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46 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27141432/idiopathic-pleuroparenchymal-fibroelastosis-a-rare-idiopathic-interstitial-pneumonia
#1
Balamugesh Thangakunam, Barney T J Isaac, Devasahayam Jesudas Christopher, Deepak Burad
Idiopathic pleuroparenchymal fibroelastosis is a rare idiopathic interstitial pneumonia. It was first described in 2004 and subsequently included in the ATS/ERS classification of idiopathic interstitial pneumonia in 2013. There have been few cases reported so far. The diagnostic criteria is still emerging and its etiology is being questioned. We report a case of pleuroparenchymal fibroelastosis probably idiopathic, the first of its kind to be reported from India, and a brief review of the literature.
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/25906089/diffuse-cystic-lung-disease-part-i
#2
REVIEW
Nishant Gupta, Robert Vassallo, Kathryn A Wikenheiser-Brokamp, Francis X McCormack
The diffuse cystic lung diseases (DCLDs) are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. Although the mechanisms of cyst formation remain incompletely defined for all DCLDs, in most cases lung remodeling associated with inflammatory or infiltrative processes results in displacement, destruction, or replacement of alveolar septa, distal airways, and small vessels within the secondary lobules of the lung...
June 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25894572/the-utility-of-thoracic-ultrasound-in-patients-with-acute-eosinophilic-pneumonia
#3
COMPARATIVE STUDY
Hee Yoon, Se Jin Kim, Kang Kim, Ji Eun Lee, Byung Woo Jhun
Thoracic ultrasound (TUS) is an easy-to-use imaging modality that aids physicians in the differential diagnosis of respiratory diseases. However, no data exist on the TUS findings of acute eosinophilic pneumonia (AEP) or their clinical utility in patients with AEP. Thus, we performed an observational study on TUS findings and their clinical utility for follow-up in patients with AEP. We prospectively screened patients who visited the emergency department for acute respiratory symptoms at the Armed Forces Capital Hospital in South Korea between February 2014 and July 2014...
2015: PloS One
https://www.readbyqxmd.com/read/25435521/management-of-pulmonary-embolism-recent-evidence-and-the-new-european-guidelines
#4
EDITORIAL
Stavros V Konstantinides, Adam Torbicki
No abstract text is available yet for this article.
December 2014: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25504993/hfe-gene-variants-and-iron-induced-oxygen-radical-generation-in-idiopathic-pulmonary-fibrosis
#5
Federica Sangiuolo, Ermanno Puxeddu, Gabriella Pezzuto, Francesco Cavalli, Giuliana Longo, Alessia Comandini, Donato Di Pierro, Marco Pallante, Gianluigi Sergiacomi, Giovanni Simonetti, Maurizio Zompatori, Augusto Orlandi, Andrea Magrini, Massimo Amicosante, Francesca Mariani, Monica Losi, Daniela Fraboni, Alberto Bisetti, Cesare Saltini
In idiopathic pulmonary fibrosis (IPF), lung accumulation of excessive extracellular iron and macrophage haemosiderin may suggest disordered iron homeostasis leading to recurring microscopic injury and fibrosing damage. The current study population comprised 89 consistent IPF patients and 107 controls. 54 patients and 11 controls underwent bronchoalveolar lavage (BAL). Haemosiderin was assessed by Perls' stain, BAL fluid malondialdehyde (MDA) by high-performance liquid chromatography, BAL cell iron-dependent oxygen radical generation by fluorimetry and the frequency of hereditary haemochromatosis HFE gene variants by reverse dot blot hybridisation...
February 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25504994/safety-and-pharmacokinetics-of-nintedanib-and-pirfenidone-in-idiopathic-pulmonary-fibrosis
#6
RANDOMIZED CONTROLLED TRIAL
Takashi Ogura, Hiroyuki Taniguchi, Arata Azuma, Yoshikazu Inoue, Yasuhiro Kondoh, Yoshinori Hasegawa, Masashi Bando, Shinji Abe, Yoshiro Mochizuki, Kingo Chida, Matthias Klüglich, Tsuyoshi Fujimoto, Kotaro Okazaki, Yusuke Tadayasu, Wataru Sakamoto, Yukihiko Sugiyama
A randomised, double-blind, phase II, dose escalation trial was conducted to assess the safety, tolerability and pharmacokinetics of the tyrosine kinase inhibitor nintedanib, alone and when added to ongoing pirfenidone therapy, in Japanese patients with idiopathic pulmonary fibrosis. 50 Japanese patients were randomised to receive nintedanib or placebo in one of three cohorts (nintedanib 50 mg twice daily or 100 mg twice daily for 14 days, or 150 mg twice daily for 28 days). Patients receiving pirfenidone at inclusion were stratified to every nintedanib dose group and placebo...
May 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25537566/nonspecific-interstitial-pneumonia-survival-is-influenced-by-the-underlying-cause
#7
Hilario Nunes, Kirsten Schubel, Diane Piver, Eline Magois, Séverine Feuillet, Yurdagul Uzunhan, Zohra Carton, Abdellatif Tazi, Pierre Levy, Pierre-Yves Brillet, Andrew G Nicholson, Marianne Kambouchner, Dominique Valeyre
Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that "idiopathic" NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying cause remains uncertain. This retrospective study included 127 biopsy-proven NSIP patients (65 women, mean ± sd age 55 ± 12 years)...
March 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25607436/rituximab-or-azathioprine-maintenance-in-anca-associated-vasculitis
#8
LETTER
Laurent Chouchana, Philippe Beaune, Marie-Anne Loriot
No abstract text is available yet for this article.
January 22, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25333685/relationship-of-dna-methylation-and-gene-expression-in-idiopathic-pulmonary-fibrosis
#9
Ivana V Yang, Brent S Pedersen, Einat Rabinovich, Corinne E Hennessy, Elizabeth J Davidson, Elissa Murphy, Brenda Juan Guardela, John R Tedrow, Yingze Zhang, Mandal K Singh, Mick Correll, Marvin I Schwarz, Mark Geraci, Frank C Sciurba, John Quackenbush, Avrum Spira, Naftali Kaminski, David A Schwartz
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease that is increasing in prevalence and is caused by complex interactions between genetic and environmental factors. Epigenetic mechanisms control gene expression and are likely to regulate the IPF transcriptome. OBJECTIVES: To identify methylation marks that modify gene expression in IPF lung. METHODS: We assessed DNA methylation (comprehensive high-throughput arrays for relative methylation arrays [CHARM]) and gene expression (Agilent gene expression arrays) in 94 patients with IPF and 67 control subjects, and performed integrative genomic analyses to define methylation-gene expression relationships in IPF lung...
December 1, 2014: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25358054/hypoxia-induced-deoxycytidine-kinase-contributes-to-epithelial-proliferation-in-pulmonary-fibrosis
#10
Tingting Weng, Jens M Poth, Harry Karmouty-Quintana, Luis J Garcia-Morales, Ernestina Melicoff, Fayong Luo, Ning-yuan Chen, Christopher M Evans, Raquel R Bunge, Brian A Bruckner, Matthias Loebe, Kelly A Volcik, Holger K Eltzschig, Michael R Blackburn
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease with few therapeutic options. Apoptosis of alveolar epithelial cells, followed by abnormal tissue repair characterized by hyperplastic epithelial cell formation, is a pathogenic process that contributes to the progression of pulmonary fibrosis. However, the signaling pathways responsible for increased proliferation of epithelial cells remain poorly understood. OBJECTIVES: To investigate the role of deoxycytidine kinase (DCK), an important enzyme for the salvage of deoxynucleotides, in the progression of pulmonary fibrosis...
December 15, 2014: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25275363/the-muc5b-promoter-polymorphism-is-associated-with-idiopathic-pulmonary-fibrosis-in-a-mexican-cohort-but-is-rare-among-asian-ancestries
#11
Anna L Peljto, Moises Selman, Dong Soon Kim, Elissa Murphy, Laura Tucker, Annie Pardo, Jung Su Lee, Wonjun Ji, Marvin I Schwarz, Ivana V Yang, David A Schwartz, Tasha E Fingerlin
BACKGROUND: Polymorphisms in the MUC5B promoter, TOLLIP, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic white populations. It is unknown whether these variants account for risk of IPF in other racial/ethnic populations. We conducted a candidate single nucleotide polymorphism (SNP) association study in cohorts of Mexican and Korean patients with IPF. METHODS: We chose 12 SNPs from 11 loci that are associated with IPF among non-Hispanic whites and genotyped these SNPs in cohorts of Mexican (83 patients, 111 control subjects) and Korean (239 patients, 87 control subjects) people...
February 2015: Chest
https://www.readbyqxmd.com/read/25217476/heterogeneous-gene-expression-signatures-correspond-to-distinct-lung-pathologies-and-biomarkers-of-disease-severity-in-idiopathic-pulmonary-fibrosis
#12
Daryle J DePianto, Sanjay Chandriani, Alexander R Abbas, Guiquan Jia, Elsa N N'Diaye, Patrick Caplazi, Steven E Kauder, Sabyasachi Biswas, Satyajit K Karnik, Connie Ha, Zora Modrusan, Michael A Matthay, Jasleen Kukreja, Harold R Collard, Jackson G Egen, Paul J Wolters, Joseph R Arron
BACKGROUND: There is microscopic spatial and temporal heterogeneity of pathological changes in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity in pathophysiological mediators of disease and clinical progression. We assessed relationships between gene expression patterns, pathological features, and systemic biomarkers to identify biomarkers that reflect the aggregate disease burden in patients with IPF. METHODS: Gene expression microarrays (N=40 IPF; 8 controls) and immunohistochemical analyses (N=22 IPF; 8 controls) of lung biopsies...
January 2015: Thorax
https://www.readbyqxmd.com/read/25205586/inhaled-corticosteroids-modulate-the-insert-smooth-muscle-myosin-heavy-chain-in-the-equine-asthmatic-airways
#13
Roxane Boivin, Amandine Vargas, Josiane Lefebvre-Lavoie, Anne-Marie Lauzon, Jean-Pierre Lavoie
RATIONALE: Overexpression of the (+)insert smooth muscle myosin heavy chain (SMMHC) isoform could contribute to airway bronchospasm by increasing the velocity of contraction. Whether the (+)insert isoform is present in the small airways and its expression is reversible in asthma are unknown. OBJECTIVES: To determine the anatomical location and the expression kinetics of the (+)insert SMMHC isoform in airways of horses with heaves and to evaluate its modulation in response to disease status...
December 2014: Thorax
https://www.readbyqxmd.com/read/25192356/genome-sequencing-of-idiopathic-pulmonary-fibrosis-in-conjunction-with-a-medical-school-human-anatomy-course
#14
Akash Kumar, Max Dougherty, Gregory M Findlay, Madeleine Geisheker, Jason Klein, John Lazar, Heather Machkovech, Jesse Resnick, Rebecca Resnick, Alexander I Salter, Faezeh Talebi-Liasi, Christopher Arakawa, Jacob Baudin, Andrew Bogaard, Rebecca Salesky, Qian Zhou, Kelly Smith, John I Clark, Jay Shendure, Marshall S Horwitz
Even in cases where there is no obvious family history of disease, genome sequencing may contribute to clinical diagnosis and management. Clinical application of the genome has not yet become routine, however, in part because physicians are still learning how best to utilize such information. As an educational research exercise performed in conjunction with our medical school human anatomy course, we explored the potential utility of determining the whole genome sequence of a patient who had died following a clinical diagnosis of idiopathic pulmonary fibrosis (IPF)...
2014: PloS One
https://www.readbyqxmd.com/read/25191954/a-decision-analytic-view-of-anticoagulant-prohylaxis-for-thromboembolism-in-heart-disease
#15
(no author information available yet)
No abstract text is available yet for this article.
February 1, 1986: Chest
https://www.readbyqxmd.com/read/25146621/giant-cell-interstitial-pneumonia-unusual-lung-disorder-and-an-update
#16
Jinghong Dai, Mei Huang, Min Cao, Liyun Miao, Yonglong Xiao, Yi Shi, Fanqing Meng, Hourong Cai
BACKGROUND: Giant cell interstitial pneumonia (GIP) was a rare form of pneumoconiosis, associated with exposure to hard metals, which had been reported mostly as isolated case reports. We described eight cases of GIP diagnosed in our hospital during the past seven years, with particular reference to new findings. METHODS: Eight patients with GIP confirmed by biopsy in the Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University from 2005 to 2011 were retrospectively analyzed...
2014: Chinese Medical Journal
https://www.readbyqxmd.com/read/25140952/fda-approval-of-bedaquiline-the-benefit-risk-balance-for-drug-resistant-tuberculosis
#17
COMMENT
Edward Cox, Katherine Laessig
Bedaquiline was approved by the Food and Drug Administration (FDA) at the end of 2012 for the treatment of adults with multidrug-resistant pulmonary tuberculosis for whom an effective treatment regimen is not otherwise available. One complexity facing the FDA in reviewing the bedaquiline marketing..
August 21, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25122433/toxicities-of-organs-at-risk-in-the-mediastinal-and-hilar-regions-following-stereotactic-body-radiotherapy-for-centrally-located-lung-tumors
#18
Shuichi Nishimura, Atsuya Takeda, Naoko Sanuki, Satoshi Ishikura, Yohei Oku, Yousuke Aoki, Etsuo Kunieda, Naoyuki Shigematsu
INTRODUCTION: We investigated tolerable doses to organs at risk (OARs) in the mediastinum and pulmonary hilum following stereotactic body radiotherapy for centrally located lung tumors. METHODS: Between 2005 and 2012, 381 patients with lung tumors were treated with stereotactic body radiotherapy of 40 to 60 Gy in five fractions. From among these patients, we extracted those who received greater than 25 Gy irradiation to OARs and analyzed dosimetric factors in relation to grade 3 to 5 toxicities...
September 2014: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/25127540/lung-transplantation-in-idiopathic-pulmonary-fibrosis-a-systematic-review-of-the-literature
#19
REVIEW
Kristin D Kistler, Luba Nalysnyk, Philip Rotella, Dirk Esser
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a distinct form of interstitial pneumonia with unknown origin and poor prognosis. Current pharmacologic treatments are limited and lung transplantation is a viable option for appropriate patients. The aim of this review was to summarize lung transplantation survival in IPF patients overall, between single (SLT) vs. bilateral lung transplantation (BLT), pre- and post Lung Allocation Score (LAS), and summarize wait-list survival. METHODS: A systematic review of English-language studies published in Medline or Embase between 1990 and 2013 was performed...
2014: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/25135806/antimicrobial-stewardship-and-linezolid
#20
Pauline Guillard, Arnaud de La Blanchardière, Vincent Cattoir, Marc-Olivier Fischer, Renaud Verdon, Guillaume Saint-Lorant
BACKGROUND: Since 2002, linezolid, the first representative of the oxazolidinone class, has been widely prescribed, sometimes outside of approved indications. However, several cases of clinical outbreaks due to linezolid-resistant organisms have been reported, and its relatively high cost represents an economic challenge for hospital settings. OBJECTIVES: The aim of this study was to assess the impact of different actions conducted by an antimicrobial stewardship team (AST) to control over-prescription of linezolid with regard to the defined daily dose (DDD) per 1,000 inhabitants per day...
October 2014: International Journal of Clinical Pharmacy
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