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By Mario Garcia Médico pediatra
Deanna Menapace, Mario Mitkov, Richard Towbin, Marcia Hogeling
Infantile hemangiomas are the most common vascular tumors of infancy. A multidisciplinary approach including dermatologists, otolaryngologists, plastic surgeons, hematologists/oncologists and interventional/diagnostic radiologists is crucial for appropriate management of children with complicated infantile hemangiomas. Since its unforeseen discovery in 2008, propranolol has become the first-line treatment for infantile hemangiomas, eclipsing systemic corticosteroids and radiologic intervention. There are still, however, uncommon indications for more aggressive interventional management...
October 2016: Pediatric Radiology
William J Muller
Viral infections in the fetus or newborn often involve the central nervous system (CNS) and can lead to significant morbidity and mortality. Substantial progress has been made in identifying interventions decreasing adverse neurodevelopmental outcomes in this population. This review highlights progress in treatment of important viruses affecting the CNS in these susceptible hosts, focusing on herpes simplex virus (HSV), cytomegalovirus (CMV), human immunodeficiency virus (HIV), and enteroviruses. The observation that high-dose acyclovir improves mortality in neonatal HSV disease culminated decades of antiviral research for this disease...
January 2017: Pediatric Research
Michael Radke, Jean-Charles Picaud, Andrea Loui, Gilles Cambonie, Dirk Faas, Harry N Lafeber, Nanda de Groot, Sophie S Pecquet, Philippe G Steenhout, Jean-Michel Hascoet
BACKGROUND: Prebiotics and probiotics exert beneficial effects by modulating gut microbiota and immune system. This study evaluates efficacy and safety of an infant formula containing bovine milk-derived oligosaccharides and Bifidobacterium animalis ssp lactis (B. lactis) (CNCM I-3446) on incidence of diarrhea and febrile infections during the first year of life (primary outcome). METHODS: Full-term infants receiving Test or Control (without bovine milk-derived oligosaccharide and B...
April 2017: Pediatric Research
W Allan Walker
The fetus does not reside in a sterile intrauterine environment and is exposed to commensal bacteria from the maternal gut/blood stream that cross the placenta and enter the amniotic fluid. This intestinal exposure to colonizing bacteria continues at birth and during the first year of life and has a profound influence on lifelong health. Why is this important? Intestinal crosstalk with colonizing bacteria in the developing intestine affects the infant's adaptation to extrauterine life (immune homeostasis) and provides protection against disease expression (allergy, autoimmune disease, obesity, etc...
May 17, 2017: Pediatric Research
Chih-Heng Hung, Yi-Chun Chen, Shun-Ling Lin, Wei-Lun Chen
BACKGROUND: To report the success rates of office probing for congenital nasolacrimal duct obstruction (NLDO) among children of different age groups in Taiwan. METHODS: In this single-center, retrospective study, 564 eyes of 477 patients under the age of 5 years diagnosed with congenital NLDO were treated in a stepwise manner between 2001 and 2013. For infants aged < 6 months, treatment with massage and observation was suggested, followed by deferred probing under topical anesthesia if symptoms persisted...
December 2015: Pediatrics and Neonatology
Eva Lai-Wah Fung, Sandy Ka-Yin Chang, Karen Kwan-Ming Yam, Phyllis Yin-Ping Yau
No abstract text is available yet for this article.
December 2015: Pediatrics and Neonatology
Chang-Teng Wu, Hao-Yuan Lee, Chyi-Liang Chen
No abstract text is available yet for this article.
February 2016: Pediatrics and Neonatology
Shu-Fen Wu, Hsiang-Yu Lin, Fu-Kuei Huang, An-Chyi Chen, Bai-Horng Su, Chia-Ing Li, Hung-Chih Lin
BACKGROUND: Infantile hypertrophic pyloric stenosis (IHPS) is a common disease in infancy. Pyloromyotomy is universally considered the treatment for IHPS; however, oral or intravenous atropine has been reappraised for the treatment of IHPS in the past 20 years. We investigated the efficacy of atropine in the medical management of IHPS by using meta-analysis and investigated the sonographic changes of the pyloric canal, as well as the efficacy and adverse effects of atropine. METHODS: Information was retrieved from PubMed, Ovid, and MEDLINE...
December 2016: Pediatrics and Neonatology
Chien-Yu Huang, Po-Nien Tsao
No abstract text is available yet for this article.
December 2016: Pediatrics and Neonatology
Ching-Lun Chen, Hsun-Chin Chao, Man-Shan Kong, Shih-Yen Chen
BACKGROUND: With effective antibiotics against enteric flora and computed tomography-guided drainage for abscesses, the initial use of nonoperative therapy for children with appendicitis has increased both in recent reports and at our hospital. However, it has been reported that these patients have a relatively longer hospital stay and that their treatment is more expensive than those who undergo aggressive surgical intervention. METHODS: This was a retrospective cohort study based in a single medical center...
June 2017: Pediatrics and Neonatology
Yu-Chieh Chen, Ying-Hua Huang, Jiunn-Ming Sheen, You-Lin Tain, Hong-Ren Yu, Chih-Cheng Chen, Miao-Meng Tiao, Ho-Chang Kuo, Li-Tung Huang
BACKGROUND: There is increasing epidemiological evidence indicating that many chronic diseases originate during early life, even before birth, through what are termed fetal programming effects. Prenatal glucocorticoid is frequently used clinically to accelerate the maturation of the lung, but its long-term effects remain unclear. METHODS: We gave pregnant Sprague-Dawley rats either intraperitoneal dexamethasone (0.1 mg/kg body weight) or vehicle at Gestational Days 14-20 and assessed the effects to pancreas at Postnatal Days 7 and 120...
April 2017: Pediatrics and Neonatology
Chun-Yi Lu, Li-Min Huang
No abstract text is available yet for this article.
October 2016: Pediatrics and Neonatology
Daniele Masarone, Fabio Valente, Marta Rubino, Rossella Vastarella, Rita Gravino, Alessandra Rea, Maria Giovanna Russo, Giuseppe Pacileo, Giuseppe Limongelli
Pediatric heart failure represents an important cause of morbidity and mortality in childhood. Currently, there are well-established guidelines for the management of heart failure in the adult population, but an equivalent consensus in children is lacking. In the clinical setting, ensuring an accurate diagnosis and defining etiology is essential to optimal treatment. Diuretics and angiotensin-converting enzyme inhibition are the first-line therapies, whereas beta-blockers and devices for electric therapy are less used in children than in adults...
August 2017: Pediatrics and Neonatology
Kazuaki Nagashima, Daisuke Tanaka, Nobuya Inagaki
Neonatal diabetes mellitus (NDM) is a rare but potentially devastating metabolic disorder, with a reported incidence of one per 300 000-500 000 births generally, and hyperglycemia develops within the first 6 months of life. NDM is classified into two categories clinically. One is transient NDM (TNDM), in which insulin secretion is spontaneously recovered by several months of age, but sometimes recurs later, and the other is permanent NDM (PNDM), requiring lifelong medication. Recent molecular analysis of NDM identified at least 12 genetic abnormalities: chromosome 6q24, KCNJ11, ABCC8, INS, FOXP3, GCK, IPF1, PTF1A, EIF2AK3, GLUT2, HNF1β, and GLIS3...
February 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Tsuyoshi Kaneko, Satoru Sasaki, Naoko Baba, Katsuyoshi Koh, Kiyoshi Matsui, Hiroyuki Ohjimi, Nobukazu Hayashi, Atsuko Nakano, Kentaro Ohki, Yoshihiro Kuwano, Akira Morimoto, Zenshiro Tamaki, Mariko Kakazu, Kazuo Kishi, Tomoki Oyama, Atsushi Sato, Rumiko Kato, Takeshi Higuchi
BACKGROUND: There have been few reports on the efficacy and safety of oral propranolol at 3 mg/kg/day for infantile hemangioma (IH) in Japanese patients. METHODS: A multicenter, open-label phase III study was conducted to evaluate the efficacy and safety of oral propranolol solution in Japanese infants aged 35-150 days with proliferating IH. Thirty-two patients were enrolled in the study, received propranolol solution for 24 weeks at 3 mg/kg/day, and completed the study...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Yosuke Taguchi, Shigeharu Hosono, Kazunori Kayama, Ryota Kato, Kotaro Hine, Nobuhiko Nagano, Kayo Yoshikawa, Shigeru Takahashi, Shori Takahashi
BACKGROUND: During the neonatal resuscitation, careful oxygenation is needed. The use of pulse oximetry is recommended to evaluate the need for oxygenation, but it is not clear whether adequate peripheral perfusion is established to allow the evaluation of arterial oxygen saturation (SpO2). Additionally, there is no study of the changes in SpO2 immediately after birth in Japan, despite the indispensable need for definitive oxygenation criteria. METHODS: A prospective observational study was performed in neonates with gestational ages of 35-41 weeks...
July 17, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Guillermo José Ruiz-Argüelles
In the last 60 years, there have been substantial advances regarding the diagnosis and treatment of patients with acute and chronic leukemia in Mexico. Immunologic and molecular classifications of these diseases have improved both diagnosis and therapeutic capabilities. Although the pace of diagnostic and therapeutic advances has been slower compared with developed countries, Mexico is at the forefront among developing countries. Supporting research in these fields is expected to enhance the generation of new knowledge and improve the care of patients suffering from these diseases...
April 2016: Salud Pública de México
Miguel E Cervera-Hernández, Anabel Ordaz-Vázquez, Pedro Torres-González, Bárbara Chávez-Mazari, Orbelin Soberanis-Ramos, José Sifuentes-Osornio, Alfredo Ponce de León, Miriam Bobadilla-Del Valle
OBJECTIVE: To describe the seroprevalence and associated factors for brucellosis among dairy farm workers. MATERIALS AND METHODS: We performed a secondary analysis of a data set and sera from a previous cross-sectional study in a dairy farm. Sera were tested for Brucella spp. antibodies by the slide agglutination test. Seropositivity was defined as a titer ≥1:40; recent infection was titers ≥1:160. RESULTS: We tested 331 human sera. Seroprevalence of brucellosis was 18...
June 2016: Salud Pública de México
Gerardo Álvarez-Hernández, María Del Carmen Candia-Plata, Jesús Delgado-de la Mora, Natalia Haydeé Acuña-Meléndrez, Anabel Patricia Vargas-Ortega, Jesús David Licona-Enríquez
OBJECTIVE: Characterize clinical manifestations and predictors of mortality in children hospitalized for spotted fever. MATERIALS AND METHODS: Cross-sectional study in 210 subjects with a diagnosis of Rocky Mountain spotted fever (RMSF) in a pediatric hospital in Sonora, from January 1st, 2004 to June 30th, 2015. Data were analyzed using descriptive statistics and multivariate logistic regression. RESULTS: An upward trend was observed in RMSF morbidity and mortality...
June 2016: Salud Pública de México
Jair Jesús Sánchez-Valdés, Vianey Colín-Navarro, Felipe López-González, Francisca Avilés-Nova, Octavio Alonso Castelán-Ortega, Julieta Gertrudis Estrada-Flores
OBJECTIVE: To determine the prevalence and the degree of contamination by molds and yeasts (M&Y), aerobic mesophilic bacteria (AMB), total coliforms (TC) and Salmonella spp. (S). These microorganisms were considered indicators of quality and hygiene in the manufacturing environment of Zacazonapan cheese. MATERIALS AND METHODS: Samples from five cheese dairies at Zacazonapan municipality were collected. The samples were collected directly from hands, water, milk, curd, cheese and surface of utensils for cheese making...
August 2016: Salud Pública de México
2017-08-08 14:48:21
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