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8 papers 25 to 100 followers
Michael E Johansen, Timothy R Huerta, Caroline R Richardson
No abstract text is available yet for this article.
November 2014: JAMA Internal Medicine
Stuart J Spechler, Rhonda F Souza
New England Journal of Medicine, Volume 371, Issue 9, Page 836-845, August 2014.
August 28, 2014: New England Journal of Medicine
David Avigan, Jacalyn Rosenblatt
New England Journal of Medicine, Volume 371, Issue 10, Page 961-962, September 2014.
September 4, 2014: New England Journal of Medicine
Afsaneh Barzi, Mikkael A Sekeres
The myelodysplastic syndromes (MDS) are clonal bone marrow disorders that lead to underproduction of normal blood cells. The consequent cytopenias result in infections and bleeding complications. MDS transform to acute myeloid leukemia in one-third of patients. The number of diagnoses has exploded in the past decade as a result of increased recognition and understanding of the disease and the aging of the population. New therapies can extend life. MDS are now considered the most common form of leukemia, and in some cases deserve immediate intervention...
January 2010: Cleveland Clinic Journal of Medicine
Suzanne Oparil
No abstract text is available yet for this article.
August 14, 2014: New England Journal of Medicine
Antonio Omuro, Kathryn Beal, Philip Gutin, Sasan Karimi, Denise D Correa, Thomas J Kaley, Lisa M DeAngelis, Timothy A Chan, Igor T Gavrilovic, Craig Nolan, Adilia Hormigo, Andrew B Lassman, Ingo Mellinghoff, Christian Grommes, Anne S Reiner, Katherine S Panageas, Raymond E Baser, Viviane Tabar, Elena Pentsova, Juan Sanchez, Renata Barradas-Panchal, Jianan Zhang, Geraldine Faivre, Cameron W Brennan, Lauren E Abrey, Jason T Huse
PURPOSE: Bevacizumab is associated with decreased vascular permeability that allows for more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed glioblastoma utilizing a novel hypofractionated stereotactic radiotherapy (HFSRT) schedule combined with temozolomide and bevacizumab. EXPERIMENTAL DESIGN: Patients with tumor volume ≤60 cc were treated with HFSRT (6 × 6 Gy to contrast enhancement and 6 × 4 Gy to FLAIR hyperintensity with dose painting) combined with concomitant/adjuvant temozolomide and bevacizumab at standard doses...
October 1, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Peter M Wilson, Peter V Danenberg, Patrick G Johnston, Heinz-Josef Lenz, Robert D Ladner
Over the past 60 years, chemotherapeutic agents that target thymidylate biosynthesis and the enzyme thymidylate synthase (TS) have remained among the most-successful drugs used in the treatment of cancer. Fluoropyrimidines, such as 5-fluorouracil and capecitabine, and antifolates, such as methotrexate and pemetrexed, induce a state of thymidylate deficiency and imbalances in the nucleotide pool that impair DNA replication and repair. TS-targeted agents are used to treat numerous solid and haematological malignancies, either alone or as foundational therapeutics in combination treatment regimens...
May 2014: Nature Reviews. Clinical Oncology
Christopher L Wolfgang, Joseph M Herman, Daniel A Laheru, Alison P Klein, Michael A Erdek, Elliot K Fishman, Ralph H Hruban
Pancreatic cancer is currently one of the deadliest of the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and less invasive than ever, novel drug combinations have been shown to improve survival, advances in radiation therapy have resulted in less toxicity, and enormous strides have been made in the understanding of the fundamental genetics of pancreatic cancer. These advances provide hope but they also increase the complexity of caring for patients. It is clear that multidisciplinary care that provides comprehensive and coordinated evaluation and treatment is the most effective way to manage patients with pancreatic cancer...
September 2013: CA: a Cancer Journal for Clinicians
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