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By ZS Bao
Zhao-Shi Bao, Hui-Min Chen, Ming-Yu Yang, Chuan-Bao Zhang, Kai Yu, Wan-Lu Ye, Bo-Qiang Hu, Wei Yan, Wei Zhang, Johnny Akers, Valya Ramakrishnan, Jie Li, Bob Carter, Yan-Wei Liu, Hui-Min Hu, Zheng Wang, Ming-Yang Li, Kun Yao, Xiao-Guang Qiu, Chun-Sheng Kang, Yong-Ping You, Xiao-Long Fan, Wei Sonya Song, Rui-Qiang Li, Xiao-Dong Su, Clark C Chen, Tao Jiang
Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid the foundation for targeted cancer therapy. To identify oncogenic fusions associated with glioma progression, we catalogued fusion transcripts by RNA-seq of 272 gliomas. Fusion transcripts were more frequently found in high-grade gliomas, in the classical subtype of gliomas, and in gliomas treated with radiation/temozolomide. Sixty-seven in-frame fusion transcripts were identified, including three recurrent fusion transcripts: FGFR3-TACC3, RNF213-SLC26A11, and PTPRZ1-MET (ZM)...
November 2014: Genome Research
Rafael Bejar, Kristen E Stevenson, Bennett Caughey, R Coleman Lindsley, Brenton G Mar, Petar Stojanov, Gad Getz, David P Steensma, Jerome Ritz, Robert Soiffer, Joseph H Antin, Edwin Alyea, Philippe Armand, Vincent Ho, John Koreth, Donna Neuberg, Corey S Cutler, Benjamin L Ebert
PURPOSE: Recurrently mutated genes in myelodysplastic syndrome (MDS) are pathogenic drivers and powerfully associated with clinical phenotype and prognosis. Whether these types of mutations predict outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with MDS is not known. PATIENTS AND METHODS: We used massively parallel sequencing to examine tumor samples collected from 87 patients with MDS before HSCT for coding mutations in 40 recurrently mutated MDS genes...
September 1, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Hugues Duffau, Luc Taillandier
Diffuse low-grade glioma grows, migrates along white matter tracts, and progresses to high-grade glioma. Rather than a "wait and see" policy, an aggressive attitude is now recommended, with early surgery as the first therapy. Intraoperative mapping, with maximal resection according to functional boundaries, is associated with a longer overall survival (OS) while minimizing morbidity. However, most studies have investigated the role of only one specific treatment (surgery, radiotherapy, chemotherapy) without taking a global view of managing the cumulative time while preserving quality of life (QoL) versus time to anaplastic transformation...
March 2015: Neuro-oncology
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