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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Mitsuhiro Nishimoto, Hiroshi Ohtsu, Takeshi Marumo, Wakako Kawarazaki, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Shigeru Shibata, Miki Nagase, Masashi Isshiki, Shigeyoshi Oba, Tatsuo Shimosawa, Toshiro Fujita
Excessive dietary salt intake can counteract the renoprotective effects of renin-angiotensin system (RAS) blockade in hypertensive patients with chronic kidney disease (CKD). In rodents, salt loading induces hypertension and renal damage by activating the mineralocorticoid receptor (MR) independently of plasma aldosterone levels. Thus, high salt-induced resistance to RAS blockade may be mediated by MR activation. To test this, a post hoc analysis of the Eplerenone Combination Versus Conventional Agents to Lower Blood Pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial was conducted...
January 11, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Endre Sulyok
This article shortly outlines the evolution of hypertonia from risk factors to end-organ damage. The pathogenetic role of salt intake is underlined and in the light of recent clinical and experimental observations, the importance of renal and extrarenal mechanism in the development of salt-sensitive hypertension is analysed. The generally accepted concept that the inefficient renal sodium excretion and the subsequent expansion of the extracellular space is the major factor in blood pressure elevation is challenged...
January 2019: Orvosi Hetilap
Maria Angeles Baker, Feng Wang, Yong Liu, Alison J Kriegel, Aron M Geurts, Kristie Usa, Hong Xue, Dandan Wang, Yiwei Kong, Mingyu Liang
MicroRNA miR-192-5p is one of the most abundant microRNAs in the kidney and targets the mRNA for ATP1B1 (β1 subunit of Na+ /K+ -ATPase). Na+ /K+ -ATPase drives renal tubular reabsorption. We hypothesized that miR-192-5p in the kidney would protect against the development of hypertension. We found miR-192-5p levels were significantly lower in kidney biopsy specimens from patients with hypertension (n=8) or hypertensive nephrosclerosis (n=32) compared with levels in controls (n=10). Similarly, Dahl salt-sensitive (SS) rats showed a reduced abundance of miR-192-5p in the renal cortex compared with congenic SS...
December 31, 2018: Hypertension
Jun Zhang, Ruowei Wen, Jinmei Yin, Ye Zhu, Lin Lin, Zengchun Ye, Hui Peng, Cheng Wang, Tanqi Lou
The relationship between resting pulse rate (PR) and the occurrence of hypertension and cardiovascular (CV) mortality has been described in the general population. Few studies have examined the relationship between ambulatory PR, ambulatory blood pressure (BP), and target organ damage (TOD) in patients with chronic kidney disease (CKD). A total of 1509 patients with CKD were recruited in our hospital. Ambulatory blood pressure monitoring (ABPM) over a 24-hours period was performed and referenced with clinical data in this cross-sectional study...
December 31, 2018: Journal of Clinical Hypertension
Kristina S Petersen, Sarah Rae, Erik Venos, Daniela Malta, Kathy Trieu, Joseph Alvin Santos, Sudhir Raj Thout, Jacqui Webster, Norm R C Campbell, JoAnne Arcand
The purpose of this review is to identify, summarize, and critically appraise studies on dietary salt and health outcomes that were published from April 2017 to March 2018. The search strategy was adapted from a previous systematic review on dietary salt and health. Identified studies were screened based on a priori defined criteria to identify publications eligible for detailed critical appraisals. Overall, 6747 citations were identified by the search strategy, and 42 health outcome studies were identified...
December 27, 2018: Journal of Clinical Hypertension
Huseyin Naci, Maximilian Salcher-Konrad, Sofia Dias, Manuel R Blum, Samali Anova Sahoo, David Nunan, John P A Ioannidis
OBJECTIVE: To compare the effect of exercise regimens and medications on systolic blood pressure (SBP). DATA SOURCES: Medline (via PubMed) and the Cochrane Library. ELIGIBILITY CRITERIA: Randomised controlled trials (RCTs) of angiotensin-converting enzyme inhibitors (ACE-I), angiotensin-2 receptor blockers (ARBs), β-blockers, calcium channel blockers (CCBs) and diuretics were identified from existing Cochrane reviews. A previously published meta-analysis of exercise interventions was updated to identify recent RCTs that tested the SBP-lowering effects of endurance, dynamic resistance, isometric resistance, and combined endurance and resistance exercise interventions (up to September 2018)...
December 18, 2018: British Journal of Sports Medicine
Hiroshi Kado, Tetsuro Kusaba, Satoaki Matoba, Tsuguru Hatta, Keiichi Tamagaki
The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups...
December 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Kevin D Platt, Amy N Thompson, Paul Lin, Tanima Basu, Ariel Linden, A Mark Fendrick
No abstract text is available yet for this article.
December 10, 2018: JAMA Internal Medicine
Hamdi A Jama, David M Kaye, Francine Z Marques
PURPOSE OF REVIEW: To summarize evidence supporting that microorganisms colonizing our gastrointestinal tract, collectively known as the gut microbiota, are implicated in the development and maintenance of hypertension in experimental models. RECENT FINDINGS: The use of gnotobiotic (germ-free) mice has been essential for advancement in this area: they develop higher blood pressure (BP) if they receive faecal transplants from hypertensive patients compared to normotensive donors, and germ-free mice have a blunted response to angiotensin II...
December 3, 2018: Current Opinion in Nephrology and Hypertension
Christine B Sethna, Dustin Kee, Pablo Casado, Megan Murphy, Lane S Palmer, Sleiman R Ghorayeb, Bradley Morganstern
The kidneys are thought to contribute to the pathogenesis of primary hypertension, but hypertension is also known to cause target organ damage in the kidney. Noninvasive methods to capture possible changes in the kidney related to hypertension are limited. A new program that has been used to quantify the heterogeneity and percent echogenicity in renal ultrasound images was implemented to assess patients with hypertension. Children and adolescents <21 years with primary hypertension diagnosed by ambulatory blood pressure monitoring were compared with normotensive age- and sex-matched controls...
December 2018: Journal of the American Society of Hypertension: JASH
Lia Alves-Cabratosa, Marc Elosua-Bayes, Maria García-Gil, Marc Comas-Cufí, Ruth Martí-Lluch, Anna Ponjoan, Jordi Blanch, Dídac Parramon, Manuel Angel Gomez-Marcos, Rafel Ramos
OBJECTIVE: Assessment of asymptomatic organ damage in the management of hypertension includes low (<0.9) ankle brachial index (ABI) values. No recommendations are given for patients with high ABI (≥1.3), despite evidence of an association with increased risk. We aimed to study the association of high ABI with all-cause mortality and cardiovascular outcomes in a hypertensive population. METHODS: In anonymized clinical records from the Catalan Primary Care (SIDIAP) database, we designed a large cohort of hypertensive patients aged 35-85 years at the start date...
January 2019: Journal of Hypertension
Masanari Kuwabara, Yaswanth Chintaluru, Mehmet Kanbay, Koichiro Niwa, Ichiro Hisatome, Ana Andres-Hernando, Carlos Roncal-Jimenez, Minoru Ohno, Richard J Johnson, Miguel A Lanaspa
OBJECTIVE: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design. METHODS: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. The cumulative incidences of hypertension over 5 years in each 10 mg/dl of fasting blood glucose levels were calculated...
January 2019: Journal of Hypertension
Bodil G Hornstrup, Pia H Gjoerup, Jost Wessels, Thomas G Lauridsen, Erling B Pedersen, Jesper N Bech
Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-matched controls...
2018: International Journal of Nephrology and Renovascular Disease
Yu Jie Chen, Liang Jin Li, Wen Lu Tang, Jia Yang Song, Ru Qiu, Qian Li, Hao Xue, James M Wright
BACKGROUND: This is the first update of a Cochrane Review first published in 2015. Renin angiotensin system (RAS) inhibitors include angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and renin inhibitors. They are widely prescribed for treatment of hypertension, especially for people with diabetes because of postulated advantages for reducing diabetic nephropathy and cardiovascular morbidity and mortality. Despite widespread use for hypertension, the efficacy and safety of RAS inhibitors compared to other antihypertensive drug classes remains unclear...
November 14, 2018: Cochrane Database of Systematic Reviews
Nestor Oliva-Damaso, Jorge Costa-Fernandez, Elena Oliva-Damaso, Rafael Bravo-Marques, Francisca Lopez, Maria Del Mar Castilla, Julia Sequeira, Juan Payan
No abstract text is available yet for this article.
November 24, 2018: Lancet
Piotr Kuczera, Katarzyna Kwiecień, Marcin Adamczak, Teresa Bączkowska, Jolanta Gozdowska, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Marian Klinger, Magdalena Durlik, Eberhard Ritz, Andrzej Wiecek
BACKGROUND/AIMS: Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascular risk and the progression of CKD in comparison with the traditional peripheral blood pressure measurements in the office conditions. The aim of the study was to assess the impact of the central, or nighttime blood pressure on the progression of CKD in patients with mild or no-proteinuria (autosomal, dominant polycystic kidney disease or IgA nephropathy)...
2018: Kidney & Blood Pressure Research
David Spirk, Sarah Noll, Michel Burnier, Stefano Rimoldi, Georg Noll, Isabella Sudano
BACKGROUND/AIMS: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient's awareness and attainment of BP goals under antihypertensive treatment with irbesartan alone or in combination with hydro-chlorothiazide. METHODS: In total, 1,268 patients with arterial hypertension were enrolled in the Factors Influencing Results in anti-hypertenSive Treatment (FIRST) study by 348 general practitioners and internal medicine specialists across Switzerland...
2018: Kidney & Blood Pressure Research
Francesca Mallamaci, Rocco Tripepi, Graziella D'Arrigo, Gaetana Porto, Maria Carmela Versace, Carmela Marino, Maria Cristina Sanguedolce, Alessandra Testa, Giovanni Tripepi, Carmine Zoccali
Background: Renal transplant patients have a high prevalence of nocturnal hypertension, and hypertension misclassification by office blood pressure (BP) is quite common in these patients. The potential impact of hypertension misclassification by office BP on hypertension management in this population has never been analysed. Methods: We performed a longitudinal study in a cohort of 260 clinically stable renal transplant patients. In all, 785 paired office and 24-h ambulatory blood pressure monitoring (24-hABPM) measurements over a median follow-up of 3...
November 23, 2018: Nephrology, Dialysis, Transplantation
Asad Ali, Muhammad Abu Zar, Ahmad Kamal, Amber E Faquih, Chandur Bhan, Waleed Iftikhar, Muhammad Bilal Malik, Malik Qistas Ahmad, Nouman Safdar Ali, Shahzad Ahmed Sami, Fnu Jitidhar, Abbas M Cheema, Annum Zulfiqar
Hypertension is the most prevalent clinical symptom arising from various cardiovascular disorders. Likewise, it is considered a precursor or sequelae to the development of acute coronary artery disease and congestive heath failure (CHF). Hypertension has been considered a cardinal criterion to determine cardiovascular function. According to the World Health Organization (WHO) global observatory data, hypertension causes more than 7.5 million deaths a year, about 12.8% of the total human mortality. Similarly, the Center for Disease Control (CDC) states that 35% of the American adults have been estimated to have a persistently high blood pressure, which makes it about one in every three adults...
August 29, 2018: Curēus
Alex R Chang, Meghan Lóser, Rakesh Malhotra, Lawrence J Appel
Hypertension affects the vast majority of patients with CKD and increases the risk of cardiovascular disease, ESKD, and death. Over the past decade, a number of hypertension guidelines have been published with varying recommendations for BP goals in patients with CKD. Most recently, the American College of Cardiology/American Heart Association 2017 hypertension guidelines set a BP goal of <130/80 mm Hg for patients with CKD and others at elevated cardiovascular risk. These guidelines were heavily influenced by the landmark Systolic Blood Pressure Intervention Trial (SPRINT), which documented that an intensive BP goal to a systolic BP <120 mm Hg decreased the risk of cardiovascular disease and mortality in nondiabetic adults at high cardiovascular risk, many of whom had CKD; the intensive BP goal did not retard CKD progression...
November 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
2018-11-22 07:33:55
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