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Renal papers

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33 papers 100 to 500 followers
Florentina E Sileanu, Raghavan Murugan, Nicole Lucko, Gilles Clermont, Sandra L Kane-Gill, Steven M Handler, John A Kellum
BACKGROUND AND OBJECTIVES: AKI in critically ill patients is usually part of multiorgan failure. However, nonrenal organ failure may not always precede AKI and patients without evidence of these organ failures may not be at low risk for AKI. This study examined the risk and outcomes associated with AKI in critically ill patients with and without cardiovascular or respiratory organ failures at presentation to the intensive care unit (ICU). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A large, academic medical center database, with records from July 2000 through October 2008, was used and the authors identified a low-risk cohort as patients without cardiovascular and respiratory organ failures defined as not receiving vasopressor support or mechanical ventilation within the first 24 hours of ICU admission...
February 6, 2015: Clinical Journal of the American Society of Nephrology: CJASN
Ibrahim Batal, Robert L Schlossman, Kassem Safa, Helmut G Rennke, Eric S Campenot
No abstract text is available yet for this article.
November 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jürgen Floege, Danilo Fliser
No abstract text is available yet for this article.
June 2015: Journal of the American Society of Nephrology: JASN
Manuel Praga, Angel Sevillano, Pilar Auñón, Ester González
Acute interstitial nephritis (AIN) is an important cause of acute kidney injury that has experienced significant epidemiological and clinical changes in the last years. The classical presentation, mostly induced by antibiotics and accompanied by evident hypersensitivity manifestations (skin rash, eosinophilia, fever) has been largely replaced by oligosymptomatic presentations that require a higher index of suspicion and are increasingly recognized in the elderly, having non-steroidal anti-inflammatory agents and proton pump inhibitors as frequent offending drugs...
September 2015: Nephrology, Dialysis, Transplantation
Marc N Turenne, Elizabeth L Cope, Shannon Porenta, Purna Mukhopadhyay, Douglas S Fuller, Jeffrey M Pearson, Claudia Dahlerus, Brett Lantz, Francesca Tentori, Bruce M Robinson
Implementation of the Medicare ESRD prospective payment system (PPS) and changes to dosing guidelines for erythropoiesis-stimulating agents (ESAs) in 2011 appear to have influenced use of injectable medications among dialysis patients. Given historically higher ESA and vitamin D use among black patients, we assessed the effect of these policy changes on racial disparities in the management of anemia and mineral metabolism. Analyses used cross-sectional monthly cohorts for a period-prevalent sample of 7384 maintenance hemodialysis patients at 132 facilities from the Dialysis Outcomes and Practice Patterns Study (DOPPS) Practice Monitor...
March 2015: Journal of the American Society of Nephrology: JASN
Michael J Kemna, Jan Damoiseaux, Jos Austen, Bjorn Winkens, Jim Peters, Pieter van Paassen, Jan Willem Cohen Tervaert
The value of measuring ANCA during follow-up to predict a relapse is controversial. On the basis of recently obtained pathophysiologic insights, we postulated that measuring ANCA is useful in patients with renal involvement but is less valuable in patients with nonrenal disease. One hundred sixty-six consecutive patients with ANCA-associated vasculitis, positive for either proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA, were included in our study, followed at regular intervals, and tested for PR3-ANCA and MPO-ANCA...
March 2015: Journal of the American Society of Nephrology: JASN
Judith Blaine, Michel Chonchol, Moshe Levi
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration...
July 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
David B Mount
The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition. The last decade has witnessed tremendous progress in the understanding of the molecular physiology and pathophysiology of this nephron segment. These advances are the subject of this review, with emphasis on particularly recent developments...
November 7, 2014: Clinical Journal of the American Society of Nephrology: CJASN
Orson W Moe, Makoto Kuro-o
Although epidemiologic associations have been informative, the elucidation of the role of fibroblast growth factor 23 (FGF23) in chronic kidney disease (CKD) requires testing with robust experimental models. Jimbo et al. used animal and cell-culture models to query whether FGF23 is a direct 'vasculotoxin.' We discuss the interpretation of their findings. At this juncture, much remains unanswered about the significance of FGF23 elevation in CKD.
May 2014: Kidney International
Dwight A Towler
No abstract text is available yet for this article.
February 2015: Journal of the American Society of Nephrology: JASN
M M Nascimento, S Y Hayashi, M C Riella, B Lindholm
Osteoprotegerin (OPG) regulates bone mass by inhibiting osteoclast differentiation and activation, and plays a role in vascular calcification. We evaluated the relationship between osteoprotegerin levels and inflammatory markers, atherosclerosis, and mortality in patients with stages 3-5 chronic kidney disease. A total of 145 subjects (median age 61 years, 61% men; 36 patients on hemodialysis, 55 patients on peritoneal dialysis, and 54 patients with stages 3-5 chronic kidney disease) were studied. Clinical characteristics, markers of mineral metabolism (including fibroblast growth factor-23 [FGF-23]) and inflammation (high-sensitivity C-reactive protein [hsCRP] and interleukin-6 [IL-6]), and the intima-media thickness (IMT) in the common carotid arteries were measured at baseline...
November 2014: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Guillaume Canaud, Joseph V Bonventre
For several decades, acute kidney injury (AKI) was generally considered a reversible process leading to complete kidney recovery if the individual survived the acute illness. Recent evidence from epidemiologic studies and animal models, however, have highlighted that AKI can lead to the development of fibrosis and facilitate the progression of chronic renal failure. When kidney injury is mild and baseline function is normal, the repair process can be adaptive with few long-term consequences. When the injury is more severe, repeated, or to a kidney with underlying disease, the repair can be maladaptive and epithelial cell cycle arrest may play an important role in the development of fibrosis...
April 2015: Nephrology, Dialysis, Transplantation
Nadine M Khouzam, Katherine Wesseling-Perry, Isidro B Salusky
Cardiovascular disease is the leading cause of death in pediatric patients with chronic kidney disease (CKD), and vascular calcifications start early in the course of CKD. Based on the growing body of evidence that alterations of bone and mineral metabolism and the therapies designed to treat the skeletal consequences of CKD are linked to cardiovascular calcifications, the Kidney Disease, Improving Global Outcomes (KDIGO) working group redefined renal osteodystrophy as a systemic disorder of mineral and bone metabolism due to CKD, and this newly defined disorder is now known as "chronic kidney disease-mineral bone disorder (CKD-MBD)"...
September 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Andrew Mente, Martin J O'Donnell, Sumathy Rangarajan, Matthew J McQueen, Paul Poirier, Andreas Wielgosz, Howard Morrison, Wei Li, Xingyu Wang, Chen Di, Prem Mony, Anitha Devanath, Annika Rosengren, Aytekin Oguz, Katarzyna Zatonska, Afzal Hussein Yusufali, Patricio Lopez-Jaramillo, Alvaro Avezum, Noorhassim Ismail, Fernando Lanas, Thandi Puoane, Rafael Diaz, Roya Kelishadi, Romaina Iqbal, Rita Yusuf, Jephat Chifamba, Rasha Khatib, Koon Teo, Salim Yusuf
BACKGROUND: Higher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potassium intake and in different populations is unknown. METHODS: We studied 102,216 adults from 18 countries. Estimates of 24-hour sodium and potassium excretion were made from a single fasting morning urine specimen and were used as surrogates for intake. We assessed the relationship between electrolyte excretion and blood pressure, as measured with an automated device...
August 14, 2014: New England Journal of Medicine
Martin O'Donnell, Andrew Mente, Sumathy Rangarajan, Matthew J McQueen, Xingyu Wang, Lisheng Liu, Hou Yan, Shun Fu Lee, Prem Mony, Anitha Devanath, Annika Rosengren, Patricio Lopez-Jaramillo, Rafael Diaz, Alvaro Avezum, Fernando Lanas, Khalid Yusoff, Romaina Iqbal, Rafal Ilow, Noushin Mohammadifard, Sadi Gulec, Afzal Hussein Yusufali, Lanthe Kruger, Rita Yusuf, Jephat Chifamba, Conrad Kabali, Gilles Dagenais, Scott A Lear, Koon Teo, Salim Yusuf
BACKGROUND: The optimal range of sodium intake for cardiovascular health is controversial. METHODS: We obtained morning fasting urine samples from 101,945 persons in 17 countries and estimated 24-hour sodium and potassium excretion (used as a surrogate for intake). We examined the association between estimated urinary sodium and potassium excretion and the composite outcome of death and major cardiovascular events. RESULTS: The mean estimated sodium and potassium excretion was 4...
August 14, 2014: New England Journal of Medicine
James N George, Carla M Nester
This review article covers the diverse pathophysiological pathways that can lead to microangiopathic hemolytic anemia and a procoagulant state with or without damage to the kidneys and other organs.
August 14, 2014: New England Journal of Medicine
Casey M Rebholz, Morgan E Grams, Josef Coresh, Elizabeth Selvin, Lesley A Inker, Andrew S Levey, Paul L Kimmel, Ramachandran S Vasan, John H Eckfeldt, Harold I Feldman, Chi-Yuan Hsu, Pamela L Lutsey
Fibroblast growth factor-23 is a bone-derived hormone that increases urinary phosphate excretion and inhibits hydroxylation of 25-hydroxyvitamin D. Recent studies suggest that fibroblast growth factor-23 may be an early biomarker of CKD progression. However, its role in kidney function decline in the general population is unknown. We assessed the relationship between baseline (1990-1992) serum levels of intact fibroblast growth factor-23 and incident ESRD in 13,448 Atherosclerosis Risk in Communities study participants (56...
January 2015: Journal of the American Society of Nephrology: JASN
Myles Wolf
No abstract text is available yet for this article.
January 2015: Journal of the American Society of Nephrology: JASN
Alex R Chang, Morgan E Grams
BACKGROUND: Serum phosphorus levels have been associated with mortality in some but not all studies. Because dietary intake prior to measurement can affect serum phosphorus levels, we hypothesized that the association between serum phosphorus level and mortality is strongest in those who have fasted longer. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Nationally representative sample of 12,984 participants 20 years or older in the Third National Health and Nutrition Examination Survey (1988-1994)...
October 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Linda F Fried, Nicholas Emanuele, Jane H Zhang, Mary Brophy, Todd A Conner, William Duckworth, David J Leehey, Peter A McCullough, Theresa O'Connor, Paul M Palevsky, Robert F Reilly, Stephen L Seliger, Stuart R Warren, Suzanne Watnick, Peter Peduzzi, Peter Guarino
Combination therapy with angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) decreases proteinuria; however, its safety and effect on the progression of kidney disease are uncertain. Methods We provided losartan (at a dose of 100 mg per day) to patients with type 2 diabetes, a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 300, and an estimated glomerular filtration rate (GFR) of 30.0 to 89.9 ml per minute per 1...
November 14, 2013: New England Journal of Medicine
2014-08-24 18:28:24
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