Read by QxMD icon Read


shared collection
7 papers 0 to 25 followers
Sara Kenyon, Peter Brocklehurst, David Jones, Neil Marlow, Alison Salt, David Taylor
BACKGROUND: The Medical Research Council (MRC) ORACLE trial evaluated the use of co-amoxiclav 375 mg and/or erythromycin 250 mg in women presenting with preterm rupture of membranes (PROM) ORACLE I or in spontaneous preterm labour (SPL) ORACLE II using a factorial design. The results showed that for women with a singleton baby with PROM the prescription of erythromycin is associated with improvements in short term neonatal outcomes, although co-amoxiclav is associated with prolongation of pregnancy, a significantly higher rate of neonatal necrotising enterocolitis was found in these babies...
April 24, 2008: BMC Pregnancy and Childbirth
R W Naef, J R Allbert, E L Ross, B M Weber, R W Martin, J C Morrison
OBJECTIVE: Our purpose was to compare induction of labor with preterm rupture of membranes between 34 and 37 weeks' gestation with expectant management. STUDY DESIGN: In this prospective investigation 120 gravid women at > or = 34 weeks 0 days and < 36 weeks 6 days of gestation were randomized to receive oxytocin induction (n = 57) or observation (n = 63). RESULTS: Estimated gestational age at rupture of membranes (34.3 +/- 1.4 weeks vs 34...
January 1998: American Journal of Obstetrics and Gynecology
David P van der Ham, Jantien L van der Heyden, Brent C Opmeer, Antonius L M Mulder, Rob M J Moonen, J Hans J van Beek, Maureen T M Franssen, Kitty W M Bloemenkamp, J Marko M Sikkema, Christianne J M de Groot, Martina Porath, Anneke Kwee, Mallory D Woiski, J Hans J Duvekot, Bettina M C Akerboom, Aren J van Loon, Jan W de Leeuw, Christine Willekes, Ben W J Mol, Jan G Nijhuis
OBJECTIVE: The evidence for the management of near term prelabor rupture of membranes is poor. From January 2007 until September 2009, we performed the PPROM Expectant Management versus Induction of Labor (PPROMEXIL) trial. In this trial, we showed that in women with preterm prelabor rupture of membranes (PPROM), the incidence of neonatal sepsis was low, and the induction of labor (IoL) did not reduce this risk. Because the PPROMEXIL trial was underpowered and because of a lower-than-expected incidence of neonatal sepsis, we performed a second trial (PPROMEXIL-2), aiming to randomize 200 patients to improve the evidence in near-term PPROM...
October 2012: American Journal of Obstetrics and Gynecology
Sara Kenyon, David J Taylor
OBJECTIVE: To estimate the short term effect of the publication of a major clinical trial on clinical practise. DESIGN: Questionnaire survey of clinical practise. SETTING: UK. POPULATION: All maternity units in the UK. METHOD: A self-administered questionnaire completed by lead consultants on delivery suite of maternity units. MAIN OUTCOME MEASURES: Changes in antibiotic prescription...
December 2002: BJOG: An International Journal of Obstetrics and Gynaecology
Aaron B Caughey, Julian N Robinson, Errol R Norwitz
Spontaneous rupture of membranes (ROM) is a normal component of labor and delivery. Premature ROM (PROM) refers to rupture of the fetal membranes prior to the onset of labor irrespective of gestational age. Once the membranes rupture, delivery is recommended when the risk of ascending infection outweighs the risk of prematurity. When PROM occurs at term, labor typically ensues spontaneously or is induced within 12 to 24 hours. The management of pregnancies complicated by preterm PROM (defined as PROM occurring prior to 37 weeks of gestation) is more challenging...
2008: Reviews in Obstetrics and Gynecology
R Devlieger, L K Millar, G Bryant-Greenwood, L Lewi, J A Deprest
In view of the important protective role of the fetal membranes, wound sealing, tissue regeneration, or wound healing could be life saving in cases of preterm premature rupture of the membranes. Although many investigators are studying the causes of preterm premature rupture of membranes, the emphasis has not been on the wound healing capacity of the fetal membranes. In this review, the relevant literature on the pathophysiologic condition that leads to preterm premature rupture of membranes will be summarized to emphasize a continuum of events between rupture and repair...
December 2006: American Journal of Obstetrics and Gynecology
S L Kenyon, D J Taylor, W Tarnow-Mordi
BACKGROUND: Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue. METHODS: 4826 women with pPROM were randomly assigned 250 mg erythromycin (n=1197), 325 mg co-amoxiclav (250 mg amoxicillin plus 125 mg clavulanic acid; n=1212), both (n=1192), or placebo (n=1225) four times daily for 10 days or until delivery...
March 31, 2001: Lancet
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"