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CKD

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27873228/hypertension-in-chronic-kidney-disease
#1
Seyed Mehrdad Hamrahian, Bonita Falkner
Hypertension, a global public health problem, is currently the leading factor in the global burden of disease. It is the major modifiable risk factor for heart disease, stroke and kidney failure. Chronic kidney disease (CKD) is both a common cause of hypertension and CKD is also a complication of uncontrolled hypertension. The interaction between hypertension and CKD is complex and increases the risk of adverse cardiovascular and cerebrovascular outcomes. This is particularly significant in the setting of resistant hypertension commonly seen in patient with CKD...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27881247/pain-management-in-ckd-a-guide-for-nephrology-providers
#2
Holly M Koncicki, Mark Unruh, Jane O Schell
Although pain is one of the most commonly experienced symptoms by patients with chronic kidney disease, it is under-recognized, the severity is underestimated, and the treatment is inadequate. Pain management is one of the general primary palliative care competencies for medical providers. This review provides nephrology providers with basic skills for pain management. These skills include recognition of types of pain (nociceptive and neuropathic) syndromes and appropriate history-taking skills. Through this history, providers can identify clinical circumstances in which specialist referral is beneficial, including those who are at high risk for addiction, at risk for adverse effects to medications, and those with complicated care needs such as patients with a limited prognosis...
November 20, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27887750/chronic-kidney-disease
#3
REVIEW
Angela C Webster, Evi V Nagler, Rachael L Morton, Philip Masson
The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m(2), or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in many low-income countries. Incidence, prevalence, and progression of CKD also vary within countries by ethnicity and social determinants of health, possibly through epigenetic influence...
November 22, 2016: Lancet
https://www.readbyqxmd.com/read/27827312/interlaboratory-variability-in-plasma-creatinine-measurement-and-the-relation-with-estimated-glomerular-filtration-rate-and-chronic-kidney-disease-diagnosis
#4
Elizabeth Lee, Christine P Collier, Christine A White
BACKGROUND AND OBJECTIVES: The tracing of creatinine (Cr) reference materials to isotope dilution mass spectrometry-assigned values was implemented worldwide to reduce interlaboratory variability and improve assay accuracy. The aims of this study were to examine the current extent of interlaboratory variability and its effect on eGFR. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Leftover plasma from 2-3 consecutive days was obtained from 53 intensive care unit patients with a range of kidney functions...
November 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27490909/multimorbidity-in-people-with-chronic-kidney-disease-implications-for-outcomes-and-treatment
#5
Simon D S Fraser, Maarten W Taal
PURPOSE OF REVIEW: With ageing populations, the prevalence of multimorbidity is increasing. This review discusses recent developments in the understanding of multimorbidity in the context of chronic kidney disease (CKD). It explores the associated treatment burden and the implications for key outcomes and patient care. RECENT FINDINGS: Comorbidity and polypharmacy are common in CKD, even at early stages, and are associated with significant treatment burden. Both 'concordant' and 'discordant' comorbidities have a negative impact on mortality, cardiovascular disease, hospitalisation and length of stay...
November 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/26981182/role-of-vitamin-d-in-diabetes-mellitus-and-chronic-kidney-disease
#6
REVIEW
Akio Nakashima, Keitaro Yokoyama, Takashi Yokoo, Mitsuyoshi Urashima
Approximately 30%-50% of people are recognized to have low levels of vitamin D, and insufficiency and deficiency of vitamin D are recognized as global health problems worldwide. Although the presence of hypovitamin D increases the risk of rickets and fractures, low vitamin D levels are also associated with hypertension, cancer, and cardiovascular disease. In addition, diabetes mellitus (DM) and chronic kidney disease (CKD) are also related to vitamin D levels. Vitamin D deficiency has been linked to onset and progression of DM...
March 10, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/26959373/a-cross-sectional-study-on-the-use-of-urinalysis-for-screening-early-stage-renal-insufficiency
#7
Ning Xue, Xiaoyan Zhang, Jie Teng, Yi Fang, Xiaoqiang Ding
BACKGROUND/AIMS: Proteinuria and hematuria detected by routine urinalysis can indicate impaired renal function. This study evaluated the effect of routine urinalysis in screening out patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 at an early stage and investigated its associated factors. METHODS: Healthy adults who underwent physical examination between September 2008 and September 2013 were enrolled in the study (n = 43,516). Urine was analyzed for protein, and red and white blood cells...
2016: Nephron
https://www.readbyqxmd.com/read/26936486/which-patients-with-chronic-kidney-disease-have-the-greatest-symptom-burden-a-comparative-study-of-advanced-ckd-stage-and-dialysis-modality
#8
Hayfa Almutary, Ann Bonner, Clint Douglas
BACKGROUND: Chronic kidney disease (CKD) leads to a range of symptoms, which are often under-recognised and little is known about the multidimensional symptom experience in advanced CKD. OBJECTIVES: To examine (1) symptom burden at CKD stages 4 and 5, and dialysis modalities, and (2) demographic and renal history correlates of symptom burden. METHODS: Using a cross-sectional design, a convenience sample of 436 people with CKD was recruited from three hospitals...
June 2016: Journal of Renal Care
https://www.readbyqxmd.com/read/26908831/chronic-kidney-disease-prevalence-in-the-general-population-heterogeneity-and-concerns
#9
Luca De Nicola, Carmine Zoccali
No abstract text is available yet for this article.
March 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26908763/methodology-used-in-studies-reporting-chronic-kidney-disease-prevalence-a-systematic-literature-review
#10
Katharina Brück, Kitty J Jager, Evangelia Dounousi, Alexander Kainz, Dorothea Nitsch, Johan Ärnlöv, Dietrich Rothenbacher, Gemma Browne, Vincenzo Capuano, Pietro Manuel Ferraro, Jean Ferrieres, Giovanni Gambaro, Idris Guessous, Stein Hallan, Mika Kastarinen, Gerjan Navis, Alfonso Otero Gonzalez, Luigi Palmieri, Solfrid Romundstad, Belinda Spoto, Benedicte Stengel, Charles Tomson, Giovanni Tripepi, Henry Völzke, Andrzej Wiȩcek, Ron Gansevoort, Ben Schöttker, Christoph Wanner, Jose Vinhas, Carmine Zoccali, Wim Van Biesen, Vianda S Stel
No abstract text is available yet for this article.
April 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26907084/the-relationship-between-plasma-whole-blood-viscosity-and-cardiovascular-events-in-patients-with-chronic-kidney-disease
#11
Turgay Celik, Mahmut Ilker Yilmaz, Sevket Balta, Cengiz Ozturk, Hilmi Umut Unal, Mustafa Aparci, Murat Karaman, Mustafa Demir, A Osman Yildirim, Mutlu Saglam, Selim Kilic, Tayfun Eyileten, İbrahim Aydin, Atila Iyisoy
BACKGROUND: Plasma levels of estimated whole blood viscosity (eWBV) have been increased by endothelial inflammation. Because there were no consistent data for assessing the eWBV levels for prediction of cardiovascular event (CVE) in patients with chronic kidney disease (CKD). We aimed to investigate the relationship between plasma eWBV levels and CVEs in patients with CKD. MATERIALS AND METHODS: We conducted a prospective, cross-sectional, long-term follow-up study, assessing the relationship between plasma eWBV levels and CVE (either fatal or nonfatal) in patients with newly diagnosed CKD...
February 22, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26905361/effect-of-statins-on-kidney-disease-outcomes-a%C3%A2-systematic%C3%A2-review-and-meta-analysis
#12
Xiaole Su, Lu Zhang, Jicheng Lv, Jinwei Wang, Wanyin Hou, Xinfang Xie, Hong Zhang
BACKGROUND: The effects of statin administration on kidney disease outcomes remain controversial. We undertook a systematic review and meta-analysis to assess the efficacy of statins on kidney outcomes. STUDY DESIGN: We conducted a meta-analysis of randomized controlled trials (RCTs) using MEDLINE (1946 to August 31, 2015), EMBASE (1966 to August 31, 2015), and the Cochrane Library database (no date restriction). SETTING & POPULATION: Adults who were not receiving dialysis, for whom kidney disease outcomes were reported...
June 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26853071/quality-of-chronic-kidney-disease-management-in-primary-care-a-retrospective-study
#13
Vincent A Van Gelder, Nynke D Scherpbier-De Haan, Wim J C De Grauw, Gerald M M Vervoort, Chris Van Weel, Marion C J Biermans, Jozé C C Braspenning, Jack F M Wetzels
BACKGROUND: Early detection and appropriate management of chronic kidney disease (CKD) in primary care are essential to reduce morbidity and mortality. AIM: To assess the quality of care (QoC) of CKD in primary healthcare in relation to patient and practice characteristics in order to tailor improvement strategies. DESIGN AND SETTING: Retrospective study using data between 2008 and 2011 from 47 general practices (207 469 patients of whom 162 562 were adults)...
2016: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/26861000/non-vitamin-k-oral-anticoagulant-drugs-for-stroke-prevention-in-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#14
Tatjana S Potpara, Vera Jokic, Nikolaos Dagres, Torben B Larsen, Deirdre A Lane, Gerhard Hindricks, Gregory Y H Lip
Atrial fibrillation (AF) and chronic kidney disease (CKD) are disorders with increasing prevalence. The presence of CKD increases the risk of incident AF and vice versa, and the presence of AF may accelerate CKD progression. Nearly a third of patients with established CKD also have AF, whilst half of AF patients may have some degree of renal dysfunction. Both AF and CKD are associated with increased cardiovascular morbidity and mortality, including significantly increased risk of stroke or systemic embolism...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26879490/evaluation-of-parathyroidectomy-for-secondary-and-tertiary-hyperparathyroidism-by-the-parathyroid-surgeons-society-of-japan
#15
Yoshihiro Tominaga, Takatoshi Kakuta, Chikao Yasunaga, Michio Nakamura, Yoshiyuki Kadokura, Hideki Tahara
Secondary hyperparathyroidism (SHPT) remains a serious complication in patients with chronic kidney disease, and some patients require parathyroidectomy. The Parathyroid Surgeons' Society of Japan (PSSJ) evaluated parathyroidectomy for SHPT and tertiary hyperparathyroidism (THPT) in Japan. The annual numbers of parathyroidectomies between 2004 and 2013 were evaluated using questionnaires. Since 2010, the PSSJ has registered the patients. In total, 826 patients from 42 institutions were registered. The annual number of parathyroidectomies for SHPT and THPT in Japan increased from 2004 to 2007 and then decreased markedly after 2007, with 296 operations performed in 2013...
February 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/26885869/special-considerations-for-the-treatment-of-chronic-kidney-disease-in-the-elderly
#16
Andrea Corsonello, Sergio Fusco, Silvia Bustacchini, Carlos Chiatti, Raffaella Moresi, Anna Rita Bonfigli, Giuseppina Di Stefano, Fabrizia Lattanzio
Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed...
2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26886110/back-to-the-future-restricted-protein-intake-for-conservative-management-of-ckd-triple-goals-of-renoprotection-uremia-mitigation-and-nutritional-health
#17
EDITORIAL
Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Lowering dietary protein intake (DPI) to approximately 0.6-0.8 g/kgBW/day may be renoprotective through various mechanisms, and it has been recommended in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) as a means to also control various metabolic consequences of advanced CKD, such as uremic symptoms, hyperparathyroidism, hypertension, hyperkalemia, and hyperphosphatemia. A meta-analysis in this issue of the Journal suggests that low-protein diet is effective and safe when used to retard progression of CKD and alleviate uremic complications...
May 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26888448/the-relationship-between-egfr-and-hospitalization-for-heart-failure-in-54-486-individuals-with-type-2-diabetes
#18
Mauro Tancredi, Annika Rosengren, Marita Olsson, Soffia Gudbjörnsdottir, Ann-Marie Svensson, B Haraldsson, Marcus Lind
BACKGROUND: To study the association between renal function and hospitalization for heart failure (HF) in individuals with type 2 diabetes. METHODS: Renal function was determined according to 3 formulas used to estimate glomerular filtration rate (eGFR): Cockcroft-Gault, Modified Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology (CKD-EPI). Proportional hazards regression models adjusted for age, sex, HbA1c, blood pressure, smoking, and cardiovascular comorbidities were constructed for each eGFR formula to estimate risk of HF hospitalization...
February 17, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26880461/body-mass-index-and-causes-of-death-in-chronic-kidney-disease
#19
Sankar D Navaneethan, Jesse D Schold, Susana Arrigain, John P Kirwan, Joseph V Nally
In chronic kidney disease (CKD), a higher body mass index (BMI) is associated with a lower risk for death, but cause-specific death details are unknown across the BMI range. To define this, we studied 54,506 patients with CKD (stage 3 CKD- [91.5%]) from an institutional electronic medical record based-registry. We examined the associations among various causes of death (cardiovascular-, malignancy- and noncardiovascular/nonmalignancy-related deaths) across the BMI range using Cox proportional hazards and competing risks regression models...
March 2016: Kidney International
https://www.readbyqxmd.com/read/26831434/epidemiology-and-mechanisms-of-uremia-related-cardiovascular-disease
#20
REVIEW
Marcello Tonelli, S Ananth Karumanchi, Ravi Thadhani
Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors that arise from accumulating toxins also contribute to the pathogenesis of CVD. In this review, we summarize the literature on the epidemiology of both traditional and uremia-related CVD and focus on postulated mechanisms of the latter...
February 2, 2016: Circulation
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