Samantha J Irving, Andrew Ives, Gwyneth Davies, Jackie Donovan, Anthony J Edey, Simon S Gill, Arjun Nair, Clare Saunders, Nevin T Wijesekera, Eric W F W Alton, David Hansell, Claire Hogg, Jane C Davies, Andrew Bush
RATIONALE: Lung clearance index (LCI) is a more sensitive measure of lung function than spirometry in cystic fibrosis (CF) and correlates well with abnormalities in high-resolution computed tomography (HRCT) scanning. We hypothesized LCI would be equally sensitive to lung disease in primary ciliary dyskinesia (PCD). OBJECTIVES: To test the relationships between LCI, spirometry, and HRCT in PCD and to compare them to the established relationships in CF. METHODS: Cross-sectional study of 127 patients with CF and 33 patients with PCD, all of whom had spirometry and LCI, of which a subset of 21 of each had HRCT performed...
September 1, 2013: American Journal of Respiratory and Critical Care Medicine