunya Uchida
BACKGROUND/AIMS: Higher level of serum uric acid (SUA) predicts early entry to dialysis in chronic kidney disease (CKD) patients. However, a short-term effect of SUA remains to be elucidated using a novel surrogate endpoint. METHODS: Japanese CKD stage 3 to 4 patients were retrospectively examined (n= 701). The follow-up level of SUA was estimated as time-averaged uric acid (TA-UA). A propensity score for 6.0, 6.5 or 7.0 mg/dL of TA-UA was respectively calculated using baseline 23 covariates...
December 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29320555/chronic-kidney-disease-associated-with-decreased-bone-mineral-density-uric-acid-and-metabolic-syndrome
#4
Bo-Lin Pan, Song-Seng Loke
OBJECTIVE: The relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. The associations among metabolic syndrome (MetS), serum uric acid and CKD are also unclear. We aimed to investigate the relationship between decreased BMD, MetS, serum uric acid and CKD in a general population. METHODS: A total of 802 subjects who visited a medical center in Southern Taiwan and underwent a BMD measured by dual-energy X-ray absorptiometry (DEXA) during a health examination were enrolled in this retrospective cross-sectional study...
2018: PloS One
https://www.readbyqxmd.com/read/29321950/manifestations-of-renal-impairment-in-fructose-induced-metabolic-syndrome
#5
Kameliya Bratoeva, George S Stoyanov, Albena Merdzhanova, Mariya Radanova
Introduction International studies show an increased incidence of chronic kidney disease (CKD) in patients with metabolic syndrome (MS). It is assumed that the major components of MS - obesity, insulin resistance, dyslipidemia, and hypertension - are linked to renal damage through the systemic release of several pro-inflammatory mediators, such as uric acid (UA), C-reactive protein (CRP), and generalized oxidative stress. The aim of the present study was to investigate the extent of kidney impairment and manifestations of dysfunction in rats with fructose-induced MS...
November 7, 2017: Curēus
https://www.readbyqxmd.com/read/29318274/lesinurad-allopurinol-duzallo-for-gout-associated-hyperuricemia
#6
(no author information available yet)
No abstract text is available yet for this article.
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29315768/the-effect-of-uric-acid-lowering-treatment-on-albuminuria-and-renal-function-in-type-1-diabetes-a-randomized-clinical-trial
#7
S Pilemann-Lyberg, F Persson, J Frystyk, P Rossing
Significant improvements have been made in the management of Type 1 diabetes over the last three decades [1]. We wanted to examine if uric acid lowering with allopurinol changes the urinary albumin excretion rate (UAER) or 51 Cr EDTA GFR in people with Type 1 diabetes and diabetic nephropathy. This article is protected by copyright. All rights reserved.
January 7, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29272515/update-on-colchicine-2017
#8
Anastasia Slobodnick, Binita Shah, Svetlana Krasnokutsky, Michael H Pillinger
Colchicine is an ancient medication that is currently approved for the treatment of gout and FMF. However, colchicine has a wide range of anti-inflammatory activities, and studies indicate that it may be beneficial in a variety of other conditions. This paper reviews the evidence for the well-established use of colchicine in gout, as well as several other rheumatic diseases. In addition, we highlight the potential benefit of colchicine in cardiac disease, including coronary artery disease in patients both with and without gout...
January 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29294051/uric-acid-in-chronic-kidney-disease-the-quest-for-causality-continues
#9
Carmine Zoccali, Francesca Mallamaci
No abstract text is available yet for this article.
December 22, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29295969/the-saudi-diabetic-kidney-disease-study-saudi-dkd-clinical-characteristics-and-biochemical-parameters
#10
Khalid Al-Rubeaan, Khalid Siddiqui, Mohammed Alghonaim, Amira M Youssef, Dhekra AlNaqeb
BACKGROUND: Saudi Arabia is facing an epidemic of type 2 diabetes that is complicated by a high rate of chronic complications such as kidney disease, which have a major impact on the healthcare system and economy. The Saudi diabetic kidney disease (SAUDI-DKD) study was launched to understand the implications of chronic diabetic kidney disease . OBJECTIVES: Examine the hematological, biochemical and metabolic parameters of the selected cohorts to look for biomarkers of diabetic nephropathy...
January 3, 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29285422/serum-uric-acid-and-mortality-risk-among-maintenance-hemodialysis-patients
#11
EDITORIAL
Inkyong Hur, Soo Jeong Choi, Kamyar Kalantar-Zadeh
No abstract text is available yet for this article.
December 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29285429/relationship-between-serum-uric-acid-and-mortality-among-hemodialysis-patients-retrospective-analysis-of-korean-end-stage-renal-disease-registry-data
#12
Chang Seong Kim, Dong-Chan Jin, Young Cheol Yun, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Background: It is thought that hyperuricemia might lower the risk of mortality among hemodialysis patients, unlike in the general population, but the evidence is controversial. The aim of the current study was to evaluate the impact of serum uric acid level on the long-term clinical outcomes of hemodialysis patients in Korea. Methods: Retrospective analysis was performed on data from the End-Stage Renal Disease Registry of the Korean Society of Nephrology. This included data for 7,333 patients (mean age, 61 ± 14 years; 61% male) who received hemodialysis from January 2001 through April 2015...
December 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29288369/assessment-of-cardiovascular-risk-profile-based-on-measurement-of-tophus-volume-in-patients-with-gout
#13
Kyung-Ann Lee, Se-Ri Ryu, Seong-Jun Park, Hae-Rim Kim, Sang-Heon Lee
Hyperuricemia and gout are associated with increased risk of cardiovascular disease and metabolic syndrome. The aim of this study was to evaluate the correlation of total tophus volumes, measured using dual-energy computed tomography, with cardiovascular risk and the presence of metabolic syndrome. Dual-energy computed tomography datasets from 91 patients with a diagnosis of gout were analyzed retrospectively. Patients who received urate lowering therapy were excluded to avoid the effect on tophus volume. The total volumes of tophaceous deposition were quantified using automated volume assessment software...
December 29, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29278214/serum-uric-acid-is-independently-associated-with-diastolic-dysfunction-in-apparently-healthy-subjects-with-essential-hypertension
#14
Georgios Georgiopoulos, Costas P Tsioufis, Theodoros Kalos, Nikolaos Magkas, Dimitrios Rousos, Christina Chrysohoou, Georgia Sarri, Kyriaki Syrmali, Panos Georgakopoulos, Dimitrios Tousoulis
OBJECTIVES: Accumulating evidence suggests a direct role of uric acid (UA) on left ventricular (LV) diastolic function in chronic kidney disease and heart failure (HF) patients. Recently, UA has been linked to LV hypertrophy (LVH) and diastolic dysfunction (DD) in women with preserved ejection fraction (pEF) but not in corresponding men. We sought to assess if UA could predict indices of DD in hypertensive subjects with pEF independently of gender. METHODS: We consecutively recruited 382 apparently healthy hypertensive subjects (age: 61...
December 26, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29275830/chronic-tophaceous-gout-as-the-first-manifestation-of-gout-in-two-cases-and-a-review-of-the-literature
#15
Amir Bieber, Naomi Schlesinger, Abdallah Fawaz, Reuven Mader
OBJECTIVES: Acute gout is a common arthritis that may eventually develop into chronic tophaceous gout (CTG). CTG usually is manifested by recurrent gout attacks. The diagnosis and treatment of CTG is challenging. Although the emergence of CTG without previous gout attacks is uncommon, it is important to recognize this unusual gout presentation. METHODS: Herein, we present two cases of CTG, occurring in elderly patients with chronic kidney disease (CKD) on diuretics, who presented without a prior history of acute gout attacks...
November 27, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29263773/major-cardiovascular-events-in-patients-with-gout-and-associated-cardiovascular-disease-or-heart-failure-and-chronic-kidney-disease-initiating-a-xanthine-oxidase-inhibitor
#16
JoAnne Foody, Robin S Turpin, Beni A Tidwell, Debra Lawrence, Kathy L Schulman
Background: Several observational studies and meta-analyses have suggested that treating hyperuricemia in patients with gout and moderate or severe chronic kidney disease (CKD) may improve renal and cardiovascular (CV) outcomes. Objective: To evaluate the impact of initiating allopurinol or febuxostat treatment on major CV events in patients with gout, preexisting CV disease (CVD) or heart failure (HF), and stage 3 or 4 CKD in a real-world setting. Methods: Patients with gout (aged >18 years) who initiated allopurinol or febuxostat treatment between 2009 and 2013 after a diagnosis of stage 3 or 4 CKD and CVD-including coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (PVD)-or HF were selected from the MarketScan databases...
November 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/29268756/the-effect-of-kidney-function-on-the-urate-lowering-effect-and-safety-of-increasing-allopurinol-above-doses-based-on-creatinine-clearance-a-post-hoc-analysis-of-a-randomized-controlled-trial
#17
Lisa K Stamp, Peter T Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth
BACKGROUND: The use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function on safety and efficacy of allopurinol dose escalation to achieve serum urate (SU) <6 mg/dl. METHODS: We undertook a post hoc analysis of a 24-month allopurinol dose escalation treat-to-target SU randomized controlled trial, in which 183 people with gout were randomized to continue current dose allopurinol for 12 months and then enter the dose escalation phase or to begin allopurinol dose escalation immediately...
December 21, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29272508/how-to-prevent-allopurinol-hypersensitivity-reactions
#18
Lisa K Stamp, Murray L Barclay
Allopurinol hypersensitivity syndrome (AHS) is a severe and sometimes life-threatening adverse drug reaction. Although AHS is rare, the number of patients with gout requiring allopurinol is high, and there are sufficient overall cases of AHS to warrant consideration of preventive measures. Most cases occur within 8-9 weeks of commencing allopurinol, and good patient education at initiation may lead to rapid drug cessation at onset of symptoms. Pretreatment testing for HLA-B*5801 and avoidance of allopurinol when positive reduces the risk of AHS and is cost-effective in some ethnic groups...
January 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29272510/cardiac-and-renal-protective-effects-of-urate-lowering-therapy
#19
Pascal Richette, Augustin Latourte, Thomas Bardin
Patients with gout often have co-morbidities such as cardiovascular disease, renal failure and metabolic syndrome components. Some studies, but not all, have suggested that hyperuricaemia and gout are associated with increased risk of myocardial infarction, renal failure and death primarily because of increased risk of cardiovascular events. Therefore, knowledge of the effects of urate-lowering therapy (ULT) on co-morbidities, in particular cardiovascular events and chronic kidney disease, is crucial. Randomized controlled trials (RCTs) have suggested that allopurinol, a xanthine oxidase inhibitor, could improve exercise capacity in patients with chronic stable angina and could decrease blood pressure in adolescents...
January 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29246027/recent-advances-on-uric-acid-transporters
#20
REVIEW
Liuqing Xu, Yingfeng Shi, Shougang Zhuang, Na Liu
Uric acid is the product of purine metabolism and its increased levels result in hyperuricemia. A number of epidemiological reports link hyperuricemia with multiple disorders, such as kidney diseases, cardiovascular diseases and diabetes. Recent studies also showed that expression and functional changes of urate transporters are associated with hyperuricemia. Uric acid transporters are divided into two categories: urate reabsorption transporters, including urate anion transporter 1 (URAT1), organic anion transporter 4 (OAT4) and glucose transporter 9 (GLUT9), and urate excretion transporetrs, including OAT1, OAT3, urate transporter (UAT), multidrug resistance protein 4 (MRP4/ABCC4), ABCG-2 and sodium-dependent phosphate transport protein...
November 21, 2017: Oncotarget
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