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Uric Acid Renal Function

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261 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Daniel H Solomon, Robert J Glynn, Jean G MacFadyen, Peter Libby, Tom Thuren, Brendan M Everett, Paul M Ridker
Background: Although studies have shown that interleukin-1β (IL-1β) inhibitors can shorten gout attacks, whether they can prevent gout attacks is unclear. Objective: To examine the relationship among canakinumab, a monoclonal antibody targeting IL-1β; serum uric acid levels; and the incidence of gout attacks. Design: Secondary exploratory analysis of a randomized controlled trial. ( NCT01327846). Setting: Many clinical sites in 39 countries...
September 18, 2018: Annals of Internal Medicine
Gerald Levy, Jiaxiao M Shi, T Craig Cheetham, Nazia Rashid
CONTEXT: Hyperuricemia is an independent risk factor for progression of kidney disease. OBJECTIVE: To determine whether lowering serum uric acid level (sUA) to below 6 mg/dL (target) improves mild to moderate chronic kidney disease (CKD) and whether CKD stage influences the benefit of lowering sUA to target. DESIGN: Retrospective epidemiologic cohort study conducted over 8 years. Estimated glomerular filtration rate (eGFR) was required in the 6 months preceding the index date (defined as first occurrence of sUA < 7 mg/dL), and at least 1 sUA and eGFR were required during follow-up...
August 30, 2018: Permanente Journal
Minning Shen, Junyu Zhang, Kai Qian, Chunmei Li, Wenyu Xu, Bingjie Gu, Xiaoqin Wang, Qijie Ren, Leilei Yang, Hai Yuan, Dinglei Su, Xingguo Chen
To retrospectively analyze the efficacy and safety of febuxostat on gout patients with low serum uric acid level. A study was conducted in Nanjing First Hospital from October 2015 to September 2016. Thirty nine acute gouty arthritis patients from the emergency and outpatient department were included. Patients met the 2015 Gout Classification Criteria revised by American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and had urate deposition around the joints detected by dual-energy computerized tomography (DECT)...
September 9, 2018: Clinical Rheumatology
Manoj Karbhari Pawar
No abstract text is available yet for this article.
July 2018: European Journal of Rheumatology
Naoyuki Otani, Shigeru Toyoda, Masashi Sakuma, Keitaro Hayashi, Motoshi Ouchi, Tomoe Fujita, Naohiko Anzai, Atsushi Tanaka, Koichi Node, Naoto Uemura, Teruo Inoue
This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed reactive hyperemia peripheral arterial tonometry using an EndoPAT 2000 device and measured serum uric acid levels in 92 outpatients with hypertension. The reactive hyperemia index (RHI) showed no correlation with serum uric acid level (R = -0.125, P = 0.235) in either overall patients or in a high-risk group of 51 patients with complications such as cardiovascular and cerebrovascular diseases, chronic kidney disease, and/or diabetes (R = -0...
September 5, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Xuzhong Liu, Kun Liu, Qing Sun, Yunyan Wang, Junsong Meng, Zongyuan Xu, Zhaofei Shi
Febuxostat is potent and well-tolerated in the management of chronic gout. However, its clinical efficacy and safety in the treatment of hyperuricemia in patients with chronic kidney disease (CKD) and in renal transplant recipients have remained to be fully determined. The MEDLINE, EMBASE and Cochrane Library databases were searched for relevant articles. Data were extracted and pooled results were estimated from the standard mean difference (SMD) with 95% confidence intervals (95% CIs). The quality of the studies included was assessed, and their publication bias was examined...
September 2018: Experimental and Therapeutic Medicine
Jiaojiao Jing, Arif B Ekici, Thomas Sitter, Kai-Uwe Eckardt, Elke Schaeffner, Yong Li, Florian Kronenberg, Anna Köttgen, Ulla T Schultheiss
We evaluated genetics of hyperuricemia and gout, their interaction with kidney function and medication intake in chronic kidney disease (CKD) patients. Genome-wide association studies (GWAS) of urate and gout were performed in 4941 CKD patients in the German Chronic Kidney Disease (GCKD) study. Effect estimates of 26 known urate-associated population-based single nucleotide polymorphisms (SNPs) were examined. Interactions of urate-associated variants with urate-altering medications and clinical characteristics of gout were evaluated...
September 4, 2018: Scientific Reports
Muhammad K Nisar
OBJECTIVES: Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine. However, the presence of comorbid conditions and advancing age, often seen in hospitalised patients, may prevent their use. We reviewed the published data on the use of ACTH in the treatment of acute gouty arthritis. METHODS: A search was performed up to June 2017. We included clinical trials or case studies/series where ACTH had been administered in human subjects as a treatment for acute gout or pseudogout...
August 29, 2018: Clinical and Experimental Rheumatology
Kenjiro Kimura, Tatsuo Hosoya, Shunya Uchida, Masaaki Inaba, Hirofumi Makino, Shoichi Maruyama, Sadayoshi Ito, Tetsuya Yamamoto, Yasuhiko Tomino, Iwao Ohno, Yugo Shibagaki, Satoshi Iimuro, Naohiko Imai, Masanari Kuwabara, Hiroshi Hayakawa, Hiroshi Ohtsu, Yasuo Ohashi
RATIONALE & OBJECTIVE: Epidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking. STUDY DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING & PARTICIPANTS: 467 patients with stage 3 CKD and asymptomatic hyperuricemia at 55 medical institutions in Japan. INTERVENTION: Participants were randomly assigned in a 1:1 ratio to receive febuxostat or placebo for 108 weeks...
August 31, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Tibor Fülöp, Christian A Koch, Lindsey T Norris, Betzaida Rodríguez, Tibor Szarvas, Zsolt Lengvárszky, Éva Csongrádi, Mehul P Dixit
OBJECTIVES: Uric acid (UA) control may be insufficient in chronic kidney disease (CKD) patients in the current era. It is unclear, however, whether this is the result of environmental effects, patient anthropometrics or insufficient dosing of medical therapy (allopurinol). METHODS: We have collected data on multiple clinical and laboratory parameters of 114 CKD clinic patients attending the nephrology clinic of the University of Mississippi Medical Center with an estimated glomerular filtration rate <45 mL · min-1 · 1...
September 2018: Southern Medical Journal
Marion Vallet, Acil Jaafar, Pierre-Yves Charles, Ivan Tack
INTRODUCTION: Estimation of volemic status can be useful in the diagnosis of some hydro-electrolytic disorders such as hyponatremia and dyskalemia. As a matter of fact, clinical examination and classical biological parameters are not discriminant enough. The aim of this study was to determine the biological parameters that are better correlated to volemic status. METHOD: Volemic status was established using extracellular fluid volume, measured by apparent distribution of inuline, in non-edematous patients and without cardiac or hepatic insufficiency...
April 2018: Néphrologie & Thérapeutique
Hiroyuki Terawaki, Tomoya Hayashi, Takayo Murase, Ryutaro Iijima, Kaito Waki, Yoshihiro Tani, Takashi Nakamura, Kazunobu Yoshimura, Shunya Uchida, Junichiro James Kazama
Xanthine oxidase (XO), an isoform of xanthine oxidoreductase (XOR), is thought to increase the cardiovascular burden among chronic kidney disease (CKD) patients via oxidative radical production. Plasma XOR redox, which is characterized by the ratio of XO to total XOR, changes under different oxidative conditions associated with kidney dysfunction. However, the relationship between plasma XOR redox and oxidative stress (OS) is unclear. Thus, we aimed to clarify whether OS is related to XOR redox. We used the redox state of human serum albumin (HSA) as a marker to investigate the status of OS in CKD patients...
2018: Oxidative Medicine and Cellular Longevity
Bin Zhu, Dong-Rong Yu, Ji-Cheng Lv, Yi Lin, Qiang Li, Jia-Zhen Yin, Yuan-Yuan Du, Xuan-Li Tang, Li-Chan Mao, Qiu-Fen Li, Yue Sun, Ling Liu, Xian-Fa Li, Dan Fei, Xin-Yi Wei, Cai-Feng Zhu, Xiao-Xia Cheng, Hong-Yu Chen, Yong-Jun Wang
BACKGROUND: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. METHODS: In a cohort of 1,965 cases with biopsy-proven IgAN, we examined the associations of SUA concentration with the primary outcome of a composite of all-cause mortality or kidney failure (defined as a reduction of estimated glomerular filtration rate [eGFR] by 40% from baseline, requirements for dialysis and transplantation), or the outcome of kidney failure alone, assessed using Cox and logistic regression models, respectively, with adjustment for confounders...
2018: American Journal of Nephrology
Mohd Noor Azreey Mukri, Wei-Yen Kong, Ruslinda Mustafar, Syahrul Sazliyana Shaharir, Shamsul Azhar Shah, Abdul Halim Abdul Gafor, Rozita Mohd, Rizna Abdul Cader, Lydia Kamaruzaman
Introduction: Hyperuricemia is associated with chronic kidney disease (CKD) progression and poor cardiovascular outcomes. We studied the effect of febuxostat on estimated glomerular filtration rate (eGFR), proteinuria and monitored the safety profile of the medication. Material and Methods: This is a prospective open-label, randomized study in CKD stage 3 and 4 patients with diabetic nephropathy and asymptomatic hyperuricemia. Patients were randomized into febuxostat 40 mg daily and no treatment group using block randomization method and were followed up for 6 months...
2018: EXCLI journal
Fengqin Li, Hui Guo, Jianan Zou, Weijun Chen, Yijun Lu, Xiaoli Zhang, Chensheng Fu, Jing Xiao, Zhibin Ye
BACKGROUND/AIMS: Hypertension and hyperuricemia are closely associated with an intermingled cause and effect relationship. Additionally, urinary sodium and potassium excretion is related to blood pressure. Whether or not it is associated with urinary uric acid excretion is not clear. Therefore, we aim to study the association of urinary sodium and potassium with renal uric acid excretion in patients with CKD. METHODS: A cross-sectional study of 428 patients with CKD recruited from our department was conducted...
August 10, 2018: Kidney & Blood Pressure Research
Mengyuan Li, Xinhua Li, Yan Liu, Xinying Liu, Yaxiang Song, Jian Zhao, Chandra Mohan, Tianfu Wu, Ai Peng, Ling Qin
It is known that inflammation and oxidative stress have strong influences on chronic kidney disease (CKD). As an antioxidant, bilirubin is currently under extensive scrutiny. However, there are disagreements with regard to the oxidative and antioxidative roles of serum uric acid (SUA). This study aimed to investigate the relationship between serum bilirubin and the progression of renal function in CKD patients with hyperuricemia (HUA). This retrospective longitudinal study included 427 CKD patients. The endpoint was renal replacement therapy or death...
August 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Deok Gie Kim, Beom Seok Kim, Hoon Young Choi, Beom Jin Lim, Kyu Ha Huh, Myoung Soo Kim, Hyeon Joo Jeong, Yu Seun Kim
Several experimental studies implicate uric acid in renal injury and fibrosis. The objective of this study was to examine the association between uric acid level and allograft fibrosis after kidney transplantation. 241 adult patients who underwent kidney transplantation between 2003 and 2014 were divided into three groups according to the sex specific tertiles of mean uric acid level within the first post-transplant year. The renal biopsies performed during 1 to 5 post-transplant year were analyzed to compare the degree of interstitial fibrosis and tubular atrophy (IF/TA)...
August 2, 2018: Scientific Reports
Kenneth G Saag, Michael A Becker, Andrew Whelton, Barbara Hunt, Majin Castillo, Krisztina Kisfalvi, Lhanoo Gunawardhana
OBJECTIVE: Assess efficacy and safety of febuxostat extended release (XR) and immediate release (IR) in patients with gout and normal or impaired renal function. METHODS: This was a multicenter 3-month, phase III, placebo-controlled, double-blind study; patients (n=1790) with a history of gout and normal or impaired (mild to severe) renal function were randomized to receive placebo, febuxostat IR 40 or 80 mg, or febuxostat XR 40 or 80 mg once daily (1:1:1:1:1 ratio)...
August 3, 2018: Arthritis & Rheumatology
Pau Redon, Alessandro Maloberti, Rita Facchetti, Josep Redon, Empar Lurbe, Michele Bombelli, Giuseppe Mancia, Guido Grassi
OBJECTIVE: Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed the gender-related relationships between serum uric acid (SUA) and cardionephrometabolic variables in central and east European hypertensive patients. METHODS: A total of 3206 treated hypertensive patients with available SUA levels from the BP-CARE study was analyzed. Correlations among SUA, BP values, BP control, diabetes mellitus, metabolic syndrome and CKD were performed according to gender...
August 1, 2018: Journal of Hypertension
Masato Furuhashi, Kazuma Mori, Marenao Tanaka, Takuto Maeda, Megumi Matsumoto, Takayo Murase, Takashi Nakamura, Masayuki Koyama, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura
Hypouricemia is a high-risk factor of exercise-induced acute kidney injury (EIAKI) probably through a lack of an antioxidant effect of uric acid. Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Activation of XOR has been proposed to promote oxidative stress-related tissue injury. We measured plasma XOR activity by a sensitive and accurate assay using a combination of liquid chromatography and triple quadrupole mass spectrometry in subjects with relatively low levels of uric acid (≤4...
August 2, 2018: Endocrine Journal
2018-08-04 15:29:28
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