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By Marcio Fossari Neonatologist in Brazil, Itajaí, Intensive care of micropremmie. A very long compromise for maternal-newborn care.
https://www.readbyqxmd.com/read/27626474/micronutrient-supplementation-adherence-and-influence-on-the-prevalences-of-anemia-and-iron-zinc-and-vitamin-a-deficiencies-in-preemies-with-a-corrected-age-of-six-months
#1
Brunnella Alcantara Chagas de Freitas, Luciana Moreira Lima, Maria Elisabeth Lopes Moreira, Silvia Eloiza Priore, Bruno David Henriques, Carla Fernanda Lisboa Valente Carlos, Jusceli Souza Nogueira Sabino, Sylvia do Carmo Castro Franceschini
OBJECTIVE: To analyze adherence to the recommended iron, zinc and multivitamin supplementation guidelines for preemies, the factors associated with this adherence, and the influence of adherence on the occurrence of anemia and iron, zinc and vitamin A deficiencies. METHODS: This prospective cohort study followed 58 preemies born in 2014 until they reached six months corrected age. The preemies were followed at a referral secondary health service and represented 63...
August 2016: Clinics
https://www.readbyqxmd.com/read/27130217/quality-of-ehr-data-extractions-for-studies-of-preterm-birth-in-a-tertiary-care-center-guidelines-for-obtaining-reliable-data
#2
Lindsey A Knake, Monika Ahuja, Erin L McDonald, Kelli K Ryckman, Nancy Weathers, Todd Burstain, John M Dagle, Jeffrey C Murray, Prakash Nadkarni
BACKGROUND: The use of Electronic Health Records (EHR) has increased significantly in the past 15 years. This study compares electronic vs. manual data abstractions from an EHR for accuracy. While the dataset is limited to preterm birth data, our work is generally applicable. We enumerate challenges to reliable extraction, and state guidelines to maximize reliability. METHODS: An Epic™ EHR data extraction of structured data values from 1,772 neonatal records born between the years 2001-2011 was performed...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27074377/zika-virus-and-birth-defects-reviewing-the-evidence-for-causality
#3
Sonja A Rasmussen, Denise J Jamieson, Margaret A Honein, Lyle R Petersen
Summary. The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse pregnancy and birth outcomes, most notably microcephaly and other serious brain anomalies. To determine whether Zika virus..
May 19, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26845716/computerized-vital-signs-analysis-and-late-onset-infections-in-extremely-low-gestational-age-infants
#4
Leena Bhattacharya Mithal, Ram Yogev, Hannah Palac, Ilan Gur, Karen K Mestan
AIM: Current clinical and laboratory diagnostics for neonatal infection are inadequate. An infant's systemic inflammatory response may be identified earlier than clinical suspicion by a computerized algorithm (RALIS) incorporating multiple vital signs (VS). We tested the ability of RALIS to detect late onset infection (LOI) earlier than clinically suspected. METHODS: We conducted a retrospective review of infants enrolled in a birth cohort study at Prentice Women's Hospital...
July 1, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/26044104/inhalation-or-instillation-of-steroids-for-the-prevention-of-bronchopulmonary-dysplasia
#5
REVIEW
Dirk Bassler
Survival of extremely preterm infants has increased over recent years, but bronchopulmonary dysplasia (BPD) remains a major cause of morbidity. In the USA, BPD is the most common chronic respiratory disorder of infancy and affects the pulmonary and overall health of 10,000 preterm infants annually. Preclinical and clinical studies suggest a crucial role for lung inflammation and host immune response in the pathogenesis of BPD. Inflammation may result from, amongst others, chorioamnionitis, postnatal infection, ventilation, and the administration of oxygen...
2015: Neonatology
https://www.readbyqxmd.com/read/25721501/meconium-aspiration-syndrome-possible-pathophysiological-mechanisms-and-future-potential-therapies
#6
REVIEW
Paal Helge Haakonsen Lindenskov, Albert Castellheim, Ola Didrik Saugstad, Tom Eirik Mollnes
Does meconium cause meconium aspiration syndrome (MAS) or is meconium discharge only a marker of fetal hypoxia? This dispute has lasted for centuries, but since the 1960s, detrimental effects of meconium itself on the lungs have been demonstrated in animal experiments. In clinical MAS, persistent pulmonary hypertension of the newborn is the leading cause of death in MAS. Regarding the complex chemical composition of meconium, it is difficult to identify a single agent responsible for the pathophysiology. However, considering that meconium is stored in the intestines, partly unexposed to the immune system, aspirated meconium could be recognized as ‘danger', representing damaged self...
2015: Neonatology
https://www.readbyqxmd.com/read/25683599/establishing-a-hypothermia-service-for-infants-with-suspected-hypoxic-ischemic-encephalopathy
#7
REVIEW
Elie Saliba, Nadine Fakhri, Thierry Debillon
The translation of new treatments based upon established evidence into clinical practice is often difficult. The establishment of a therapeutic hypothermia (TH) service and a related cooling register would provide the opportunity to examine how a new therapy becomes implemented in a country or region. The objectives of a TH program should be: to provide guidance to clinicians who are considering the introduction of this new therapy; to ensure standardized clinical practices; to audit the implementation and conduct of TH; to provide surveillance for cooling-related adverse effects; and to evaluate the subsequent neurodevelopmental outcome...
April 2015: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25683598/seizures-and-hypothermia-importance-of-electroencephalographic-monitoring-and-considerations-for-treatment
#8
REVIEW
Geraldine B Boylan, Liudmila Kharoshankaya, Courtney J Wusthoff
Hypoxic-ischemic encephalopathy is a common cause of seizures in neonates. Despite the introduction of therapeutic hypothermia, seizure rates are similar to those reported in the pre-therapeutic hypothermia era. However, the seizure profile has been altered resulting in a lower overall seizure burden, shorter individual seizure durations, and seizures that are harder to detect. Electroencephalographic (EEG) monitoring is the gold standard for detecting all seizures in neonates and this is even more critical in neonates who are cooled, as they are often sedated, making seizures more difficult to detect...
April 2015: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25667126/who-should-we-cool-after-perinatal-asphyxia
#9
REVIEW
Marianne Thoresen
Three ongoing challenges have arisen after the introduction of therapeutic hypothermia (TH) as standard of care for term newborns with moderate or severe perinatal asphyxia: (i) to ensure that the correct group of infants are cooled; (ii) to optimize the delivery of TH and intensive care in relation to the severity of the encephalopathy; (iii) to systematically follow up the long-term efficacy of TH using comparable outcome data between centers and countries. This review addresses the entry criteria for TH, and discusses potential issues regarding patient selection, and management of TH: cooling mild, moderate, and very severe perinatal asphyxia, cooling longer or deeper, and/or starting with a greater delay...
April 2015: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25032803/intrapartum-ultrasound-prior-to-kristeller-maneuver-an-observational-study
#10
Marcos Javier Cuerva, Pablo Tobias, Jose Angel Espinosa, Jose Luis Bartha
OBJECTIVES: To evaluate the accuracy of criteria followed by obstetricians when performing a Kristeller maneuver in cases of prolonged second stage of labor. METHODS: In this prospective observational study, the station of the fetal head was measured using the angle of progression (intrapartum ultrasound) just prior to the intervention of the managing obstetrician in 52 women with prolonged second stage of labor. The managing obstetricians were blinded to the sonographic results...
March 2015: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/23642047/oxygen-saturation-and-outcomes-in-preterm-infants
#11
RANDOMIZED CONTROLLED TRIAL
Ben J Stenson, William O Tarnow-Mordi, Brian A Darlow, John Simes, Edmund Juszczak, Lisa Askie, Malcolm Battin, Ursula Bowler, Roland Broadbent, Pamela Cairns, Peter Graham Davis, Sanjeev Deshpande, Mark Donoghoe, Lex Doyle, Brian W Fleck, Alpana Ghadge, Wendy Hague, Henry L Halliday, Michael Hewson, Andrew King, Adrienne Kirby, Neil Marlow, Michael Meyer, Colin Morley, Karen Simmer, Win Tin, Stephen P Wardle, Peter Brocklehurst
BACKGROUND: The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS: In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a range of 91 to 95%, on disability-free survival at 2 years in infants born before 28 weeks' gestation...
May 30, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/21631323/saliva-polymerase-chain-reaction-assay-for-cytomegalovirus-screening-in-newborns
#12
MULTICENTER STUDY
Suresh B Boppana, Shannon A Ross, Masako Shimamura, April L Palmer, Amina Ahmed, Marian G Michaels, Pablo J Sánchez, David I Bernstein, Robert W Tolan, Zdenek Novak, Nazma Chowdhury, William J Britt, Karen B Fowler
BACKGROUND: Congenital cytomegalovirus (CMV) infection is an important cause of hearing loss, and most infants at risk for CMV-associated hearing loss are not identified early in life because of failure to test for the infection. The standard assay for newborn CMV screening is rapid culture performed on saliva specimens obtained at birth, but this assay cannot be automated. Two alternatives--real-time polymerase-chain-reaction (PCR)-based testing of a liquid-saliva or dried-saliva specimen obtained at birth--have been developed...
June 2, 2011: New England Journal of Medicine
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