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RANDOMIZED CONTROLLED TRIAL
H Ijäs, M Vääräsmäki, L Morin-Papunen, R Keravuo, T Ebeling, T Saarela, T Raudaskoski
OBJECTIVE: To examine if oral metformin is as effective as insulin in the prevention of fetal macrosomy in pregnancies complicated with gestational diabetes mellitus (GDM). DESIGN: Open-label prospective randomised controlled study. SETTING: Maternity outpatient clinics in a secondary and tertiary level hospital in Finland. SAMPLE: One hundred women with GDM who did not attain euglycaemia with diet. METHODS: Women were randomised to therapy with insulin (n = 50) or oral metformin (n = 50)...
June 2011: BJOG: An International Journal of Obstetrics and Gynaecology
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REVIEW
Kjell Haram, Einar Svendsen, Ulrich Abildgaard
BACKGROUND: The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10-20% of cases with severe preeclampsia. The present review highlights occurrence, diagnosis, complications, surveillance, corticosteroid treatment, mode of delivery and risk of recurrence. METHODS: Clinical reports and reviews published between 2000 and 2008 were screened using Pub Med and Cochrane databases...
2009: BMC Pregnancy and Childbirth
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