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By Ellen Pappas Aspiring physician
Lingxia Ha, Yuhua Shi, Junli Zhao, Tao Li, Zi-Jiang Chen
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders. Evidence of familial aggregation analysis and different clinical traits among different regions and ethnicities indicated that the pathogenesis of PCOS is associated with multiple genetic and environmental factors. Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA) for PCOS in Han Chinese women. The overall aim of this study was to investigate the relationship between three susceptibility gene polymorphisms and PCOS in Hui ethnic women...
2015: PloS One
Francesca Colonese, Antonio Simone Laganà, Elisabetta Colonese, Vincenza Sofo, Francesca Maria Salmeri, Roberta Granese, Onofrio Triolo
The traditionally recognized role of vitamin D consists in the regulation of bone metabolism and calcium-phosphorus homeostasis but recently a lot of in vitro and in vivo studies recognized several "noncalcemic" effects of vitamin D metabolites. Accumulating evidence suggests that the metabolic pathways of this vitamin may play a key role in the developing of gynaecological/obstetric diseases. VDR-mediated signalling pathways and vitamin D levels seem to (deeply) affect the risk of several gynaecological diseases, such as polycystic ovary syndrome (PCOS), endometriosis, and ovarian and even breast cancer...
2015: BioMed Research International
Lúcia Alves Silva Lara, Fabiene Karine Piccki Ramos, Gislaine Satiko Kogure, Rafael Silva Costa, Marcos Felipe Silva de Sá, Rui Alberto Ferriani, Rosana Maria dos Reis
INTRODUCTION: There is a need for specific measures to address overall care in women with polycystic ovary syndrome (PCOS). Physical resistance training (PRT) has been shown to improve certain body parameters. However, the effect of PRT on the sexual function of PCOS women has not been evaluated. AIM: The study aimed to assess sexual function and emotional status of PCOS women after 16 weeks of PRT. METHODS: This case-control study involved 43 women with PCOS and 51 control ovulatory women, aged 18-37 years...
July 2015: Journal of Sexual Medicine
Nilgün Güdücü, Salih Serdar Kutay, Uzay Görmüş, Zehra Neşe Kavak, İlkkan Dünder
AIMS: To demonstrate the effects of DHEAS/free testosterone (DHEAS/FT) ratio on metabolic parameters in women with and without polycystic ovary syndrome (PCOS). METHODS: The data of 91 women with PCOS and 66 women in the control group were collected retrospectively. RESULTS: DHEAS/FT of the control group was higher than that of PCOS group (684.93 ± 300.54 to 517.2 ± 300.8, p < 0.001). DHEAS/FT correlated with BMI (r = -0...
June 2015: Gynecological Endocrinology
Voahanginirina Randriamboavonjy, W Alexander Mann, Amro Elgheznawy, Rüdiger Popp, Paul Rogowski, Imke Dornauf, Stefan Dröse, Ingrid Fleming
Polycystic ovary syndrome (PCOS) is associated with decreased fertility, insulin resistance and an increased risk of developing cardiovascular disease. Treating PCOS patients with metformin improves fertility and decreases cardiovascular complications. Given that platelet activation contributes to both infertility and cardiovascular disease development, we assessed platelet reactivity in PCOS patients and the consequences of metformin treatment. Compared to washed platelets from healthy donors, platelets from PCOS patients demonstrated enhanced reactivity and impaired activation of the AMP-activated kinase (AMPK)...
August 31, 2015: Thrombosis and Haemostasis
Dorota A Doherty, John P Newnham, Carol Bower, Roger Hart
OBJECTIVE: To study the influence of polycystic ovary syndrome (PCOS) on obstetric and perinatal outcomes and on offspring in childhood. METHODS: Using statewide data linkage systems within Western Australia, 2,566 hospitalized women with a PCOS diagnosis and at least one pregnancy at 20 weeks of gestation or greater, between 1997 and 2011, were compared with 25,660 randomly selected age-matched women not hospitalized with a PCOS diagnosis with regard to perinatal outcomes, congenital anomalies, and general health of offspring...
June 2015: Obstetrics and Gynecology
Morena Luigia Rocca, Roberta Venturella, Rita Mocciaro, Annalisa Di Cello, Angela Sacchinelli, Valentina Russo, Simona Trapasso, Fulvio Zullo, Michele Morelli
INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disease among women of childbearing age. The clinical features are heterogeneous and vary in intensity. Hirsutism, menstrual disorders and infertility are the most frequent conditions observed; however, long-term complications (dyslipidemia, hypertension, cardiovascular disease, type 2 diabetes mellitus, endometrial cancer) are also often described. Each disorder may be managed by tailored strategies, employing sequential or combined pharmacological and/or non-pharmacological treatment...
June 2015: Expert Opinion on Pharmacotherapy
Mohammad Amin Rezvanfar, Sarah Saeedi, Parisa Mansoori, Sepideh Saadat, Maziar Goosheh, Habib A Shojaei Saadi, Maryam Baeeri, Mohammad Abdollahi
CONTEXT: It is now clear that oxidative stress (OS) and chronic low-grade inflammation are two main pathways involved in polycystic ovary syndrome (PCOS) pathogenesis. Therefore, simultaneous targeting of these pathways by means of carvedilol and Semelil (ANGIPARS™), as established medicines with dual anti-cytokine and anti-oxidant potential may be a therapeutic alternative approach to the current treatments. OBJECTIVE: The objective of this study is to study the protective effects of carvedilol and ANGIPARS™ on inflammatory and oxidative response in hyperandrogenism-induced polycystic ovary (PCO)...
2016: Pharmaceutical Biology
Roberta Venturella, Daniela Lico, Alessia Sarica, Maria Pia Falbo, Elio Gulletta, Michele Morelli, Errico Zupi, Gabriele Cevenini, Mario Cannataro, Fulvio Zullo
BACKGROUND: In the last decade, both endocrine and ultrasound data have been tested to verify their usefulness for assessing ovarian reserve, but the ideal marker does not yet exist. The purpose of this study was to find, if any, a statistical advanced model able to identify a simple, easy to understand and intuitive modality for defining ovarian age by combining clinical, biochemical and 3D-ultrasonographic data. METHODS: This is a population-based observational study...
April 8, 2015: Journal of Ovarian Research
Zeynep Ozcan Dag, Omer Oguzturk, Yuksel Isik, Yakup Turkel, Emel Bulcun
AIM: To investigate the personality traits of patients with polycystic ovary syndrome (PCOS). METHODS: Forty-nine patients with PCOS and 34 healthy controls were enrolled in the study. Psychometric evaluation was made with the Minnesota Multiphasic Personality Inventory. Additionally, Short Form-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) were also performed. RESULTS: Polycystic ovary syndrome patients had significantly higher absolute and clinical elevation scores on depression, hysteria, psychasthenia and hypomania compared with the controls...
July 2015: Gynecological Endocrinology
Antonio Cianci, Marco Panella, Michele Fichera, Cristina Falduzzi, Manuela Bartolo, Salvatore Caruso
AIM: To evaluate the effects of the combination of d-chiro-inositol (DCI) and alpha lipoic acid on menses and metabolic disorders in women with polycystic ovary syndrome (PCOS). METHODS: Forty-six women (26 study group subjects and 20 controls) of reproductive age with PCOS according to Rotterdam criteria were enrolled in this prospective study. Fasting serum samples were collected from each woman. Homeostasis model of insulin resistance, insulin levels, lipid profile, frequency of menstrual cycles, number of ovarian peripheral cysts and BMI of both groups were investigated at baseline and after 180 days...
June 2015: Gynecological Endocrinology
Lan Li, Ji Eun Ryoo, Kyung-Ju Lee, Bum-Chae Choi, Kwang-Hyun Baek
Monocyte chemoattractant protein-1 (MCP-1) is a pivotal chemokine in the inflammatory response, which plays an important role in recruiting monocytes to sites of injury and infection. However, the exact mechanism of Mcp-1 associated with PCOS risk was unknown. In this study, we explored whether the Mcp-1 -2518G>A polymorphism increases the risk of PCOS. We performed a comparative study of -2518G>A polymorphism of the Mcp-1 gene with PCOS. In addition, luciferase reporter assay was performed to evaluate the Mcp-1 transcriptional activity...
2015: PloS One
Ashraf Moini, Nooshin Shirzad, Marzieh Ahmadzadeh, Reihaneh Hosseini, Ladan Hosseini, Shahideh Jahanian Sadatmahalleh
BACKGROUND: Given the relationship of vitamin D deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (PCOS), the main aim of this study was to compare serum level of 25hydroxyvitamin D [25(OH)D] between PCOS patients and normal individuals. MATERIALS AND METHODS: A cross sectional study was conducted to compare 25(OH)D level between117 normal and 125 untreated PCOS cases at our clinic in Arash Hospital, Tehran, Iran, during 2011-2012...
April 2015: International Journal of Fertility & Sterility
Elisabeth A Lambert, Helena Teede, Carolina Ika Sari, Eveline Jona, Soulmaz Shorakae, Kiri Woodington, Robyn Hemmes, Nina Eikelis, Nora E Straznicky, Barbora De Courten, John B Dixon, Markus P Schlaich, Gavin W Lambert
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrine condition underpinned by insulin resistance and associated with increased risk of obesity, type 2 diabetes and adverse cardiovascular risk profile. Previous data suggest autonomic imbalance [elevated sympathetic nervous system (SNS) activity and decreased heart rate variability (HRV)] as well as endothelial dysfunction in PCOS. However, it is not clear whether these abnormalities are driven by obesity and metabolic disturbance or whether they are independently related to PCOS...
December 2015: Clinical Endocrinology
Abdulrahim Rouzi, Mohammed Saleh Ardawi
INTRODUCTION: To examine the effect of vitamin D3 supplementation on the changes in serum receptor for advanced glycation end products (sRAGE) and serum anti-Müllerian hormone (AMH) among vitamin D-deficient women with polycystic ovary syndrome (PCOS). METHODS: A total of 136 women with (n=68) or without (age-matched control; n=68) PCOS who were diagnosed with vitamin D deficiency were studied. All participants received supplemental oral vitamin D3 (50,000 international units/wk) for 8 weeks, followed by 1,000 international units vitamin D3 supplementation for 16 weeks...
May 2015: Obstetrics and Gynecology
Jeong Hyun Kim, Cecilia Karin Wieslander, Christine H Holschneider, Catherine M Crespi
OBJECTIVE: Current American College of Obstetricians and Gynecologists guidelines recommend performing endometrial sampling in women with abnormal uterine bleeding (AUB) who are 45 years and older. However, there is little evidence supporting this age cutoff. We thus aimed to determine whether age is an independent risk factor for endometrial hyperplasia or cancer in premenopausal women with AUB. METHODS: A retrospective review was performed on premenopausal women with AUB who underwent endometrial sampling from March 2008 to December 2009...
May 2015: Obstetrics and Gynecology
L Li, K-H Baek
Polycystic ovary syndrome (PCOS) is a complex genetic disorder caused by interplay between several 'susceptibility' genes and environment factors. In the past few years, numerous studies of genomics and transcriptomics attempted to discover genes affecting PCOS. Pre-genome wide association study (GWAS) plays a stepping stone effect on the progress of PCOS, even though most of the strongest associations are for loci rather than functional variants. A trend towards large-scale GWAS has succeeded in identifying many additional novel PCOS loci...
2015: Current Molecular Medicine
Ying-Ying Yu, Cui-Xiang Sun, Yin-Kun Liu, Yan Li, Li Wang, Wei Zhang
OBJECTIVE: To compare genome-wide DNA methylation profiles in ovary tissue from women with polycystic ovary syndrome (PCOS) and healthy controls. DESIGN: Case-control study matched for age and body mass index. SETTING: University-affiliated hospital. PATIENT(S): Ten women with PCOS who underwent ovarian drilling to induce ovulation and 10 healthy women who were undergoing laparoscopic sterilization, hysterectomy for benign conditions, diagnostic laparoscopy for pelvic pain, or oophorectomy for nonovarian indications...
July 2015: Fertility and Sterility
Lisa J Moran, R L Thomson, J D Buckley, M Noakes, P M Clifton, R J Norman, G D Brinkworth
Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged women with features including hyperandrogenism and menstrual irregularity frequently treated with hormonal steroidal contraceptives. Women with PCOS appear to have lower bone mineral density (BMD). While steroidal contraceptives may positively affect bone health, their effect on BMD in PCOS is not known. The aim of this study was to assess BMD in women with PCOS according to recent contraceptive use. A cross-sectional analysis of 95 pre-menopausal overweight or obese sedentary women with PCOS [age 29...
December 2015: Endocrine
Zeina Haoula, Srinivasarao Ravipati, Dov J Stekel, Catharine A Ortori, Charlie Hodgman, Clare Daykin, Nick Raine-Fenning, David A Barrett, William Atiomo
Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagnostic. A lipidomic approach using liquid chromatography coupled with accurate mass high-resolution mass-spectrometry (LC-HRMS) was used to investigate if there were any differences in plasma lipidomic profiles in women with PCOS compared with control women at different stages of menstrual cycle...
2015: Metabolomics: Official Journal of the Metabolomic Society
2015-05-17 21:32:27
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