Chenyang Zhan, Qingrong Yan, Yury Patskovsky, Zhenhong Li, Rafael Toro, Amanda Meyer, Huiyong Cheng, Michael Brenowitz, Stanley G Nathenson, Steven C Almo
TNF-like 1A (TL1A) is a newly described member of the TNF superfamily that is directly implicated in the pathogenesis of autoimmune diseases, including inflammatory bowel disease, atherosclerosis, and rheumatoid arthritis. We report the crystal structure of the human TL1A extracellular domain at a resolution of 2.5 A, which reveals a jelly-roll fold typical of the TNF superfamily. This structural information, in combination with complementary mutagenesis and biochemical characterization, provides insights into the binding interface and the specificity of the interactions between TL1A and the DcR3 and DR3 receptors...
August 18, 2009: Biochemistry