J A Rosenfeld, M E Tucker, L F Escobar, N J Neill, B S Torchia, L D McDaniel, R A Schultz, K Chong, D Chitayat
OBJECTIVES: To determine the frequency of clinically significant chromosomal abnormalities identified by chromosomal microarray in pregnancy losses at any gestational age and to compare microarray performance with that of traditional cytogenetic analysis when testing pregnancy losses. METHODS: Among 535 fetal demise specimens of any gestational age, clinical microarray-based comparative genomic hybridization (aCGH) was performed successfully on 515, and a subset of 107 specimens underwent additional single nucleotide polymorphism (SNP) analysis...
October 2015: Ultrasound in Obstetrics & Gynecology