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JOURNAL ARTICLE
Martina Uzzo, Andreas Kronbichler, Federico Alberici, Ingeborg Bajema
BACKGROUND: The presence of a full house pattern at immunofluorescence on kidney biopsy in a patient without clinical and laboratory features of systemic lupus erythematosus (SLE) has led to the descriptive term non-lupus full house nephropathy. This systematic review and meta-analysis focus on non-lupus full house nephropathy nomenclature, clinical findings and outcomes. METHODS: In a reiterative process, all identified terms for non-lupus full house nephropathy and other MeSH terms were searched in PubMed...
March 26, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#2
REVIEW
Jack A Gilbert, John Alverdy
A study from Long et al. shows that many pathogens that cause surgical site infections during spine surgery come from the patient's own microbiome, suggesting a paradigm shift in the understanding of surgical site infections that questions the effectiveness of current enhanced sterility and antibiotic protocols.
April 10, 2024: Science Translational Medicine
#3
JOURNAL ARTICLE
Guillermo Ruiz-Irastorza, Diana Paredes-Ruiz, Maria Herrero-Galvan, Victor Moreno-Torres, Halbert Hernandez-Negrin, Ioana Ruiz-Arruza, Cedric Leonard, Christophe Richez, Estibaliz Lazaro
OBJECTIVES: To analyze the effect of methyl-prednisolone pulses (MP), given during the first year after the diagnosis of systemic lupus erythematosus (SLE), in achieving prolonged remission according to the degree of lupus activity at presentation. METHODS: Observational study of routine clinical care data of the Lupus Cruces-Bordeaux cohort. The endpoint was prolonged remission, i.e. during 5 consecutive yearly visits. The effect on remission of MP during the first year was analyzed in the whole cohort and according to the baseline SLEDAI-2K score: <6, 6-12 and >12, reflecting mild, moderate and severe activity, respectively...
March 26, 2024: Arthritis Care & Research
#4
REVIEW
Richard de Reuver, Jonathan Maelfait
Recent progress in human and mouse genetics has transformed our understanding of the molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) causes immunopathology. Novel mouse models recapitulate loss-of-function mutations in the RNA editing enzyme ADAR1 that are found in patients with Aicardi-Goutières syndrome (AGS) - a monogenic inflammatory disease associated with increased levels of type I interferon. Extensive analyses of the genotype-phenotype relationships in these mice have now firmly established a causal relationship between increased intracellular concentrations of endogenous immunostimulatory dsRNA and type I interferon-driven immunopathology...
September 26, 2023: Nature Reviews. Immunology
#5
JOURNAL ARTICLE
Nicolas Tchitchek, Marie Binvignat, Alexandra Roux, Fabien Pitoiset, Johanna Dubois, Gwendolyn Marguerit, David Saadoun, Patrice Cacoub, Jérémie Sellam, Francis Berenbaum, Agnès Hartemann, Chloé Amouyal, Roberta Lorenzon, Encarnita Mariotti-Ferrandiz, Michelle Rosenzwajg, David Klatzmann
OBJECTIVES: Based on genetic associations, McGonagle and McDermott suggested a classification of autoimmune and autoinflammatory diseases as a continuum ranging from purely autoimmune to purely autoinflammatory diseases and comprising diseases with both components. We used deep immunophenotyping to identify immune cell populations and molecular targets characterising this continuum. METHODS: We collected blood from 443 patients with one of 15 autoimmune or autoinflammatory diseases and 71 healthy volunteers...
January 5, 2024: Annals of the Rheumatic Diseases
#6
JOURNAL ARTICLE
Riccardo Papa, Marco Gattorno
No abstract text is available yet for this article.
December 14, 2023: Nature Reviews. Rheumatology
#7
JOURNAL ARTICLE
Lingzhen Hu, Jianxin Tu, Jiajun Gui, Mengyuan Fang, Li Sun
OBJECTIVES: To analyze the immune cell and B cell receptor (BCR) profiles of patients with systematic lupus erythematosus (SLE), with or without Epstein-Barr virus (EBV) infection, and identify the differences between them. METHODS: We included two patients with SLE and positive detection of EBV infections (SLE-EBV+), four with SLE with negative detection of EBV infections (SLE-EBV-), and two healthy controls (HC). Single-cell RNA sequencing (scRNA-seq) was used to investigate the heterogeneity of cell populations by combining the transcriptomic profiles and BCR repertoires...
December 11, 2023: Rheumatology
#8
JOURNAL ARTICLE
Steven R Fiddaman, Evangelos A Dimopoulos, Ophélie Lebrasseur, Louis du Plessis, Bram Vrancken, Sophy Charlton, Ashleigh F Haruda, Kristina Tabbada, Patrik G Flammer, Stefan Dascalu, Nemanja Marković, Hannah Li, Gabrielle Franklin, Robert Symmons, Henriette Baron, László Daróczi-Szabó, Dilyara N Shaymuratova, Igor V Askeyev, Olivier Putelat, Maria Sana, Hossein Davoudi, Homa Fathi, Amir Saed Mucheshi, Ali Akbar Vahdati, Liangren Zhang, Alison Foster, Naomi Sykes, Gabrielle Cass Baumberg, Jelena Bulatović, Arthur O Askeyev, Oleg V Askeyev, Marjan Mashkour, Oliver G Pybus, Venugopal Nair, Greger Larson, Adrian L Smith, Laurent A F Frantz
The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years...
December 15, 2023: Science
#9
JOURNAL ARTICLE
Fernanda Gutierrez-Rodrigues, Kristina V Wells, Adrianna I Jones, Dalton Hironaka, Cameron Rankin, Massimo Gadina, Keith A Sikora, Lemlem Alemu, Rodrigo T Calado, Kaitlin A Quinn, Bhavisha Patel, Neal S Young, Peter C Grayson
OBJECTIVES: Ageing and inflammation are associated with clonal haematopoiesis (CH), the emergence of somatic mutations in haematopoietic cells. This study details CH in patients with systemic vasculitis in association with clinical, haematological and immunological parameters. METHODS: Patients with three forms of vasculitis were screened for CH in peripheral blood by error-corrected sequencing. Relative contributions of age and vasculitis on CH prevalence were calculated using multivariable logistic regression...
November 29, 2023: Annals of the Rheumatic Diseases
#10
JOURNAL ARTICLE
Md Rashedul Hoque, J Antonio Aviña-Zubieta, Diane Lacaille, Mary A De Vera, Yi Qian, Lawrence McCandless, John M Esdaile, Hui Xie
OBJECTIVE: To assess the association between antimalarial adherence and cardiovascular events among incident rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) population-based cohorts. METHODS: All patients with incident RA/SLE and incident antimalarial use in British Columbia, Canada, between 01/1997 and 03/2015 were identified using provincial administrative databases. The outcomes were incident cardiovascular events, including myocardial infarction (MI), stroke, or venous thromboembolism (VTE)...
September 10, 2023: Arthritis Care & Research
#11
JOURNAL ARTICLE
Jose Manuel Mascaro, Ignasi Rodriguez-Pinto, Gabriela Poza, Anna Mensa-Vilaro, Julian Fernandez-Martin, Luis Caminal-Montero, Gerard Espinosa, Jose Hernández-Rodríguez, Marina Diaz, Joana Rita-Marques, Raimon Sanmarti, Santos Castañeda, Dolores Colunga, Rubén Coto-Hernández, Patricia Fanlo, Jose Ignacio Elejalde, Segundo Bujan, Ignasi Figueras, Francisco Manuel Marco, Mariano Andrés, Silvia Suárez, Andres Gonzalez-Garcia, Xavier Fustà-Novell, Clara Garcia-Belando, Ana Granados, Maria Teresa Fernandez-Figueras, Neus Quilis, Maria Orriols-Caba, Ricardo Gómez de la Torre, Maria Cinta Cid, Georgina Espígol-Frigolé, Alba Alvarez-Abella, Eztizen Labrador, Maria Rozman, Monica Lopez-Guerra, Paola Castillo, Jose R Alamo-Moreno, Eva Gonzalez-Roca, Susana Plaza, Virginia Fabregat, Rocio Lara, Esther F Vicente-Rabaneda, Sonia Tejedor-Vaquero, Giuliana Magri, Nuria Bonet, Manuel Solis-Moruno, Andrea Cerutti, Oscar Fornas, Ferran Casals, Jordi Yagüe, Juan I Aróstegui
BACKGROUND: The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease (AID) due to postzygotic UBA1 variants. OBJECTIVES: To investigate the presence of VEXAS syndrome among patients with adult-onset undiagnosed AID. Additional studies evaluated the mosaicism distribution and the circulating cytokines. METHODS: Gene analyses were performed by both Sanger and amplicon-based deep sequencing...
December 2023: Annals of the Rheumatic Diseases
#12
REVIEW
Adla B Hassan, Reham F Hozayen, Zahra S Mustafa, Ingrid E Lundberg, Haitham A Jahrami
OBJECTIVES: The prevalence and outcome of mixed connective tissue disease-associated pulmonary arterial hypertension (MCTD-PAH) has not been well understood. Our aim was to review the current knowledge on the prevalence, severity, and mortality of MCTD-PAH. We also aimed to examine the prevalence trend of MCTD-PAH over the years. METHODS: PubMed/Medline, Embase, Scopus and Web of Science electronic databases were searched for the published randomised controlled clinical trials (RCTs) and observational/original studies on PAH in patients with MCTD from January 1972 to December 2020...
July 24, 2023: Clinical and Experimental Rheumatology
#13
REVIEW
Shervin Assassi, Sudhakar Tumuluri, Robert W Levin
The SENSCIS trial of nintedanib versus placebo is the largest trial conducted to date in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). This trial enrolled 576 patients with an extent of fibrotic ILD on high-resolution computed tomography of >10%. Median time since first non-Raynaud symptom was 3.4 years. Almost half of the patients were receiving a stable dose of mycophenolate at baseline. Key findings of the trial included that at baseline, despite having significant lung fibrosis on HRCT and impairment in lung function, 20% of the patients did not have cough and 30% did not have dyspnoea...
August 2023: Clinical and Experimental Rheumatology
#14
COMMENT
Bruno Fautrel
No abstract text is available yet for this article.
October 2023: Nature Reviews. Rheumatology
#15
REVIEW
Changming Zhang, Jiahui Peng, Zhihong Liu, Qing Zhou
BACKGROUND: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and caused by dysregulation of the innate immune system, leading to episodes of systemic inflammation. Advances in next-generation sequencing and biological technology have resulted in the identification of new monogenic diseases and the corresponding signaling pathways that may guide us in targeted therapy. The kidney is a major target organ of various inflammatory processes. SUMMARY: During systemic inflammation, increased pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF, lead to over-transcription and release of acute phase reactant serum amyloid A (SAA)...
May 2023: Kidney Diseases
#16
JOURNAL ARTICLE
Philippe Guilpain
No abstract text is available yet for this article.
August 4, 2023: Rheumatology
#17
JOURNAL ARTICLE
Amy Robison
No abstract text is available yet for this article.
August 4, 2023: Science
#18
JOURNAL ARTICLE
Abhishek Abhishek, Sara K Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang-Korng Ea, Georgios Filippou, John Fitzgerald, AnnaMaria Iagnocco, Frédéric Lioté, Geraldine M McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andrés, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L Jansen, Minna J Kohler, Lisa K Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A Fang, Fabiana A Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M Navarro, Piercarlo Sarzi-Puttini, Carlo Scirè, Ettore Silvagni, Silvia Sirotti, John R Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M Hendry, Robert Terkeltaub, William J Taylor, Hyon K Choi
OBJECTIVE: Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease. METHODS: Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria...
October 2023: Annals of the Rheumatic Diseases
#19
COMPARATIVE STUDY
Natalie McCormick, Chio Yokose, Jie Wei, Na Lu, Deborah J Wexler, J Antonio Aviña-Zubieta, Mary A De Vera, Yuqing Zhang, Hyon K Choi
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2is) decrease serum urate levels, but whether this translates into prevention of recurrent flares among patients with gout and gout-primary emergency department (ED) visits or hospitalizations is unknown. OBJECTIVE: To compare gout flares and cardiovascular events among patients with gout initiating SGLT2is versus dipeptidyl peptidase 4 inhibitors (DPP-4is), another second-line glucose-lowering agent not associated with serum urate levels or cardiovascular risk...
August 2023: Annals of Internal Medicine
#20
REVIEW
Norihisa Mikami, Shimon Sakaguchi
Regulatory T (Treg ) cells that express the transcription factor forkhead box protein P3 (FOXP3) are naturally present in the immune system and have roles in the maintenance of immunological self-tolerance and immune system and tissue homeostasis. Treg cells suppress T cell activation, expansion and effector functions by various mechanisms, particularly by controlling the functions of antigen-presenting cells. They can also contribute to tissue repair by suppressing inflammation and facilitating tissue regeneration, for example, via the production of growth factors and the promotion of stem cell differentiation and proliferation...
September 2023: Nature Reviews. Nephrology
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