Seetha Shankaran, Abbot R Laptook, Athina Pappas, Scott A McDonald, Abhik Das, Jon E Tyson, Brenda B Poindexter, Kurt Schibler, Edward F Bell, Roy J Heyne, Claudia Pedroza, Rebecca Bara, Krisa P Van Meurs, Cathy Grisby, Carolyn M Petrie Huitema, Meena Garg, Richard A Ehrenkranz, Edward G Shepherd, Lina F Chalak, Shannon E G Hamrick, Amir M Khan, Anne Marie Reynolds, Matthew M Laughon, William E Truog, Kevin C Dysart, Waldemar A Carlo, Michele C Walsh, Kristi L Watterberg, Rosemary D Higgins
IMPORTANCE: Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models. OBJECTIVE: To determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both are superior to cooling at 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy. DESIGN, SETTING, AND PARTICIPANTS: A randomized, 2 × 2 factorial design clinical trial performed in 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network between October 2010 and November 2013...
December 24, 2014: JAMA: the Journal of the American Medical Association