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Tranexamic acid

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67 papers 1000+ followers Used to reduce bleeding and in some cases mortality
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
https://www.readbyqxmd.com/read/26660675/pharmacological-adjuncts-to-stop-bleeding-options-and-effectiveness
#1
M Panteli, I Pountos, P V Giannoudis
Severe trauma and massive haemorrhage represent the leading cause of death and disability in patients under the age of 45 years in the developed world. Even though much advancement has been made in our understanding of the pathophysiology and management of trauma, outcomes from massive haemorrhage remain poor. This can be partially explained by the development of coagulopathy, acidosis and hypothermia, a pathological process collectively known as the "lethal triad" of trauma. A number of pharmacological adjuncts have been utilised to stop bleeding, with a wide variation in the safety and efficacy profiles...
June 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26681525/evaluating-three-hundred-and-fifty-two-admissions-and-predictors-of-re-admissions-for-epistaxis-is-it-time-to-re-evaluate-tranexamic-acid-in-epistaxis
#2
S Jervis, T Saunders, J Belcher, D Skinner
Epistaxis is a common indication for admission under ENT care. Such patients usually have nasal packing for a short period and social circumstances or medical co-morbidities may prevent discharge home with packs in-situ. With bed pressures and an elderly epistaxis population, these admissions are far from ideal but are unavoidable in those with significant bleeds. This article is protected by copyright. All rights reserved.
December 18, 2015: Clinical Otolaryngology
https://www.readbyqxmd.com/read/26088087/tranexamic-acid-for-epistaxis-a-promising-treatment-that-deserves-further-study
#3
COMMENT
David Clinkard, David Barbic
CLINICAL QUESTION: Does the application of topical tranexamic acid reduce bleeding as compared to anterior packing? ARTICLE CHOSEN: Zahed R, Moharamzadeh P, Alizadeharasi S, et al. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med 2013;31(9):1389-92. OBJECTIVES: To determine if topically applied tranexamic acid reduces bleeding time in epistaxis...
January 2016: CJEM
https://www.readbyqxmd.com/read/25926984/recent-advances-in-managing-and-understanding-menstrual-disorders
#4
REVIEW
Luis Bahamondes, Moazzam Ali
Menstrual disorders are a major reason for gynaecological consultations worldwide and, unfortunately there are many different definitions and classifications of this condition. Clear definitions and terminology are necessary for scientific literature, particularly for clinicians, and for clinical trials comparing two treatments. The International Federation of Gynaecology and Obstetrics (FIGO) Menstrual Disorders Working Group has proposed abandoning the use of one common term, dysfunctional uterine bleeding (DUB), while continuing to use the terms abnormal uterine bleeding (AUB) and heavy menstrual bleeding (HMB)...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/25948575/the-use-of-an-anti-fibrinolytic-agent-to-reduce-endoleak-following-endovascular-repair-of-multiple-aortic-aneurysms
#5
Takeshi Uzuka, Masanori Nakamura, Yohsuke Kuroda, Noriyasu Watanabe
This paper reports on the therapeutic use of tranexamic acid in an elderly patient with severe comorbidities that precluded even endovascular reintervention. Orally administered tranexamic acid mitigated and partially reversed two and a half years of progressive aneurysmal expansion and closed a persistent endoleak after thoracic endovascular aneurysm repair and endovascular aneurysm repair for coexisting lesions. Reappearance of the endoleak when tranexamic acid was accidentally stopped and its re-closure after the resumption of tranexamic acid treatment confirmed causality...
August 2015: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/25954976/the-safety-and-efficacy-of-antifibrinolytic-therapy-in-neonatal-cardiac-surgery
#6
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula
BACKGROUND: Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is seldom studied in the neonatal age group. The aim of this study was to compare the efficacy and adverse effects of aprotinin and tranexamic acid in neonates undergoing open-heart surgery at a single centre. METHODS: Between October 2003 and March 2008, perioperative data of 552 consecutive neonatal patients undergoing open-heart surgery in Children's Hospital Boston were reviewed...
2015: PloS One
https://www.readbyqxmd.com/read/25956410/antifibrinolytic-drugs-for-acute-traumatic-injury
#7
REVIEW
Katharine Ker, Ian Roberts, Haleema Shakur, Tim J Coats
BACKGROUND: Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma. OBJECTIVES: To assess the effect of antifibrinolytic drugs in patients with acute traumatic injury. SEARCH METHODS: We ran the most recent search in January 2015. We searched the Cochrane Injuries Group's Specialised Register, The Cochrane Library, Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R), Embase Classic+Embase (OvidSP), PubMed and clinical trials registries...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25970597/withdrawn-haemostatic-drugs-for-traumatic-brain-injury
#8
REVIEW
Pablo Perel, Ian Roberts, Haleema Shakur, Bandit Thinkhamrop, Nakornchai Phuenpathom, Surakrant Yutthakasemsunt
No abstract text is available yet for this article.
May 13, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25240920/does-tranexamic-acid-improve-outcomes-in-patients-undergoing-urgent-or-emergency-surgery
#9
EDITORIAL
Jennifer Robertson, Alex Koyfman
No abstract text is available yet for this article.
April 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25559460/tranexamic-acid-an-old-drug-still-going-strong-and-making-a-revival
#10
REVIEW
Lilian Tengborn, Margareta Blombäck, Erik Berntorp
Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females with heavy menstrual blood loss and to patients with hereditary bleeding disorders. Soon the indications were widened to elective surgery because of its blood saving effects. Contraindications are few, most important is ongoing venous or arterial thrombosis and allergy to tranexamic acid, and the doses has to be reduced in renal insufficiency...
February 2015: Thrombosis Research
https://www.readbyqxmd.com/read/25605262/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary-bet-1-tranexamic-acid-in-life-threatening-haematuria
#11
REVIEW
(no author information available yet)
A shortcut review was carried out to establish whether tranexamic acid improves outcomes for patients with life-threatening haematuria. Sixteen papers were found in Medline using the reported searches, of which four presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that the evidence is limited, but there may be a role for tranexamic acid in life-threatening haematuria, particularly in patients with autosomal-dominant polycystic kidney disease...
February 2015: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/25498484/mechanism-of-action-of-tranexamic-acid-in-bleeding-trauma-patients-an-exploratory-analysis-of-data-from-the-crash-2-trial
#12
RANDOMIZED CONTROLLED TRIAL
Ian Roberts, David Prieto-Merino, Daniela Manno
INTRODUCTION: To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality. We hypothesised that if TXA reduces mortality by decreasing blood loss, its effect should be greatest on the day of the injury when bleeding is most profuse. However, if TXA reduces mortality via an anti-inflammatory mechanism its effect should be greater over the subsequent days. METHODS: Exploratory analysis, including per-protocol analyses, of data from the CRASH-2 trial, a randomised placebo controlled trial of the effect of TXA on mortality in 20,211 trauma patients with, or at risk of, significant bleeding...
December 13, 2014: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25550024/review-article-perioperative-care-in-enhanced-recovery-for-total-hip-and-knee-arthroplasty
#13
REVIEW
Marinus D J Stowers, Daniel P Lemanu, Brendan Coleman, Andrew G Hill, Jacob T Munro
Enhanced recovery pathways for total hip and knee arthroplasty can reduce length of hospital stay and perioperative morbidity. 22 studies were reviewed for identification of perioperative care interventions, including preoperative (n=4), intra-operative (n=8), and postoperative (n=4) care interventions. Factors that improve outcomes included use of pre-emptive and multimodal analgesia regimens to reduce opioid consumption, identification of patients with poor nutritional status and provision of supplements preoperatively to improve wound healing and reduce length of hospital stay, use of warming systems and tranexamic acid, avoidance of drains to reduce operative blood loss and subsequent transfusion, and early ambulation with pharmacological and mechanical prophylaxis to reduce venous thromboembolism and to speed recovery...
December 2014: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/25385695/damage-control-resuscitation
#14
James N Bogert, John A Harvin, Bryan A Cotton
Resuscitation of the hemorrhaging patient has undergone significant changes in the last decade resulting in the concept of damage control resuscitation (DCR). Hemostatic resuscitation aims to address the physiologic derangements found in the hemorrhaging patient, namely coagulopathy, acidosis, and hypothermia. Strategies to achieve this are permissive hypotension, high ratio of plasma and platelet transfusion to packed red blood cell transfusion, and limitation of crystalloid administration. Damage control surgery aims for early hemorrhage control and minimizing operative time by delaying definitive repair until the patient's physiologic status has normalized...
March 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/25257237/venous-thromboembolism-and-mortality-associated-with-tranexamic-acid-use-during-total-hip-and-knee-arthroplasty
#15
Christopher M Duncan, Blake P Gillette, Adam K Jacob, Rafael J Sierra, Joaquin Sanchez-Sotelo, Hugh M Smith
TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR=0.98; 95% CI 0.67-1.45; P=0.939) or adjusted odds of death (OR=0.26; 95% CI 0.04-1...
February 2015: Journal of Arthroplasty
https://www.readbyqxmd.com/read/25247858/effects-and-timing-of-tranexamic-acid-on-transfusion-requirements-in-patients-undergoing-cardiac-surgery-with-cardiopulmonary-bypass
#16
LETTER
Filippo Sanfilippo, Marinella Astuto, Marc O Maybauer
No abstract text is available yet for this article.
October 2014: Anesthesiology
https://www.readbyqxmd.com/read/25227879/-interdisciplinary-management-of-trauma-patients-update-3-years-after-implementation-of-the-s3-guidelines-on-treatment-of-patients-with-severe-and-multiple-injuries
#17
REVIEW
B Donaubauer, J Fakler, A Gries, U X Kaisers, C Josten, M Bernhard
BACKGROUND: The recommendations still have to be implemented 3 years after publication of the S3 guidelines on the treatment of patients with severe and multiple injuries. AIM: This article reiterates some of the essential core statements of the S3 guidelines and also gives an overview of new scientific studies. MATERIAL AND METHODS: In a selective literature search new studies on airway management, traumatic cardiac arrest, shock classification, coagulation therapy, whole-body computed tomography, air rescue and trauma centers were identified and are discussed in the light of the S3 guideline recommendations...
November 2014: Der Anaesthesist
https://www.readbyqxmd.com/read/25183383/tranexamic-acid-and-fibrinogen-restore-clotting-in-vitro-and-in-vivo-in-cardiac-thrombus-associated-hyperfibrinolysis-with-overt-bleedings
#18
LETTER
Michael Schwameis, Johannes Thaler, Andreas Schober, Christian Schörgenhofer, Christiane Kulinna-Cosentini, Anton Laggner, Martin Röggla, Bernd Jilma
No abstract text is available yet for this article.
November 2014: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/24875032/the-relative-efficacy-of-antifibrinolytics-in-adolescent-idiopathic-scoliosis-a-prospective-randomized-trial
#19
RANDOMIZED CONTROLLED TRIAL
Kushagra Verma, Thomas Errico, Chris Diefenbach, Christian Hoelscher, Austin Peters, Joseph Dryer, Tessa Huncke, Kirstin Boenigk, Baron S Lonner
BACKGROUND: Antifibrinolytics can reduce intraoperative blood loss. The primary aim of this study was to determine the efficacy of intraoperative tranexamic acid, epsilon-aminocaproic acid, and placebo at reducing perioperative blood loss and the transfusion rate in patients with adolescent idiopathic scoliosis undergoing posterior spinal arthrodesis. METHODS: This is a prospective, randomized, double-blind comparison of tranexamic acid, epsilon-aminocaproic acid, and placebo used intraoperatively in patients with adolescent idiopathic scoliosis...
May 21, 2014: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/23990381/antifibrinolytic-therapy-for-aneurysmal-subarachnoid-haemorrhage
#20
REVIEW
Merih I Baharoglu, Menno R Germans, Gabriel J E Rinkel, Ale Algra, Marinus Vermeulen, Jan van Gijn, Yvo B W E M Roos
BACKGROUND: Rebleeding is an important cause of death and disability in people with aneurysmal subarachnoid haemorrhage. Rebleeding is probably related to dissolution of the blood clot at the site of aneurysm rupture by natural fibrinolytic activity. This review is an update of a previously published Cochrane review. OBJECTIVES: To assess the effects of antifibrinolytic treatment in people with aneurysmal subarachnoid haemorrhage. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register (February 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 1), MEDLINE (1948 to December 2012), and EMBASE (1947 to December 2012)...
August 30, 2013: Cochrane Database of Systematic Reviews
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