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Psc

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By Carlos Jeismann Md hi/std and pediatrician
https://www.readbyqxmd.com/read/24284287/trimethoprim-sulfamethoxazole-versus-trimethoprim-sulfamethoxazole-plus-doxycycline-as-oral-eradicative-treatment-for-melioidosis-merth-a-multicentre-double-blind-non-inferiority-randomised-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
Ploenchan Chetchotisakd, Wirongrong Chierakul, Wipada Chaowagul, Siriluck Anunnatsiri, Kriangsak Phimda, Piroon Mootsikapun, Seksan Chaisuksant, Jiraporn Pilaikul, Bandit Thinkhamrop, Sunchai Phiphitaporn, Wattanachai Susaengrat, Chalongchai Toondee, Surasakdi Wongrattanacheewin, Vanaporn Wuthiekanun, Narisara Chantratita, Janjira Thaipadungpanit, Nicholas P Day, Direk Limmathurotsakul, Sharon J Peacock
BACKGROUND: Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial evidence is trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline. This regimen is used in Thailand but is associated with side-effects and poor adherence by patients, and TMP-SMX alone is recommended in Australia...
March 1, 2014: Lancet
https://www.readbyqxmd.com/read/23827861/pathogenesis-of-primary-sclerosing-cholangitis-and-advances-in-diagnosis-and-management
#2
REVIEW
John E Eaton, Jayant A Talwalkar, Konstantinos N Lazaridis, Gregory J Gores, Keith D Lindor
Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver disease that is heterogeneous in its presentation. PSC is characterized by chronic cholestasis associated with chronic inflammation of the biliary epithelium, resulting in multifocal bile duct strictures that can affect the entire biliary tree. Chronic inflammation leads to fibrosis involving the hepatic parenchyma and biliary tree, which can lead to cirrhosis and malignancy. The etiology of PSC is not fully understood, which in part explains the lack of effective medical therapy for this condition...
September 2013: Gastroenterology
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